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P56476

- GBRR2_MOUSE

UniProt

P56476 - GBRR2_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit rho-2

Gene

Gabrr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 4 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission By similarity.By similarity

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: MGI

    GO - Biological processi

    1. chloride transport Source: MGI
    2. gamma-aminobutyric acid signaling pathway Source: MGI
    3. visual perception Source: MGI

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198557. GABA A (rho) receptor activation.
    REACT_198558. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit rho-2
    Alternative name(s):
    GABA(A) receptor subunit rho-2
    GABA(C) receptor
    Gene namesi
    Name:Gabrr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95626. Gabrr2.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. cell junction Source: UniProtKB-KW
    3. chloride channel complex Source: UniProtKB-KW
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 465445Gamma-aminobutyric acid receptor subunit rho-2PRO_0000000489Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi178 ↔ 192By similarity
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP56476.

    PTM databases

    PhosphoSiteiP56476.

    Expressioni

    Gene expression databases

    BgeeiP56476.
    GenevestigatoriP56476.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP56476.
    SMRiP56476. Positions 64-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 260240ExtracellularCuratedAdd
    BLAST
    Topological domaini347 – 44397CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77438.
    GeneTreeiENSGT00630000089571.
    HOGENOMiHOG000231335.
    HOVERGENiHBG051707.
    InParanoidiQ6PEP0.
    KOiK05190.
    OMAiDEHDFSM.
    OrthoDBiEOG712TVZ.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008059. GABAAa_rho2_rcpt.
    IPR008057. GABAAa_rho_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    PR01670. GABAARRHO.
    PR01672. GABAARRHO2.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: P56476-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPYLMRLALV LFCLMALVES RKPRRKRWTG LLETSKPSHL YKKNLDVTKM    50
    RPGKPRPLLR VEDHDFTMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM 100
    TLYLRHYWRD ERLAFPSSSN KSMTFDGRLV KKIWVPDVFF VHSKRSFIHD 150
    TTTDNIMLRV FPDGHVLYSM RITVTAMCNM DFSHFPLDSQ TCSLELESYA 200
    YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA FYSSTGWYNR 250
    LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDHRAV PARVSLGIMT 300
    VLTMSTIITG VNASMPRVSY IRAVDIYLWV SFVFVFLSVL EYAAVNYLTT 350
    LQEQKERKFR EKLPCMCGML HSRTMMLDGS YSESEANSLA GYPRSHILPE 400
    EERPDNIVVH LALNSELTSS RKKGLLKGQM GLYIFQNTHA IDKYSRLIFP 450
    AFYIVFNLIY WSVFS 465
    Length:465
    Mass (Da):54,231
    Last modified:October 31, 2012 - v4
    Checksum:iB44B51B572468A20
    GO
    Isoform 2 (identifier: P56476-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MVKPGGILPIKSPCTAACCIIDMCRM

    Note: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available.

    Show »
    Length:490
    Mass (Da):56,834
    Checksum:i18BBEDC2346C52D3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331E → D in AAB81965. 1 PublicationCurated
    Sequence conflicti52 – 521P → A in AAB81965. 1 PublicationCurated
    Sequence conflicti59 – 591L → F in AAB81965. 1 PublicationCurated
    Sequence conflicti88 – 881L → V in AAB81965. 1 PublicationCurated
    Sequence conflicti105 – 1051R → K in AAB81965. 1 PublicationCurated
    Sequence conflicti109 – 1091R → K in AAB81965. 1 PublicationCurated
    Sequence conflicti149 – 1491H → Q in AAB81965. 1 PublicationCurated
    Sequence conflicti357 – 3571R → L in AAB81965. 1 PublicationCurated
    Sequence conflicti366 – 3661M → V in AAB81965. 1 PublicationCurated
    Sequence conflicti372 – 3721S → A in AAB81965. 1 PublicationCurated
    Sequence conflicti394 – 3941R → T in AAB81965. 1 PublicationCurated
    Sequence conflicti400 – 4001E → K in AAB81965. 1 PublicationCurated
    Sequence conflicti421 – 4211R → K in AAB81965. 1 PublicationCurated
    Sequence conflicti429 – 4291Q → R in AAB81965. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MVKPGGILPIKSPCTAACCI IDMCRM in isoform 2. 1 PublicationVSP_044374

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024621 mRNA. Translation: AAB81965.1.
    CH466538 Genomic DNA. Translation: EDL05492.1.
    BC057957 mRNA. Translation: AAH57957.2.
    CCDSiCCDS18020.1. [P56476-2]
    RefSeqiNP_032102.2. NM_008076.3. [P56476-2]
    UniGeneiMm.6227.

    Genome annotation databases

    EnsembliENSMUST00000024035; ENSMUSP00000024035; ENSMUSG00000023267. [P56476-2]
    ENSMUST00000108162; ENSMUSP00000103797; ENSMUSG00000023267. [P56476-1]
    GeneIDi14409.
    KEGGimmu:14409.
    UCSCiuc008sfq.1. mouse. [P56476-1]

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024621 mRNA. Translation: AAB81965.1 .
    CH466538 Genomic DNA. Translation: EDL05492.1 .
    BC057957 mRNA. Translation: AAH57957.2 .
    CCDSi CCDS18020.1. [P56476-2 ]
    RefSeqi NP_032102.2. NM_008076.3. [P56476-2 ]
    UniGenei Mm.6227.

    3D structure databases

    ProteinModelPortali P56476.
    SMRi P56476. Positions 64-353.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 421.

    PTM databases

    PhosphoSitei P56476.

    Proteomic databases

    PRIDEi P56476.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024035 ; ENSMUSP00000024035 ; ENSMUSG00000023267 . [P56476-2 ]
    ENSMUST00000108162 ; ENSMUSP00000103797 ; ENSMUSG00000023267 . [P56476-1 ]
    GeneIDi 14409.
    KEGGi mmu:14409.
    UCSCi uc008sfq.1. mouse. [P56476-1 ]

    Organism-specific databases

    CTDi 2570.
    MGIi MGI:95626. Gabrr2.

    Phylogenomic databases

    eggNOGi NOG77438.
    GeneTreei ENSGT00630000089571.
    HOGENOMi HOG000231335.
    HOVERGENi HBG051707.
    InParanoidi Q6PEP0.
    KOi K05190.
    OMAi DEHDFSM.
    OrthoDBi EOG712TVZ.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_198557. GABA A (rho) receptor activation.
    REACT_198558. Ligand-gated ion channel transport.

    Miscellaneous databases

    NextBioi 285985.
    PROi P56476.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56476.
    Genevestigatori P56476.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008059. GABAAa_rho2_rcpt.
    IPR008057. GABAAa_rho_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    PR01670. GABAARRHO.
    PR01672. GABAARRHO2.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of GABA rho subunits in the mouse retina."
      Greka A., Koolen J.A., Lipton S.A., Zhang D.
      Abstr. - Soc. Neurosci. 23:1262-1262(1997)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.

    Entry informationi

    Entry nameiGBRR2_MOUSE
    AccessioniPrimary (citable) accession number: P56476
    Secondary accession number(s): Q6PEP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 122 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3