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P56476

- GBRR2_MOUSE

UniProt

P56476 - GBRR2_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit rho-2

Gene

Gabrr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (By similarity).By similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: MGI

GO - Biological processi

  1. chloride transport Source: MGI
  2. gamma-aminobutyric acid signaling pathway Source: MGI
  3. visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198557. GABA A (rho) receptor activation.
REACT_198558. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-2
Alternative name(s):
GABA(A) receptor subunit rho-2
GABA(C) receptor
Gene namesi
Name:Gabrr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95626. Gabrr2.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cell junction Source: UniProtKB-KW
  3. chloride channel complex Source: UniProtKB-KW
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 465445Gamma-aminobutyric acid receptor subunit rho-2PRO_0000000489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi178 ↔ 192By similarity
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP56476.

PTM databases

PhosphoSiteiP56476.

Expressioni

Gene expression databases

BgeeiP56476.
ExpressionAtlasiP56476. baseline and differential.
GenevestigatoriP56476.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP56476.
SMRiP56476. Positions 56-464.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 260240ExtracellularCuratedAdd
BLAST
Topological domaini347 – 44397CytoplasmicCuratedAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei261 – 28121HelicalSequence AnalysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP56476.
KOiK05190.
OMAiDEHDFSM.
OrthoDBiEOG712TVZ.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008059. GABAAa_rho2_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01672. GABAARRHO2.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: P56476-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYLMRLALV LFCLMALVES RKPRRKRWTG LLETSKPSHL YKKNLDVTKM
60 70 80 90 100
RPGKPRPLLR VEDHDFTMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM
110 120 130 140 150
TLYLRHYWRD ERLAFPSSSN KSMTFDGRLV KKIWVPDVFF VHSKRSFIHD
160 170 180 190 200
TTTDNIMLRV FPDGHVLYSM RITVTAMCNM DFSHFPLDSQ TCSLELESYA
210 220 230 240 250
YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA FYSSTGWYNR
260 270 280 290 300
LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDHRAV PARVSLGIMT
310 320 330 340 350
VLTMSTIITG VNASMPRVSY IRAVDIYLWV SFVFVFLSVL EYAAVNYLTT
360 370 380 390 400
LQEQKERKFR EKLPCMCGML HSRTMMLDGS YSESEANSLA GYPRSHILPE
410 420 430 440 450
EERPDNIVVH LALNSELTSS RKKGLLKGQM GLYIFQNTHA IDKYSRLIFP
460
AFYIVFNLIY WSVFS
Length:465
Mass (Da):54,231
Last modified:October 31, 2012 - v4
Checksum:iB44B51B572468A20
GO
Isoform 2 (identifier: P56476-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVKPGGILPIKSPCTAACCIIDMCRM

Note: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available.

Show »
Length:490
Mass (Da):56,834
Checksum:i18BBEDC2346C52D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331E → D in AAB81965. 1 PublicationCurated
Sequence conflicti52 – 521P → A in AAB81965. 1 PublicationCurated
Sequence conflicti59 – 591L → F in AAB81965. 1 PublicationCurated
Sequence conflicti88 – 881L → V in AAB81965. 1 PublicationCurated
Sequence conflicti105 – 1051R → K in AAB81965. 1 PublicationCurated
Sequence conflicti109 – 1091R → K in AAB81965. 1 PublicationCurated
Sequence conflicti149 – 1491H → Q in AAB81965. 1 PublicationCurated
Sequence conflicti357 – 3571R → L in AAB81965. 1 PublicationCurated
Sequence conflicti366 – 3661M → V in AAB81965. 1 PublicationCurated
Sequence conflicti372 – 3721S → A in AAB81965. 1 PublicationCurated
Sequence conflicti394 – 3941R → T in AAB81965. 1 PublicationCurated
Sequence conflicti400 – 4001E → K in AAB81965. 1 PublicationCurated
Sequence conflicti421 – 4211R → K in AAB81965. 1 PublicationCurated
Sequence conflicti429 – 4291Q → R in AAB81965. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVKPGGILPIKSPCTAACCI IDMCRM in isoform 2. 1 PublicationVSP_044374

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024621 mRNA. Translation: AAB81965.1.
CH466538 Genomic DNA. Translation: EDL05492.1.
BC057957 mRNA. Translation: AAH57957.2.
CCDSiCCDS18020.1. [P56476-2]
RefSeqiNP_032102.2. NM_008076.3. [P56476-2]
UniGeneiMm.6227.

Genome annotation databases

EnsembliENSMUST00000024035; ENSMUSP00000024035; ENSMUSG00000023267. [P56476-2]
ENSMUST00000108162; ENSMUSP00000103797; ENSMUSG00000023267. [P56476-1]
GeneIDi14409.
KEGGimmu:14409.
UCSCiuc008sfq.1. mouse. [P56476-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024621 mRNA. Translation: AAB81965.1 .
CH466538 Genomic DNA. Translation: EDL05492.1 .
BC057957 mRNA. Translation: AAH57957.2 .
CCDSi CCDS18020.1. [P56476-2 ]
RefSeqi NP_032102.2. NM_008076.3. [P56476-2 ]
UniGenei Mm.6227.

3D structure databases

ProteinModelPortali P56476.
SMRi P56476. Positions 56-464.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 421.

PTM databases

PhosphoSitei P56476.

Proteomic databases

PRIDEi P56476.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024035 ; ENSMUSP00000024035 ; ENSMUSG00000023267 . [P56476-2 ]
ENSMUST00000108162 ; ENSMUSP00000103797 ; ENSMUSG00000023267 . [P56476-1 ]
GeneIDi 14409.
KEGGi mmu:14409.
UCSCi uc008sfq.1. mouse. [P56476-1 ]

Organism-specific databases

CTDi 2570.
MGIi MGI:95626. Gabrr2.

Phylogenomic databases

eggNOGi NOG77438.
GeneTreei ENSGT00760000118821.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi P56476.
KOi K05190.
OMAi DEHDFSM.
OrthoDBi EOG712TVZ.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_198557. GABA A (rho) receptor activation.
REACT_198558. Ligand-gated ion channel transport.

Miscellaneous databases

NextBioi 285985.
PROi P56476.
SOURCEi Search...

Gene expression databases

Bgeei P56476.
ExpressionAtlasi P56476. baseline and differential.
Genevestigatori P56476.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008059. GABAAa_rho2_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01672. GABAARRHO2.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of GABA rho subunits in the mouse retina."
    Greka A., Koolen J.A., Lipton S.A., Zhang D.
    Abstr. - Soc. Neurosci. 23:1262-1262(1997)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.

Entry informationi

Entry nameiGBRR2_MOUSE
AccessioniPrimary (citable) accession number: P56476
Secondary accession number(s): Q6PEP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 31, 2012
Last modified: October 29, 2014
This is version 123 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3