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P56476 (GBRR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit rho-2
Alternative name(s):
GABA(A) receptor subunit rho-2
GABA(C) receptor
Gene names
Name:Gabrr2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission By similarity.

Subunit structure

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 By similarity.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform 1 (identifier: P56476-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P56476-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVKPGGILPIKSPCTAACCIIDMCRM
Note: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 465445Gamma-aminobutyric acid receptor subunit rho-2
PRO_0000000489

Regions

Topological domain21 – 260240Extracellular Probable
Transmembrane261 – 28121Helical; Potential
Transmembrane294 – 31421Helical; Potential
Transmembrane326 – 34621Helical; Potential
Topological domain347 – 44397Cytoplasmic Probable
Transmembrane444 – 46421Helical; Potential

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation2541N-linked (GlcNAc...) Potential
Disulfide bond178 ↔ 192 By similarity

Natural variations

Alternative sequence11M → MVKPGGILPIKSPCTAACCI IDMCRM in isoform 2.
VSP_044374

Experimental info

Sequence conflict331E → D in AAB81965. Ref.1
Sequence conflict521P → A in AAB81965. Ref.1
Sequence conflict591L → F in AAB81965. Ref.1
Sequence conflict881L → V in AAB81965. Ref.1
Sequence conflict1051R → K in AAB81965. Ref.1
Sequence conflict1091R → K in AAB81965. Ref.1
Sequence conflict1491H → Q in AAB81965. Ref.1
Sequence conflict3571R → L in AAB81965. Ref.1
Sequence conflict3661M → V in AAB81965. Ref.1
Sequence conflict3721S → A in AAB81965. Ref.1
Sequence conflict3941R → T in AAB81965. Ref.1
Sequence conflict4001E → K in AAB81965. Ref.1
Sequence conflict4211R → K in AAB81965. Ref.1
Sequence conflict4291Q → R in AAB81965. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 31, 2012. Version 4.
Checksum: B44B51B572468A20

FASTA46554,231
        10         20         30         40         50         60 
MPYLMRLALV LFCLMALVES RKPRRKRWTG LLETSKPSHL YKKNLDVTKM RPGKPRPLLR 

        70         80         90        100        110        120 
VEDHDFTMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM TLYLRHYWRD ERLAFPSSSN 

       130        140        150        160        170        180 
KSMTFDGRLV KKIWVPDVFF VHSKRSFIHD TTTDNIMLRV FPDGHVLYSM RITVTAMCNM 

       190        200        210        220        230        240 
DFSHFPLDSQ TCSLELESYA YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA 

       250        260        270        280        290        300 
FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDHRAV PARVSLGIMT 

       310        320        330        340        350        360 
VLTMSTIITG VNASMPRVSY IRAVDIYLWV SFVFVFLSVL EYAAVNYLTT LQEQKERKFR 

       370        380        390        400        410        420 
EKLPCMCGML HSRTMMLDGS YSESEANSLA GYPRSHILPE EERPDNIVVH LALNSELTSS 

       430        440        450        460 
RKKGLLKGQM GLYIFQNTHA IDKYSRLIFP AFYIVFNLIY WSVFS 

« Hide

Isoform 2 [UniParc].

Checksum: 18BBEDC2346C52D3
Show »

FASTA49056,834

References

« Hide 'large scale' references
[1]"Molecular cloning of GABA rho subunits in the mouse retina."
Greka A., Koolen J.A., Lipton S.A., Zhang D.
Abstr. - Soc. Neurosci. 23:1262-1262(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Retina.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF024621 mRNA. Translation: AAB81965.1.
CH466538 Genomic DNA. Translation: EDL05492.1.
BC057957 mRNA. Translation: AAH57957.2.
CCDSCCDS18020.1. [P56476-2]
RefSeqNP_032102.2. NM_008076.3. [P56476-2]
UniGeneMm.6227.

3D structure databases

ProteinModelPortalP56476.
SMRP56476. Positions 64-353.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY421.

PTM databases

PhosphoSiteP56476.

Proteomic databases

PRIDEP56476.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024035; ENSMUSP00000024035; ENSMUSG00000023267. [P56476-2]
ENSMUST00000108162; ENSMUSP00000103797; ENSMUSG00000023267. [P56476-1]
GeneID14409.
KEGGmmu:14409.
UCSCuc008sfq.1. mouse. [P56476-1]

Organism-specific databases

CTD2570.
MGIMGI:95626. Gabrr2.

Phylogenomic databases

eggNOGNOG77438.
GeneTreeENSGT00630000089571.
HOGENOMHOG000231335.
HOVERGENHBG051707.
InParanoidQ6PEP0.
KOK05190.
OMADEHDFSM.
OrthoDBEOG712TVZ.
TreeFamTF315453.

Gene expression databases

BgeeP56476.
GenevestigatorP56476.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA/Glycine_rcpt.
IPR008059. GABAAa_rho2_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01672. GABAARRHO2.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285985.
PROP56476.
SOURCESearch...

Entry information

Entry nameGBRR2_MOUSE
AccessionPrimary (citable) accession number: P56476
Secondary accession number(s): Q6PEP0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 31, 2012
Last modified: July 9, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot