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P56475

- GBRR1_MOUSE

UniProt

P56475 - GBRR1_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit rho-1

Gene

Gabrr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission By similarity.By similarity

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: InterPro

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198557. GABA A (rho) receptor activation.
    REACT_198558. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit rho-1
    Alternative name(s):
    GABA(A) receptor subunit rho-1
    GABA(C) receptor
    Gene namesi
    Name:Gabrr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95625. Gabrr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 480459Gamma-aminobutyric acid receptor subunit rho-1PRO_0000000486Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi199 ↔ 213By similarity
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP56475.

    PTM databases

    PhosphoSiteiP56475.

    Expressioni

    Gene expression databases

    BgeeiP56475.
    GenevestigatoriP56475.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP56475.
    SMRiP56475. Positions 85-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 282261ExtracellularCuratedAdd
    BLAST
    Topological domaini367 – 45892CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei283 – 30624HelicalCuratedAdd
    BLAST
    Transmembranei310 – 33223HelicalCuratedAdd
    BLAST
    Transmembranei344 – 36623HelicalCuratedAdd
    BLAST
    Transmembranei459 – 48022HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77438.
    GeneTreeiENSGT00630000089571.
    HOGENOMiHOG000231335.
    HOVERGENiHBG051707.
    InParanoidiA3KG51.
    KOiK05190.
    OMAiRMMVQLA.
    PhylomeDBiP56475.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008058. GABAAa_rho1_rcpt.
    IPR008057. GABAAa_rho_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    PR01670. GABAARRHO.
    PR01671. GABAARRHO1.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56475-1 [UniParc]FASTAAdd to Basket

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    MLAVQNMKFG IFLLWWGWVL AAESTAHWPG REVHEPSRKG SRPQRQRRGA    50
    HDDAHKQGSP ILRRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV 100
    GVDVQVESLD SISEVDMDFT MTLYLRHYWK DERLSFPSSN NLSMTFDGRL 150
    VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR VQPDGKVLYS LRVTVTAMCN 200
    MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT DERISLSQFL 250
    IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS 300
    WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW 350
    VSFVFVFLSV LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS 400
    SYSDGEVNDL GGYMPENGEK PDRMMVQLTL ASERGSPQRK GQRGSYVSMR 450
    INTHAIDKYS RIIFPAAYIL FNLIYWSIFS 480
    Length:480
    Mass (Da):55,488
    Last modified:February 10, 2009 - v2
    Checksum:iBF071780C464FCCA
    GO

    Sequence cautioni

    The sequence AAB81964.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAM45896.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti414 – 4141M → L in AAB81964. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024620 mRNA. Translation: AAB81964.1. Different initiation.
    AL670464 Genomic DNA. Translation: CAM45896.1. Different initiation.
    CCDSiCCDS18021.2.
    RefSeqiNP_032101.3. NM_008075.2.
    UniGeneiMm.14116.

    Genome annotation databases

    EnsembliENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280.
    GeneIDi14408.
    KEGGimmu:14408.
    UCSCiuc008sfr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024620 mRNA. Translation: AAB81964.1 . Different initiation.
    AL670464 Genomic DNA. Translation: CAM45896.1 . Different initiation.
    CCDSi CCDS18021.2.
    RefSeqi NP_032101.3. NM_008075.2.
    UniGenei Mm.14116.

    3D structure databases

    ProteinModelPortali P56475.
    SMRi P56475. Positions 85-374.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 420.

    PTM databases

    PhosphoSitei P56475.

    Proteomic databases

    PRIDEi P56475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029947 ; ENSMUSP00000029947 ; ENSMUSG00000028280 .
    GeneIDi 14408.
    KEGGi mmu:14408.
    UCSCi uc008sfr.1. mouse.

    Organism-specific databases

    CTDi 2569.
    MGIi MGI:95625. Gabrr1.

    Phylogenomic databases

    eggNOGi NOG77438.
    GeneTreei ENSGT00630000089571.
    HOGENOMi HOG000231335.
    HOVERGENi HBG051707.
    InParanoidi A3KG51.
    KOi K05190.
    OMAi RMMVQLA.
    PhylomeDBi P56475.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_198557. GABA A (rho) receptor activation.
    REACT_198558. Ligand-gated ion channel transport.

    Miscellaneous databases

    NextBioi 285981.
    PROi P56475.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56475.
    Genevestigatori P56475.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008058. GABAAa_rho1_rcpt.
    IPR008057. GABAAa_rho_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    PR01670. GABAARRHO.
    PR01671. GABAARRHO1.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of GABA rho subunits in the mouse retina."
      Greka A., Koolen J.A., Lipton S.A., Zhang D.
      Abstr. - Soc. Neurosci. 23:1262-1262(1997)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiGBRR1_MOUSE
    AccessioniPrimary (citable) accession number: P56475
    Secondary accession number(s): A3KG51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3