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Protein

Gamma-aminobutyric acid receptor subunit rho-1

Gene

Gabrr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-MMU-977442 GABA A (rho) receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-1
Alternative name(s):
GABA(A) receptor subunit rho-1
GABA(C) receptor
Gene namesi
Name:Gabrr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95625 Gabrr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 282ExtracellularCuratedAdd BLAST261
Transmembranei283 – 306HelicalCuratedAdd BLAST24
Transmembranei310 – 332HelicalCuratedAdd BLAST23
Transmembranei344 – 366HelicalCuratedAdd BLAST23
Topological domaini367 – 458CytoplasmicCuratedAdd BLAST92
Transmembranei459 – 480HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000048622 – 480Gamma-aminobutyric acid receptor subunit rho-1Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi199 ↔ 213By similarity
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56475
PRIDEiP56475

PTM databases

iPTMnetiP56475
PhosphoSitePlusiP56475

Expressioni

Gene expression databases

BgeeiENSMUSG00000028280
GenevisibleiP56475 MM

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029947

Structurei

3D structure databases

ProteinModelPortaliP56475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiP56475
KOiK05190
OMAiCNMDLSR
OrthoDBiEOG091G0805
PhylomeDBiP56475
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008058 GABAAa_rho1_rcpt
IPR008057 GABAAa_rho_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01670 GABAARRHO
PR01671 GABAARRHO1
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVQNMKFG IFLLWWGWVL AAESTAHWPG REVHEPSRKG SRPQRQRRGA
60 70 80 90 100
HDDAHKQGSP ILRRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV
110 120 130 140 150
GVDVQVESLD SISEVDMDFT MTLYLRHYWK DERLSFPSSN NLSMTFDGRL
160 170 180 190 200
VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR VQPDGKVLYS LRVTVTAMCN
210 220 230 240 250
MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT DERISLSQFL
260 270 280 290 300
IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS
310 320 330 340 350
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW
360 370 380 390 400
VSFVFVFLSV LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS
410 420 430 440 450
SYSDGEVNDL GGYMPENGEK PDRMMVQLTL ASERGSPQRK GQRGSYVSMR
460 470 480
INTHAIDKYS RIIFPAAYIL FNLIYWSIFS
Length:480
Mass (Da):55,488
Last modified:February 10, 2009 - v2
Checksum:iBF071780C464FCCA
GO

Sequence cautioni

The sequence AAB81964 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM45896 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti414M → L in AAB81964 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024620 mRNA Translation: AAB81964.1 Different initiation.
AL670464 Genomic DNA Translation: CAM45896.1 Different initiation.
CCDSiCCDS18021.2
RefSeqiNP_032101.3, NM_008075.2
UniGeneiMm.14116

Genome annotation databases

EnsembliENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280
GeneIDi14408
KEGGimmu:14408
UCSCiuc008sfr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGBRR1_MOUSE
AccessioniPrimary (citable) accession number: P56475
Secondary accession number(s): A3KG51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 10, 2009
Last modified: April 25, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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