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Protein

Gamma-aminobutyric acid receptor subunit rho-1

Gene

Gabrr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_293019. Ligand-gated ion channel transport.
REACT_296711. GABA A (rho) receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-1
Alternative name(s):
GABA(A) receptor subunit rho-1
GABA(C) receptor
Gene namesi
Name:Gabrr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95625. Gabrr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 282261ExtracellularCuratedAdd
BLAST
Transmembranei283 – 30624HelicalCuratedAdd
BLAST
Transmembranei310 – 33223HelicalCuratedAdd
BLAST
Transmembranei344 – 36623HelicalCuratedAdd
BLAST
Topological domaini367 – 45892CytoplasmicCuratedAdd
BLAST
Transmembranei459 – 48022HelicalCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 480459Gamma-aminobutyric acid receptor subunit rho-1PRO_0000000486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi199 ↔ 213By similarity
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP56475.

PTM databases

PhosphoSiteiP56475.

Expressioni

Gene expression databases

BgeeiP56475.
GenevisibleiP56475. MM.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029947.

Structurei

3D structure databases

ProteinModelPortaliP56475.
SMRiP56475. Positions 85-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP56475.
KOiK05190.
OMAiRMMVQLA.
PhylomeDBiP56475.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008058. GABAAa_rho1_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01671. GABAARRHO1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVQNMKFG IFLLWWGWVL AAESTAHWPG REVHEPSRKG SRPQRQRRGA
60 70 80 90 100
HDDAHKQGSP ILRRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV
110 120 130 140 150
GVDVQVESLD SISEVDMDFT MTLYLRHYWK DERLSFPSSN NLSMTFDGRL
160 170 180 190 200
VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR VQPDGKVLYS LRVTVTAMCN
210 220 230 240 250
MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT DERISLSQFL
260 270 280 290 300
IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS
310 320 330 340 350
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW
360 370 380 390 400
VSFVFVFLSV LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS
410 420 430 440 450
SYSDGEVNDL GGYMPENGEK PDRMMVQLTL ASERGSPQRK GQRGSYVSMR
460 470 480
INTHAIDKYS RIIFPAAYIL FNLIYWSIFS
Length:480
Mass (Da):55,488
Last modified:February 10, 2009 - v2
Checksum:iBF071780C464FCCA
GO

Sequence cautioni

The sequence AAB81964.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAM45896.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti414 – 4141M → L in AAB81964 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024620 mRNA. Translation: AAB81964.1. Different initiation.
AL670464 Genomic DNA. Translation: CAM45896.1. Different initiation.
CCDSiCCDS18021.2.
RefSeqiNP_032101.3. NM_008075.2.
UniGeneiMm.14116.

Genome annotation databases

EnsembliENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280.
GeneIDi14408.
KEGGimmu:14408.
UCSCiuc008sfr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024620 mRNA. Translation: AAB81964.1. Different initiation.
AL670464 Genomic DNA. Translation: CAM45896.1. Different initiation.
CCDSiCCDS18021.2.
RefSeqiNP_032101.3. NM_008075.2.
UniGeneiMm.14116.

3D structure databases

ProteinModelPortaliP56475.
SMRiP56475. Positions 85-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029947.

Chemistry

GuidetoPHARMACOLOGYi420.

PTM databases

PhosphoSiteiP56475.

Proteomic databases

PRIDEiP56475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280.
GeneIDi14408.
KEGGimmu:14408.
UCSCiuc008sfr.2. mouse.

Organism-specific databases

CTDi2569.
MGIiMGI:95625. Gabrr1.

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP56475.
KOiK05190.
OMAiRMMVQLA.
PhylomeDBiP56475.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiREACT_293019. Ligand-gated ion channel transport.
REACT_296711. GABA A (rho) receptor activation.

Miscellaneous databases

NextBioi285981.
PROiP56475.
SOURCEiSearch...

Gene expression databases

BgeeiP56475.
GenevisibleiP56475. MM.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008058. GABAAa_rho1_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01671. GABAARRHO1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of GABA rho subunits in the mouse retina."
    Greka A., Koolen J.A., Lipton S.A., Zhang D.
    Abstr. - Soc. Neurosci. 23:1262-1262(1997)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiGBRR1_MOUSE
AccessioniPrimary (citable) accession number: P56475
Secondary accession number(s): A3KG51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 10, 2009
Last modified: July 22, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.