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P56475

- GBRR1_MOUSE

UniProt

P56475 - GBRR1_MOUSE

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Protein
Gamma-aminobutyric acid receptor subunit rho-1
Gene
Gabrr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission By similarity.

GO - Molecular functioni

  1. GABA-A receptor activity Source: InterPro
  2. chloride channel activity Source: UniProtKB-KW
  3. extracellular ligand-gated ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198557. GABA A (rho) receptor activation.
REACT_198558. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-1
Alternative name(s):
GABA(A) receptor subunit rho-1
GABA(C) receptor
Gene namesi
Name:Gabrr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95625. Gabrr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 282261Extracellular Inferred
Add
BLAST
Transmembranei283 – 30624Helical; Inferred
Add
BLAST
Transmembranei310 – 33223Helical; Inferred
Add
BLAST
Transmembranei344 – 36623Helical; Inferred
Add
BLAST
Topological domaini367 – 45892Cytoplasmic Inferred
Add
BLAST
Transmembranei459 – 48022Helical; Inferred
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 480459Gamma-aminobutyric acid receptor subunit rho-1
PRO_0000000486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi199 ↔ 213 By similarity
Glycosylationi235 – 2351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi275 – 2751N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP56475.

PTM databases

PhosphoSiteiP56475.

Expressioni

Gene expression databases

BgeeiP56475.
GenevestigatoriP56475.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP56475.
SMRiP56475. Positions 85-374.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00630000089571.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiA3KG51.
KOiK05190.
OMAiRMMVQLA.
PhylomeDBiP56475.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008058. GABAAa_rho1_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01671. GABAARRHO1.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56475-1 [UniParc]FASTAAdd to Basket

« Hide

MLAVQNMKFG IFLLWWGWVL AAESTAHWPG REVHEPSRKG SRPQRQRRGA    50
HDDAHKQGSP ILRRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV 100
GVDVQVESLD SISEVDMDFT MTLYLRHYWK DERLSFPSSN NLSMTFDGRL 150
VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR VQPDGKVLYS LRVTVTAMCN 200
MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT DERISLSQFL 250
IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS 300
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW 350
VSFVFVFLSV LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS 400
SYSDGEVNDL GGYMPENGEK PDRMMVQLTL ASERGSPQRK GQRGSYVSMR 450
INTHAIDKYS RIIFPAAYIL FNLIYWSIFS 480
Length:480
Mass (Da):55,488
Last modified:February 10, 2009 - v2
Checksum:iBF071780C464FCCA
GO

Sequence cautioni

The sequence AAB81964.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAM45896.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti414 – 4141M → L in AAB81964. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024620 mRNA. Translation: AAB81964.1. Different initiation.
AL670464 Genomic DNA. Translation: CAM45896.1. Different initiation.
CCDSiCCDS18021.2.
RefSeqiNP_032101.3. NM_008075.2.
UniGeneiMm.14116.

Genome annotation databases

EnsembliENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280.
GeneIDi14408.
KEGGimmu:14408.
UCSCiuc008sfr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024620 mRNA. Translation: AAB81964.1 . Different initiation.
AL670464 Genomic DNA. Translation: CAM45896.1 . Different initiation.
CCDSi CCDS18021.2.
RefSeqi NP_032101.3. NM_008075.2.
UniGenei Mm.14116.

3D structure databases

ProteinModelPortali P56475.
SMRi P56475. Positions 85-374.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 420.

PTM databases

PhosphoSitei P56475.

Proteomic databases

PRIDEi P56475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029947 ; ENSMUSP00000029947 ; ENSMUSG00000028280 .
GeneIDi 14408.
KEGGi mmu:14408.
UCSCi uc008sfr.1. mouse.

Organism-specific databases

CTDi 2569.
MGIi MGI:95625. Gabrr1.

Phylogenomic databases

eggNOGi NOG77438.
GeneTreei ENSGT00630000089571.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi A3KG51.
KOi K05190.
OMAi RMMVQLA.
PhylomeDBi P56475.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_198557. GABA A (rho) receptor activation.
REACT_198558. Ligand-gated ion channel transport.

Miscellaneous databases

NextBioi 285981.
PROi P56475.
SOURCEi Search...

Gene expression databases

Bgeei P56475.
Genevestigatori P56475.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008058. GABAAa_rho1_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01671. GABAARRHO1.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of GABA rho subunits in the mouse retina."
    Greka A., Koolen J.A., Lipton S.A., Zhang D.
    Abstr. - Soc. Neurosci. 23:1262-1262(1997)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiGBRR1_MOUSE
AccessioniPrimary (citable) accession number: P56475
Secondary accession number(s): A3KG51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi