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P56475 (GBRR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor subunit rho-1
Alternative name(s):
GABA(A) receptor subunit rho-1
GABA(C) receptor
Gene names
Name:Gabrr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission By similarity.

Subunit structure

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 By similarity.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily. [View classification]

Sequence caution

The sequence AAB81964.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAM45896.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 480459Gamma-aminobutyric acid receptor subunit rho-1
PRO_0000000486

Regions

Topological domain22 – 282261Extracellular Probable
Transmembrane283 – 30624Helical; Probable
Transmembrane310 – 33223Helical; Probable
Transmembrane344 – 36623Helical; Probable
Topological domain367 – 45892Cytoplasmic Probable
Transmembrane459 – 48022Helical; Probable

Amino acid modifications

Glycosylation1411N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2751N-linked (GlcNAc...) Potential
Disulfide bond199 ↔ 213 By similarity

Experimental info

Sequence conflict4141M → L in AAB81964. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P56475 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: BF071780C464FCCA

FASTA48055,488
        10         20         30         40         50         60 
MLAVQNMKFG IFLLWWGWVL AAESTAHWPG REVHEPSRKG SRPQRQRRGA HDDAHKQGSP 

        70         80         90        100        110        120 
ILRRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV GVDVQVESLD SISEVDMDFT 

       130        140        150        160        170        180 
MTLYLRHYWK DERLSFPSSN NLSMTFDGRL VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR 

       190        200        210        220        230        240 
VQPDGKVLYS LRVTVTAMCN MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT 

       250        260        270        280        290        300 
DERISLSQFL IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS 

       310        320        330        340        350        360 
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW VSFVFVFLSV 

       370        380        390        400        410        420 
LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS SYSDGEVNDL GGYMPENGEK 

       430        440        450        460        470        480 
PDRMMVQLTL ASERGSPQRK GQRGSYVSMR INTHAIDKYS RIIFPAAYIL FNLIYWSIFS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of GABA rho subunits in the mouse retina."
Greka A., Koolen J.A., Lipton S.A., Zhang D.
Abstr. - Soc. Neurosci. 23:1262-1262(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF024620 mRNA. Translation: AAB81964.1. Different initiation.
AL670464 Genomic DNA. Translation: CAM45896.1. Different initiation.
CCDSCCDS18021.2.
RefSeqNP_032101.3. NM_008075.2.
UniGeneMm.14116.

3D structure databases

ProteinModelPortalP56475.
SMRP56475. Positions 85-374.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY420.

PTM databases

PhosphoSiteP56475.

Proteomic databases

PRIDEP56475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280.
GeneID14408.
KEGGmmu:14408.
UCSCuc008sfr.1. mouse.

Organism-specific databases

CTD2569.
MGIMGI:95625. Gabrr1.

Phylogenomic databases

eggNOGNOG77438.
GeneTreeENSGT00630000089571.
HOGENOMHOG000231335.
HOVERGENHBG051707.
InParanoidA3KG51.
KOK05190.
OMARMMVQLA.
PhylomeDBP56475.
TreeFamTF315453.

Gene expression databases

BgeeP56475.
GenevestigatorP56475.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA/Glycine_rcpt.
IPR008058. GABAAa_rho1_rcpt.
IPR008057. GABAAa_rho_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00253. GABAARECEPTR.
PR01670. GABAARRHO.
PR01671. GABAARRHO1.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285981.
PROP56475.
SOURCESearch...

Entry information

Entry nameGBRR1_MOUSE
AccessionPrimary (citable) accession number: P56475
Secondary accession number(s): A3KG51
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot