ID   AGRP_MOUSE              Reviewed;         131 AA.
AC   P56473; O35967;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   16-NOV-2011, entry version 86.
DE   RecName: Full=Agouti-related protein;
DE   Flags: Precursor;
GN   Name=Agrp; Synonyms=Agrt, Art;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129;
RX   MEDLINE=97458244; PubMed=9311920; DOI=10.1126/science.278.5335.135;
RA   Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I.,
RA   Barsh G.S.;
RT   "Antagonism of central melanocortin receptors in vitro and in vivo by
RT   agouti-related protein.";
RL   Science 278:135-138(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=97230362; PubMed=9119224;
RA   Shutter J.R., Graham M., Kinsey A.C., Scully S., Luethy R.,
RA   Stark K.L.;
RT   "Hypothalamic expression of ART, a novel gene related to agouti, is
RT   up-regulated in obese and diabetic mutant mice.";
RL   Genes Dev. 11:593-602(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH MELANOCORTIN RECEPTORS MC3R; MC4R AND
RP   MC5R.
RX   PubMed=9892020; DOI=10.1210/me.13.1.148;
RA   Yang Y.K., Thompson D.A., Dickinson C.J., Wilken J., Barsh G.S.,
RA   Kent S.B., Gantz I.;
RT   "Characterization of Agouti-related protein binding to melanocortin
RT   receptors.";
RL   Mol. Endocrinol. 13:148-155(1999).
CC   -!- FUNCTION: Plays a role in weight homeostasis. Plays a role in the
CC       central control of feeding. Reduces food intake. Inhibits cAMP
CC       production mediated by stimulation of melanocortin receptors
CC       within the hypothalamus and adrenal gland. Acts primarily on MC3R
CC       and MC4R.
CC   -!- SUBUNIT: Interacts with melanocortin receptors MC3R, MC4R and
CC       MC5R.
CC   -!- SUBCELLULAR LOCATION: Secreted. Golgi apparatus lumen (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in arcuate nucleus and median
CC       eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
CC   -!- INDUCTION: Hypothalamic expression is elevated circa 10-fold in
CC       ob/ob and db/db mice.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin (By similarity).
CC   -!- SIMILARITY: Contains 1 agouti domain.
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DR   EMBL; U89484; AAB68620.1; -; mRNA.
DR   EMBL; U89486; AAB68622.1; -; Genomic_DNA.
DR   EMBL; BC079902; AAH79902.1; -; mRNA.
DR   IPI; IPI00113784; -.
DR   RefSeq; NP_031453.1; NM_007427.2.
DR   UniGene; Mm.441696; -.
DR   ProteinModelPortal; P56473; -.
DR   SMR; P56473; 86-119.
DR   STRING; P56473; -.
DR   PRIDE; P56473; -.
DR   Ensembl; ENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705.
DR   GeneID; 11604; -.
DR   KEGG; mmu:11604; -.
DR   CTD; 181; -.
DR   MGI; MGI:892013; Agrp.
DR   eggNOG; roNOG16557; -.
DR   HOGENOM; HBG126983; -.
DR   HOVERGEN; HBG050467; -.
DR   InParanoid; P56473; -.
DR   OMA; HESCLGH; -.
DR   OrthoDB; EOG4X3H2X; -.
DR   PhylomeDB; P56473; -.
DR   NextBio; 279132; -.
DR   ArrayExpress; P56473; -.
DR   Bgee; P56473; -.
DR   CleanEx; MM_AGRP; -.
DR   Genevestigator; P56473; -.
DR   GermOnline; ENSMUSG00000005705; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0031781; F:type 3 melanocortin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031782; F:type 4 melanocortin receptor binding; ISS:UniProtKB.
DR   GO; GO:0008343; P:adult feeding behavior; IDA:MGI.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR   GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
DR   InterPro; IPR007733; Agouti.
DR   Gene3D; G3DSA:4.10.760.10; Agouti; 1.
DR   KO; K05231; -.
DR   PANTHER; PTHR16551; Agouti; 1.
DR   Pfam; PF05039; Agouti; 1.
DR   SMART; SM00792; Agouti; 1.
DR   SUPFAM; SSF57055; Agouti; 1.
DR   PROSITE; PS60024; AGOUTI_1; 1.
DR   PROSITE; PS51150; AGOUTI_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Disulfide bond; Golgi apparatus; Knottin;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    131       Agouti-related protein.
FT                                /FTId=PRO_0000001035.
FT   DOMAIN       86    128       Agouti.
FT   REGION      110    112       Interaction with melanocortin receptors
FT                                (By similarity).
FT   DISULFID     86    101       By similarity.
FT   DISULFID     93    107       By similarity.
FT   DISULFID    100    118       By similarity.
FT   DISULFID    104    128       By similarity.
FT   DISULFID    109    116       By similarity.
SQ   SEQUENCE   131 AA;  14432 MW;  25D9766D074C6834 CRC64;
     MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL KKTTADRAEE
     VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC CDPCATCYCR FFNAFCYCRK
     LGTATNLCSR T
//