ID   AGRP_MOUSE              Reviewed;         131 AA.
AC   P56473; O35967;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   24-NOV-2009, entry version 73.
DE   RecName: Full=Agouti-related protein;
DE   Flags: Precursor;
GN   Name=Agrp; Synonyms=Agrt, Art;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129;
RX   MEDLINE=97458244; PubMed=9311920; DOI=10.1126/science.278.5335.135;
RA   Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I.,
RA   Barsh G.S.;
RT   "Antagonism of central melanocortin receptors in vitro and in vivo by
RT   agouti-related protein.";
RL   Science 278:135-138(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=97230362; PubMed=9119224;
RA   Shutter J.R., Graham M., Kinsey A.C., Scully S., Luethy R.,
RA   Stark K.L.;
RT   "Hypothalamic expression of ART, a novel gene related to agouti, is
RT   up-regulated in obese and diabetic mutant mice.";
RL   Genes Dev. 11:593-602(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in weight homeostasis. May play a role in
CC       the regulation of melanocortin receptors within the hypothalamus
CC       and adrenal gland, and therefore in the central control of
CC       feeding.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in arcuate nucleus and median
CC       eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
CC   -!- INDUCTION: Hypothalamic expression is elevated circa 10-fold in
CC       ob/ob and db/db mice.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin (By similarity).
CC   -!- SIMILARITY: Contains 1 agouti domain.
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DR   EMBL; U89484; AAB68620.1; -; mRNA.
DR   EMBL; U89486; AAB68622.1; -; Genomic_DNA.
DR   EMBL; BC079902; AAH79902.1; -; mRNA.
DR   IPI; IPI00113784; -.
DR   RefSeq; NP_031453.1; -.
DR   UniGene; Mm.441696; -.
DR   SMR; P56473; 86-131.
DR   STRING; P56473; -.
DR   PRIDE; P56473; -.
DR   Ensembl; ENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705; Mus musculus.
DR   GeneID; 11604; -.
DR   KEGG; mmu:11604; -.
DR   UCSC; uc009ndh.1; mouse.
DR   CTD; 11604; -.
DR   MGI; MGI:892013; Agrp.
DR   HOGENOM; P56473; -.
DR   HOVERGEN; P56473; -.
DR   OMA; LAPLEGI; -.
DR   OrthoDB; EOG9S4S23; -.
DR   NextBio; 279132; -.
DR   ArrayExpress; P56473; -.
DR   Bgee; P56473; -.
DR   CleanEx; MM_AGRP; -.
DR   Genevestigator; P56473; -.
DR   GermOnline; ENSMUSG00000005705; Mus musculus.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IDA:MGI.
DR   GO; GO:0008343; P:adult feeding behavior; IDA:MGI.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR   InterPro; IPR007733; Agouti.
DR   Gene3D; G3DSA:4.10.760.10; Agouti; 1.
DR   PANTHER; PTHR16551; Agouti; 1.
DR   Pfam; PF05039; Agouti; 1.
DR   SMART; SM00792; Agouti; 1.
DR   PROSITE; PS60024; AGOUTI_1; 1.
DR   PROSITE; PS51150; AGOUTI_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    131       Agouti-related protein.
FT                                /FTId=PRO_0000001035.
FT   DOMAIN       86    128       Agouti.
FT   DISULFID     86    101       By similarity.
FT   DISULFID     93    107       By similarity.
FT   DISULFID    100    118       By similarity.
FT   DISULFID    104    128       By similarity.
FT   DISULFID    109    116       By similarity.
SQ   SEQUENCE   131 AA;  14432 MW;  25D9766D074C6834 CRC64;
     MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL KKTTADRAEE
     VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC CDPCATCYCR FFNAFCYCRK
     LGTATNLCSR T
//