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P56473

- AGRP_MOUSE

UniProt

P56473 - AGRP_MOUSE

Protein

Agouti-related protein

Gene

Agrp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity By similarity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner By similarity.By similarity

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: UniProtKB
    2. type 3 melanocortin receptor binding Source: UniProtKB
    3. type 4 melanocortin receptor binding Source: UniProtKB

    GO - Biological processi

    1. adult feeding behavior Source: MGI
    2. eating behavior Source: Ensembl
    3. hormone-mediated signaling pathway Source: InterPro
    4. maternal process involved in female pregnancy Source: Ensembl
    5. neuropeptide signaling pathway Source: UniProtKB
    6. photoperiodism Source: Ensembl
    7. positive regulation of feeding behavior Source: Ensembl
    8. regulation of feeding behavior Source: UniProtKB
    9. response to insulin Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Agouti-related protein
    Gene namesi
    Name:Agrp
    Synonyms:Agrt, Art
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:892013. Agrp.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. Golgi lumen Source: UniProtKB
    3. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Golgi apparatus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 131111Agouti-related proteinPRO_0000001035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi86 ↔ 101PROSITE-ProRule annotation
    Disulfide bondi93 ↔ 107PROSITE-ProRule annotation
    Disulfide bondi100 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi104 ↔ 128PROSITE-ProRule annotation
    Disulfide bondi109 ↔ 116PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP56473.

    Expressioni

    Tissue specificityi

    Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.

    Inductioni

    Hypothalamic expression is elevated circa 10-fold in ob/ob and db/db mice.

    Gene expression databases

    ArrayExpressiP56473.
    BgeeiP56473.
    CleanExiMM_AGRP.
    GenevestigatoriP56473.

    Interactioni

    Subunit structurei

    Interacts with melanocortin receptors MC3R, MC4R and MC5R.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000005849.

    Structurei

    3D structure databases

    ProteinModelPortaliP56473.
    SMRiP56473. Positions 86-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 12843AgoutiPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 1123Interaction with melanocortin receptorsBy similarity

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

    Sequence similaritiesi

    Contains 1 agouti domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Knottin, Signal

    Phylogenomic databases

    eggNOGiNOG44906.
    HOGENOMiHOG000033861.
    HOVERGENiHBG050467.
    InParanoidiP56473.
    KOiK05231.
    OMAiDPEGREP.
    OrthoDBiEOG74TX1T.
    PhylomeDBiP56473.
    TreeFamiTF330729.

    Family and domain databases

    Gene3Di4.10.760.10. 1 hit.
    InterProiIPR007733. Agouti.
    IPR027300. Agouti_dom.
    [Graphical view]
    PANTHERiPTHR16551. PTHR16551. 1 hit.
    PfamiPF05039. Agouti. 1 hit.
    [Graphical view]
    SMARTiSM00792. Agouti. 1 hit.
    [Graphical view]
    SUPFAMiSSF57055. SSF57055. 1 hit.
    PROSITEiPS60024. AGOUTI_1. 1 hit.
    PS51150. AGOUTI_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56473-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL    50
    KKTTADRAEE VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC 100
    CDPCATCYCR FFNAFCYCRK LGTATNLCSR T 131
    Length:131
    Mass (Da):14,432
    Last modified:July 15, 1998 - v1
    Checksum:i25D9766D074C6834
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89484 mRNA. Translation: AAB68620.1.
    U89486 Genomic DNA. Translation: AAB68622.1.
    BC079902 mRNA. Translation: AAH79902.1.
    CCDSiCCDS22605.1.
    RefSeqiNP_001258735.1. NM_001271806.1.
    NP_031453.1. NM_007427.3.
    UniGeneiMm.441696.
    Mm.491630.

    Genome annotation databases

    EnsembliENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705.
    GeneIDi11604.
    KEGGimmu:11604.
    UCSCiuc009ndh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89484 mRNA. Translation: AAB68620.1 .
    U89486 Genomic DNA. Translation: AAB68622.1 .
    BC079902 mRNA. Translation: AAH79902.1 .
    CCDSi CCDS22605.1.
    RefSeqi NP_001258735.1. NM_001271806.1.
    NP_031453.1. NM_007427.3.
    UniGenei Mm.441696.
    Mm.491630.

    3D structure databases

    ProteinModelPortali P56473.
    SMRi P56473. Positions 86-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000005849.

    Proteomic databases

    PRIDEi P56473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005849 ; ENSMUSP00000005849 ; ENSMUSG00000005705 .
    GeneIDi 11604.
    KEGGi mmu:11604.
    UCSCi uc009ndh.1. mouse.

    Organism-specific databases

    CTDi 181.
    MGIi MGI:892013. Agrp.

    Phylogenomic databases

    eggNOGi NOG44906.
    HOGENOMi HOG000033861.
    HOVERGENi HBG050467.
    InParanoidi P56473.
    KOi K05231.
    OMAi DPEGREP.
    OrthoDBi EOG74TX1T.
    PhylomeDBi P56473.
    TreeFami TF330729.

    Miscellaneous databases

    NextBioi 279132.
    PROi P56473.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56473.
    Bgeei P56473.
    CleanExi MM_AGRP.
    Genevestigatori P56473.

    Family and domain databases

    Gene3Di 4.10.760.10. 1 hit.
    InterProi IPR007733. Agouti.
    IPR027300. Agouti_dom.
    [Graphical view ]
    PANTHERi PTHR16551. PTHR16551. 1 hit.
    Pfami PF05039. Agouti. 1 hit.
    [Graphical view ]
    SMARTi SM00792. Agouti. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57055. SSF57055. 1 hit.
    PROSITEi PS60024. AGOUTI_1. 1 hit.
    PS51150. AGOUTI_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein."
      Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S.
      Science 278:135-138(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129.
    2. "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice."
      Shutter J.R., Graham M., Kinsey A.C., Scully S., Luethy R., Stark K.L.
      Genes Dev. 11:593-602(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    4. "Characterization of Agouti-related protein binding to melanocortin receptors."
      Yang Y.K., Thompson D.A., Dickinson C.J., Wilken J., Barsh G.S., Kent S.B., Gantz I.
      Mol. Endocrinol. 13:148-155(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MELANOCORTIN RECEPTORS MC3R; MC4R AND MC5R.

    Entry informationi

    Entry nameiAGRP_MOUSE
    AccessioniPrimary (citable) accession number: P56473
    Secondary accession number(s): O35967
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3