Agouti-related protein precursor - Mus musculus (Mouse)

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P56473 (AGRP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Agouti-related protein

Gene names

Name:	Agrp
Synonyms:	Agrt, Art

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Ref.4
Subunit structure	Interacts with melanocortin receptors MC3R, MC4R and MC5R. Ref.4
Subcellular location	Secreted. Golgi apparatus lumen By similarity.
Tissue specificity	Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
Induction	Hypothalamic expression is elevated circa 10-fold in ob/ob and db/db mice.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.
Sequence similarities	Contains 1 agouti domain.

Ontologies

Keywords
Cellular component	Golgi apparatus Secreted
Domain	Knottin Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adult feeding behavior Inferred from direct assay. Source: MGI hormone-mediated signaling pathway Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB regulation of feeding behavior Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	Golgi lumen Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	neuropeptide hormone activity Inferred from sequence or structural similarity. Source: UniProtKB type 3 melanocortin receptor binding Inferred from sequence or structural similarity. Source: UniProtKB type 4 melanocortin receptor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Potential

Chain

21 – 131

111

Agouti-related protein

PRO_0000001035

Regions

Domain

86 – 128

Agouti

Region

110 – 112

Interaction with melanocortin receptors By similarity

Amino acid modifications

Disulfide bond

86 ↔ 101

By similarity

Disulfide bond

93 ↔ 107

By similarity

Disulfide bond

100 ↔ 118

By similarity

Disulfide bond

104 ↔ 128

By similarity

Disulfide bond

109 ↔ 116

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P56473 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 25D9766D074C6834
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FASTA

131

14,432

        10         20         30         40         50         60 
MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL KKTTADRAEE 

        70         80         90        100        110        120 
VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC CDPCATCYCR FFNAFCYCRK 

       130 
LGTATNLCSR T

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein." Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S. Science 278:135-138(1997) [PubMed: 9311920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129.
[2]	"Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice." Shutter J.R., Graham M., Kinsey A.C., Scully S., Luethy R., Stark K.L. Genes Dev. 11:593-602(1997) [PubMed: 9119224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
[4]	"Characterization of Agouti-related protein binding to melanocortin receptors." Yang Y.K., Thompson D.A., Dickinson C.J., Wilken J., Barsh G.S., Kent S.B., Gantz I. Mol. Endocrinol. 13:148-155(1999) [PubMed: 9892020] [Abstract] Cited for: FUNCTION, INTERACTION WITH MELANOCORTIN RECEPTORS MC3R; MC4R AND MC5R.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U89484 mRNA. Translation: AAB68620.1. U89486 Genomic DNA. Translation: AAB68622.1. BC079902 mRNA. Translation: AAH79902.1.
IPI	IPI00113784.
RefSeq	NP_031453.1. NM_007427.2.
UniGene	Mm.441696.
3D structure databases
ProteinModelPortal	P56473.
SMR	P56473. Positions 86-119.
ModBase	Search...
Protein-protein interaction databases
STRING	P56473.
Proteomic databases
PRIDE	P56473.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705.
GeneID	11604.
KEGG	mmu:11604.
Organism-specific databases
CTD	181.
MGI	MGI:892013. Agrp.
Phylogenomic databases
eggNOG	roNOG16557.
HOGENOM	HBG126983.
HOVERGEN	HBG050467.
InParanoid	P56473.
OMA	HESCLGH.
OrthoDB	EOG4X3H2X.
PhylomeDB	P56473.
Gene expression databases
ArrayExpress	P56473.
Bgee	P56473.
CleanEx	MM_AGRP.
Genevestigator	P56473.
GermOnline	ENSMUSG00000005705. Mus musculus.
Family and domain databases
InterPro	IPR007733. Agouti. [Graphical view]
Gene3D	G3DSA:4.10.760.10. Agouti. 1 hit.
KO	K05231.
PANTHER	PTHR16551. Agouti. 1 hit.
Pfam	PF05039. Agouti. 1 hit. [Graphical view]
SMART	SM00792. Agouti. 1 hit. [Graphical view]
SUPFAM	SSF57055. Agouti. 1 hit.
PROSITE	PS60024. AGOUTI_1. 1 hit. PS51150. AGOUTI_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279132.
SOURCE	Search...

Entry information

Entry name

AGRP_MOUSE

Accession

Primary (citable) accession number: P56473
Secondary accession number(s): O35967

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	November 16, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents