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Protein

Agouti-related protein

Gene

Agrp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity (By similarity). It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-related protein
Gene namesi
Name:Agrp
Synonyms:Agrt, Art
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:892013. Agrp.

Subcellular locationi

  • Secreted By similarity
  • Golgi apparatus lumen By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000043404521 – 81By similarityAdd BLAST61
ChainiPRO_000000103582 – 131Agouti-related proteinAdd BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi86 ↔ 101PROSITE-ProRule annotationBy similarity
Disulfide bondi93 ↔ 107PROSITE-ProRule annotationBy similarity
Disulfide bondi100 ↔ 118PROSITE-ProRule annotationBy similarity
Disulfide bondi104 ↔ 128PROSITE-ProRule annotationBy similarity
Disulfide bondi109 ↔ 116PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei81 – 82Cleavage; by PCSK1By similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP56473.
PRIDEiP56473.

Expressioni

Tissue specificityi

Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.

Inductioni

Hypothalamic expression is elevated circa 10-fold in ob/ob and db/db mice.

Gene expression databases

BgeeiENSMUSG00000005705.
CleanExiMM_AGRP.
ExpressionAtlasiP56473. baseline and differential.
GenevisibleiP56473. MM.

Interactioni

Subunit structurei

Interacts with melanocortin receptors MC3R, MC4R and MC5R.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005849.

Structurei

3D structure databases

ProteinModelPortaliP56473.
SMRiP56473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 128AgoutiPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 112Interaction with melanocortin receptorsBy similarity3

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Contains 1 agouti domain.PROSITE-ProRule annotation

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

eggNOGiENOG410J14P. Eukaryota.
ENOG410Z66T. LUCA.
GeneTreeiENSGT00510000048590.
HOGENOMiHOG000033861.
HOVERGENiHBG050467.
InParanoidiP56473.
KOiK05231.
OMAiMQGAQMG.
OrthoDBiEOG091G1506.
PhylomeDBiP56473.
TreeFamiTF330729.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL
60 70 80 90 100
KKTTADRAEE VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC
110 120 130
CDPCATCYCR FFNAFCYCRK LGTATNLCSR T
Length:131
Mass (Da):14,432
Last modified:July 15, 1998 - v1
Checksum:i25D9766D074C6834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89484 mRNA. Translation: AAB68620.1.
U89486 Genomic DNA. Translation: AAB68622.1.
BC079902 mRNA. Translation: AAH79902.1.
CCDSiCCDS22605.1.
RefSeqiNP_001258735.1. NM_001271806.1.
NP_031453.1. NM_007427.3.
UniGeneiMm.441696.
Mm.491630.

Genome annotation databases

EnsembliENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705.
ENSMUST00000194091; ENSMUSP00000142044; ENSMUSG00000005705.
GeneIDi11604.
KEGGimmu:11604.
UCSCiuc009ndh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89484 mRNA. Translation: AAB68620.1.
U89486 Genomic DNA. Translation: AAB68622.1.
BC079902 mRNA. Translation: AAH79902.1.
CCDSiCCDS22605.1.
RefSeqiNP_001258735.1. NM_001271806.1.
NP_031453.1. NM_007427.3.
UniGeneiMm.441696.
Mm.491630.

3D structure databases

ProteinModelPortaliP56473.
SMRiP56473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005849.

Proteomic databases

PaxDbiP56473.
PRIDEiP56473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705.
ENSMUST00000194091; ENSMUSP00000142044; ENSMUSG00000005705.
GeneIDi11604.
KEGGimmu:11604.
UCSCiuc009ndh.2. mouse.

Organism-specific databases

CTDi181.
MGIiMGI:892013. Agrp.

Phylogenomic databases

eggNOGiENOG410J14P. Eukaryota.
ENOG410Z66T. LUCA.
GeneTreeiENSGT00510000048590.
HOGENOMiHOG000033861.
HOVERGENiHBG050467.
InParanoidiP56473.
KOiK05231.
OMAiMQGAQMG.
OrthoDBiEOG091G1506.
PhylomeDBiP56473.
TreeFamiTF330729.

Miscellaneous databases

PROiP56473.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005705.
CleanExiMM_AGRP.
ExpressionAtlasiP56473. baseline and differential.
GenevisibleiP56473. MM.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiIPR007733. Agouti.
IPR027300. Agouti_dom.
[Graphical view]
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiPF05039. Agouti. 1 hit.
[Graphical view]
SMARTiSM00792. Agouti. 1 hit.
[Graphical view]
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiPS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRP_MOUSE
AccessioniPrimary (citable) accession number: P56473
Secondary accession number(s): O35967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.