Reviewed, UniProtKB/Swiss-Prot P56473 (AGRP_MOUSE)

Names and origin

Protein names

Recommended name:
    Agouti-related protein

Gene names

Name:	Agrp
Synonyms:	Agrt, Art

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.
Subcellular location	Secreted.
Tissue specificity	Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
Induction	Hypothalamic expression is elevated circa 10-fold in ob/ob and db/db mice.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.
Sequence similarities	Contains 1 agouti domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	adult feeding behavior Inferred from direct assay. Source: MGI hormone-mediated signaling pathway Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathway Ref.1 Inferred from direct assay. Source: MGI
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	neuropeptide hormone activity Ref.1 Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 131	111	Agouti-related protein		PRO_0000001035
Regions
	Domain	86 – 128	43	Agouti
Amino acid modifications
	Disulfide bond	86 ↔ 101		By similarity
	Disulfide bond	93 ↔ 107		By similarity
	Disulfide bond	100 ↔ 118		By similarity
	Disulfide bond	104 ↔ 128		By similarity
	Disulfide bond	109 ↔ 116		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56473-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 25D9766D074C6834	FASTA	131	14,432
	10 20 30 40 50 60 MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL KKTTADRAEE 70 80 90 100 110 120 VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC CDPCATCYCR FFNAFCYCRK 130 LGTATNLCSR T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein." Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S. Science 278:135-138(1997) [PubMed: 9311920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129.
[2]	"Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice." Shutter J.R., Graham M., Kinsey A.C., Scully S., Luethy R., Stark K.L. Genes Dev. 11:593-602(1997) [PubMed: 9119224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U89484 mRNA. Translation: AAB68620.1. U89486 Genomic DNA. Translation: AAB68622.1. BC079902 mRNA. Translation: AAH79902.1.
IPI	IPI00113784.
RefSeq	NP_031453.1.
UniGene	Mm.441696
3D structure databases
SMR	P56473. Positions 86-131.
ModBase	Search...
Protein-protein interaction databases
STRING	P56473.
Proteomic databases
PRIDE	P56473.
Genome annotation databases
Ensembl	ENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705; Mus musculus. [Genome view]
GeneID	11604.
KEGG	mmu:11604.
UCSC	uc009ndh.1. mouse.
Organism-specific databases
CTD	11604.
MGI	MGI:892013. Agrp.
Phylogenomic databases
eggNOG	roNOG16557.
HOGENOM	HBG126983.
HOVERGEN	P56473.
InParanoid	P56473.
OMA	LAPLEGI.
OrthoDB	EOG9S4S23.
PhylomeDB	P56473.
Gene expression databases
ArrayExpress	P56473.
Bgee	P56473.
CleanEx	MM_AGRP.
Genevestigator	P56473.
GermOnline	ENSMUSG00000005705. Mus musculus.
Family and domain databases
InterPro	IPR007733. Agouti. [Graphical view]
Gene3D	G3DSA:4.10.760.10. Agouti. 1 hit.
PANTHER	PTHR16551. Agouti. 1 hit.
Pfam	PF05039. Agouti. 1 hit. [Graphical view]
SMART	SM00792. Agouti. 1 hit. [Graphical view]
PROSITE	PS60024. AGOUTI_1. 1 hit. PS51150. AGOUTI_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	279132.
SOURCE	Search...

Entry information

Entry name

AGRP_MOUSE

Accession

Primary (citable) accession number: P56473
Secondary accession number(s): O35967

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	January 19, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)