Reviewed, UniProtKB/Swiss-Prot P56472 (IDH3B_PIG)

Names and origin

Protein names

Recommended name:
    Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    EC=1.1.1.41
Alternative name(s):
    Isocitric dehydrogenase
    NAD(+)-specific ICDH

Gene names

Name:

IDH3B

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	103 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.
Subunit structure	Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial		PRO_0000083591
Experimental info
	Non-adjacent residues	33 – 34	2
	Non-adjacent residues	40 – 41	2
	Non-adjacent residues	59 – 60	2
	Non-adjacent residues	79 – 80	2

Sequences

	Sequence		Length	Mass (Da)
	P56472-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 83D811D29EA7756B	FASTA	103	10,803
	10 20 30 40 50 60 ASRSQAEDVR VEGAFPVTML PGDGVGPELM AAVGVIECLK LGDGLFLQCC EEVAELYPKN 70 80 90 100 IANPTATLLA SCMMLDHLKT SDMGGYATCQ DFTEAVIGAL SHP

References

[1]	"Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase." Huang Y.C., Colman R.F. Biochemistry 29:8266-8273(1990) [PubMed: 2252888] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart.

Cross-references

Sequence databases
PIR	B35834.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P56472.
Enzyme and pathway databases
BRENDA	1.1.1.41. 249.
Family and domain databases
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit.
PROSITE	PS00470. IDH_IMDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDH3B_PIG

Accession

Primary (citable) accession number: P56472

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)