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Protein

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Gene

IDH3B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit beta
NAD(+)-specific ICDH subunit beta
Gene namesi
Name:IDH3B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialPRO_0000083591Add
BLAST

Proteomic databases

PaxDbiP56472.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Structurei

3D structure databases

ProteinModelPortaliP56472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0473.
InParanoidiP56472.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR024084. IsoPropMal-DH-like_dom.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

P56472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASRSQAEDVR VEGAFPVTML PGDGVGPELM AAVGVIECLK LGDGLFLQCC
60 70 80 90 100
EEVAELYPKN IANPTATLLA SCMMLDHLKT SDMGGYATCQ DFTEAVIGAL

SHP
Length:103
Mass (Da):10,803
Last modified:July 15, 1998 - v1
Checksum:i83D811D29EA7756B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi33 – 342Curated
Non-adjacent residuesi40 – 412Curated
Non-adjacent residuesi59 – 602Curated
Non-adjacent residuesi79 – 802Curated

Sequence databases

PIRiB35834.

Cross-referencesi

Sequence databases

PIRiB35834.

3D structure databases

ProteinModelPortaliP56472.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP56472.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG0473.
InParanoidiP56472.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase."
    Huang Y.C., Colman R.F.
    Biochemistry 29:8266-8273(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Heart.

Entry informationi

Entry nameiIDH3B_PIG
AccessioniPrimary (citable) accession number: P56472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.