P56472 (IDH3B_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
EC=1.1.1.41

Alternative name(s):
Isocitric dehydrogenase subunit beta
NAD(+)-specific ICDH subunit beta

Gene names

Name:

IDH3B

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	103 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.
Subunit structure	Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	isocitrate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial		PRO_0000083591
Experimental info
	Non-adjacent residues	33 – 34	2
	Non-adjacent residues	40 – 41	2
	Non-adjacent residues	59 – 60	2
	Non-adjacent residues	79 – 80	2

Sequences

	Sequence		Length	Mass (Da)
	P56472 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 83D811D29EA7756B	FASTA	103	10,803
	10 20 30 40 50 60 ASRSQAEDVR VEGAFPVTML PGDGVGPELM AAVGVIECLK LGDGLFLQCC EEVAELYPKN 70 80 90 100 IANPTATLLA SCMMLDHLKT SDMGGYATCQ DFTEAVIGAL SHP

References

[1]	"Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase." Huang Y.C., Colman R.F. Biochemistry 29:8266-8273(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart.

Cross-references

Sequence databases
PIR	B35834.
3D structure databases
ProteinModelPortal	P56472.
ModBase	Search...
Proteomic databases
PaxDb	P56472.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0473.
Family and domain databases
Gene3D	3.40.718.10. 2 hits.
InterPro	IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PROSITE	PS00470. IDH_IMDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDH3B_PIG

Accession

Primary (citable) accession number: P56472

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program