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Protein

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Gene

IDH3B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit beta
NAD(+)-specific ICDH subunit beta
Gene namesi
Name:IDH3B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835911 – 103Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialAdd BLAST103

Proteomic databases

PaxDbiP56472.
PeptideAtlasiP56472.
PRIDEiP56472.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007635.

Structurei

3D structure databases

ProteinModelPortaliP56472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0784. Eukaryota.
COG0473. LUCA.
InParanoidiP56472.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.

Sequencei

Sequence statusi: Fragments.

P56472-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASRSQAEDVR VEGAFPVTML PGDGVGPELM AAVGVIECLK LGDGLFLQCC
60 70 80 90 100
EEVAELYPKN IANPTATLLA SCMMLDHLKT SDMGGYATCQ DFTEAVIGAL

SHP
Length:103
Mass (Da):10,803
Last modified:July 15, 1998 - v1
Checksum:i83D811D29EA7756B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-adjacent residuesi33 – 34Curated2
Non-adjacent residuesi40 – 41Curated2
Non-adjacent residuesi59 – 60Curated2
Non-adjacent residuesi79 – 80Curated2

Sequence databases

PIRiB35834.
UniGeneiSsc.3464.

Cross-referencesi

Sequence databases

PIRiB35834.
UniGeneiSsc.3464.

3D structure databases

ProteinModelPortaliP56472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007635.

Proteomic databases

PaxDbiP56472.
PeptideAtlasiP56472.
PRIDEiP56472.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0784. Eukaryota.
COG0473. LUCA.
InParanoidiP56472.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIDH3B_PIG
AccessioniPrimary (citable) accession number: P56472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.