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P56472 (IDH3B_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

EC=1.1.1.41
Alternative name(s):
Isocitric dehydrogenase subunit beta
NAD(+)-specific ICDH subunit beta
Gene names
Name:IDH3B
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length103 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Subunit structure

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentMitochondrion
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate dehydrogenase (NAD+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 103103Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
PRO_0000083591

Experimental info

Non-adjacent residues33 – 342
Non-adjacent residues40 – 412
Non-adjacent residues59 – 602
Non-adjacent residues79 – 802

Sequences

Sequence LengthMass (Da)Tools
P56472 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 83D811D29EA7756B

FASTA10310,803
        10         20         30         40         50         60 
ASRSQAEDVR VEGAFPVTML PGDGVGPELM AAVGVIECLK LGDGLFLQCC EEVAELYPKN 

        70         80         90        100 
IANPTATLLA SCMMLDHLKT SDMGGYATCQ DFTEAVIGAL SHP 

« Hide

References

[1]"Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase."
Huang Y.C., Colman R.F.
Biochemistry 29:8266-8273(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Heart.

Cross-references

Sequence databases

PIRB35834.

3D structure databases

ProteinModelPortalP56472.
ModBaseSearch...

Proteomic databases

PaxDbP56472.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0473.

Family and domain databases

Gene3D3.40.718.10. 2 hits.
InterProIPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PROSITEPS00470. IDH_IMDH. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH3B_PIG
AccessionPrimary (citable) accession number: P56472
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families