Reviewed,
UniProtKB/Swiss-Prot P56471 (IDH3A_PIG)
Last modified
November 25, 2008.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial EC=1.1.1.41 Alternative name(s): Isocitric dehydrogenase NAD(+)-specific ICDH | ||
| Gene names |
| ||
| Organism | Sus scrofa (Pig) | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 90 AA. |
| Sequence status | Fragments. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH. |
| Subunit structure | Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1. |
| Subcellular location | |
| Sequence similarities | Belongs to the isocitrate and isopropylmalate dehydrogenases family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Mitochondrion |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Ref.1Inferred from direct assay. Source: UniProtKB |
| Cellular component | mitochondrion Ref.1 Inferred from direct assay. Source: UniProtKB |
| Molecular function | isocitrate dehydrogenase (NAD+) activity Ref.1 Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – ›90 | ›90 | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | PRO_0000083590 | |||||
Experimental info | |||||||||
| Non-adjacent residues | 35 – 36 | 2 | |||||||
| Non-adjacent residues | 48 – 49 | 2 | |||||||
| Non-adjacent residues | 60 – 61 | 2 | |||||||
| Non-adjacent residues | 70 – 71 | 2 | |||||||
| Non-terminal residue | 90 | 1 | |||||||
Sequences
References
| [1] | "Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase." Huang Y.C., Colman R.F. Biochemistry 29:8266-8273(1990) [PubMed: 2252888] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart. |
Cross-references
3D structure databases | |
|---|---|
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P56471. |
Family and domain databases | |
| InterPro | IPR001804. IsoCit_IM_DHase. [Graphical view] |
| Pfam | PF00180. Iso_dh. 1 hit. [Graphical view] |
| PROSITE | PS00470. IDH_IMDH. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IDH3A_PIG | ||||||||
| Accession | Primary (citable) accession number: P56471 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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