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P56471

- IDH3A_PIG

UniProt

P56471 - IDH3A_PIG

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Protein

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Gene
IDH3A
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit alpha
NAD(+)-specific ICDH subunit alpha
Gene namesi
Name:IDH3A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›90›90Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialPRO_0000083590Add
BLAST

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

Structurei

3D structure databases

ProteinModelPortaliP56471.
SMRiP56471. Positions 2-38.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

P56471-1 [UniParc]FASTAAdd to Basket

« Hide

AGGVKTVTLI PGDGIGPEIS AAVMKIFDAA KAPIQANVRP CVSIEGYKFN   50
EMYLDTVCLN IETACFATIK CSDFTEEICR EVAENCKDIK 90
Length:90
Mass (Da):9,691
Last modified:July 15, 1998 - v1
Checksum:iC843422E73477480
GO

Non-adjacent residues

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi35 – 362
Non-adjacent residuesi48 – 492
Non-adjacent residuesi60 – 612
Non-adjacent residuesi70 – 712

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei90 – 901

Cross-referencesi

3D structure databases

ProteinModelPortali P56471.
SMRi P56471. Positions 2-38.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase."
    Huang Y.C., Colman R.F.
    Biochemistry 29:8266-8273(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Heart.

Entry informationi

Entry nameiIDH3A_PIG
AccessioniPrimary (citable) accession number: P56471
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3