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P56470 (LEG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-4

Short name=Gal-4
Alternative name(s):
Antigen NY-CO-27
L-36 lactose-binding protein
Short name=L36LBP
Lactose-binding lectin 4
Gene names
Name:LGALS4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

Subunit structure

Monomer By similarity.

Domain

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similarities

Contains 2 galectin domains.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
   LigandLectin
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Traceable author statement Ref.3. Source: ProtInc

   Cellular_componentcytosol

Traceable author statement Ref.3. Source: ProtInc

plasma membrane

Traceable author statement Ref.3. Source: ProtInc

   Molecular_functioncarbohydrate binding

Traceable author statement Ref.3. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Galectin-4
PRO_0000076934

Regions

Domain19 – 150132Galectin 1
Domain194 – 323130Galectin 2
Region256 – 2627Beta-galactoside binding By similarity

Natural variations

Natural variant161T → M.
Corresponds to variant rs8106404 [ dbSNP | Ensembl ].
VAR_049769

Secondary structure

.......................... 323
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56470 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: E79EC0A9AB3990EF

FASTA32335,941
        10         20         30         40         50         60 
MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF VVGQDPGSDV 

        70         80         90        100        110        120 
AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA FELVFIVLAE HYKVVVNGNP 

       130        140        150        160        170        180 
FYEYGHRLPL QMVTHLQVDG DLQLQSINFI GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP 

       190        200        210        220        230        240 
TMEGPPTFNP PVPYFGRLQG GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR 

       250        260        270        280        290        300 
MGNGTVVRNS LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR 

       310        320 
LSAFQRVDTL EIQGDVTLSY VQI 

« Hide

References

« Hide 'large scale' references
[1]Kato S.
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Gastric carcinoma.
[2]"Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer."
Rechreche H., Mallo G.V., Montalto G., Dagorn J.-C., Iovanna J.L.
Eur. J. Biochem. 248:225-230(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon carcinoma.
[3]"Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion."
Huflejt M.E., Jordan E.T., Gitt M.A., Barondes S.H., Leffler H.
J. Biol. Chem. 272:14294-14303(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Skin.
[5]"Solution structure of the C-terminal Gal-bind lectin domain from human galectin-4."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 173-323.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006781 mRNA. Translation: BAA22165.1.
AF014838 mRNA. Translation: AAC51763.1.
U82953 mRNA. Translation: AAB86590.1.
BC003661 mRNA. Translation: AAH03661.1.
BC005146 mRNA. Translation: AAH05146.1.
BC034750 mRNA. Translation: AAH34750.1.
RefSeqNP_006140.1. NM_006149.3.
UniGeneHs.5302.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1X50NMR-A173-323[»]
ProteinModelPortalP56470.
SMRP56470. Positions 13-154, 173-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110151. 4 interactions.
IntActP56470. 5 interactions.
MINTMINT-1401408.
STRING9606.ENSP00000302100.

Chemistry

BindingDBP56470.
ChEMBLCHEMBL1671608.

PTM databases

PhosphoSiteP56470.

Polymorphism databases

DMDM3024079.

Proteomic databases

PaxDbP56470.
PRIDEP56470.

Protocols and materials databases

DNASU3960.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307751; ENSP00000302100; ENSG00000171747.
GeneID3960.
KEGGhsa:3960.
UCSCuc002ojg.3. human.

Organism-specific databases

CTD3960.
GeneCardsGC19M039292.
HGNCHGNC:6565. LGALS4.
HPACAB025653.
MIM602518. gene.
neXtProtNX_P56470.
PharmGKBPA30342.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG264430.
HOGENOMHOG000290194.
HOVERGENHBG002412.
InParanoidP56470.
KOK10091.
OMAFYEYGHR.
PhylomeDBP56470.
TreeFamTF315551.

Gene expression databases

ArrayExpressP56470.
BgeeP56470.
CleanExHS_LGALS4.
GenevestigatorP56470.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERPTHR11346:SF23. PTHR11346:SF23. 1 hit.
PfamPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLGALS4. human.
EvolutionaryTraceP56470.
GeneWikiLGALS4.
GenomeRNAi3960.
NextBio15540.
PROP56470.
SOURCESearch...

Entry information

Entry nameLEG4_HUMAN
AccessionPrimary (citable) accession number: P56470
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 19, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM