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Protein

Galectin-4

Gene

LGALS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

GO - Molecular functioni

  1. carbohydrate binding Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-4
Short name:
Gal-4
Alternative name(s):
Antigen NY-CO-27
L-36 lactose-binding protein
Short name:
L36LBP
Lactose-binding lectin 4
Gene namesi
Name:LGALS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6565. LGALS4.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: ProtInc
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Galectin-4PRO_0000076934Add
BLAST

Proteomic databases

PaxDbiP56470.
PRIDEiP56470.

PTM databases

PhosphoSiteiP56470.

Expressioni

Gene expression databases

BgeeiP56470.
CleanExiHS_LGALS4.
ExpressionAtlasiP56470. baseline and differential.
GenevestigatoriP56470.

Organism-specific databases

HPAiCAB025653.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi110151. 4 interactions.
IntActiP56470. 5 interactions.
MINTiMINT-1401408.
STRINGi9606.ENSP00000302100.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi187 – 1893Combined sources
Beta strandi192 – 1976Combined sources
Beta strandi206 – 2138Combined sources
Beta strandi221 – 2266Combined sources
Beta strandi228 – 2303Combined sources
Beta strandi234 – 2385Combined sources
Turni241 – 2433Combined sources
Beta strandi247 – 2493Combined sources
Beta strandi272 – 2809Combined sources
Beta strandi282 – 29817Combined sources
Helixi302 – 3065Combined sources
Beta strandi309 – 3157Combined sources
Beta strandi317 – 3237Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X50NMR-A173-323[»]
ProteinModelPortaliP56470.
SMRiP56470. Positions 13-154, 173-323.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56470.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 150132Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini194 – 323130Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 2627Beta-galactoside bindingBy similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP56470.
KOiK10091.
OMAiFYEYGHR.
PhylomeDBiP56470.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56470-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF
60 70 80 90 100
VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA
110 120 130 140 150
FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI
160 170 180 190 200
GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG
210 220 230 240 250
GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS
260 270 280 290 300
LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR
310 320
LSAFQRVDTL EIQGDVTLSY VQI
Length:323
Mass (Da):35,941
Last modified:July 15, 1998 - v1
Checksum:iE79EC0A9AB3990EF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161T → M.
Corresponds to variant rs8106404 [ dbSNP | Ensembl ].
VAR_049769

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006781 mRNA. Translation: BAA22165.1.
AF014838 mRNA. Translation: AAC51763.1.
U82953 mRNA. Translation: AAB86590.1.
BC003661 mRNA. Translation: AAH03661.1.
BC005146 mRNA. Translation: AAH05146.1.
BC034750 mRNA. Translation: AAH34750.1.
CCDSiCCDS12521.1.
RefSeqiNP_006140.1. NM_006149.3.
UniGeneiHs.5302.

Genome annotation databases

EnsembliENST00000307751; ENSP00000302100; ENSG00000171747.
GeneIDi3960.
KEGGihsa:3960.
UCSCiuc002ojg.3. human.

Polymorphism databases

DMDMi3024079.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006781 mRNA. Translation: BAA22165.1.
AF014838 mRNA. Translation: AAC51763.1.
U82953 mRNA. Translation: AAB86590.1.
BC003661 mRNA. Translation: AAH03661.1.
BC005146 mRNA. Translation: AAH05146.1.
BC034750 mRNA. Translation: AAH34750.1.
CCDSiCCDS12521.1.
RefSeqiNP_006140.1. NM_006149.3.
UniGeneiHs.5302.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X50NMR-A173-323[»]
ProteinModelPortaliP56470.
SMRiP56470. Positions 13-154, 173-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110151. 4 interactions.
IntActiP56470. 5 interactions.
MINTiMINT-1401408.
STRINGi9606.ENSP00000302100.

Chemistry

BindingDBiP56470.
ChEMBLiCHEMBL1671608.

PTM databases

PhosphoSiteiP56470.

Polymorphism databases

DMDMi3024079.

Proteomic databases

PaxDbiP56470.
PRIDEiP56470.

Protocols and materials databases

DNASUi3960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307751; ENSP00000302100; ENSG00000171747.
GeneIDi3960.
KEGGihsa:3960.
UCSCiuc002ojg.3. human.

Organism-specific databases

CTDi3960.
GeneCardsiGC19M039292.
HGNCiHGNC:6565. LGALS4.
HPAiCAB025653.
MIMi602518. gene.
neXtProtiNX_P56470.
PharmGKBiPA30342.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP56470.
KOiK10091.
OMAiFYEYGHR.
PhylomeDBiP56470.
TreeFamiTF315551.

Miscellaneous databases

ChiTaRSiLGALS4. human.
EvolutionaryTraceiP56470.
GeneWikiiLGALS4.
GenomeRNAii3960.
NextBioi15540.
PROiP56470.
SOURCEiSearch...

Gene expression databases

BgeeiP56470.
CleanExiHS_LGALS4.
ExpressionAtlasiP56470. baseline and differential.
GenevestigatoriP56470.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kato S.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gastric carcinoma.
  2. "Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer."
    Rechreche H., Mallo G.V., Montalto G., Dagorn J.-C., Iovanna J.L.
    Eur. J. Biochem. 248:225-230(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  3. "Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion."
    Huflejt M.E., Jordan E.T., Gitt M.A., Barondes S.H., Leffler H.
    J. Biol. Chem. 272:14294-14303(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Skin.
  5. "Solution structure of the C-terminal Gal-bind lectin domain from human galectin-4."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 173-323.

Entry informationi

Entry nameiLEG4_HUMAN
AccessioniPrimary (citable) accession number: P56470
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: January 7, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.