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P56470

- LEG4_HUMAN

UniProt

P56470 - LEG4_HUMAN

Protein

Galectin-4

Gene

LGALS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

    GO - Molecular functioni

    1. carbohydrate binding Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: ProtInc

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-4
    Short name:
    Gal-4
    Alternative name(s):
    Antigen NY-CO-27
    L-36 lactose-binding protein
    Short name:
    L36LBP
    Lactose-binding lectin 4
    Gene namesi
    Name:LGALS4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6565. LGALS4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: ProtInc
    2. plasma membrane Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30342.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Galectin-4PRO_0000076934Add
    BLAST

    Proteomic databases

    PaxDbiP56470.
    PRIDEiP56470.

    PTM databases

    PhosphoSiteiP56470.

    Expressioni

    Gene expression databases

    ArrayExpressiP56470.
    BgeeiP56470.
    CleanExiHS_LGALS4.
    GenevestigatoriP56470.

    Organism-specific databases

    HPAiCAB025653.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi110151. 4 interactions.
    IntActiP56470. 5 interactions.
    MINTiMINT-1401408.
    STRINGi9606.ENSP00000302100.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi187 – 1893
    Beta strandi192 – 1976
    Beta strandi206 – 2138
    Beta strandi221 – 2266
    Beta strandi228 – 2303
    Beta strandi234 – 2385
    Turni241 – 2433
    Beta strandi247 – 2493
    Beta strandi272 – 2809
    Beta strandi282 – 29817
    Helixi302 – 3065
    Beta strandi309 – 3157
    Beta strandi317 – 3237

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X50NMR-A173-323[»]
    ProteinModelPortaliP56470.
    SMRiP56470. Positions 13-154, 173-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56470.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 150132Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 323130Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni256 – 2627Beta-galactoside bindingBy similarity

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG264430.
    HOGENOMiHOG000290194.
    HOVERGENiHBG002412.
    InParanoidiP56470.
    KOiK10091.
    OMAiFYEYGHR.
    PhylomeDBiP56470.
    TreeFamiTF315551.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR015533. Galectin4/6.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56470-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF    50
    VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA 100
    FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI 150
    GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG 200
    GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS 250
    LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR 300
    LSAFQRVDTL EIQGDVTLSY VQI 323
    Length:323
    Mass (Da):35,941
    Last modified:July 15, 1998 - v1
    Checksum:iE79EC0A9AB3990EF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161T → M.
    Corresponds to variant rs8106404 [ dbSNP | Ensembl ].
    VAR_049769

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006781 mRNA. Translation: BAA22165.1.
    AF014838 mRNA. Translation: AAC51763.1.
    U82953 mRNA. Translation: AAB86590.1.
    BC003661 mRNA. Translation: AAH03661.1.
    BC005146 mRNA. Translation: AAH05146.1.
    BC034750 mRNA. Translation: AAH34750.1.
    CCDSiCCDS12521.1.
    RefSeqiNP_006140.1. NM_006149.3.
    UniGeneiHs.5302.

    Genome annotation databases

    EnsembliENST00000307751; ENSP00000302100; ENSG00000171747.
    GeneIDi3960.
    KEGGihsa:3960.
    UCSCiuc002ojg.3. human.

    Polymorphism databases

    DMDMi3024079.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Galectin-4

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006781 mRNA. Translation: BAA22165.1 .
    AF014838 mRNA. Translation: AAC51763.1 .
    U82953 mRNA. Translation: AAB86590.1 .
    BC003661 mRNA. Translation: AAH03661.1 .
    BC005146 mRNA. Translation: AAH05146.1 .
    BC034750 mRNA. Translation: AAH34750.1 .
    CCDSi CCDS12521.1.
    RefSeqi NP_006140.1. NM_006149.3.
    UniGenei Hs.5302.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X50 NMR - A 173-323 [» ]
    ProteinModelPortali P56470.
    SMRi P56470. Positions 13-154, 173-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110151. 4 interactions.
    IntActi P56470. 5 interactions.
    MINTi MINT-1401408.
    STRINGi 9606.ENSP00000302100.

    Chemistry

    BindingDBi P56470.
    ChEMBLi CHEMBL1671608.

    PTM databases

    PhosphoSitei P56470.

    Polymorphism databases

    DMDMi 3024079.

    Proteomic databases

    PaxDbi P56470.
    PRIDEi P56470.

    Protocols and materials databases

    DNASUi 3960.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307751 ; ENSP00000302100 ; ENSG00000171747 .
    GeneIDi 3960.
    KEGGi hsa:3960.
    UCSCi uc002ojg.3. human.

    Organism-specific databases

    CTDi 3960.
    GeneCardsi GC19M039292.
    HGNCi HGNC:6565. LGALS4.
    HPAi CAB025653.
    MIMi 602518. gene.
    neXtProti NX_P56470.
    PharmGKBi PA30342.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264430.
    HOGENOMi HOG000290194.
    HOVERGENi HBG002412.
    InParanoidi P56470.
    KOi K10091.
    OMAi FYEYGHR.
    PhylomeDBi P56470.
    TreeFami TF315551.

    Miscellaneous databases

    ChiTaRSi LGALS4. human.
    EvolutionaryTracei P56470.
    GeneWikii LGALS4.
    GenomeRNAii 3960.
    NextBioi 15540.
    PROi P56470.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56470.
    Bgeei P56470.
    CleanExi HS_LGALS4.
    Genevestigatori P56470.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR015533. Galectin4/6.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    PANTHERi PTHR11346:SF32. PTHR11346:SF32. 1 hit.
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kato S.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Gastric carcinoma.
    2. "Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer."
      Rechreche H., Mallo G.V., Montalto G., Dagorn J.-C., Iovanna J.L.
      Eur. J. Biochem. 248:225-230(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon carcinoma.
    3. "Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion."
      Huflejt M.E., Jordan E.T., Gitt M.A., Barondes S.H., Leffler H.
      J. Biol. Chem. 272:14294-14303(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Skin.
    5. "Solution structure of the C-terminal Gal-bind lectin domain from human galectin-4."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 173-323.

    Entry informationi

    Entry nameiLEG4_HUMAN
    AccessioniPrimary (citable) accession number: P56470
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3