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Protein

Galectin-4

Gene

LGALS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • galactoside binding Source: Ensembl

GO - Biological processi

  • cell adhesion Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171747-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-4
Short name:
Gal-4
Alternative name(s):
Antigen NY-CO-27
L-36 lactose-binding protein
Short name:
L36LBP
Lactose-binding lectin 4
Gene namesi
Name:LGALS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6565. LGALS4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: ProtInc
  • extracellular space Source: Ensembl
  • plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi3960.
OpenTargetsiENSG00000171747.
ENSG00000282992.
PharmGKBiPA30342.

Chemistry databases

ChEMBLiCHEMBL1671608.

Polymorphism and mutation databases

BioMutaiLGALS4.
DMDMi3024079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769341 – 323Galectin-4Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP56470.
PeptideAtlasiP56470.
PRIDEiP56470.

PTM databases

iPTMnetiP56470.
PhosphoSitePlusiP56470.

Expressioni

Gene expression databases

BgeeiENSG00000171747.
CleanExiHS_LGALS4.
ExpressionAtlasiP56470. baseline and differential.
GenevisibleiP56470. HS.

Organism-specific databases

HPAiCAB025653.
HPA031184.
HPA031185.
HPA031186.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi110151. 4 interactors.
IntActiP56470. 10 interactors.
MINTiMINT-1401408.
STRINGi9606.ENSP00000302100.

Chemistry databases

BindingDBiP56470.

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 14Combined sources3
Beta strandi17 – 22Combined sources6
Beta strandi32 – 38Combined sources7
Beta strandi46 – 55Combined sources10
Beta strandi60 – 67Combined sources8
Beta strandi69 – 71Combined sources3
Beta strandi73 – 80Combined sources8
Beta strandi88 – 91Combined sources4
Beta strandi100 – 107Combined sources8
Beta strandi109 – 116Combined sources8
Beta strandi119 – 125Combined sources7
Helixi130 – 132Combined sources3
Beta strandi135 – 150Combined sources16
Beta strandi187 – 189Combined sources3
Beta strandi192 – 197Combined sources6
Beta strandi206 – 213Combined sources8
Beta strandi220 – 226Combined sources7
Turni228 – 230Combined sources3
Beta strandi233 – 240Combined sources8
Turni241 – 244Combined sources4
Beta strandi245 – 251Combined sources7
Beta strandi273 – 280Combined sources8
Beta strandi282 – 289Combined sources8
Beta strandi292 – 298Combined sources7
Beta strandi300 – 302Combined sources3
Helixi304 – 306Combined sources3
Beta strandi309 – 315Combined sources7
Beta strandi317 – 322Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X50NMR-A173-323[»]
4XZPX-ray1.48A1-152[»]
4YLZX-ray2.10A/B/C/D171-323[»]
4YM0X-ray2.30A/B/C/D171-323[»]
4YM1X-ray2.00A/B/C/D171-323[»]
4YM2X-ray2.10A/B/C/D171-323[»]
4YM3X-ray1.89A/B/C/D171-323[»]
5CBLX-ray1.78A/B/C/D179-323[»]
5DUUX-ray2.00A/B/C/D1-155[»]
5DUVX-ray1.90A/B/C/D1-155[»]
5DUWX-ray1.70A/B/C/D1-155[»]
5DUXX-ray1.85A/B/C/D1-155[»]
ProteinModelPortaliP56470.
SMRiP56470.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56470.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 150Galectin 1PROSITE-ProRule annotationAdd BLAST132
Domaini194 – 323Galectin 2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 262Beta-galactoside bindingBy similarity7

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP56470.
KOiK10091.
OMAiSVGMSIY.
OrthoDBiEOG091G0WP8.
PhylomeDBiP56470.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF
60 70 80 90 100
VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA
110 120 130 140 150
FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI
160 170 180 190 200
GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG
210 220 230 240 250
GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS
260 270 280 290 300
LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR
310 320
LSAFQRVDTL EIQGDVTLSY VQI
Length:323
Mass (Da):35,941
Last modified:July 15, 1998 - v1
Checksum:iE79EC0A9AB3990EF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04976916T → M.Corresponds to variant rs8106404dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006781 mRNA. Translation: BAA22165.1.
AF014838 mRNA. Translation: AAC51763.1.
U82953 mRNA. Translation: AAB86590.1.
BC003661 mRNA. Translation: AAH03661.1.
BC005146 mRNA. Translation: AAH05146.1.
BC034750 mRNA. Translation: AAH34750.1.
CCDSiCCDS12521.1.
RefSeqiNP_006140.1. NM_006149.3.
UniGeneiHs.5302.

Genome annotation databases

EnsembliENST00000307751; ENSP00000302100; ENSG00000171747.
ENST00000634573; ENSP00000489411; ENSG00000282992.
GeneIDi3960.
KEGGihsa:3960.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006781 mRNA. Translation: BAA22165.1.
AF014838 mRNA. Translation: AAC51763.1.
U82953 mRNA. Translation: AAB86590.1.
BC003661 mRNA. Translation: AAH03661.1.
BC005146 mRNA. Translation: AAH05146.1.
BC034750 mRNA. Translation: AAH34750.1.
CCDSiCCDS12521.1.
RefSeqiNP_006140.1. NM_006149.3.
UniGeneiHs.5302.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X50NMR-A173-323[»]
4XZPX-ray1.48A1-152[»]
4YLZX-ray2.10A/B/C/D171-323[»]
4YM0X-ray2.30A/B/C/D171-323[»]
4YM1X-ray2.00A/B/C/D171-323[»]
4YM2X-ray2.10A/B/C/D171-323[»]
4YM3X-ray1.89A/B/C/D171-323[»]
5CBLX-ray1.78A/B/C/D179-323[»]
5DUUX-ray2.00A/B/C/D1-155[»]
5DUVX-ray1.90A/B/C/D1-155[»]
5DUWX-ray1.70A/B/C/D1-155[»]
5DUXX-ray1.85A/B/C/D1-155[»]
ProteinModelPortaliP56470.
SMRiP56470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110151. 4 interactors.
IntActiP56470. 10 interactors.
MINTiMINT-1401408.
STRINGi9606.ENSP00000302100.

Chemistry databases

BindingDBiP56470.
ChEMBLiCHEMBL1671608.

PTM databases

iPTMnetiP56470.
PhosphoSitePlusiP56470.

Polymorphism and mutation databases

BioMutaiLGALS4.
DMDMi3024079.

Proteomic databases

PaxDbiP56470.
PeptideAtlasiP56470.
PRIDEiP56470.

Protocols and materials databases

DNASUi3960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307751; ENSP00000302100; ENSG00000171747.
ENST00000634573; ENSP00000489411; ENSG00000282992.
GeneIDi3960.
KEGGihsa:3960.

Organism-specific databases

CTDi3960.
DisGeNETi3960.
GeneCardsiLGALS4.
HGNCiHGNC:6565. LGALS4.
HPAiCAB025653.
HPA031184.
HPA031185.
HPA031186.
MIMi602518. gene.
neXtProtiNX_P56470.
OpenTargetsiENSG00000171747.
ENSG00000282992.
PharmGKBiPA30342.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP56470.
KOiK10091.
OMAiSVGMSIY.
OrthoDBiEOG091G0WP8.
PhylomeDBiP56470.
TreeFamiTF315551.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171747-MONOMER.

Miscellaneous databases

ChiTaRSiLGALS4. human.
EvolutionaryTraceiP56470.
GeneWikiiLGALS4.
GenomeRNAii3960.
PROiP56470.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171747.
CleanExiHS_LGALS4.
ExpressionAtlasiP56470. baseline and differential.
GenevisibleiP56470. HS.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEG4_HUMAN
AccessioniPrimary (citable) accession number: P56470
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.