ID   CORT_MOUSE              Reviewed;         109 AA.
AC   P56469; A2AH76; Q9R1P8;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Cortistatin;
DE   Contains:
DE     RecName: Full=Cortistatin-14;
DE   Flags: Precursor;
GN   Name=Cort;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=9205124; DOI=10.1006/geno.1997.4763;
RA   de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E.,
RA   Frankel W.N., Sutcliffe J.G.;
RT   "Cloning, mRNA expression, and chromosomal mapping of mouse and human
RT   preprocortistatin.";
RL   Genomics 42:499-506(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=129/Sv;
RX   PubMed=10521599; DOI=10.1016/s0169-328x(99)00220-x;
RA   Calbet M., Guadano-Ferraz A., Spier A.D., Maj M., Sutcliffe J.G.,
RA   Przewlocki R., de Lecea L.;
RT   "Cortistatin and somatostatin mRNAs are differentially regulated in
RT   response to kainate.";
RL   Brain Res. Mol. Brain Res. 72:55-64(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in a subset of GABAergic cells in the
CC       cortex and hippocampus.
CC   -!- INDUCTION: Not induced by kainate. {ECO:0000269|PubMed:10521599}.
CC   -!- SIMILARITY: Belongs to the somatostatin family. {ECO:0000305}.
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DR   EMBL; AF013253; AAB66896.1; -; mRNA.
DR   EMBL; AF050156; AAD51127.1; -; Genomic_DNA.
DR   EMBL; AK013496; BAB28882.1; -; mRNA.
DR   EMBL; AL731655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS18953.1; -.
DR   RefSeq; NP_031771.1; NM_007745.4.
DR   AlphaFoldDB; P56469; -.
DR   STRING; 10090.ENSMUSP00000030815; -.
DR   PhosphoSitePlus; P56469; -.
DR   PaxDb; 10090-ENSMUSP00000030815; -.
DR   Antibodypedia; 57276; 52 antibodies from 12 providers.
DR   DNASU; 12854; -.
DR   Ensembl; ENSMUST00000030815.3; ENSMUSP00000030815.3; ENSMUSG00000028971.5.
DR   GeneID; 12854; -.
DR   KEGG; mmu:12854; -.
DR   UCSC; uc008vvs.1; mouse.
DR   AGR; MGI:109538; -.
DR   CTD; 1325; -.
DR   MGI; MGI:109538; Cort.
DR   VEuPathDB; HostDB:ENSMUSG00000028971; -.
DR   eggNOG; ENOG502S1NT; Eukaryota.
DR   GeneTree; ENSGT00730000111752; -.
DR   HOGENOM; CLU_124515_0_0_1; -.
DR   InParanoid; P56469; -.
DR   OMA; TRCKNFF; -.
DR   OrthoDB; 5360457at2759; -.
DR   PhylomeDB; P56469; -.
DR   Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   BioGRID-ORCS; 12854; 2 hits in 75 CRISPR screens.
DR   PRO; PR:P56469; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; P56469; Protein.
DR   Bgee; ENSMUSG00000028971; Expressed in embryonic brain and 67 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISO:MGI.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:MGI.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISO:MGI.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; ISO:MGI.
DR   InterPro; IPR004250; Somatostatin.
DR   InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR   PANTHER; PTHR10558:SF1; CORTISTATIN; 1.
DR   PANTHER; PTHR10558; SOMATOSTATIN; 1.
DR   Pfam; PF03002; Somatostatin; 1.
DR   PIRSF; PIRSF001814; Somatostatin; 1.
DR   Genevisible; P56469; MM.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..93
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033157"
FT   PEPTIDE         96..109
FT                   /note="Cortistatin-14"
FT                   /id="PRO_0000033158"
FT   REGION          64..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        97..108
FT                   /evidence="ECO:0000250"
FT   CONFLICT        40
FT                   /note="Missing (in Ref. 2; AAD51127)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        57..59
FT                   /note="Missing (in Ref. 2; AAD51127)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   109 AA;  11613 MW;  630D3BDD0488F722 CRC64;
     MMGGRGTGGK WPSAFGLLLL WGVAASALPL ESGPTGQDSV QEATEGRSGL LTFLAWWHEW
     ASQASSSTPV GGGTPGLSKS QERPPPQQPP HLDKKPCKNF FWKTFSSCK
//