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P56469 (CORT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cortistatin

Cleaved into the following chain:

  1. Cortistatin-14
Gene names
Name:Cort
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length109 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted.

Tissue specificity

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Induction

Not induced by kainate. Ref.2

Sequence similarities

Belongs to the somatostatin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 9368 Potential
PRO_0000033157
Peptide96 – 10914Cortistatin-14
PRO_0000033158

Amino acid modifications

Disulfide bond97 ↔ 108 By similarity

Experimental info

Sequence conflict401Missing in AAD51127. Ref.2
Sequence conflict57 – 593Missing in AAD51127. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P56469 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 630D3BDD0488F722

FASTA10911,613
        10         20         30         40         50         60 
MMGGRGTGGK WPSAFGLLLL WGVAASALPL ESGPTGQDSV QEATEGRSGL LTFLAWWHEW 

        70         80         90        100 
ASQASSSTPV GGGTPGLSKS QERPPPQQPP HLDKKPCKNF FWKTFSSCK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin."
de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E., Frankel W.N., Sutcliffe J.G.
Genomics 42:499-506(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate."
Calbet M., Guadano-Ferraz A., Spier A.D., Maj M., Sutcliffe J.G., Przewlocki R., de Lecea L.
Brain Res. Mol. Brain Res. 72:55-64(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
Strain: 129/Sv.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF013253 mRNA. Translation: AAB66896.1.
AF050156 Genomic DNA. Translation: AAD51127.1.
AK013496 mRNA. Translation: BAB28882.1.
AL731655 Genomic DNA. Translation: CAM18589.1.
CCDSCCDS18953.1.
RefSeqNP_031771.1. NM_007745.3.
UniGeneMm.6204.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000030815.

Proteomic databases

PRIDEP56469.

Protocols and materials databases

DNASU12854.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030815; ENSMUSP00000030815; ENSMUSG00000028971.
GeneID12854.
KEGGmmu:12854.
UCSCuc008vvs.1. mouse.

Organism-specific databases

CTD1325.
MGIMGI:109538. Cort.

Phylogenomic databases

eggNOGNOG47299.
GeneTreeENSGT00730000111752.
HOGENOMHOG000036630.
HOVERGENHBG017816.
InParanoidA2AH76.
KOK05238.
OMARGITSAD.
OrthoDBEOG77Q506.
PhylomeDBP56469.

Gene expression databases

BgeeP56469.
CleanExMM_CORT.
GenevestigatorP56469.

Family and domain databases

InterProIPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamPF03002. Somatostatin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282404.
PROP56469.
SOURCESearch...

Entry information

Entry nameCORT_MOUSE
AccessionPrimary (citable) accession number: P56469
Secondary accession number(s): A2AH76, Q9R1P8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot