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P56469

- CORT_MOUSE

UniProt

P56469 - CORT_MOUSE

Protein

Cortistatin

Gene

Cort

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cortistatin
    Cleaved into the following chain:
    Gene namesi
    Name:Cort
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:109538. Cort.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 9368Sequence AnalysisPRO_0000033157Add
    BLAST
    Peptidei96 – 10914Cortistatin-14PRO_0000033158Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi97 ↔ 108By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP56469.

    Expressioni

    Tissue specificityi

    Expressed in a subset of GABAergic cells in the cortex and hippocampus.

    Inductioni

    Not induced by kainate.1 Publication

    Gene expression databases

    BgeeiP56469.
    CleanExiMM_CORT.
    GenevestigatoriP56469.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000030815.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatostatin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47299.
    GeneTreeiENSGT00730000111752.
    HOGENOMiHOG000036630.
    HOVERGENiHBG017816.
    InParanoidiA2AH76.
    KOiK05238.
    OMAiRGITSAD.
    OrthoDBiEOG77Q506.
    PhylomeDBiP56469.

    Family and domain databases

    InterProiIPR018142. Somatostatin/Cortistatin_C.
    [Graphical view]
    PfamiPF03002. Somatostatin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56469-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMGGRGTGGK WPSAFGLLLL WGVAASALPL ESGPTGQDSV QEATEGRSGL    50
    LTFLAWWHEW ASQASSSTPV GGGTPGLSKS QERPPPQQPP HLDKKPCKNF 100
    FWKTFSSCK 109
    Length:109
    Mass (Da):11,613
    Last modified:July 15, 1998 - v1
    Checksum:i630D3BDD0488F722
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401Missing in AAD51127. (PubMed:10521599)Curated
    Sequence conflicti57 – 593Missing in AAD51127. (PubMed:10521599)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013253 mRNA. Translation: AAB66896.1.
    AF050156 Genomic DNA. Translation: AAD51127.1.
    AK013496 mRNA. Translation: BAB28882.1.
    AL731655 Genomic DNA. Translation: CAM18589.1.
    CCDSiCCDS18953.1.
    RefSeqiNP_031771.1. NM_007745.3.
    UniGeneiMm.6204.

    Genome annotation databases

    EnsembliENSMUST00000030815; ENSMUSP00000030815; ENSMUSG00000028971.
    GeneIDi12854.
    KEGGimmu:12854.
    UCSCiuc008vvs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013253 mRNA. Translation: AAB66896.1 .
    AF050156 Genomic DNA. Translation: AAD51127.1 .
    AK013496 mRNA. Translation: BAB28882.1 .
    AL731655 Genomic DNA. Translation: CAM18589.1 .
    CCDSi CCDS18953.1.
    RefSeqi NP_031771.1. NM_007745.3.
    UniGenei Mm.6204.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000030815.

    Proteomic databases

    PRIDEi P56469.

    Protocols and materials databases

    DNASUi 12854.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030815 ; ENSMUSP00000030815 ; ENSMUSG00000028971 .
    GeneIDi 12854.
    KEGGi mmu:12854.
    UCSCi uc008vvs.1. mouse.

    Organism-specific databases

    CTDi 1325.
    MGIi MGI:109538. Cort.

    Phylogenomic databases

    eggNOGi NOG47299.
    GeneTreei ENSGT00730000111752.
    HOGENOMi HOG000036630.
    HOVERGENi HBG017816.
    InParanoidi A2AH76.
    KOi K05238.
    OMAi RGITSAD.
    OrthoDBi EOG77Q506.
    PhylomeDBi P56469.

    Miscellaneous databases

    NextBioi 282404.
    PROi P56469.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56469.
    CleanExi MM_CORT.
    Genevestigatori P56469.

    Family and domain databases

    InterProi IPR018142. Somatostatin/Cortistatin_C.
    [Graphical view ]
    Pfami PF03002. Somatostatin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin."
      de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E., Frankel W.N., Sutcliffe J.G.
      Genomics 42:499-506(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate."
      Calbet M., Guadano-Ferraz A., Spier A.D., Maj M., Sutcliffe J.G., Przewlocki R., de Lecea L.
      Brain Res. Mol. Brain Res. 72:55-64(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
      Strain: 129/Sv.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCORT_MOUSE
    AccessioniPrimary (citable) accession number: P56469
    Secondary accession number(s): A2AH76, Q9R1P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3