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Protein

Cortistatin

Gene

Cort

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cortistatin
Cleaved into the following chain:
Gene namesi
Name:Cort
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109538. Cort.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000003315726 – 93Sequence analysisAdd BLAST68
PeptideiPRO_000003315896 – 109Cortistatin-14Add BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 108By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP56469.
PRIDEiP56469.

PTM databases

PhosphoSitePlusiP56469.

Expressioni

Tissue specificityi

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Inductioni

Not induced by kainate.1 Publication

Gene expression databases

BgeeiENSMUSG00000028971.
CleanExiMM_CORT.
GenevisibleiP56469. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030815.

Structurei

3D structure databases

ProteinModelPortaliP56469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3SG. Eukaryota.
ENOG411196C. LUCA.
GeneTreeiENSGT00730000111752.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP56469.
KOiK05238.
OrthoDBiEOG091G157X.
PhylomeDBiP56469.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGGRGTGGK WPSAFGLLLL WGVAASALPL ESGPTGQDSV QEATEGRSGL
60 70 80 90 100
LTFLAWWHEW ASQASSSTPV GGGTPGLSKS QERPPPQQPP HLDKKPCKNF

FWKTFSSCK
Length:109
Mass (Da):11,613
Last modified:July 15, 1998 - v1
Checksum:i630D3BDD0488F722
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40Missing in AAD51127 (PubMed:10521599).Curated1
Sequence conflicti57 – 59Missing in AAD51127 (PubMed:10521599).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013253 mRNA. Translation: AAB66896.1.
AF050156 Genomic DNA. Translation: AAD51127.1.
AK013496 mRNA. Translation: BAB28882.1.
AL731655 Genomic DNA. Translation: CAM18589.1.
CCDSiCCDS18953.1.
RefSeqiNP_031771.1. NM_007745.4.
UniGeneiMm.6204.

Genome annotation databases

EnsembliENSMUST00000030815; ENSMUSP00000030815; ENSMUSG00000028971.
GeneIDi12854.
KEGGimmu:12854.
UCSCiuc008vvs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013253 mRNA. Translation: AAB66896.1.
AF050156 Genomic DNA. Translation: AAD51127.1.
AK013496 mRNA. Translation: BAB28882.1.
AL731655 Genomic DNA. Translation: CAM18589.1.
CCDSiCCDS18953.1.
RefSeqiNP_031771.1. NM_007745.4.
UniGeneiMm.6204.

3D structure databases

ProteinModelPortaliP56469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030815.

PTM databases

PhosphoSitePlusiP56469.

Proteomic databases

PaxDbiP56469.
PRIDEiP56469.

Protocols and materials databases

DNASUi12854.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030815; ENSMUSP00000030815; ENSMUSG00000028971.
GeneIDi12854.
KEGGimmu:12854.
UCSCiuc008vvs.1. mouse.

Organism-specific databases

CTDi1325.
MGIiMGI:109538. Cort.

Phylogenomic databases

eggNOGiENOG410J3SG. Eukaryota.
ENOG411196C. LUCA.
GeneTreeiENSGT00730000111752.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP56469.
KOiK05238.
OrthoDBiEOG091G157X.
PhylomeDBiP56469.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP56469.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028971.
CleanExiMM_CORT.
GenevisibleiP56469. MM.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCORT_MOUSE
AccessioniPrimary (citable) accession number: P56469
Secondary accession number(s): A2AH76, Q9R1P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.