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Protein

Cortistatin

Gene

Cort

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: MGI
  2. neuropeptide hormone activity Source: MGI

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Cortistatin
Cleaved into the following chain:
Gene namesi
Name:Cort
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:109538. Cort.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 9368Sequence AnalysisPRO_0000033157Add
BLAST
Peptidei96 – 10914Cortistatin-14PRO_0000033158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 108By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP56469.

Expressioni

Tissue specificityi

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Inductioni

Not induced by kainate.1 Publication

Gene expression databases

BgeeiP56469.
CleanExiMM_CORT.
GenevestigatoriP56469.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030815.

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47299.
GeneTreeiENSGT00730000111752.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP56469.
KOiK05238.
OrthoDBiEOG77Q506.
PhylomeDBiP56469.

Family and domain databases

InterProiIPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGGRGTGGK WPSAFGLLLL WGVAASALPL ESGPTGQDSV QEATEGRSGL
60 70 80 90 100
LTFLAWWHEW ASQASSSTPV GGGTPGLSKS QERPPPQQPP HLDKKPCKNF

FWKTFSSCK
Length:109
Mass (Da):11,613
Last modified:July 15, 1998 - v1
Checksum:i630D3BDD0488F722
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401Missing in AAD51127 (PubMed:10521599).Curated
Sequence conflicti57 – 593Missing in AAD51127 (PubMed:10521599).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013253 mRNA. Translation: AAB66896.1.
AF050156 Genomic DNA. Translation: AAD51127.1.
AK013496 mRNA. Translation: BAB28882.1.
AL731655 Genomic DNA. Translation: CAM18589.1.
CCDSiCCDS18953.1.
RefSeqiNP_031771.1. NM_007745.3.
UniGeneiMm.6204.

Genome annotation databases

EnsembliENSMUST00000030815; ENSMUSP00000030815; ENSMUSG00000028971.
GeneIDi12854.
KEGGimmu:12854.
UCSCiuc008vvs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013253 mRNA. Translation: AAB66896.1.
AF050156 Genomic DNA. Translation: AAD51127.1.
AK013496 mRNA. Translation: BAB28882.1.
AL731655 Genomic DNA. Translation: CAM18589.1.
CCDSiCCDS18953.1.
RefSeqiNP_031771.1. NM_007745.3.
UniGeneiMm.6204.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030815.

Proteomic databases

PRIDEiP56469.

Protocols and materials databases

DNASUi12854.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030815; ENSMUSP00000030815; ENSMUSG00000028971.
GeneIDi12854.
KEGGimmu:12854.
UCSCiuc008vvs.1. mouse.

Organism-specific databases

CTDi1325.
MGIiMGI:109538. Cort.

Phylogenomic databases

eggNOGiNOG47299.
GeneTreeiENSGT00730000111752.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP56469.
KOiK05238.
OrthoDBiEOG77Q506.
PhylomeDBiP56469.

Miscellaneous databases

NextBioi282404.
PROiP56469.
SOURCEiSearch...

Gene expression databases

BgeeiP56469.
CleanExiMM_CORT.
GenevestigatoriP56469.

Family and domain databases

InterProiIPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin."
    de Lecea L., Ruiz-Lozano P., Danielson P.E., Peelle-Kirley J., Foye P.E., Frankel W.N., Sutcliffe J.G.
    Genomics 42:499-506(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate."
    Calbet M., Guadano-Ferraz A., Spier A.D., Maj M., Sutcliffe J.G., Przewlocki R., de Lecea L.
    Brain Res. Mol. Brain Res. 72:55-64(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: 129/Sv.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCORT_MOUSE
AccessioniPrimary (citable) accession number: P56469
Secondary accession number(s): A2AH76, Q9R1P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.