Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56468

- PUR8_HELPY

UniProt

P56468 - PUR8_HELPY

Protein

Adenylosuccinate lyase

Gene

purB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
    (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei141 – 1411Proton donor/acceptorBy similarity
    Binding sitei212 – 2121SubstrateBy similarity
    Active sitei262 – 2621Proton donor/acceptorBy similarity
    Binding sitei276 – 2761SubstrateBy similarity
    Binding sitei301 – 3011SubstrateBy similarity
    Binding sitei306 – 3061SubstrateBy similarity

    GO - Molecular functioni

    1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
    2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
    2. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciHPY:HP1112-MONOMER.
    UniPathwayiUPA00074; UER00132.
    UPA00075; UER00336.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylosuccinate lyase (EC:4.3.2.2)
    Short name:
    ASL
    Alternative name(s):
    Adenylosuccinase
    Short name:
    ASase
    Gene namesi
    Name:purB
    Ordered Locus Names:HP_1112
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Adenylosuccinate lyasePRO_0000137881Add
    BLAST

    Proteomic databases

    PRIDEiP56468.

    Interactioni

    Subunit structurei

    Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site By similarity.By similarity

    Protein-protein interaction databases

    STRINGi85962.HP1112.

    Structurei

    3D structure databases

    ProteinModelPortaliP56468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4 – 52Substrate bindingBy similarity
    Regioni67 – 693Substrate bindingBy similarity
    Regioni93 – 942Substrate bindingBy similarity
    Regioni268 – 2703Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0015.
    KOiK01756.
    OMAiEMKYVWS.
    OrthoDBiEOG686NDB.

    Family and domain databases

    Gene3Di1.10.275.10. 1 hit.
    InterProiIPR019468. AdenyloSucc_lyase_C.
    IPR024083. Fumarase/histidase_N.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    IPR004769. Pur_lyase.
    [Graphical view]
    PANTHERiPTHR11444. PTHR11444. 1 hit.
    PfamiPF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view]
    PRINTSiPR00149. FUMRATELYASE.
    SMARTiSM00998. ADSL_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48557. SSF48557. 1 hit.
    TIGRFAMsiTIGR00928. purB. 1 hit.
    PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56468-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLERYANEEM KALWNEQTKF ETYLEVEKAV VRAWNKLGQI QDSDCEKICA    50
    KAAFNLERIK EIEKTTKHDL IAFTTCVAES LGEESRFFHY GITSSDCIDT 100
    AMALLMTKSL KLIQKGVKNL YETLKNRALE HKDTLMVGRS HGVFGEPITF 150
    GLVLALFADE IKRHLKALDL TMEFISVGAI SGAMGNFAHA PLELEELACE 200
    FLGLKTANIS NQVIQRDRYA RLACDLALLA SSCEKIAVNI RHLQRSEVYE 250
    VEEAFSTGQK GSSAMPHKRN PILSENITGL CRVIRSFTTP MLENVALWHE 300
    RDMSHSSVER FALPDLFITS DFMLSRLNSV IKNLVVYPKN MLKNLALSGG 350
    LVFSQRVLLE LPKKGLSREE SYSIVQENAM KIWEVLQQGA FKNTDENLFL 400
    NALLNDERLK KYLSEDEIKA CFDYNYYTKN VGAIFKRVFE 440
    Length:440
    Mass (Da):50,029
    Last modified:July 15, 1998 - v1
    Checksum:i59587A4517404A46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08156.1.
    PIRiH64658.
    RefSeqiNP_207903.1. NC_000915.1.
    YP_006935027.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08156; AAD08156; HP_1112.
    GeneIDi13870305.
    899648.
    KEGGiheo:C694_05735.
    hpy:HP1112.
    PATRICi20593565. VBIHelPyl33062_1162.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08156.1 .
    PIRi H64658.
    RefSeqi NP_207903.1. NC_000915.1.
    YP_006935027.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP1112.

    Proteomic databases

    PRIDEi P56468.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08156 ; AAD08156 ; HP_1112 .
    GeneIDi 13870305.
    899648.
    KEGGi heo:C694_05735.
    hpy:HP1112.
    PATRICi 20593565. VBIHelPyl33062_1162.

    Phylogenomic databases

    eggNOGi COG0015.
    KOi K01756.
    OMAi EMKYVWS.
    OrthoDBi EOG686NDB.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00132 .
    UPA00075 ; UER00336 .
    BioCyci HPY:HP1112-MONOMER.

    Family and domain databases

    Gene3Di 1.10.275.10. 1 hit.
    InterProi IPR019468. AdenyloSucc_lyase_C.
    IPR024083. Fumarase/histidase_N.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    IPR004769. Pur_lyase.
    [Graphical view ]
    PANTHERi PTHR11444. PTHR11444. 1 hit.
    Pfami PF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00149. FUMRATELYASE.
    SMARTi SM00998. ADSL_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48557. SSF48557. 1 hit.
    TIGRFAMsi TIGR00928. purB. 1 hit.
    PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiPUR8_HELPY
    AccessioniPrimary (citable) accession number: P56468
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3