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P56467

- FOLD_HELPY

UniProt

P56467 - FOLD_HELPY

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Protein

Bifunctional protein FolD

Gene

folD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.UniRule annotation
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941NADP; via amide nitrogenUniRule annotation
Binding sitei235 – 2351NADP; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1713NADPUniRule annotation

GO - Molecular functioni

  1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-HAMAP
  2. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. histidine biosynthetic process Source: UniProtKB-KW
  3. methionine biosynthetic process Source: UniProtKB-KW
  4. purine nucleotide biosynthetic process Source: UniProtKB-KW
  5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein FolDUniRule annotation
Including the following 2 domains:
Methylenetetrahydrofolate dehydrogenaseUniRule annotation (EC:1.5.1.5UniRule annotation)
Methenyltetrahydrofolate cyclohydrolaseUniRule annotation (EC:3.5.4.9UniRule annotation)
Gene namesi
Name:folDUniRule annotation
Ordered Locus Names:HP_0577
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Bifunctional protein FolDPRO_0000199308Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP56467. 2 interactions.
STRINGi85962.HP0577.

Structurei

3D structure databases

ProteinModelPortaliP56467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0190.
KOiK01491.
OMAiHAYVNSK.
OrthoDBiEOG6K6VBB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01576. THF_DHG_CYH.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
PROSITEiPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56467-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNRGVVLLD GQALADNIEK DLKHKIQIIT AQTHKRPKLA VILVGKDPAS
60 70 80 90 100
ITYVNMKIKA CERVGMDFDL KTLQENITEA KLLSLIKDYN TDQNISGVLV
110 120 130 140 150
QLPLPRHIDT KMILEAIDPN KDVDGFHPLN IGKLCTQKES FLPATPMGVM
160 170 180 190 200
RLLEHYHIEI KGKDVAIIGA SNIIGKPLSM LMLNAGASVS VCHILTKDIS
210 220 230 240 250
FYTQNADIVC VGVGKPDLIK ASMLKKGAVV VDIGINHLND GRIVGDVDFN
260 270 280 290
NVQKVAGFIT PVPKGVGPMT IVSLLENTLI AFEKQQRKGF
Length:290
Mass (Da):31,686
Last modified:December 1, 2000 - v2
Checksum:i263F8C6DE9712D47
GO

Sequence cautioni

The sequence AAD07644.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07644.1. Different initiation.
PIRiA64592.
RefSeqiNP_207372.1. NC_000915.1.
YP_006934499.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07644; AAD07644; HP_0577.
GeneIDi13869767.
900029.
KEGGiheo:C694_02975.
hpy:HP0577.
PATRICi20592427. VBIHelPyl33062_0602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07644.1 . Different initiation.
PIRi A64592.
RefSeqi NP_207372.1. NC_000915.1.
YP_006934499.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56467. 2 interactions.
STRINGi 85962.HP0577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07644 ; AAD07644 ; HP_0577 .
GeneIDi 13869767.
900029.
KEGGi heo:C694_02975.
hpy:HP0577.
PATRICi 20592427. VBIHelPyl33062_0602.

Phylogenomic databases

eggNOGi COG0190.
KOi K01491.
OMAi HAYVNSK.
OrthoDBi EOG6K6VBB.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01576. THF_DHG_CYH.
InterProi IPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view ]
Pfami PF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view ]
PRINTSi PR00085. THFDHDRGNASE.
PROSITEi PS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiFOLD_HELPY
AccessioniPrimary (citable) accession number: P56467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: October 1, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3