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P56467 (FOLD_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional protein FolD

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD
Ordered Locus Names:HP_0577
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP-Rule MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP-Rule MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP-Rule MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01576

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence caution

The sequence AAD07644.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Bifunctional protein FolD HAMAP-Rule MF_01576
PRO_0000199308

Regions

Nucleotide binding169 – 1713NADP By similarity

Sites

Binding site1941NADP; via amide nitrogen By similarity
Binding site2351NADP; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
P56467 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 263F8C6DE9712D47

FASTA29031,686
        10         20         30         40         50         60 
MPNRGVVLLD GQALADNIEK DLKHKIQIIT AQTHKRPKLA VILVGKDPAS ITYVNMKIKA 

        70         80         90        100        110        120 
CERVGMDFDL KTLQENITEA KLLSLIKDYN TDQNISGVLV QLPLPRHIDT KMILEAIDPN 

       130        140        150        160        170        180 
KDVDGFHPLN IGKLCTQKES FLPATPMGVM RLLEHYHIEI KGKDVAIIGA SNIIGKPLSM 

       190        200        210        220        230        240 
LMLNAGASVS VCHILTKDIS FYTQNADIVC VGVGKPDLIK ASMLKKGAVV VDIGINHLND 

       250        260        270        280        290 
GRIVGDVDFN NVQKVAGFIT PVPKGVGPMT IVSLLENTLI AFEKQQRKGF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07644.1. Different initiation.
PIRA64592.
RefSeqNP_207372.1. NC_000915.1.
YP_006934499.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56467.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0577.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07644; AAD07644; HP_0577.
GeneID13869767.
900029.
KEGGheo:C694_02975.
hpy:HP0577.
PATRIC20592427. VBIHelPyl33062_0602.

Phylogenomic databases

eggNOGCOG0190.
KOK01491.
OMADLKHKIQ.
OrthoDBEOG6K6VBB.
ProtClustDBPRK14191.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01576. THF_DHG_CYH.
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD_HELPY
AccessionPrimary (citable) accession number: P56467
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: February 19, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names