Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56467

- FOLD_HELPY

UniProt

P56467 - FOLD_HELPY

Protein

Bifunctional protein FolD

Gene

folD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.UniRule annotation
    5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei194 – 1941NADP; via amide nitrogenUniRule annotation
    Binding sitei235 – 2351NADP; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi169 – 1713NADPUniRule annotation

    GO - Molecular functioni

    1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-HAMAP
    2. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. histidine biosynthetic process Source: UniProtKB-KW
    3. methionine biosynthetic process Source: UniProtKB-KW
    4. purine nucleotide biosynthetic process Source: UniProtKB-KW
    5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein FolDUniRule annotation
    Including the following 2 domains:
    Methylenetetrahydrofolate dehydrogenaseUniRule annotation (EC:1.5.1.5UniRule annotation)
    Methenyltetrahydrofolate cyclohydrolaseUniRule annotation (EC:3.5.4.9UniRule annotation)
    Gene namesi
    Name:folDUniRule annotation
    Ordered Locus Names:HP_0577
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Bifunctional protein FolDPRO_0000199308Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiP56467. 2 interactions.
    STRINGi85962.HP0577.

    Structurei

    3D structure databases

    ProteinModelPortaliP56467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0190.
    KOiK01491.
    OMAiHAYVNSK.
    OrthoDBiEOG6K6VBB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01576. THF_DHG_CYH.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view]
    PRINTSiPR00085. THFDHDRGNASE.
    PROSITEiPS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56467-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNRGVVLLD GQALADNIEK DLKHKIQIIT AQTHKRPKLA VILVGKDPAS    50
    ITYVNMKIKA CERVGMDFDL KTLQENITEA KLLSLIKDYN TDQNISGVLV 100
    QLPLPRHIDT KMILEAIDPN KDVDGFHPLN IGKLCTQKES FLPATPMGVM 150
    RLLEHYHIEI KGKDVAIIGA SNIIGKPLSM LMLNAGASVS VCHILTKDIS 200
    FYTQNADIVC VGVGKPDLIK ASMLKKGAVV VDIGINHLND GRIVGDVDFN 250
    NVQKVAGFIT PVPKGVGPMT IVSLLENTLI AFEKQQRKGF 290
    Length:290
    Mass (Da):31,686
    Last modified:December 1, 2000 - v2
    Checksum:i263F8C6DE9712D47
    GO

    Sequence cautioni

    The sequence AAD07644.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07644.1. Different initiation.
    PIRiA64592.
    RefSeqiNP_207372.1. NC_000915.1.
    YP_006934499.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07644; AAD07644; HP_0577.
    GeneIDi13869767.
    900029.
    KEGGiheo:C694_02975.
    hpy:HP0577.
    PATRICi20592427. VBIHelPyl33062_0602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07644.1 . Different initiation.
    PIRi A64592.
    RefSeqi NP_207372.1. NC_000915.1.
    YP_006934499.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56467. 2 interactions.
    STRINGi 85962.HP0577.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07644 ; AAD07644 ; HP_0577 .
    GeneIDi 13869767.
    900029.
    KEGGi heo:C694_02975.
    hpy:HP0577.
    PATRICi 20592427. VBIHelPyl33062_0602.

    Phylogenomic databases

    eggNOGi COG0190.
    KOi K01491.
    OMAi HAYVNSK.
    OrthoDBi EOG6K6VBB.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01576. THF_DHG_CYH.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00085. THFDHDRGNASE.
    PROSITEi PS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiFOLD_HELPY
    AccessioniPrimary (citable) accession number: P56467
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3