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P56466 (RHO_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription termination factor Rho

EC=3.6.4.-
Alternative name(s):
ATP-dependent helicase Rho
Gene names
Name:rho
Ordered Locus Names:HP_0550
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template By similarity. HAMAP-Rule MF_01884

Subunit structure

Homohexamer. The homohexamer assembles into an open ring structure By similarity.

Sequence similarities

Belongs to the Rho family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Transcription termination factor Rho HAMAP-Rule MF_01884
PRO_0000188966

Regions

Nucleotide binding188 – 1936ATP Potential
Nucleotide binding200 – 2056ATP By similarity

Sites

Binding site2311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P56466 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: D4D06E6CD1E300F6

FASTA43849,547
        10         20         30         40         50         60 
MNENAPTHKS SHKVKTHTPV SGYHIEDLRT YPTEKLLEIA NKLKVENPQE FKRQDLMFEI 

        70         80         90        100        110        120 
LKTQVTQGGY ILFTGILEIM PDGYGFLRGF DGSFSDGHND TYVSPSQIRR FALRNGDIVT 

       130        140        150        160        170        180 
GQVRSPKDQE KYYALLKIEA INYSPSDEIR NRPLFDNLTP LFPDEQIKLE YEPTKVTGRM 

       190        200        210        220        230        240 
LDLFSPVGKG QRALIVAPPR TGKTELMKEL AQGITSNHPE VELIILLVDE RPEEVTDMQR 

       250        260        270        280        290        300 
SVKGQVFSST FDLPANNHIR IAELVLERAK RRVEMGKDVV VLLDSITRLA RAYNAVTPSS 

       310        320        330        340        350        360 
GKVLSGGVDA NALHRPKRFF GAARNIEEGG SLTIIATALI ETGSRMDEVI FEEFKGTGNS 

       370        380        390        400        410        420 
EIVLARNIAD RRIYPAFDIL KSGTRKDNIL LGKDRLTKVW VLRNVMQQMD DIEALSFVYS 

       430 
KMQQTKDNEE FLNLMNEK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07616.1.
PIRF64588.
RefSeqNP_207345.1. NC_000915.1.
YP_006934473.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56466.
SMRP56466. Positions 53-373.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3446N.
IntActP56466. 3 interactions.
MINTMINT-182559.
STRING85962.HP0550.

Proteomic databases

PRIDEP56466.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07616; AAD07616; HP_0550.
GeneID13869741.
898947.
KEGGheo:C694_02845.
hpy:HP0550.
PATRIC20592375. VBIHelPyl33062_0576.

Phylogenomic databases

eggNOGCOG1158.
KOK03628.
OMAFGFLRAP.
OrthoDBEOG6N681W.
ProtClustDBPRK09376.

Enzyme and pathway databases

BioCycHPY:HP0550-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01884. Rho.
InterProIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsTIGR00767. rho. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRHO_HELPY
AccessionPrimary (citable) accession number: P56466
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names