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Protein

Transcription termination factor Rho

Gene

rho

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi188 – 1936ATPUniRule annotation
Nucleotide bindingi200 – 2056ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP0550-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:HP_0550
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Transcription termination factor RhoPRO_0000188966Add
BLAST

Proteomic databases

PRIDEiP56466.

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3446N.
IntActiP56466. 4 interactions.
MINTiMINT-182559.
STRINGi85962.HP0550.

Structurei

3D structure databases

ProteinModelPortaliP56466.
SMRiP56466. Positions 53-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1158.
KOiK03628.
OMAiDYNYLPG.
OrthoDBiEOG6N681W.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

P56466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENAPTHKS SHKVKTHTPV SGYHIEDLRT YPTEKLLEIA NKLKVENPQE
60 70 80 90 100
FKRQDLMFEI LKTQVTQGGY ILFTGILEIM PDGYGFLRGF DGSFSDGHND
110 120 130 140 150
TYVSPSQIRR FALRNGDIVT GQVRSPKDQE KYYALLKIEA INYSPSDEIR
160 170 180 190 200
NRPLFDNLTP LFPDEQIKLE YEPTKVTGRM LDLFSPVGKG QRALIVAPPR
210 220 230 240 250
TGKTELMKEL AQGITSNHPE VELIILLVDE RPEEVTDMQR SVKGQVFSST
260 270 280 290 300
FDLPANNHIR IAELVLERAK RRVEMGKDVV VLLDSITRLA RAYNAVTPSS
310 320 330 340 350
GKVLSGGVDA NALHRPKRFF GAARNIEEGG SLTIIATALI ETGSRMDEVI
360 370 380 390 400
FEEFKGTGNS EIVLARNIAD RRIYPAFDIL KSGTRKDNIL LGKDRLTKVW
410 420 430
VLRNVMQQMD DIEALSFVYS KMQQTKDNEE FLNLMNEK
Length:438
Mass (Da):49,547
Last modified:July 15, 1998 - v1
Checksum:iD4D06E6CD1E300F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07616.1.
PIRiF64588.
RefSeqiNP_207345.1. NC_000915.1.
WP_001004715.1. NC_018939.1.
YP_006934473.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07616; AAD07616; HP_0550.
GeneIDi898947.
KEGGiheo:C694_02845.
hpy:HP0550.
PATRICi20592375. VBIHelPyl33062_0576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07616.1.
PIRiF64588.
RefSeqiNP_207345.1. NC_000915.1.
WP_001004715.1. NC_018939.1.
YP_006934473.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56466.
SMRiP56466. Positions 53-373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3446N.
IntActiP56466. 4 interactions.
MINTiMINT-182559.
STRINGi85962.HP0550.

Proteomic databases

PRIDEiP56466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07616; AAD07616; HP_0550.
GeneIDi898947.
KEGGiheo:C694_02845.
hpy:HP0550.
PATRICi20592375. VBIHelPyl33062_0576.

Phylogenomic databases

eggNOGiCOG1158.
KOiK03628.
OMAiDYNYLPG.
OrthoDBiEOG6N681W.

Enzyme and pathway databases

BioCyciHPY:HP0550-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRHO_HELPY
AccessioniPrimary (citable) accession number: P56466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 27, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.