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P56466

- RHO_HELPY

UniProt

P56466 - RHO_HELPY

Protein

Transcription termination factor Rho

Gene

rho

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei231 – 2311ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi188 – 1936ATPUniRule annotation
    Nucleotide bindingi200 – 2056ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. helicase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP
    4. RNA-dependent ATPase activity Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Transcription, Transcription regulation, Transcription termination

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0550-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
    Alternative name(s):
    ATP-dependent helicase RhoUniRule annotation
    Gene namesi
    Name:rhoUniRule annotation
    Ordered Locus Names:HP_0550
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Transcription termination factor RhoPRO_0000188966Add
    BLAST

    Proteomic databases

    PRIDEiP56466.

    Interactioni

    Subunit structurei

    Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-3446N.
    IntActiP56466. 4 interactions.
    MINTiMINT-182559.
    STRINGi85962.HP0550.

    Structurei

    3D structure databases

    ProteinModelPortaliP56466.
    SMRiP56466. Positions 53-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Rho family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1158.
    KOiK03628.
    OMAiQHIAHSI.
    OrthoDBiEOG6N681W.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01884. Rho.
    InterProiIPR003593. AAA+_ATPase.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR011129. Cold_shock_prot.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    IPR011112. Rho_N.
    IPR011113. Rho_RNA-bd.
    IPR004665. Term_rho.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF07498. Rho_N. 1 hit.
    PF07497. Rho_RNA_bind. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00357. CSP. 1 hit.
    SM00959. Rho_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF68912. SSF68912. 1 hit.
    TIGRFAMsiTIGR00767. rho. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56466-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNENAPTHKS SHKVKTHTPV SGYHIEDLRT YPTEKLLEIA NKLKVENPQE    50
    FKRQDLMFEI LKTQVTQGGY ILFTGILEIM PDGYGFLRGF DGSFSDGHND 100
    TYVSPSQIRR FALRNGDIVT GQVRSPKDQE KYYALLKIEA INYSPSDEIR 150
    NRPLFDNLTP LFPDEQIKLE YEPTKVTGRM LDLFSPVGKG QRALIVAPPR 200
    TGKTELMKEL AQGITSNHPE VELIILLVDE RPEEVTDMQR SVKGQVFSST 250
    FDLPANNHIR IAELVLERAK RRVEMGKDVV VLLDSITRLA RAYNAVTPSS 300
    GKVLSGGVDA NALHRPKRFF GAARNIEEGG SLTIIATALI ETGSRMDEVI 350
    FEEFKGTGNS EIVLARNIAD RRIYPAFDIL KSGTRKDNIL LGKDRLTKVW 400
    VLRNVMQQMD DIEALSFVYS KMQQTKDNEE FLNLMNEK 438
    Length:438
    Mass (Da):49,547
    Last modified:July 15, 1998 - v1
    Checksum:iD4D06E6CD1E300F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07616.1.
    PIRiF64588.
    RefSeqiNP_207345.1. NC_000915.1.
    YP_006934473.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07616; AAD07616; HP_0550.
    GeneIDi13869741.
    898947.
    KEGGiheo:C694_02845.
    hpy:HP0550.
    PATRICi20592375. VBIHelPyl33062_0576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07616.1 .
    PIRi F64588.
    RefSeqi NP_207345.1. NC_000915.1.
    YP_006934473.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56466.
    SMRi P56466. Positions 53-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3446N.
    IntActi P56466. 4 interactions.
    MINTi MINT-182559.
    STRINGi 85962.HP0550.

    Proteomic databases

    PRIDEi P56466.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07616 ; AAD07616 ; HP_0550 .
    GeneIDi 13869741.
    898947.
    KEGGi heo:C694_02845.
    hpy:HP0550.
    PATRICi 20592375. VBIHelPyl33062_0576.

    Phylogenomic databases

    eggNOGi COG1158.
    KOi K03628.
    OMAi QHIAHSI.
    OrthoDBi EOG6N681W.

    Enzyme and pathway databases

    BioCyci HPY:HP0550-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01884. Rho.
    InterProi IPR003593. AAA+_ATPase.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR011129. Cold_shock_prot.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    IPR011112. Rho_N.
    IPR011113. Rho_RNA-bd.
    IPR004665. Term_rho.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF07498. Rho_N. 1 hit.
    PF07497. Rho_RNA_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00357. CSP. 1 hit.
    SM00959. Rho_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF68912. SSF68912. 1 hit.
    TIGRFAMsi TIGR00767. rho. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiRHO_HELPY
    AccessioniPrimary (citable) accession number: P56466
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3