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P56466

- RHO_HELPY

UniProt

P56466 - RHO_HELPY

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Protein

Transcription termination factor Rho

Gene

rho

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi188 – 1936ATPUniRule annotation
Nucleotide bindingi200 – 2056ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. helicase activity Source: UniProtKB-HAMAP
  3. RNA binding Source: UniProtKB-HAMAP
  4. RNA-dependent ATPase activity Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP0550-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:HP_0550
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Transcription termination factor RhoPRO_0000188966Add
BLAST

Proteomic databases

PRIDEiP56466.

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3446N.
IntActiP56466. 4 interactions.
MINTiMINT-182559.
STRINGi85962.HP0550.

Structurei

3D structure databases

ProteinModelPortaliP56466.
SMRiP56466. Positions 53-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1158.
KOiK03628.
OMAiQHIAHSI.
OrthoDBiEOG6N681W.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

P56466-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNENAPTHKS SHKVKTHTPV SGYHIEDLRT YPTEKLLEIA NKLKVENPQE
60 70 80 90 100
FKRQDLMFEI LKTQVTQGGY ILFTGILEIM PDGYGFLRGF DGSFSDGHND
110 120 130 140 150
TYVSPSQIRR FALRNGDIVT GQVRSPKDQE KYYALLKIEA INYSPSDEIR
160 170 180 190 200
NRPLFDNLTP LFPDEQIKLE YEPTKVTGRM LDLFSPVGKG QRALIVAPPR
210 220 230 240 250
TGKTELMKEL AQGITSNHPE VELIILLVDE RPEEVTDMQR SVKGQVFSST
260 270 280 290 300
FDLPANNHIR IAELVLERAK RRVEMGKDVV VLLDSITRLA RAYNAVTPSS
310 320 330 340 350
GKVLSGGVDA NALHRPKRFF GAARNIEEGG SLTIIATALI ETGSRMDEVI
360 370 380 390 400
FEEFKGTGNS EIVLARNIAD RRIYPAFDIL KSGTRKDNIL LGKDRLTKVW
410 420 430
VLRNVMQQMD DIEALSFVYS KMQQTKDNEE FLNLMNEK
Length:438
Mass (Da):49,547
Last modified:July 15, 1998 - v1
Checksum:iD4D06E6CD1E300F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07616.1.
PIRiF64588.
RefSeqiNP_207345.1. NC_000915.1.
YP_006934473.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07616; AAD07616; HP_0550.
GeneIDi13869741.
898947.
KEGGiheo:C694_02845.
hpy:HP0550.
PATRICi20592375. VBIHelPyl33062_0576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07616.1 .
PIRi F64588.
RefSeqi NP_207345.1. NC_000915.1.
YP_006934473.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56466.
SMRi P56466. Positions 53-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3446N.
IntActi P56466. 4 interactions.
MINTi MINT-182559.
STRINGi 85962.HP0550.

Proteomic databases

PRIDEi P56466.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07616 ; AAD07616 ; HP_0550 .
GeneIDi 13869741.
898947.
KEGGi heo:C694_02845.
hpy:HP0550.
PATRICi 20592375. VBIHelPyl33062_0576.

Phylogenomic databases

eggNOGi COG1158.
KOi K03628.
OMAi QHIAHSI.
OrthoDBi EOG6N681W.

Enzyme and pathway databases

BioCyci HPY:HP0550-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01884. Rho.
InterProi IPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsi TIGR00767. rho. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRHO_HELPY
AccessioniPrimary (citable) accession number: P56466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 1, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3