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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei4Purine nucleoside; shared with dimeric partnerBy similarity1
Binding sitei20Phosphate; via amide nitrogenBy similarity1
Binding sitei24PhosphateBy similarity1
Binding sitei43Phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciHPY:HP1178-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
Ordered Locus Names:HP_1178
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000631371 – 233Purine nucleoside phosphorylase DeoD-typeAdd BLAST233

Proteomic databases

PaxDbiP56463

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

IntActiP56463, 1 interactor
STRINGi85962.HP1178

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 20Combined sources7
Helixi22 – 32Combined sources11
Beta strandi34 – 40Combined sources7
Helixi42 – 44Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi55 – 61Combined sources7
Helixi66 – 78Combined sources13
Beta strandi84 – 93Combined sources10
Beta strandi103 – 112Combined sources10
Helixi115 – 119Combined sources5
Turni120 – 122Combined sources3
Helixi131 – 144Combined sources14
Beta strandi149 – 155Combined sources7
Helixi164 – 166Combined sources3
Helixi167 – 172Combined sources6
Beta strandi175 – 181Combined sources7
Helixi182 – 191Combined sources10
Beta strandi195 – 205Combined sources11
Turni206 – 208Combined sources3
Helixi214 – 219Combined sources6
Helixi222 – 232Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LU0X-ray1.73A/B/C/D/E/F1-233[»]
5MX6X-ray2.41A/B/C/D/E/F1-233[»]
5MX8X-ray2.40A1-233[»]
6F4WX-ray2.29A/B/C/D/E/F1-233[»]
6F4XX-ray1.69A/B/C/D/E/F1-233[»]
6F52X-ray2.00A/B/C/D/E/F1-233[»]
6F5AX-ray2.20A/B/C/D/E/F1-233[»]
6F5IX-ray2.30A/B/C/D/E/F1-233[»]
ProteinModelPortaliP56463
SMRiP56463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 90Phosphate bindingBy similarity4
Regioni179 – 181Purine nucleoside bindingBy similarity3
Regioni203 – 204Purine nucleoside bindingBy similarity2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3A Bacteria
COG0813 LUCA
KOiK03784
OMAiPQCLLCG

Family and domain databases

HAMAPiMF_01627 Pur_nucleosid_phosp, 1 hit
InterProiView protein in InterPro
IPR004402 DeoD-type
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PANTHERiPTHR43691:SF2 PTHR43691:SF2, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR00107 deoD, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

P56463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPHINAKIG DFYPQCLLCG DPLRVSYIAK KFLQDAKEIT NVRNMLGFSG
60 70 80 90 100
KYKGRGISLM GHGMGIASCT IYVTELIKTY QVKELLRIGT CGAISPKVGL
110 120 130 140 150
KDIIMATGAS TDSKTNRVRF LNHDLSATPD FELSLRAYQT AKRLGIDLKV
160 170 180 190 200
GNVFSSDFFY SFETHAFDLM AKYNHLAIEM EAAGLYATAM ELNAKALCLC
210 220 230
SVSDHLITKE ALSPKERVES FDNMIILALE MMS
Length:233
Mass (Da):25,786
Last modified:July 15, 1998 - v1
Checksum:i1E44E717F8BDAC9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08222.1
PIRiB64667
RefSeqiNP_207969.1, NC_000915.1
WP_000187711.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08222; AAD08222; HP_1178
GeneIDi899938
KEGGiheo:C694_06090
hpy:HP1178
PATRICifig|85962.47.peg.1266

Similar proteinsi

Entry informationi

Entry nameiDEOD_HELPY
AccessioniPrimary (citable) accession number: P56463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health