P56463 (DEOD_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Purine nucleoside phosphorylase DeoD-type
Short name=PNP
EC=2.4.2.1

Gene names

Name:	deoD
Ordered Locus Names:	HP_1178

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01627
Subunit structure	Homohexamer By similarity.
Sequence similarities	Belongs to the PNP/UDP phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	purine nucleoside metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	purine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Purine nucleoside phosphorylase DeoD-type HAMAP-Rule MF_01627		PRO_0000063137

Sequences

	Sequence		Length	Mass (Da)
	P56463 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 1E44E717F8BDAC9D	FASTA	233	25,786
	10 20 30 40 50 60 MTPHINAKIG DFYPQCLLCG DPLRVSYIAK KFLQDAKEIT NVRNMLGFSG KYKGRGISLM 70 80 90 100 110 120 GHGMGIASCT IYVTELIKTY QVKELLRIGT CGAISPKVGL KDIIMATGAS TDSKTNRVRF 130 140 150 160 170 180 LNHDLSATPD FELSLRAYQT AKRLGIDLKV GNVFSSDFFY SFETHAFDLM AKYNHLAIEM 190 200 210 220 230 EAAGLYATAM ELNAKALCLC SVSDHLITKE ALSPKERVES FDNMIILALE MMS

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08222.1.
PIR	B64667.
RefSeq	NP_207969.1. NC_000915.1. YP_006935096.1. NC_018939.1.
3D structure databases
ProteinModelPortal	P56463.
SMR	P56463. Positions 1-231.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP1178.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08222; AAD08222; HP_1178.
GeneID	13870375. 899938.
KEGG	heo:C694_06090. hpy:HP1178.
PATRIC	20593709. VBIHelPyl33062_1233.
Phylogenomic databases
eggNOG	COG0813.
KO	K03784.
OMA	SFETHAF.
ProtClustDB	CLSK496399.
Family and domain databases
HAMAP	MF_01627. Pur_nucleosid_phosp.
InterPro	IPR004402. DeoD-type. IPR018017. Nucleoside_phosphorylase. IPR018016. Nucleoside_phosphorylase_CS. IPR000845. Nucleoside_phosphorylase_d. [Graphical view]
PANTHER	PTHR21234. PTHR21234. 1 hit.
Pfam	PF01048. PNP_UDP_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00107. deoD. 1 hit.
PROSITE	PS01232. PNP_UDP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DEOD_HELPY

Accession

Primary (citable) accession number: P56463

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program