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P56462 (GCH1_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:HP_0928
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 180180GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119413

Sites

Metal binding711Zinc By similarity
Metal binding741Zinc By similarity
Metal binding1421Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P56462 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 95521F3F3AE863FF

FASTA18020,858
        10         20         30         40         50         60 
MENFFNQFFE SIGEDKNREG LKETPKRVQE LWKFLYKGYK EDPRVALKSA YFQGVCDEMI 

        70         80         90        100        110        120 
VAQNIEFYST CEHHLLPFLG NISVGYIPKE KIVGISAIAK LIEIYSRRLQ IQERLTIQIA 

       130        140        150        160        170        180 
ETFDEIIEPR GVIVVCEAKH LCMSMQGVQK QNAIIKTSVL RGLFKKDSKT RAEFMQLLKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07973.1.
PIRH64635.
RefSeqNP_207720.1. NC_000915.1.
YP_006934843.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3586N.
IntActP56462. 5 interactions.
MINTMINT-164654.
STRING85962.HP0928.

Proteomic databases

PRIDEP56462.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07973; AAD07973; HP_0928.
GeneID899457.
KEGGheo:C694_04775.
hpy:HP0928.
PATRIC20593157. VBIHelPyl33062_0964.

Phylogenomic databases

eggNOGCOG0302.
KOK01495.
OMAGENPARE.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycHPY:HP0928-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_HELPY
AccessionPrimary (citable) accession number: P56462
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names