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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1141-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:HP_1141
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829741 – 303Methionyl-tRNA formyltransferaseAdd BLAST303

Proteomic databases

PaxDbiP56461

Interactioni

Protein-protein interaction databases

IntActiP56461, 1 interactor
STRINGi85962.HP1141

Structurei

3D structure databases

ProteinModelPortaliP56461
SMRiP56461
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

P56461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVFMGTPG FAEVILRALV GDKDIEVVGL FTQMDKPFGR KKELKAPETK
60 70 80 90 100
TYILENHLNI PIFQPQSLKE PEVQILKDLK PNFIVVVAYG KILPKEVLTI
110 120 130 140 150
APCINLHASL LPKYRGASPI HEMILNDNKI YGISTMLMDV ELDSGDILES
160 170 180 190 200
ASFLREDYLD LDALSLKLAH MGAALLLSTL KNFSSITRKS QDHMQASFCK
210 220 230 240 250
KITKSDGLVG FKDAKSLFLK SLAFKSWPEI FLENGLKLLE VELVENEKSH
260 270 280 290 300
KEGEILEIDE KGVLVGCLKG SVRIARLQAV GKKPLKAKDY LNGKRLKIGG

ILA
Length:303
Mass (Da):33,730
Last modified:July 15, 1998 - v1
Checksum:iD74728EF64731124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08187.1
PIRiE64662
RefSeqiNP_207932.1, NC_000915.1
WP_001223483.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08187; AAD08187; HP_1141
GeneIDi899678
KEGGiheo:C694_05885
hpy:HP1141
PATRICifig|85962.47.peg.1223

Similar proteinsi

Entry informationi

Entry nameiFMT_HELPY
AccessioniPrimary (citable) accession number: P56461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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