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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity).By similarity

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1141-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase (EC:2.1.2.9)
Gene namesi
Name:fmt
Ordered Locus Names:HP_1141
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829741 – 303Methionyl-tRNA formyltransferaseAdd BLAST303

Proteomic databases

PaxDbiP56461.

Interactioni

Protein-protein interaction databases

IntActiP56461. 1 interactor.
STRINGi85962.HP1141.

Structurei

3D structure databases

ProteinModelPortaliP56461.
SMRiP56461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingBy similarity4

Sequence similaritiesi

Belongs to the Fmt family.Curated

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
KOiK00604.
OMAiLRIVFMG.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

P56461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVFMGTPG FAEVILRALV GDKDIEVVGL FTQMDKPFGR KKELKAPETK
60 70 80 90 100
TYILENHLNI PIFQPQSLKE PEVQILKDLK PNFIVVVAYG KILPKEVLTI
110 120 130 140 150
APCINLHASL LPKYRGASPI HEMILNDNKI YGISTMLMDV ELDSGDILES
160 170 180 190 200
ASFLREDYLD LDALSLKLAH MGAALLLSTL KNFSSITRKS QDHMQASFCK
210 220 230 240 250
KITKSDGLVG FKDAKSLFLK SLAFKSWPEI FLENGLKLLE VELVENEKSH
260 270 280 290 300
KEGEILEIDE KGVLVGCLKG SVRIARLQAV GKKPLKAKDY LNGKRLKIGG

ILA
Length:303
Mass (Da):33,730
Last modified:July 15, 1998 - v1
Checksum:iD74728EF64731124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08187.1.
PIRiE64662.
RefSeqiNP_207932.1. NC_000915.1.
WP_001223483.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08187; AAD08187; HP_1141.
GeneIDi899678.
KEGGiheo:C694_05885.
hpy:HP1141.
PATRICifig|85962.47.peg.1223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08187.1.
PIRiE64662.
RefSeqiNP_207932.1. NC_000915.1.
WP_001223483.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56461.
SMRiP56461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56461. 1 interactor.
STRINGi85962.HP1141.

Proteomic databases

PaxDbiP56461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08187; AAD08187; HP_1141.
GeneIDi899678.
KEGGiheo:C694_05885.
hpy:HP1141.
PATRICifig|85962.47.peg.1223.

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
KOiK00604.
OMAiLRIVFMG.

Enzyme and pathway databases

BioCyciHPY:HP1141-MONOMER.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFMT_HELPY
AccessioniPrimary (citable) accession number: P56461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 7, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.