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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei575ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1547-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HP_1547
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520261 – 806Leucine--tRNA ligaseAdd BLAST806

Proteomic databases

PaxDbiP56457

Interactioni

Protein-protein interaction databases

DIPiDIP-3469N
IntActiP56457, 1 interactor
MINTiP56457
STRINGi85962.HP1547

Structurei

3D structure databases

ProteinModelPortaliP56457
SMRiP56457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 48"HIGH" regionAdd BLAST11
Motifi572 – 576"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

P56457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFINIEKKW QEFWWKNKSF EPKDDFNLPK KYILSMLPYP SGEIHMGHVR
60 70 80 90 100
NYTIGDALAR YYRLHHYNVL HPMGFDSFGM PAENAAIKHG IHPKTWTYEN
110 120 130 140 150
IENMQKEFEA LGFSFSKNRE FATSDPDYTK FEQRFFIDLW EKGLIYRKKA
160 170 180 190 200
MLNWCPNDKT VLANEQVIDG RCWRCDTEVI QKELYQYYLK ITNYAEELLK
210 220 230 240 250
DLEALEDHWP SQVLIMQKNW IGKSSGLQFG FKIADECLKA CNGIQEIEVF
260 270 280 290 300
TTRADTIYGV TYIAIAPEHP LVEHAIKQVS QEVSKMIKAI LNTTQRERAL
310 320 330 340 350
EKKGAFLGIY AIHPLTKQKI PVWVANFALA NYGSGALMGV PACDERDFEF
360 370 380 390 400
ANLYHIPIKV ITQSPQNLPH TKEEVLKNSG EWSDLSSSVA REQIIAYFEK
410 420 430 440 450
ENLGKRVINY RLQDWGVSRQ RYWGAPIPMI HCNHCGIVPE TQLPVTLPED
460 470 480 490 500
IVIDGEGNPL EKHASWKFTQ CPKCHKNALR ETDTMDTFIQ SSWYFLRYTT
510 520 530 540 550
PKNQRENQAF DQNYLKYFMP VDTYIGGIEH AILHLLYARF FTKALRDLGY
560 570 580 590 600
LHLDEPFKQL ITQGMVLKNG AKMSKSKGNV VSPKEILKKY GADAARLFIL
610 620 630 640 650
FAAPPAKELE WNDSALEGAH RFIKRLYDKA NAINPTTSKP EFKEVSLNEA
660 670 680 690 700
QKLGRKKVYE ALKKSHEIFN KAESAYSFNT LIASCMEALN ALSAQNNERI
710 720 730 740 750
LCEGYFVLLQ ILEPIIPHTA WELSERLFKR ENFKPIAIDE DALMEDFMTL
760 770 780 790 800
GLTINGKRRA ELKVNINASK EEIIVLAKKE LEKYLENASV KKEIYVPNKL

VNFVIA
Length:806
Mass (Da):93,164
Last modified:July 15, 1998 - v1
Checksum:i731807226C288678
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08585.1
PIRiC64713
RefSeqiNP_208338.1, NC_000915.1
WP_000345715.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08585; AAD08585; HP_1547
GeneIDi899744
KEGGiheo:C694_08015
hpy:HP1547
PATRICifig|85962.47.peg.1662

Similar proteinsi

Entry informationi

Entry nameiSYL_HELPY
AccessioniPrimary (citable) accession number: P56457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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