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P56457

- SYL_HELPY

UniProt

P56457 - SYL_HELPY

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei575 – 5751ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1547-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:HP_1547
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806Leucine--tRNA ligasePRO_0000152026Add
    BLAST

    Proteomic databases

    PRIDEiP56457.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3469N.
    IntActiP56457. 1 interaction.
    MINTiMINT-160274.
    STRINGi85962.HP1547.

    Structurei

    3D structure databases

    ProteinModelPortaliP56457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 4811"HIGH" regionAdd
    BLAST
    Motifi572 – 5765"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56457-1 [UniParc]FASTAAdd to Basket

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    MDFINIEKKW QEFWWKNKSF EPKDDFNLPK KYILSMLPYP SGEIHMGHVR    50
    NYTIGDALAR YYRLHHYNVL HPMGFDSFGM PAENAAIKHG IHPKTWTYEN 100
    IENMQKEFEA LGFSFSKNRE FATSDPDYTK FEQRFFIDLW EKGLIYRKKA 150
    MLNWCPNDKT VLANEQVIDG RCWRCDTEVI QKELYQYYLK ITNYAEELLK 200
    DLEALEDHWP SQVLIMQKNW IGKSSGLQFG FKIADECLKA CNGIQEIEVF 250
    TTRADTIYGV TYIAIAPEHP LVEHAIKQVS QEVSKMIKAI LNTTQRERAL 300
    EKKGAFLGIY AIHPLTKQKI PVWVANFALA NYGSGALMGV PACDERDFEF 350
    ANLYHIPIKV ITQSPQNLPH TKEEVLKNSG EWSDLSSSVA REQIIAYFEK 400
    ENLGKRVINY RLQDWGVSRQ RYWGAPIPMI HCNHCGIVPE TQLPVTLPED 450
    IVIDGEGNPL EKHASWKFTQ CPKCHKNALR ETDTMDTFIQ SSWYFLRYTT 500
    PKNQRENQAF DQNYLKYFMP VDTYIGGIEH AILHLLYARF FTKALRDLGY 550
    LHLDEPFKQL ITQGMVLKNG AKMSKSKGNV VSPKEILKKY GADAARLFIL 600
    FAAPPAKELE WNDSALEGAH RFIKRLYDKA NAINPTTSKP EFKEVSLNEA 650
    QKLGRKKVYE ALKKSHEIFN KAESAYSFNT LIASCMEALN ALSAQNNERI 700
    LCEGYFVLLQ ILEPIIPHTA WELSERLFKR ENFKPIAIDE DALMEDFMTL 750
    GLTINGKRRA ELKVNINASK EEIIVLAKKE LEKYLENASV KKEIYVPNKL 800
    VNFVIA 806
    Length:806
    Mass (Da):93,164
    Last modified:July 15, 1998 - v1
    Checksum:i731807226C288678
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08585.1.
    PIRiC64713.
    RefSeqiNP_208338.1. NC_000915.1.
    YP_006935473.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08585; AAD08585; HP_1547.
    GeneIDi13870766.
    899744.
    KEGGiheo:C694_08015.
    hpy:HP1547.
    PATRICi20594517. VBIHelPyl33062_1626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08585.1 .
    PIRi C64713.
    RefSeqi NP_208338.1. NC_000915.1.
    YP_006935473.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3469N.
    IntActi P56457. 1 interaction.
    MINTi MINT-160274.
    STRINGi 85962.HP1547.

    Proteomic databases

    PRIDEi P56457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08585 ; AAD08585 ; HP_1547 .
    GeneIDi 13870766.
    899744.
    KEGGi heo:C694_08015.
    hpy:HP1547.
    PATRICi 20594517. VBIHelPyl33062_1626.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HPY:HP1547-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiSYL_HELPY
    AccessioniPrimary (citable) accession number: P56457
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3