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P56455

- SYH_HELPY

UniProt

P56455 - SYH_HELPY

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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1190-MONOMER.
BRENDAi6.1.1.21. 2605.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:HP_1190
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidine--tRNA ligasePRO_0000136174Add
BLAST

Proteomic databases

PRIDEiP56455.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi85962.HP1190.

Structurei

3D structure databases

ProteinModelPortaliP56455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiRGDYLIR.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56455-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITPKVLSGF KDRLPKDAIQ KAQLLAKVSV VFQSFGFVPI ETPHLEYAQT
60 70 80 90 100
LLPDASSDIQ KEIYRFKDHG DRDVALRFDL TVPLARFVSL HHQTLGMPFK
110 120 130 140 150
RYAIGNVFRG ERAQKGRYRE FTQCDFDFIG SESLVCDAEI IQVIVASLKA
160 170 180 190 200
LDLEDFCVSI NHRKILNGIC EYFGISQVNE ALRIVDKLEK IGLNGVEEEL
210 220 230 240 250
KKECGLNSNT IKELLELIQI KQNDLSHAEF FEKIAYLKDY NENLKKGIQD
260 270 280 290 300
LERLYQLLGD LQISQNLYKI DFSIARGLGY YTGIVYETTL NEMKSLGSVC
310 320 330 340 350
SGGRYDHLTK NFSKENLQGV GASIGIDRLI VALSEMQLLD ERSTQAKVLI
360 370 380 390 400
ACMHEEYFSY ANRLAESLRQ SGIFSEVYPE AQKIKKPFSY ANHKGHEFVA
410 420 430 440
VIGEEEFKSE TLSLKNMHSG MQLNCLSFLK ALEIIGENDE DL
Length:442
Mass (Da):50,172
Last modified:July 15, 1998 - v1
Checksum:i7D3282ED693E2B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08236.1.
PIRiF64668.
RefSeqiNP_207981.1. NC_000915.1.
YP_006935110.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08236; AAD08236; HP_1190.
GeneIDi13870390.
899952.
KEGGiheo:C694_06160.
hpy:HP1190.
PATRICi20593739. VBIHelPyl33062_1247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08236.1 .
PIRi F64668.
RefSeqi NP_207981.1. NC_000915.1.
YP_006935110.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP1190.

Proteomic databases

PRIDEi P56455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08236 ; AAD08236 ; HP_1190 .
GeneIDi 13870390.
899952.
KEGGi heo:C694_06160.
hpy:HP1190.
PATRICi 20593739. VBIHelPyl33062_1247.

Phylogenomic databases

eggNOGi COG0124.
KOi K01892.
OMAi RGDYLIR.
OrthoDBi EOG6BPDH4.

Enzyme and pathway databases

BioCyci HPY:HP1190-MONOMER.
BRENDAi 6.1.1.21. 2605.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSYH_HELPY
AccessioniPrimary (citable) accession number: P56455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3