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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. histidine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1190-MONOMER.
BRENDAi6.1.1.21. 2605.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:HP_1190
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidine--tRNA ligasePRO_0000136174Add
BLAST

Proteomic databases

PRIDEiP56455.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi85962.HP1190.

Structurei

3D structure databases

ProteinModelPortaliP56455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiRRYQMQR.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56455-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITPKVLSGF KDRLPKDAIQ KAQLLAKVSV VFQSFGFVPI ETPHLEYAQT
60 70 80 90 100
LLPDASSDIQ KEIYRFKDHG DRDVALRFDL TVPLARFVSL HHQTLGMPFK
110 120 130 140 150
RYAIGNVFRG ERAQKGRYRE FTQCDFDFIG SESLVCDAEI IQVIVASLKA
160 170 180 190 200
LDLEDFCVSI NHRKILNGIC EYFGISQVNE ALRIVDKLEK IGLNGVEEEL
210 220 230 240 250
KKECGLNSNT IKELLELIQI KQNDLSHAEF FEKIAYLKDY NENLKKGIQD
260 270 280 290 300
LERLYQLLGD LQISQNLYKI DFSIARGLGY YTGIVYETTL NEMKSLGSVC
310 320 330 340 350
SGGRYDHLTK NFSKENLQGV GASIGIDRLI VALSEMQLLD ERSTQAKVLI
360 370 380 390 400
ACMHEEYFSY ANRLAESLRQ SGIFSEVYPE AQKIKKPFSY ANHKGHEFVA
410 420 430 440
VIGEEEFKSE TLSLKNMHSG MQLNCLSFLK ALEIIGENDE DL
Length:442
Mass (Da):50,172
Last modified:July 15, 1998 - v1
Checksum:i7D3282ED693E2B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08236.1.
PIRiF64668.
RefSeqiNP_207981.1. NC_000915.1.
YP_006935110.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08236; AAD08236; HP_1190.
GeneIDi13870390.
899952.
KEGGiheo:C694_06160.
hpy:HP1190.
PATRICi20593739. VBIHelPyl33062_1247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08236.1.
PIRiF64668.
RefSeqiNP_207981.1. NC_000915.1.
YP_006935110.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP1190.

Proteomic databases

PRIDEiP56455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08236; AAD08236; HP_1190.
GeneIDi13870390.
899952.
KEGGiheo:C694_06160.
hpy:HP1190.
PATRICi20593739. VBIHelPyl33062_1247.

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiRRYQMQR.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

BioCyciHPY:HP1190-MONOMER.
BRENDAi6.1.1.21. 2605.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSYH_HELPY
AccessioniPrimary (citable) accession number: P56455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 4, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.