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P56455 (SYH_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:HP_1190
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_0000136174

Sequences

Sequence LengthMass (Da)Tools
P56455 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 7D3282ED693E2B7D

FASTA44250,172
        10         20         30         40         50         60 
MITPKVLSGF KDRLPKDAIQ KAQLLAKVSV VFQSFGFVPI ETPHLEYAQT LLPDASSDIQ 

        70         80         90        100        110        120 
KEIYRFKDHG DRDVALRFDL TVPLARFVSL HHQTLGMPFK RYAIGNVFRG ERAQKGRYRE 

       130        140        150        160        170        180 
FTQCDFDFIG SESLVCDAEI IQVIVASLKA LDLEDFCVSI NHRKILNGIC EYFGISQVNE 

       190        200        210        220        230        240 
ALRIVDKLEK IGLNGVEEEL KKECGLNSNT IKELLELIQI KQNDLSHAEF FEKIAYLKDY 

       250        260        270        280        290        300 
NENLKKGIQD LERLYQLLGD LQISQNLYKI DFSIARGLGY YTGIVYETTL NEMKSLGSVC 

       310        320        330        340        350        360 
SGGRYDHLTK NFSKENLQGV GASIGIDRLI VALSEMQLLD ERSTQAKVLI ACMHEEYFSY 

       370        380        390        400        410        420 
ANRLAESLRQ SGIFSEVYPE AQKIKKPFSY ANHKGHEFVA VIGEEEFKSE TLSLKNMHSG 

       430        440 
MQLNCLSFLK ALEIIGENDE DL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08236.1.
PIRF64668.
RefSeqNP_207981.1. NC_000915.1.
YP_006935110.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP1190.

Proteomic databases

PRIDEP56455.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08236; AAD08236; HP_1190.
GeneID13870390.
899952.
KEGGheo:C694_06160.
hpy:HP1190.
PATRIC20593739. VBIHelPyl33062_1247.

Phylogenomic databases

eggNOGCOG0124.
KOK01892.
OMAIFSITKA.
OrthoDBEOG6BPDH4.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycHPY:HP1190-MONOMER.
BRENDA6.1.1.21. 2605.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_HELPY
AccessionPrimary (citable) accession number: P56455
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries