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P56455

- SYH_HELPY

UniProt

P56455 - SYH_HELPY

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1190-MONOMER.
    BRENDAi6.1.1.21. 2605.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligase (EC:6.1.1.21)
    Alternative name(s):
    Histidyl-tRNA synthetase
    Short name:
    HisRS
    Gene namesi
    Name:hisS
    Ordered Locus Names:HP_1190
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Histidine--tRNA ligasePRO_0000136174Add
    BLAST

    Proteomic databases

    PRIDEiP56455.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi85962.HP1190.

    Structurei

    3D structure databases

    ProteinModelPortaliP56455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0124.
    KOiK01892.
    OMAiRGDYLIR.
    OrthoDBiEOG6BPDH4.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56455-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITPKVLSGF KDRLPKDAIQ KAQLLAKVSV VFQSFGFVPI ETPHLEYAQT    50
    LLPDASSDIQ KEIYRFKDHG DRDVALRFDL TVPLARFVSL HHQTLGMPFK 100
    RYAIGNVFRG ERAQKGRYRE FTQCDFDFIG SESLVCDAEI IQVIVASLKA 150
    LDLEDFCVSI NHRKILNGIC EYFGISQVNE ALRIVDKLEK IGLNGVEEEL 200
    KKECGLNSNT IKELLELIQI KQNDLSHAEF FEKIAYLKDY NENLKKGIQD 250
    LERLYQLLGD LQISQNLYKI DFSIARGLGY YTGIVYETTL NEMKSLGSVC 300
    SGGRYDHLTK NFSKENLQGV GASIGIDRLI VALSEMQLLD ERSTQAKVLI 350
    ACMHEEYFSY ANRLAESLRQ SGIFSEVYPE AQKIKKPFSY ANHKGHEFVA 400
    VIGEEEFKSE TLSLKNMHSG MQLNCLSFLK ALEIIGENDE DL 442
    Length:442
    Mass (Da):50,172
    Last modified:July 15, 1998 - v1
    Checksum:i7D3282ED693E2B7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08236.1.
    PIRiF64668.
    RefSeqiNP_207981.1. NC_000915.1.
    YP_006935110.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08236; AAD08236; HP_1190.
    GeneIDi13870390.
    899952.
    KEGGiheo:C694_06160.
    hpy:HP1190.
    PATRICi20593739. VBIHelPyl33062_1247.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08236.1 .
    PIRi F64668.
    RefSeqi NP_207981.1. NC_000915.1.
    YP_006935110.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP1190.

    Proteomic databases

    PRIDEi P56455.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08236 ; AAD08236 ; HP_1190 .
    GeneIDi 13870390.
    899952.
    KEGGi heo:C694_06160.
    hpy:HP1190.
    PATRICi 20593739. VBIHelPyl33062_1247.

    Phylogenomic databases

    eggNOGi COG0124.
    KOi K01892.
    OMAi RGDYLIR.
    OrthoDBi EOG6BPDH4.

    Enzyme and pathway databases

    BioCyci HPY:HP1190-MONOMER.
    BRENDAi 6.1.1.21. 2605.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiSYH_HELPY
    AccessioniPrimary (citable) accession number: P56455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3