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P56455

- SYH_HELPY

UniProt

P56455 - SYH_HELPY

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Protein
Histidine--tRNA ligase
Gene
hisS, HP_1190
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1190-MONOMER.
BRENDAi6.1.1.21. 2605.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:HP_1190
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidine--tRNA ligaseUniRule annotation
PRO_0000136174Add
BLAST

Proteomic databases

PRIDEiP56455.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP1190.

Structurei

3D structure databases

ProteinModelPortaliP56455.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiRGDYLIR.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56455-1 [UniParc]FASTAAdd to Basket

« Hide

MITPKVLSGF KDRLPKDAIQ KAQLLAKVSV VFQSFGFVPI ETPHLEYAQT    50
LLPDASSDIQ KEIYRFKDHG DRDVALRFDL TVPLARFVSL HHQTLGMPFK 100
RYAIGNVFRG ERAQKGRYRE FTQCDFDFIG SESLVCDAEI IQVIVASLKA 150
LDLEDFCVSI NHRKILNGIC EYFGISQVNE ALRIVDKLEK IGLNGVEEEL 200
KKECGLNSNT IKELLELIQI KQNDLSHAEF FEKIAYLKDY NENLKKGIQD 250
LERLYQLLGD LQISQNLYKI DFSIARGLGY YTGIVYETTL NEMKSLGSVC 300
SGGRYDHLTK NFSKENLQGV GASIGIDRLI VALSEMQLLD ERSTQAKVLI 350
ACMHEEYFSY ANRLAESLRQ SGIFSEVYPE AQKIKKPFSY ANHKGHEFVA 400
VIGEEEFKSE TLSLKNMHSG MQLNCLSFLK ALEIIGENDE DL 442
Length:442
Mass (Da):50,172
Last modified:July 15, 1998 - v1
Checksum:i7D3282ED693E2B7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08236.1.
PIRiF64668.
RefSeqiNP_207981.1. NC_000915.1.
YP_006935110.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08236; AAD08236; HP_1190.
GeneIDi13870390.
899952.
KEGGiheo:C694_06160.
hpy:HP1190.
PATRICi20593739. VBIHelPyl33062_1247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08236.1 .
PIRi F64668.
RefSeqi NP_207981.1. NC_000915.1.
YP_006935110.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56455.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85962.HP1190.

Proteomic databases

PRIDEi P56455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08236 ; AAD08236 ; HP_1190 .
GeneIDi 13870390.
899952.
KEGGi heo:C694_06160.
hpy:HP1190.
PATRICi 20593739. VBIHelPyl33062_1247.

Phylogenomic databases

eggNOGi COG0124.
KOi K01892.
OMAi RGDYLIR.
OrthoDBi EOG6BPDH4.

Enzyme and pathway databases

BioCyci HPY:HP1190-MONOMER.
BRENDAi 6.1.1.21. 2605.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiSYH_HELPY
AccessioniPrimary (citable) accession number: P56455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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