Melanocortin receptor 4 - Mus musculus (Mouse)

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P56450 (MC4R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Melanocortin receptor 4
Short name=MC4-R

Gene names

Name:

Mc4r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.
Subunit structure	Interacts with ATRNL1. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production By similarity. Ref.6
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	diet induced thermogenesis Inferred from electronic annotation. Source: Compara energy reserve metabolic process Inferred from electronic annotation. Source: Compara feeding behavior Inferred from mutant phenotype PubMed 12796784. Source: MGI insulin secretion Inferred from genetic interaction PubMed 16141392. Source: MGI negative regulation of feeding behavior Inferred from electronic annotation. Source: Compara positive regulation of bone resorption Inferred from mutant phenotype PubMed 16614075. Source: HGNC positive regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: Compara regulation of metabolic process Inferred from mutant phenotype PubMed 12796784. Source: MGI response to insulin stimulus Inferred from mutant phenotype PubMed 16141392. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	melanocyte-stimulating hormone receptor activity Inferred from direct assay PubMed 9454589. Source: MGI neuropeptide binding Inferred from electronic annotation. Source: Compara peptide hormone binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 332

332

Melanocortin receptor 4

PRO_0000069724

Regions

Topological domain

1 – 43

Extracellular Potential

Transmembrane

44 – 69

Helical; Name=1; Potential

Topological domain

70 – 81

Cytoplasmic Potential

Transmembrane

82 – 106

Helical; Name=2; Potential

Topological domain

107 – 123

Extracellular Potential

Transmembrane

124 – 145

Helical; Name=3; Potential

Topological domain

146 – 165

Cytoplasmic Potential

Transmembrane

166 – 186

Helical; Name=4; Potential

Topological domain

187 – 191

Extracellular Potential

Transmembrane

192 – 215

Helical; Name=5; Potential

Topological domain

216 – 248

Cytoplasmic Potential

Transmembrane

249 – 271

Helical; Name=6; Potential

Topological domain

272 – 280

Extracellular Potential

Transmembrane

281 – 304

Helical; Name=7; Potential

Topological domain

305 – 332

Cytoplasmic Potential

Amino acid modifications

Lipidation

318

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

108

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

G → S in AAG35602. Ref.1

Sequence conflict

291

I → M in BAA24015. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P56450 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: BAD7018E30CF4FC1
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FASTA

332

36,959

        10         20         30         40         50         60 
MNSTHHHGMY TSLHLWNRSS YGLHGNASES LGKGHPDGGC YEQLFVSPEV FVTLGVISLL 

        70         80         90        100        110        120 
ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE TIVITLLNST DTDAQSFTVN 

       130        140        150        160        170        180 
IDNVIDSVIC SSLLASICSL LSIAVDRYFT IFYALQYHNI MTVRRVGIII SCIWAACTVS 

       190        200        210        220        230        240 
GVLFIIYSDS SAVIICLISM FFTMLVLMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGTN 

       250        260        270        280        290        300 
MKGAITLTIL IGVFVVCWAP FFLHLLFYIS CPQNPYCVCF MSHFNLYLIL IMCNAVIDPL 

       310        320        330 
IYALRSQELR KTFKEIICFY PLGGICELSS RY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the melanocortin-4 receptor gene." Dumont L.M., Wu C.S., Mountjoy K.G. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	Morooka Y., Oomizu S., Takeuchi S., Takahashi S. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 112-295. Strain: ICR. Tissue: Pituitary anterior lobe.
[3]	"Analysis of Mc4r locus in DIO and DR mice." Reichwald K., Petz U., Klingenspor M., Platzer M. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A/J, AKR/J, C57BL/6J, CAST/Ei, SJL/J and SWR/J. Tissue: Spleen.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Diencephalon.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein." Haqq A.M., Rene P., Kishi T., Khong K., Lee C.E., Liu H., Friedman J.M., Elmquist J.K., Cone R.D. Biochem. J. 376:595-605(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ATRNL1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF201662 Genomic DNA. Translation: AAG35602.1. AY684813 Genomic DNA. Translation: AAV92649.1. AY684814 Genomic DNA. Translation: AAV92650.1. AY684815 Genomic DNA. Translation: AAV92651.1. AY684818 Genomic DNA. Translation: AAV92654.1. AY684819 Genomic DNA. Translation: AAV92655.1. AY684820 Genomic DNA. Translation: AAV92656.1. AK136793 mRNA. Translation: BAE23130.1. BC116957 mRNA. Translation: AAI16958.1. BC116959 mRNA. Translation: AAI16960.1. AB009664 Genomic DNA. Translation: BAA24015.1.
IPI	IPI00111301.
RefSeq	NP_058673.2. NM_016977.4.
UniGene	Mm.229447.
3D structure databases
ProteinModelPortal	P56450.
SMR	P56450. Positions 50-317.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P56450.
Proteomic databases
PRIDE	P56450.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000057942; ENSMUSP00000054776; ENSMUSG00000047259.
GeneID	17202.
KEGG	mmu:17202.
Organism-specific databases
CTD	4160.
MGI	MGI:99457. Mc4r.
Phylogenomic databases
eggNOG	NOG269550.
GeneTree	ENSGT00700000104085.
HOGENOM	HOG000246927.
HOVERGEN	HBG108148.
InParanoid	Q49NR4.
KO	K04202.
OMA	TSLHFWN.
OrthoDB	EOG45DWPS.
Gene expression databases
Bgee	P56450.
CleanEx	MM_MC4R.
Genevestigator	P56450.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000155. Mcort_rcpt_4. IPR001908. Melancort_rcpt. IPR001671. Melcrt_ACTH_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00534. MCRFAMILY. PR00535. MELNOCORTINR. PR01062. MELNOCORTN4R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P56450.
ChEMBL	CHEMBL3719.
NextBio	291586.
SOURCE	Search...

Entry information

Entry name

MC4R_MOUSE

Accession

Primary (citable) accession number: P56450
Secondary accession number(s): Q49NR4, Q9EQM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents