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Protein

Melanocortin receptor 4

Gene

Mc4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).1 Publication

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • diet induced thermogenesis Source: Ensembl
  • energy reserve metabolic process Source: Ensembl
  • feeding behavior Source: MGI
  • insulin secretion Source: MGI
  • negative regulation of feeding behavior Source: Ensembl
  • positive regulation of bone resorption Source: HGNC
  • regulation of grooming behavior Source: Ensembl
  • regulation of metabolic process Source: MGI
  • response to insulin Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 4
Short name:
MC4-R
Gene namesi
Name:Mc4r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:99457 Mc4r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 69Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini70 – 81CytoplasmicSequence analysisAdd BLAST12
Transmembranei82 – 106Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini107 – 123ExtracellularSequence analysisAdd BLAST17
Transmembranei124 – 145Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini146 – 165CytoplasmicSequence analysisAdd BLAST20
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 191ExtracellularSequence analysis5
Transmembranei192 – 215Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini216 – 248CytoplasmicSequence analysisAdd BLAST33
Transmembranei249 – 271Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini272 – 280ExtracellularSequence analysis9
Transmembranei281 – 304Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini305 – 332CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3719
GuidetoPHARMACOLOGYi285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697241 – 332Melanocortin receptor 4Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84InterchainPROSITE-ProRule annotation
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi318S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56450
PRIDEiP56450

PTM databases

PhosphoSitePlusiP56450

Expressioni

Gene expression databases

BgeeiENSMUSG00000047259
CleanExiMM_MC4R

Interactioni

Subunit structurei

Interacts with ATRNL1. Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production (By similarity). Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201341, 2 interactors
STRINGi10090.ENSMUSP00000054776

Chemistry databases

BindingDBiP56450

Structurei

3D structure databases

ProteinModelPortaliP56450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
HOGENOMiHOG000246927
HOVERGENiHBG108148
InParanoidiP56450
KOiK04202
OMAiMHTSLHF
OrthoDBiEOG091G0BVW
TreeFamiTF332646

Family and domain databases

CDDicd15353 7tmA_MC4R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000155 Mcort_rcpt_4
IPR001908 Melancort_rcpt
IPR001671 Melcrt_ACTH_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00535 MELNOCORTINR
PR01062 MELNOCORTN4R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTHHHGMY TSLHLWNRSS YGLHGNASES LGKGHPDGGC YEQLFVSPEV
60 70 80 90 100
FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE
110 120 130 140 150
TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT
160 170 180 190 200
IFYALQYHNI MTVRRVGIII SCIWAACTVS GVLFIIYSDS SAVIICLISM
210 220 230 240 250
FFTMLVLMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGTN MKGAITLTIL
260 270 280 290 300
IGVFVVCWAP FFLHLLFYIS CPQNPYCVCF MSHFNLYLIL IMCNAVIDPL
310 320 330
IYALRSQELR KTFKEIICFY PLGGICELSS RY
Length:332
Mass (Da):36,959
Last modified:July 27, 2011 - v3
Checksum:iBAD7018E30CF4FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → S in AAG35602 (Ref. 1) Curated1
Sequence conflicti291I → M in BAA24015 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201662 Genomic DNA Translation: AAG35602.1
AY684813 Genomic DNA Translation: AAV92649.1
AY684814 Genomic DNA Translation: AAV92650.1
AY684815 Genomic DNA Translation: AAV92651.1
AY684818 Genomic DNA Translation: AAV92654.1
AY684819 Genomic DNA Translation: AAV92655.1
AY684820 Genomic DNA Translation: AAV92656.1
AK136793 mRNA Translation: BAE23130.1
BC116957 mRNA Translation: AAI16958.1
BC116959 mRNA Translation: AAI16960.1
AB009664 Genomic DNA Translation: BAA24015.1
CCDSiCCDS29316.1
RefSeqiNP_058673.2, NM_016977.4
UniGeneiMm.229447
Mm.491749

Genome annotation databases

EnsembliENSMUST00000057942; ENSMUSP00000054776; ENSMUSG00000047259
GeneIDi17202
KEGGimmu:17202
UCSCiuc008ffv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMC4R_MOUSE
AccessioniPrimary (citable) accession number: P56450
Secondary accession number(s): Q49NR4, Q9EQM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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