Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanocortin receptor 4

Gene

Mc4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).1 Publication

GO - Molecular functioni

GO - Biological processi

  • diet induced thermogenesis Source: Ensembl
  • energy reserve metabolic process Source: Ensembl
  • feeding behavior Source: MGI
  • insulin secretion Source: MGI
  • negative regulation of feeding behavior Source: Ensembl
  • positive regulation of bone resorption Source: HGNC
  • positive regulation of cAMP biosynthetic process Source: MGI
  • regulation of grooming behavior Source: Ensembl
  • regulation of metabolic process Source: MGI
  • response to insulin Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 4
Short name:
MC4-R
Gene namesi
Name:Mc4r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:99457. Mc4r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 69Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini70 – 81CytoplasmicSequence analysisAdd BLAST12
Transmembranei82 – 106Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini107 – 123ExtracellularSequence analysisAdd BLAST17
Transmembranei124 – 145Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini146 – 165CytoplasmicSequence analysisAdd BLAST20
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 191ExtracellularSequence analysis5
Transmembranei192 – 215Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini216 – 248CytoplasmicSequence analysisAdd BLAST33
Transmembranei249 – 271Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini272 – 280ExtracellularSequence analysis9
Transmembranei281 – 304Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini305 – 332CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3719.
GuidetoPHARMACOLOGYi285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697241 – 332Melanocortin receptor 4Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi84InterchainPROSITE-ProRule annotation
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Lipidationi318S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56450.
PRIDEiP56450.

PTM databases

iPTMnetiP56450.
PhosphoSitePlusiP56450.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047259.
CleanExiMM_MC4R.

Interactioni

Subunit structurei

Interacts with ATRNL1. Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production (By similarity). Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201341. 3 interactors.
STRINGi10090.ENSMUSP00000054776.

Chemistry databases

BindingDBiP56450.

Structurei

3D structure databases

ProteinModelPortaliP56450.
SMRiP56450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP56450.
KOiK04202.
OMAiGTGTIRQ.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000155. Mcort_rcpt_4.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01062. MELNOCORTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTHHHGMY TSLHLWNRSS YGLHGNASES LGKGHPDGGC YEQLFVSPEV
60 70 80 90 100
FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE
110 120 130 140 150
TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT
160 170 180 190 200
IFYALQYHNI MTVRRVGIII SCIWAACTVS GVLFIIYSDS SAVIICLISM
210 220 230 240 250
FFTMLVLMAS LYVHMFLMAR LHIKRIAVLP GTGTIRQGTN MKGAITLTIL
260 270 280 290 300
IGVFVVCWAP FFLHLLFYIS CPQNPYCVCF MSHFNLYLIL IMCNAVIDPL
310 320 330
IYALRSQELR KTFKEIICFY PLGGICELSS RY
Length:332
Mass (Da):36,959
Last modified:July 27, 2011 - v3
Checksum:iBAD7018E30CF4FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → S in AAG35602 (Ref. 1) Curated1
Sequence conflicti291I → M in BAA24015 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201662 Genomic DNA. Translation: AAG35602.1.
AY684813 Genomic DNA. Translation: AAV92649.1.
AY684814 Genomic DNA. Translation: AAV92650.1.
AY684815 Genomic DNA. Translation: AAV92651.1.
AY684818 Genomic DNA. Translation: AAV92654.1.
AY684819 Genomic DNA. Translation: AAV92655.1.
AY684820 Genomic DNA. Translation: AAV92656.1.
AK136793 mRNA. Translation: BAE23130.1.
BC116957 mRNA. Translation: AAI16958.1.
BC116959 mRNA. Translation: AAI16960.1.
AB009664 Genomic DNA. Translation: BAA24015.1.
CCDSiCCDS29316.1.
RefSeqiNP_058673.2. NM_016977.4.
UniGeneiMm.229447.
Mm.491749.

Genome annotation databases

EnsembliENSMUST00000057942; ENSMUSP00000054776; ENSMUSG00000047259.
GeneIDi17202.
KEGGimmu:17202.
UCSCiuc008ffv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201662 Genomic DNA. Translation: AAG35602.1.
AY684813 Genomic DNA. Translation: AAV92649.1.
AY684814 Genomic DNA. Translation: AAV92650.1.
AY684815 Genomic DNA. Translation: AAV92651.1.
AY684818 Genomic DNA. Translation: AAV92654.1.
AY684819 Genomic DNA. Translation: AAV92655.1.
AY684820 Genomic DNA. Translation: AAV92656.1.
AK136793 mRNA. Translation: BAE23130.1.
BC116957 mRNA. Translation: AAI16958.1.
BC116959 mRNA. Translation: AAI16960.1.
AB009664 Genomic DNA. Translation: BAA24015.1.
CCDSiCCDS29316.1.
RefSeqiNP_058673.2. NM_016977.4.
UniGeneiMm.229447.
Mm.491749.

3D structure databases

ProteinModelPortaliP56450.
SMRiP56450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201341. 3 interactors.
STRINGi10090.ENSMUSP00000054776.

Chemistry databases

BindingDBiP56450.
ChEMBLiCHEMBL3719.
GuidetoPHARMACOLOGYi285.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP56450.
PhosphoSitePlusiP56450.

Proteomic databases

PaxDbiP56450.
PRIDEiP56450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057942; ENSMUSP00000054776; ENSMUSG00000047259.
GeneIDi17202.
KEGGimmu:17202.
UCSCiuc008ffv.2. mouse.

Organism-specific databases

CTDi4160.
MGIiMGI:99457. Mc4r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP56450.
KOiK04202.
OMAiGTGTIRQ.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP56450.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047259.
CleanExiMM_MC4R.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000155. Mcort_rcpt_4.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01062. MELNOCORTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMC4R_MOUSE
AccessioniPrimary (citable) accession number: P56450
Secondary accession number(s): Q49NR4, Q9EQM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.