Reviewed, UniProtKB/Swiss-Prot P56434 (FUT6_PANTR)

Names and origin

Protein names

Recommended name:
    Alpha-(1,3)-fucosyltransferase
    EC=2.4.1.65
Alternative name(s):
    Galactoside 3-L-fucosyltransferase
    Fucosyltransferase 6
    Fucosyltransferase VI
      Short name=FucT-VI
      Short name=Fuc-TVI

Gene names

Name:

FUT6

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates By similarity.
Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Polymorphism	There are two alleles, A and B. Allele A has Pro-124, Gln-172 and Val-192. Allele B has Leu-124, Glu-172 and Ala-192.
Sequence similarities	Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Alpha-(1,3)-fucosyltransferase		PRO_0000221111
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 34	20	Signal-anchor for type II membrane protein Potential
	Topological domain	35 – 359	325	Lumenal Potential
Amino acid modifications
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	124	1	P → L in allele B. Ref.1		VAR_018694
	Natural variant	172	1	Q → E in allele B. Ref.1		VAR_018695
	Natural variant	192	1	V → A in allele B. Ref.1		VAR_018696

Sequences

	Sequence		Length	Mass (Da)
	P56434-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 207C3DC29B2BFDD3	FASTA	359	41,893
	10 20 30 40 50 60 MDPLGPAKPQ WSWRCCLTTL LFQLLVAVCF FSYLRVSRDD PTVYPNGSHF PDSTGTPAHS 70 80 90 100 110 120 IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP QADAVIVHHR EVMYNPSAQL 130 140 150 160 170 180 PRSPRRQGQR WIWFSMESPS NCRHLEALDG YFNLTMSYRS DSDIFTPYGW LQPWSGQPVH 190 200 210 220 230 240 PPLNLSAKTE LVAWAVSNWG PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY 250 260 270 280 290 300 KFYLAFENSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 310 320 330 340 350 LARYLQELDK DHARYLSYFR WRETLRPRFF SWALAFCKAC WKLQEESRYQ TRSIAAWFT

References

[1]

"Evolution of fucosyltransferase genes in vertebrates." Costache M., Apoil P.-A., Cailleau A., Elmgren A., Larson G., Henry S., Blancher A., Iordachescu D., Oriol R., Mollicone R. J. Biol. Chem. 272:29721-29728(1997) [PubMed: 9368041] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-124; GLU-172 AND ALA-192.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y14035 Genomic DNA. Translation: CAA74362.1.
RefSeq	NP_001009150.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P56434.
Protein family/group databases
CAZy	GT10. Glycosyltransferase Family 10.
Genome annotation databases
Ensembl	ENSPTRT00000019019; ENSPTRP00000049080; ENSPTRG00000010345; Pan troglodytes. [Genome view] ENSPTRT00000019021; ENSPTRP00000017604; ENSPTRG00000010345; Pan troglodytes. [Genome view]
GeneID	493976.
KEGG	ptr:493976.
Organism-specific databases
CTD	493976.
Phylogenomic databases
HOVERGEN	P56434.
Enzyme and pathway databases
BRENDA	2.4.1.152. 264977. 2.4.1.65. 264977.
Family and domain databases
InterPro	IPR001503. Glyco_trans_10. [Graphical view]
PANTHER	PTHR11929. Glyco_trans_10. 1 hit.
Pfam	PF00852. Glyco_transf_10. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT6_PANTR

Accession

Primary (citable) accession number: P56434

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	October 13, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)