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Protein

Thioredoxin reductase

Gene

trxB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39FADBy similarity9
Nucleotide bindingi32 – 39FADBy similarity8
Nucleotide bindingi281 – 290FADBy similarity10

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciHPY:HP0825-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:HP_0825
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001667331 – 311Thioredoxin reductaseAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi133 ↔ 136Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP56431.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

DIPiDIP-3417N.
IntActiP56431. 8 interactors.
MINTiMINT-170981.
STRINGi85962.HP0825.

Structurei

Secondary structure

1311
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi11 – 22Combined sources12
Beta strandi26 – 31Combined sources6
Beta strandi33 – 36Combined sources4
Helixi39 – 42Combined sources4
Helixi58 – 70Combined sources13
Beta strandi75 – 77Combined sources3
Beta strandi81 – 87Combined sources7
Beta strandi90 – 95Combined sources6
Beta strandi100 – 108Combined sources9
Beta strandi112 – 114Combined sources3
Helixi122 – 125Combined sources4
Turni127 – 129Combined sources3
Beta strandi130 – 132Combined sources3
Helixi134 – 137Combined sources4
Helixi138 – 141Combined sources4
Beta strandi144 – 149Combined sources6
Helixi153 – 163Combined sources11
Beta strandi166 – 172Combined sources7
Beta strandi174 – 177Combined sources4
Helixi182 – 189Combined sources8
Beta strandi194 – 197Combined sources4
Beta strandi200 – 208Combined sources9
Beta strandi211 – 219Combined sources9
Turni220 – 222Combined sources3
Beta strandi225 – 229Combined sources5
Beta strandi231 – 235Combined sources5
Beta strandi239 – 241Combined sources3
Helixi244 – 246Combined sources3
Beta strandi253 – 255Combined sources3
Beta strandi276 – 278Combined sources3
Helixi290 – 309Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q0KX-ray1.70A/B1-311[»]
2Q0LX-ray1.45A/B1-311[»]
3ISHX-ray2.43A/B/C1-311[»]
ProteinModelPortaliP56431.
SMRiP56431.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56431.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.
OMAiKQEDNSM.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDCAIIGGG PAGLSAGLYA TRGGVKNAVL FEKGMPGGQI TGSSEIENYP
60 70 80 90 100
GVKEVVSGLD FMQPWQEQCF RFGLKHEMTA VQRVSKKDSH FVILAEDGKT
110 120 130 140 150
FEAKSVIIAT GGSPKRTGIK GESEYWGKGV STCATCDGFF YKNKEVAVLG
160 170 180 190 200
GGDTAVEEAI YLANICKKVY LIHRRDGFRC APITLEHAKN NDKIEFLTPY
210 220 230 240 250
VVEEIKGDAS GVSSLSIKNT ATNEKRELVV PGFFIFVGYD VNNAVLKQED
260 270 280 290 300
NSMLCKCDEY GSIVVDFSMK TNVQGLFAAG DIRIFAPKQV VCAASDGATA
310
ALSVISYLEH H
Length:311
Mass (Da):33,538
Last modified:July 15, 1998 - v1
Checksum:i0718EFE4A43A478D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07875.1.
PIRiA64623.
RefSeqiNP_207618.1. NC_000915.1.
WP_000564420.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07875; AAD07875; HP_0825.
GeneIDi899063.
KEGGiheo:C694_04225.
hpy:HP0825.
PATRICi20592939. VBIHelPyl33062_0858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07875.1.
PIRiA64623.
RefSeqiNP_207618.1. NC_000915.1.
WP_000564420.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q0KX-ray1.70A/B1-311[»]
2Q0LX-ray1.45A/B1-311[»]
3ISHX-ray2.43A/B/C1-311[»]
ProteinModelPortaliP56431.
SMRiP56431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3417N.
IntActiP56431. 8 interactors.
MINTiMINT-170981.
STRINGi85962.HP0825.

Proteomic databases

PaxDbiP56431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07875; AAD07875; HP_0825.
GeneIDi899063.
KEGGiheo:C694_04225.
hpy:HP0825.
PATRICi20592939. VBIHelPyl33062_0858.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.
OMAiKQEDNSM.

Enzyme and pathway databases

BioCyciHPY:HP0825-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP56431.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRXB_HELPY
AccessioniPrimary (citable) accession number: P56431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.