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Reviewed, UniProtKB/Swiss-Prot P56431 (TRXB_HELPY)

Last modified February 9, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thioredoxin reductase
      Short name=TRXR
    EC=1.8.1.9
Gene names
Name: trxB
Ordered Locus Names: HP_0825
OrganismHelicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]
Taxonomic identifier210 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

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Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

removal of superoxide radicals

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

thioredoxin-disulfide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Thioredoxin reductase
PRO_0000166733

Regions

Nucleotide binding31 – 399FAD By similarity
Nucleotide binding281 – 29010FAD By similarity

Amino acid modifications

Disulfide bond133 ↔ 136Redox-active By similarity

Secondary structure

1 .............................................................. 311
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P56431-1 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 0718EFE4A43A478D

FASTA31133,538
        10         20         30         40         50         60 
MIDCAIIGGG PAGLSAGLYA TRGGVKNAVL FEKGMPGGQI TGSSEIENYP GVKEVVSGLD 

        70         80         90        100        110        120 
FMQPWQEQCF RFGLKHEMTA VQRVSKKDSH FVILAEDGKT FEAKSVIIAT GGSPKRTGIK 

       130        140        150        160        170        180 
GESEYWGKGV STCATCDGFF YKNKEVAVLG GGDTAVEEAI YLANICKKVY LIHRRDGFRC 

       190        200        210        220        230        240 
APITLEHAKN NDKIEFLTPY VVEEIKGDAS GVSSLSIKNT ATNEKRELVV PGFFIFVGYD 

       250        260        270        280        290        300 
VNNAVLKQED NSMLCKCDEY GSIVVDFSMK TNVQGLFAAG DIRIFAPKQV VCAASDGATA 

       310 
ALSVISYLEH H

« Hide

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD07875.1.
PIRA64623.
RefSeqNP_207618.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q0KX-ray1.70A/B1-311[»]
2Q0LX-ray1.45A/B1-311[»]
3ISHX-ray2.43A/B/C1-311[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3417N.

Genome annotation databases

GeneID899063.
GenomeReviewsGene locus HP_0825 in contig AE000511_GR.
KEGGhpy:HP0825.
NMPDRfig|85962.1.peg.816.
TIGRHP_0825.

Phylogenomic databases

HOGENOMHBG669726.
OMAFVGYDVN.

Enzyme and pathway databases

BRENDA1.8.1.9. 1131.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR001327. Pyr_OxRdtase_NAD_bd.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
TIGRFAMsTIGR01292. TRX_reduct. 1 hit.
PROSITEPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameTRXB_HELPY
AccessionPrimary (citable) accession number: P56431
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 9, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents