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Protein

Thioredoxin reductase

Gene

trxB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399FADBy similarity
Nucleotide bindingi32 – 398FADBy similarity
Nucleotide bindingi281 – 29010FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciHPY:HP0825-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Name:trxB
Ordered Locus Names:HP_0825
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Thioredoxin reductasePRO_0000166733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi133 ↔ 136Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP56431.
PRIDEiP56431.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

DIPiDIP-3417N.
IntActiP56431. 8 interactions.
MINTiMINT-170981.
STRINGi85962.HP0825.

Structurei

Secondary structure

1
311
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Helixi11 – 2212Combined sources
Beta strandi26 – 316Combined sources
Beta strandi33 – 364Combined sources
Helixi39 – 424Combined sources
Helixi58 – 7013Combined sources
Beta strandi75 – 773Combined sources
Beta strandi81 – 877Combined sources
Beta strandi90 – 956Combined sources
Beta strandi100 – 1089Combined sources
Beta strandi112 – 1143Combined sources
Helixi122 – 1254Combined sources
Turni127 – 1293Combined sources
Beta strandi130 – 1323Combined sources
Helixi134 – 1374Combined sources
Helixi138 – 1414Combined sources
Beta strandi144 – 1496Combined sources
Helixi153 – 16311Combined sources
Beta strandi166 – 1727Combined sources
Beta strandi174 – 1774Combined sources
Helixi182 – 1898Combined sources
Beta strandi194 – 1974Combined sources
Beta strandi200 – 2089Combined sources
Beta strandi211 – 2199Combined sources
Turni220 – 2223Combined sources
Beta strandi225 – 2295Combined sources
Beta strandi231 – 2355Combined sources
Beta strandi239 – 2413Combined sources
Helixi244 – 2463Combined sources
Beta strandi253 – 2553Combined sources
Beta strandi276 – 2783Combined sources
Helixi290 – 30920Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q0KX-ray1.70A/B1-311[»]
2Q0LX-ray1.45A/B1-311[»]
3ISHX-ray2.43A/B/C1-311[»]
ProteinModelPortaliP56431.
SMRiP56431. Positions 1-311.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56431.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.
OMAiKQEDNSM.
OrthoDBiEOG65XN2W.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDCAIIGGG PAGLSAGLYA TRGGVKNAVL FEKGMPGGQI TGSSEIENYP
60 70 80 90 100
GVKEVVSGLD FMQPWQEQCF RFGLKHEMTA VQRVSKKDSH FVILAEDGKT
110 120 130 140 150
FEAKSVIIAT GGSPKRTGIK GESEYWGKGV STCATCDGFF YKNKEVAVLG
160 170 180 190 200
GGDTAVEEAI YLANICKKVY LIHRRDGFRC APITLEHAKN NDKIEFLTPY
210 220 230 240 250
VVEEIKGDAS GVSSLSIKNT ATNEKRELVV PGFFIFVGYD VNNAVLKQED
260 270 280 290 300
NSMLCKCDEY GSIVVDFSMK TNVQGLFAAG DIRIFAPKQV VCAASDGATA
310
ALSVISYLEH H
Length:311
Mass (Da):33,538
Last modified:July 15, 1998 - v1
Checksum:i0718EFE4A43A478D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07875.1.
PIRiA64623.
RefSeqiNP_207618.1. NC_000915.1.
WP_000564420.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07875; AAD07875; HP_0825.
GeneIDi899063.
KEGGiheo:C694_04225.
hpy:HP0825.
PATRICi20592939. VBIHelPyl33062_0858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07875.1.
PIRiA64623.
RefSeqiNP_207618.1. NC_000915.1.
WP_000564420.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q0KX-ray1.70A/B1-311[»]
2Q0LX-ray1.45A/B1-311[»]
3ISHX-ray2.43A/B/C1-311[»]
ProteinModelPortaliP56431.
SMRiP56431. Positions 1-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3417N.
IntActiP56431. 8 interactions.
MINTiMINT-170981.
STRINGi85962.HP0825.

Proteomic databases

PaxDbiP56431.
PRIDEiP56431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07875; AAD07875; HP_0825.
GeneIDi899063.
KEGGiheo:C694_04225.
hpy:HP0825.
PATRICi20592939. VBIHelPyl33062_0858.

Phylogenomic databases

eggNOGiENOG4105C3M. Bacteria.
COG0492. LUCA.
KOiK00384.
OMAiKQEDNSM.
OrthoDBiEOG65XN2W.

Enzyme and pathway databases

BioCyciHPY:HP0825-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP56431.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
IPR005982. Thioredox_Rdtase.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01292. TRX_reduct. 1 hit.
PROSITEiPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiTRXB_HELPY
AccessioniPrimary (citable) accession number: P56431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: January 20, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.