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Protein

Homoserine dehydrogenase

Gene

hom

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 3 of the subpathway that synthesizes L-homoserine from L-aspartate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (lysC)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (lysC)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031NADPBy similarity
Binding sitei186 – 1861SubstrateBy similarity
Active sitei201 – 2011Proton donorSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP0822-MONOMER.
UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine dehydrogenase (EC:1.1.1.3)
Short name:
HDH
Gene namesi
Name:hom
Ordered Locus Names:HP_0822
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Homoserine dehydrogenasePRO_0000066694Add
BLAST

Proteomic databases

PaxDbiP56429.
PRIDEiP56429.

Interactioni

Protein-protein interaction databases

DIPiDIP-3530N.
IntActiP56429. 3 interactions.
MINTiMINT-160517.
STRINGi85962.HP0822.

Structurei

3D structure databases

ProteinModelPortaliP56429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini343 – 41876ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the homoserine dehydrogenase family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105D6E. Bacteria.
COG0460. LUCA.
KOiK00003.
OMAiEWIAGII.
OrthoDBiEOG6XM7CQ.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRLNIGLV GLGCVGSAVA KILQENQEII KDRAGVGIGI KKAVVRDVKK
60 70 80 90 100
HKGYPFEISN DLESLIEDEE IDIVVELMGG VEAPYLLAKK TLAKQKAFVT
110 120 130 140 150
ANKAMLAYHR YELEQTAKNT PIGFEASVCG GIPIIKALKD GLSANHILSF
160 170 180 190 200
KGILNGTSNY ILSQMFKNQA SFKDALKDAQ HLGYAELNPE FDIKGIDAAH
210 220 230 240 250
KLLILASLAY GIDAKLEEIL IEGIEKIEPD DMEFAKEFGY SIKLLGIAKK
260 270 280 290 300
HPDCIELRVH PSMIKNECML SKVDGVMNAI SVIGDKVGET LYYGAGAGGE
310 320 330 340 350
PTASAVISDI IEIARKKSSL MLGFETPQKL PLKPKEEIQC AYYARLLVSD
360 370 380 390 400
EKGVFSQISA ILAQNDISLN NVLQKEILHS NKAKILFSTH TTNEKSMLNA
410 420
LKELENLQSV LDTPKMIRLE N
Length:421
Mass (Da):46,168
Last modified:July 15, 1998 - v1
Checksum:i1C10A8C37D2C975B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07869.1.
PIRiF64622.
RefSeqiNP_207615.1. NC_000915.1.
WP_000746824.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07869; AAD07869; HP_0822.
GeneIDi898826.
KEGGiheo:C694_04210.
hpy:HP0822.
PATRICi20592933. VBIHelPyl33062_0855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07869.1.
PIRiF64622.
RefSeqiNP_207615.1. NC_000915.1.
WP_000746824.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3530N.
IntActiP56429. 3 interactions.
MINTiMINT-160517.
STRINGi85962.HP0822.

Proteomic databases

PaxDbiP56429.
PRIDEiP56429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07869; AAD07869; HP_0822.
GeneIDi898826.
KEGGiheo:C694_04210.
hpy:HP0822.
PATRICi20592933. VBIHelPyl33062_0855.

Phylogenomic databases

eggNOGiENOG4105D6E. Bacteria.
COG0460. LUCA.
KOiK00003.
OMAiEWIAGII.
OrthoDBiEOG6XM7CQ.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00063.
UPA00051; UER00465.
BioCyciHPY:HP0822-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002912. ACT_dom.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR016204. HDH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000098. Homoser_dehydrog. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDHOM_HELPY
AccessioniPrimary (citable) accession number: P56429
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: December 9, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.