Reviewed,
UniProtKB/Swiss-Prot P56429 (DHOM_HELPY)
Last modified
July 22, 2008.
Version 53.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Homoserine dehydrogenase Short name=HDH EC=1.1.1.3 | ||||
| Gene names |
| ||||
| Organism | Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 210 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter |
Protein attributes
| Sequence length | 421 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H. |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. |
| Sequence similarities | Belongs to the homoserine dehydrogenase family. Contains 1 ACT domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 421 | 421 | Homoserine dehydrogenase | |||||
Regions | ||||||||
| Domain | 342 – 419 | 78 | ACT | |||||
| Nucleotide binding | 10 – 17 | 8 | NADP By similarity | |||||
Sites | ||||||||
| Active site | 201 | 1 | Proton donor Potential | |||||
| Binding site | 103 | 1 | NADP By similarity | |||||
| Binding site | 186 | 1 | Substrate By similarity | |||||
Sequences
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References
| [1] | "The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C.Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695. |
Cross-references
Sequence databases | |
|---|---|
| AE000511 Genomic DNA. Translation: AAD07869.1. | |
| PIR | F64622. |
| RefSeq | NP_207615.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:3530N. |
Genome annotation databases | |
| GeneID | 898826. |
| GenomeReviews | Gene locus HP_0822 in contig AE000511_GR. |
| KEGG | hpy:HP0822. |
| NMPDR | fig|85962.1.peg.813. |
| TIGR | HP_0822. |
Phylogenomic databases | |
| HOGENOM | P56429. |
Family and domain databases | |
| InterPro | IPR002912. ACT_bd. IPR005106. Asp/hSer_DHase_NAD-bd. IPR016204. hSer_DHase. IPR001342. hSer_DHase_cat. [Graphical view] |
| Pfam | PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view] |
| PIRSF | PIRSF000098. Homoser_dehydrog. 1 hit. |
| PROSITE | PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view] |
| ProDom | P56429. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | DHOM_HELPY | ||||||||
| Accession | Primary (citable) accession number: P56429 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Helicobacter pylori Helicobacter pylori (strain 26695): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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