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Protein

Cathelicidin-7

Gene

CATHL7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Exerts a potent antimicrobial activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin-7
Alternative name(s):
Antibacterial peptide BMAP-34
Gene namesi
Name:CATHL7
Synonyms:BMAP34
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Propeptidei30 – 130101Sequence analysisPRO_0000004718Add
BLAST
Peptidei131 – 16434Cathelicidin-7PRO_0000004719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi86 ↔ 97By similarity
Disulfide bondi108 ↔ 125By similarity
Modified residuei164 – 1641Arginine amideSequence analysis

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PaxDbiP56425.
PeptideAtlasiP56425.
PRIDEiP56425.

Expressioni

Tissue specificityi

Expressed in bone marrow myeloid cells, spleen and testis.

Gene expression databases

BgeeiENSBTAG00000003022.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003930.

Structurei

3D structure databases

ProteinModelPortaliP56425.
SMRiP56425. Positions 30-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP56425.
KOiK13916.
OMAiRIKDIFR.
OrthoDBiEOG091G0XQS.
TreeFamiTF338457.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQRASFSL GRSSLWLLLL GLVVPSASAQ DLSYREAVLR AVDQFNERSS
60 70 80 90 100
EANLYRLLEL DPPPEQDVEH PGARKPVSFT VKETVCPRTT PQPPEQCDFK
110 120 130 140 150
ENGLVKQCVG TVTRYWIRGD FDITCNNIQS AGLFRRLRDS IRRGQQKILE
160
KARRIGERIK DIFRG
Length:165
Mass (Da):18,848
Last modified:July 15, 1998 - v1
Checksum:i21F14A0A68C6FBF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12729, Y12728 Genomic DNA. Translation: CAA73261.1.
EU380709 Genomic DNA. Translation: ACC61287.1.
EU380711 Genomic DNA. Translation: ACC61289.1.
EU380715 Genomic DNA. Translation: ACC61293.1.
BC149488 mRNA. Translation: AAI49489.1.
BC149577 mRNA. Translation: AAI49578.1.
RefSeqiNP_777256.1. NM_174831.2.
UniGeneiBt.33468.

Genome annotation databases

EnsembliENSBTAT00000003930; ENSBTAP00000003930; ENSBTAG00000003022.
GeneIDi317650.
KEGGibta:317650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12729, Y12728 Genomic DNA. Translation: CAA73261.1.
EU380709 Genomic DNA. Translation: ACC61287.1.
EU380711 Genomic DNA. Translation: ACC61289.1.
EU380715 Genomic DNA. Translation: ACC61293.1.
BC149488 mRNA. Translation: AAI49489.1.
BC149577 mRNA. Translation: AAI49578.1.
RefSeqiNP_777256.1. NM_174831.2.
UniGeneiBt.33468.

3D structure databases

ProteinModelPortaliP56425.
SMRiP56425. Positions 30-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003930.

Proteomic databases

PaxDbiP56425.
PeptideAtlasiP56425.
PRIDEiP56425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003930; ENSBTAP00000003930; ENSBTAG00000003022.
GeneIDi317650.
KEGGibta:317650.

Organism-specific databases

CTDi820.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP56425.
KOiK13916.
OMAiRIKDIFR.
OrthoDBiEOG091G0XQS.
TreeFamiTF338457.

Gene expression databases

BgeeiENSBTAG00000003022.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
IPR022746. Cathlecidin_C.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF12153. CAP18_C. 1 hit.
[Graphical view]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTHL7_BOVIN
AccessioniPrimary (citable) accession number: P56425
Secondary accession number(s): A6QPU1, B9TUC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.