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P56419

- DEF_HELPY

UniProt

P56419 - DEF_HELPY

Protein

Peptide deformylase

Gene

def

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.By similarity

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

    Cofactori

    Binds 1 Fe2+ ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi96 – 961IronBy similarity
    Metal bindingi138 – 1381IronBy similarity
    Active sitei139 – 1391By similarity
    Metal bindingi142 – 1421IronBy similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0793-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase (EC:3.5.1.88)
    Short name:
    PDF
    Alternative name(s):
    Polypeptide deformylase
    Gene namesi
    Name:def
    Ordered Locus Names:HP_0793
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 174174Peptide deformylasePRO_0000082790Add
    BLAST

    Proteomic databases

    PRIDEiP56419.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3266N.
    IntActiP56419. 5 interactions.
    MINTiMINT-165640.
    STRINGi85962.HP0793.

    Structurei

    3D structure databases

    ProteinModelPortaliP56419.
    SMRiP56419. Positions 2-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0242.
    KOiK01462.
    OMAiTHRAWYA.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56419-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLEIIHYP SKILRTISKE VVSFDSKLHQ QLDDMHETMI ASEGIGLAAI    50
    QVGLPLRMLI INLPQEDGVQ HKEDCLEIIN PKFIETGGSM MYREGCLSVP 100
    GFYEEVERFE KVKIEYQNRF AEVKVLEASE LLAVAIQHEI DHLNGVLFVD 150
    KLSILKRKKF EKELKELQKK QKHE 174
    Length:174
    Mass (Da):20,057
    Last modified:July 15, 1998 - v1
    Checksum:i375525F45E5CC774
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07841.1.
    PIRiA64619.
    RefSeqiNP_207586.1. NC_000915.1.
    YP_006934707.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07841; AAD07841; HP_0793.
    GeneIDi13869976.
    899348.
    KEGGiheo:C694_04065.
    hpy:HP0793.
    PATRICi20592873. VBIHelPyl33062_0825.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07841.1 .
    PIRi A64619.
    RefSeqi NP_207586.1. NC_000915.1.
    YP_006934707.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56419.
    SMRi P56419. Positions 2-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3266N.
    IntActi P56419. 5 interactions.
    MINTi MINT-165640.
    STRINGi 85962.HP0793.

    Proteomic databases

    PRIDEi P56419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07841 ; AAD07841 ; HP_0793 .
    GeneIDi 13869976.
    899348.
    KEGGi heo:C694_04065.
    hpy:HP0793.
    PATRICi 20592873. VBIHelPyl33062_0825.

    Phylogenomic databases

    eggNOGi COG0242.
    KOi K01462.
    OMAi THRAWYA.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci HPY:HP0793-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDEF_HELPY
    AccessioniPrimary (citable) accession number: P56419
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3