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P56414 (MOAA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyclic pyranopterin monophosphate synthase

EC=4.1.99.18
Alternative name(s):
Molybdenum cofactor biosynthesis protein A
Gene names
Name:moaA
Ordered Locus Names:HP_0768
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) By similarity. HAMAP-Rule MF_01225

Catalytic activity

GTP = cyclic pyranopterin phosphate + diphosphate. HAMAP-Rule MF_01225

Cofactor

Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate By similarity.

Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis. HAMAP-Rule MF_01225

Subunit structure

Monomer and homodimer By similarity. HAMAP-Rule MF_01225

Sequence similarities

Belongs to the radical SAM superfamily. MoaA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Cyclic pyranopterin monophosphate synthase HAMAP-Rule MF_01225
PRO_0000152967

Regions

Region254 – 2563GTP binding By similarity

Sites

Metal binding211Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal binding251Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal binding281Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal binding2491Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal binding2521Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal binding2661Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Binding site141GTP By similarity
Binding site271S-adenosyl-L-methionine By similarity
Binding site641GTP By similarity
Binding site681S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site951GTP By similarity
Binding site1191S-adenosyl-L-methionine By similarity
Binding site1551GTP By similarity
Binding site1891S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P56414 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 3308D812C8A6950C

FASTA32136,657
        10         20         30         40         50         60 
MLVDSFNRVI DYIRVSVTKQ CNFRCQYCMP ATPLNFFDNE ELLPLDNVLE FLKIAIDEGV 

        70         80         90        100        110        120 
KKIRITGGEP LLRKGLDEFI AKLHAYNKEV ELVLSTNGFL LKKMAKDLKN AGLAQVNVSL 

       130        140        150        160        170        180 
DSLKSDRVLK ISQKDALKNT LEGIEESLKV GLKLKLNTVV IKSVNDDEIL ELLEYAKNRH 

       190        200        210        220        230        240 
IQIRYIEFME NTHAKSLVKG LKEREILDLI AQKYQIIEAE KPKQGSSKIY TLENGYQFGI 

       250        260        270        280        290        300 
IAPHSDDFCQ SCNRIRLASD GKICPCLYYQ DAIDAKEAII NKDTKNIKRL LKQSVINKPE 

       310        320 
KNMWNDKNSE TPTRAFYYTG G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07817.1.
PIRH64615.
RefSeqNP_207561.1. NC_000915.1.
YP_006934683.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0768.

Proteomic databases

PRIDEP56414.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07817; AAD07817; HP_0768.
GeneID13869952.
899338.
KEGGheo:C694_03945.
hpy:HP0768.
PATRIC20592825. VBIHelPyl33062_0801.

Phylogenomic databases

eggNOGCOG2896.
KOK03639.
OMAEVFDKDY.
OrthoDBEOG64XXNN.
ProtClustDBPRK00164.

Enzyme and pathway databases

BioCycHPY:HP0768-MONOMER.
UniPathwayUPA00344.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01225_B. MoaA_B.
InterProIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view]
PfamPF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsTIGR02666. moaA. 1 hit.
PROSITEPS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMOAA_HELPY
AccessionPrimary (citable) accession number: P56414
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names