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P56414

- MOAA_HELPY

UniProt

P56414 - MOAA_HELPY

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Protein

Cyclic pyranopterin monophosphate synthase

Gene
moaA, HP_0768
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) By similarity.UniRule annotation

Catalytic activityi

GTP = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate By similarity.
Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141GTP By similarity
Metal bindingi21 – 211Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi25 – 251Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei27 – 271S-adenosyl-L-methionine By similarity
Metal bindingi28 – 281Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei64 – 641GTP By similarity
Binding sitei68 – 681S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei95 – 951GTP By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Binding sitei155 – 1551GTP By similarity
Binding sitei189 – 1891S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi249 – 2491Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi252 – 2521Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi266 – 2661Iron-sulfur 2 (4Fe-4S-substrate) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
  3. GTP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP0768-MONOMER.
UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic pyranopterin monophosphate synthase (EC:4.1.99.18)
Alternative name(s):
Molybdenum cofactor biosynthesis protein A
Gene namesi
Name:moaA
Ordered Locus Names:HP_0768
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. molybdopterin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Cyclic pyranopterin monophosphate synthaseUniRule annotationPRO_0000152967Add
BLAST

Proteomic databases

PRIDEiP56414.

Interactioni

Subunit structurei

Monomer and homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP0768.

Structurei

3D structure databases

ProteinModelPortaliP56414.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 2563GTP binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2896.
KOiK03639.
OMAiREYPGDI.
OrthoDBiEOG64XXNN.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01225_B. MoaA_B.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view]
PfamiPF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02666. moaA. 1 hit.
PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56414-1 [UniParc]FASTAAdd to Basket

« Hide

MLVDSFNRVI DYIRVSVTKQ CNFRCQYCMP ATPLNFFDNE ELLPLDNVLE    50
FLKIAIDEGV KKIRITGGEP LLRKGLDEFI AKLHAYNKEV ELVLSTNGFL 100
LKKMAKDLKN AGLAQVNVSL DSLKSDRVLK ISQKDALKNT LEGIEESLKV 150
GLKLKLNTVV IKSVNDDEIL ELLEYAKNRH IQIRYIEFME NTHAKSLVKG 200
LKEREILDLI AQKYQIIEAE KPKQGSSKIY TLENGYQFGI IAPHSDDFCQ 250
SCNRIRLASD GKICPCLYYQ DAIDAKEAII NKDTKNIKRL LKQSVINKPE 300
KNMWNDKNSE TPTRAFYYTG G 321
Length:321
Mass (Da):36,657
Last modified:July 15, 1998 - v1
Checksum:i3308D812C8A6950C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07817.1.
PIRiH64615.
RefSeqiNP_207561.1. NC_000915.1.
YP_006934683.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07817; AAD07817; HP_0768.
GeneIDi13869952.
899338.
KEGGiheo:C694_03945.
hpy:HP0768.
PATRICi20592825. VBIHelPyl33062_0801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07817.1 .
PIRi H64615.
RefSeqi NP_207561.1. NC_000915.1.
YP_006934683.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0768.

Proteomic databases

PRIDEi P56414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07817 ; AAD07817 ; HP_0768 .
GeneIDi 13869952.
899338.
KEGGi heo:C694_03945.
hpy:HP0768.
PATRICi 20592825. VBIHelPyl33062_0801.

Phylogenomic databases

eggNOGi COG2896.
KOi K03639.
OMAi REYPGDI.
OrthoDBi EOG64XXNN.

Enzyme and pathway databases

UniPathwayi UPA00344 .
BioCyci HPY:HP0768-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01225_B. MoaA_B.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view ]
Pfami PF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02666. moaA. 1 hit.
PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiMOAA_HELPY
AccessioniPrimary (citable) accession number: P56414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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