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P56414

- MOAA_HELPY

UniProt

P56414 - MOAA_HELPY

Protein

Cyclic pyranopterin monophosphate synthase

Gene

moaA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).UniRule annotation

    Catalytic activityi

    GTP = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate.UniRule annotation
    Binds 1 S-adenosyl-L-methionine per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141GTPUniRule annotation
    Metal bindingi21 – 211Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi25 – 251Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Binding sitei27 – 271S-adenosyl-L-methionineUniRule annotation
    Metal bindingi28 – 281Iron-sulfur 1 (4Fe-4S-S-AdoMet)UniRule annotation
    Binding sitei64 – 641GTPUniRule annotation
    Binding sitei68 – 681S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei95 – 951GTPUniRule annotation
    Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
    Binding sitei155 – 1551GTPUniRule annotation
    Binding sitei189 – 1891S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenUniRule annotation
    Metal bindingi249 – 2491Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation
    Metal bindingi252 – 2521Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation
    Metal bindingi266 – 2661Iron-sulfur 2 (4Fe-4S-substrate)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
    3. GTP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Molybdenum cofactor biosynthesis

    Keywords - Ligandi

    4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHPY:HP0768-MONOMER.
    UniPathwayiUPA00344.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic pyranopterin monophosphate synthaseUniRule annotation (EC:4.1.99.18UniRule annotation)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein AUniRule annotation
    Gene namesi
    Name:moaAUniRule annotation
    Ordered Locus Names:HP_0768
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. molybdopterin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Cyclic pyranopterin monophosphate synthasePRO_0000152967Add
    BLAST

    Proteomic databases

    PRIDEiP56414.

    Interactioni

    Subunit structurei

    Monomer and homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi85962.HP0768.

    Structurei

    3D structure databases

    ProteinModelPortaliP56414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 2563GTP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. MoaA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2896.
    KOiK03639.
    OMAiREYPGDI.
    OrthoDBiEOG64XXNN.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01225_B. MoaA_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view]
    PfamiPF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02666. moaA. 1 hit.
    PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56414-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVDSFNRVI DYIRVSVTKQ CNFRCQYCMP ATPLNFFDNE ELLPLDNVLE    50
    FLKIAIDEGV KKIRITGGEP LLRKGLDEFI AKLHAYNKEV ELVLSTNGFL 100
    LKKMAKDLKN AGLAQVNVSL DSLKSDRVLK ISQKDALKNT LEGIEESLKV 150
    GLKLKLNTVV IKSVNDDEIL ELLEYAKNRH IQIRYIEFME NTHAKSLVKG 200
    LKEREILDLI AQKYQIIEAE KPKQGSSKIY TLENGYQFGI IAPHSDDFCQ 250
    SCNRIRLASD GKICPCLYYQ DAIDAKEAII NKDTKNIKRL LKQSVINKPE 300
    KNMWNDKNSE TPTRAFYYTG G 321
    Length:321
    Mass (Da):36,657
    Last modified:July 15, 1998 - v1
    Checksum:i3308D812C8A6950C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07817.1.
    PIRiH64615.
    RefSeqiNP_207561.1. NC_000915.1.
    YP_006934683.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07817; AAD07817; HP_0768.
    GeneIDi13869952.
    899338.
    KEGGiheo:C694_03945.
    hpy:HP0768.
    PATRICi20592825. VBIHelPyl33062_0801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07817.1 .
    PIRi H64615.
    RefSeqi NP_207561.1. NC_000915.1.
    YP_006934683.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0768.

    Proteomic databases

    PRIDEi P56414.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07817 ; AAD07817 ; HP_0768 .
    GeneIDi 13869952.
    899338.
    KEGGi heo:C694_03945.
    hpy:HP0768.
    PATRICi 20592825. VBIHelPyl33062_0801.

    Phylogenomic databases

    eggNOGi COG2896.
    KOi K03639.
    OMAi REYPGDI.
    OrthoDBi EOG64XXNN.

    Enzyme and pathway databases

    UniPathwayi UPA00344 .
    BioCyci HPY:HP0768-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01225_B. MoaA_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR013483. MoaA.
    IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
    IPR010505. Mob_synth_C.
    IPR007197. rSAM.
    [Graphical view ]
    Pfami PF06463. Mob_synth_C. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02666. moaA. 1 hit.
    PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiMOAA_HELPY
    AccessioniPrimary (citable) accession number: P56414
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3