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Protein

Ovotransferrin

Gene
N/A
Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Ovotransferrin has a bacteriostatic function. Its concentration in avian egg is the highest concentration of any transferrin in vivo (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ovotransferrin
OrganismiAnas platyrhynchos (Mallard) (Anas boschas)
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnas
Proteomesi
  • UP000016666 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2104. Ana p 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000824401 – 686OvotransferrinAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 45
Disulfide bondi20 ↔ 36
Disulfide bondi115 ↔ 197
Disulfide bondi160 ↔ 174
Disulfide bondi171 ↔ 182
Disulfide bondi228 ↔ 242
Disulfide bondi348 ↔ 380
Disulfide bondi358 ↔ 371
Disulfide bondi405 ↔ 680
Disulfide bondi421 ↔ 643
Disulfide bondi454 ↔ 530
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi478 ↔ 671
Disulfide bondi488 ↔ 502
Disulfide bondi499 ↔ 513
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi570 ↔ 584

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP56410.

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1686
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 13Combined sources8
Helixi16 – 23Combined sources8
Turni24 – 29Combined sources6
Beta strandi30 – 38Combined sources9
Helixi42 – 50Combined sources9
Turni51 – 53Combined sources3
Beta strandi56 – 59Combined sources4
Helixi61 – 67Combined sources7
Beta strandi75 – 81Combined sources7
Beta strandi84 – 86Combined sources3
Beta strandi92 – 99Combined sources8
Helixi106 – 108Combined sources3
Beta strandi113 – 117Combined sources5
Turni122 – 125Combined sources4
Helixi126 – 134Combined sources9
Beta strandi136 – 138Combined sources3
Helixi143 – 145Combined sources3
Helixi148 – 155Combined sources8
Beta strandi156 – 160Combined sources5
Helixi168 – 171Combined sources4
Turni178 – 182Combined sources5
Beta strandi183 – 186Combined sources4
Helixi190 – 199Combined sources10
Beta strandi204 – 209Combined sources6
Helixi212 – 216Combined sources5
Helixi218 – 223Combined sources6
Beta strandi224 – 227Combined sources4
Turni229 – 231Combined sources3
Beta strandi233 – 235Combined sources3
Helixi236 – 241Combined sources6
Beta strandi244 – 247Combined sources4
Beta strandi251 – 254Combined sources4
Beta strandi256 – 258Combined sources3
Helixi260 – 274Combined sources15
Beta strandi275 – 277Combined sources3
Beta strandi279 – 281Combined sources3
Helixi293 – 295Combined sources3
Beta strandi296 – 300Combined sources5
Beta strandi306 – 309Combined sources4
Helixi316 – 320Combined sources5
Helixi323 – 332Combined sources10
Beta strandi344 – 351Combined sources8
Helixi352 – 365Combined sources14
Beta strandi367 – 377Combined sources11
Helixi378 – 385Combined sources8
Beta strandi391 – 394Combined sources4
Helixi396 – 403Combined sources8
Turni404 – 406Combined sources3
Beta strandi408 – 415Combined sources8
Beta strandi419 – 424Combined sources6
Beta strandi431 – 437Combined sources7
Helixi445 – 447Combined sources3
Beta strandi454 – 456Combined sources3
Turni461 – 464Combined sources4
Helixi465 – 475Combined sources11
Helixi480 – 482Combined sources3
Beta strandi484 – 486Combined sources3
Helixi497 – 499Combined sources3
Beta strandi505 – 509Combined sources5
Turni510 – 513Combined sources4
Helixi523 – 533Combined sources11
Beta strandi538 – 541Combined sources4
Helixi545 – 547Combined sources3
Beta strandi548 – 552Combined sources5
Turni557 – 559Combined sources3
Helixi563 – 565Combined sources3
Beta strandi567 – 569Combined sources3
Beta strandi575 – 577Combined sources3
Beta strandi586 – 589Combined sources4
Beta strandi593 – 596Combined sources4
Turni598 – 600Combined sources3
Helixi601 – 615Combined sources15
Turni620 – 624Combined sources5
Beta strandi631 – 634Combined sources4
Beta strandi643 – 646Combined sources4
Helixi653 – 657Combined sources5
Helixi659 – 668Combined sources10
Helixi675 – 683Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOVX-ray4.00A1-686[»]
1DOTX-ray2.35A1-686[»]
1GV8X-ray1.95A91-249[»]
1GVCX-ray1.90A91-247[»]
1OVBX-ray2.30A91-249[»]
ProteinModelPortaliP56410.
SMRiP56410.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56410.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 333Transferrin-like 1PROSITE-ProRule annotationAdd BLAST327
Domaini345 – 670Transferrin-like 2PROSITE-ProRule annotationAdd BLAST326

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni333 – 341Connecting region9

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000055.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
APPKTTVRWC TISSAEEKKC NSLKDHMQQE RVTLSCVQKA TYLDCIKAIS
60 70 80 90 100
NNEADAISLD GGQVFEAGLA PYKLKPIAAE VYERSGGSTT SYYAVAVVKK
110 120 130 140 150
GTDFMIKDLR GKTSCHTGLG RSAGWNIPIG TLIHREDIEW EGIESGISEQ
160 170 180 190 200
AVAKFFSASC VPGATIEQKL CRQCKGDAKT KCLRNGPYSG YSGAFQCLKD
210 220 230 240 250
GKGDVAFVKH TTVQENAPEE KDEYELLCLD GSRQPVDSYK TCNWARVAAH
260 270 280 290 300
AVVARDDSKI DDIWSFLGMQ AYSLGVDTTS DFHLFGPPGK KDPVLKDLLF
310 320 330 340 350
KDSAIMLKRV PELMDSQLYL GFEYYSAIQS LRKDQLTVGP RENKIQWCAV
360 370 380 390 400
GKDEKSKCDR WSVVSNGEVE CTILDDNKDC IVKITKGEAD AISLDGGFVY
410 420 430 440 450
TAGVCGLVPV VGESYEDETQ CSKDEEQPAY YFAVAVVKKS SAITWNNLQG
460 470 480 490 500
KKSCHTAVGR TAGWNIPMGL IHNKTGSCDF DDYFSEGCAP GSPPNSRLCK
510 520 530 540 550
LCQGSGENLL EKCVASSHEK YYGYTGALRC LVEQGDVAFI KHSTVGENVS
560 570 580 590 600
GSNKDDWAKG LTRDDFELLC TNGKRAKTMD YKTCHLAKVP THAVVARPEK
610 620 630 640 650
ANKIRELLEG QEKLFGLHGT EKERFMMFQS QTKDLLFKAL TKCLVKLRQG
660 670 680
ITYKEFLGDE YYASVASLNT CNPSDLLQVC TFLEDK
Length:686
Mass (Da):75,633
Last modified:July 15, 1998 - v1
Checksum:i963FCF4727C3EBDD
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOVX-ray4.00A1-686[»]
1DOTX-ray2.35A1-686[»]
1GV8X-ray1.95A91-249[»]
1GVCX-ray1.90A91-247[»]
1OVBX-ray2.30A91-249[»]
ProteinModelPortaliP56410.
SMRiP56410.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2104. Ana p 3.

Proteomic databases

PRIDEiP56410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000055.

Miscellaneous databases

EvolutionaryTraceiP56410.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRFE_ANAPL
AccessioniPrimary (citable) accession number: P56410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.