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Protein

Aquaporin-8

Gene

Aqp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel; mercury-sensitive. Also permeable to urea but not to glycerol.

GO - Molecular functioni

GO - Biological processi

  • cellular response to cAMP Source: Ensembl
  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • water transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-8
Short name:
AQP-8
Gene namesi
Name:Aqp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1195271. Aqp8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 84ExtracellularSequence analysisAdd BLAST27
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 107CytoplasmicSequence analysis2
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 156ExtracellularSequence analysisAdd BLAST28
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 183CytoplasmicSequence analysis6
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 228ExtracellularSequence analysisAdd BLAST24
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 261CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • apical part of cell Source: MGI
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639621 – 261Aquaporin-8Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP56404.
PRIDEiP56404.

Expressioni

Tissue specificityi

Colon, liver, heart and placenta.

Gene expression databases

BgeeiENSMUSG00000030762.
CleanExiMM_AQP8.
ExpressionAtlasiP56404. baseline and differential.
GenevisibleiP56404. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033023.

Structurei

3D structure databases

ProteinModelPortaliP56404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92 – 94NPA 13
Motifi210 – 212NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG100478.
InParanoidiP56404.
KOiK09869.
OMAiASMCDLE.
OrthoDBiEOG091G166T.
PhylomeDBiP56404.
TreeFamiTF312940.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023277. Aquaporin_8.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02020. AQUAPORIN8.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEQTPMCS MDLPEVKVKT SMAGRCRVFW YEQYVQPCIV ELVGSALFIF
60 70 80 90 100
IGCLSVIENS PNTGLLQPAL AHGLALGLII ATLGNISGGH FNPAVSLAVT
110 120 130 140 150
VIGGLKTMLL IPYWISQLFG GLIGAALAKV VSPEERFWNA SGAAFAIVQE
160 170 180 190 200
QEQVAEALGI EIILTMLLVL AVCMGAVNEK TMGPLAPFSI GFSVIVDILA
210 220 230 240 250
GGSISGACMN PARAFGPAVM AGYWDFHWIY WLGPLLAGLF VGLLIRLLIG
260
DEKTRLILKS R
Length:261
Mass (Da):27,797
Last modified:July 15, 1998 - v1
Checksum:i9CB48ACA1FB5E589
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5Missing in AAH10982 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018952 mRNA. Translation: AAB68847.1.
AF107543
, AF107538, AF107539, AF107540, AF107541, AF107542 Genomic DNA. Translation: AAD55972.1.
BC010982 mRNA. Translation: AAH10982.1.
CCDSiCCDS72038.1.
PIRiJC5806.
RefSeqiNP_001102515.1. NM_001109045.1.
NP_031500.1. NM_007474.2.
UniGeneiMm.273175.

Genome annotation databases

EnsembliENSMUST00000098056; ENSMUSP00000095664; ENSMUSG00000030762.
GeneIDi11833.
KEGGimmu:11833.
UCSCiuc012ftk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018952 mRNA. Translation: AAB68847.1.
AF107543
, AF107538, AF107539, AF107540, AF107541, AF107542 Genomic DNA. Translation: AAD55972.1.
BC010982 mRNA. Translation: AAH10982.1.
CCDSiCCDS72038.1.
PIRiJC5806.
RefSeqiNP_001102515.1. NM_001109045.1.
NP_031500.1. NM_007474.2.
UniGeneiMm.273175.

3D structure databases

ProteinModelPortaliP56404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033023.

Proteomic databases

PaxDbiP56404.
PRIDEiP56404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098056; ENSMUSP00000095664; ENSMUSG00000030762.
GeneIDi11833.
KEGGimmu:11833.
UCSCiuc012ftk.2. mouse.

Organism-specific databases

CTDi343.
MGIiMGI:1195271. Aqp8.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG100478.
InParanoidiP56404.
KOiK09869.
OMAiASMCDLE.
OrthoDBiEOG091G166T.
PhylomeDBiP56404.
TreeFamiTF312940.

Enzyme and pathway databases

ReactomeiR-MMU-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiP56404.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030762.
CleanExiMM_AQP8.
ExpressionAtlasiP56404. baseline and differential.
GenevisibleiP56404. MM.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023277. Aquaporin_8.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02020. AQUAPORIN8.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP8_MOUSE
AccessioniPrimary (citable) accession number: P56404
Secondary accession number(s): Q91XC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.