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Protein

Aquaporin-7

Gene

Aqp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a channel for water, glycerol and urea. It is possible that testis-specific glycerol kinase and AQP7 are functionally coupled and that the major function of AQP7 is glycerol transport rather than water transport. May have an important role in spermatogenesis and possibly in fertilization. It is mercury-resistant.

GO - Molecular functioni

  • glycerol channel activity Source: RGD
  • urea channel activity Source: RGD
  • water channel activity Source: RGD

GO - Biological processi

  • glycerol transport Source: RGD
  • response to drug Source: RGD
  • spermatogenesis Source: RGD
  • urea transport Source: RGD
  • water transport Source: RGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-432030 Transport of glycerol from adipocytes to the liver by Aquaporins
R-RNO-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-7
Short name:
AQP-7
Alternative name(s):
Aquaglyceroporin-7
Gene namesi
Name:Aqp7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2145 Aqp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 51ExtracellularSequence analysis6
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 97CytoplasmicSequence analysisAdd BLAST25
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 154ExtracellularSequence analysisAdd BLAST36
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 188CytoplasmicSequence analysisAdd BLAST13
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 239ExtracellularSequence analysisAdd BLAST30
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 269CytoplasmicSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639601 – 269Aquaporin-7Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP56403

PTM databases

iPTMnetiP56403
PhosphoSitePlusiP56403

Expressioni

Tissue specificityi

Abundantly expressed in testis.

Developmental stagei

Expressed at late stages of spermatogenesis, from late to maturing spermatids.

Gene expression databases

BgeeiENSRNOG00000009686
GenevisibleiP56403 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012974

Structurei

3D structure databases

ProteinModelPortaliP56403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 80NPA 13
Motifi210 – 212NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0224 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00510000046311
HOGENOMiHOG000288287
HOVERGENiHBG106057
InParanoidiP56403
KOiK08771
OMAiYLGGIIY
OrthoDBiEOG091G0FMS
PhylomeDBiP56403
TreeFamiTF313173

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR015686 Aquaporin_7
IPR000425 MIP
PANTHERiPTHR43829:SF15 PTHR43829:SF15, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

P56403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSVLENIQ SVLQKTWVRE FLAEFLSTYV LMVFGLGSVA HMVLGERLGS
60 70 80 90 100
YLGVNLGFGF GVTMGIHVAG GISGAHMNAA VTFTNCALGR MAWKKFPIYV
110 120 130 140 150
LGQFLGSFLA AATTYLIFYG AINHYAGGEL LVTGPKSTAN IFATYLPEHM
160 170 180 190 200
TLWRGFVDEV FVTGMLQLCI FAITDKLNSP ALQGTEPLMI GILVCVLGVS
210 220 230 240 250
LGMNTGYAIN PSRDLPPRFF TFIAGWGKKV FSAGNNWWWV PVVAPLLGAY
260
LGGIVYLGLI HAGIPPQGS
Length:269
Mass (Da):28,882
Last modified:June 20, 2003 - v2
Checksum:iA2F4B8BB5E775745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000507 mRNA Translation: BAA22053.2
AY120935 mRNA Translation: AAM81581.1
AY157737 mRNA Translation: AAN52930.1
BC072695 mRNA Translation: AAH72695.1
RefSeqiNP_062030.2, NM_019157.2
XP_017448684.1, XM_017593195.1
UniGeneiRn.11111

Genome annotation databases

EnsembliENSRNOT00000012975; ENSRNOP00000012974; ENSRNOG00000009686
GeneIDi29171
KEGGirno:29171
UCSCiRGD:2145 rat

Similar proteinsi

Entry informationi

Entry nameiAQP7_RAT
AccessioniPrimary (citable) accession number: P56403
Secondary accession number(s): Q8K3F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2003
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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