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P56400

- GP1BB_MOUSE

UniProt

P56400 - GP1BB_MOUSE

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Protein

Platelet glycoprotein Ib beta chain

Gene

Gp1bb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.By similarity

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. cell adhesion Source: MGI
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_225107. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein Ib beta chain
Short name:
GP-Ib beta
Short name:
GPIb-beta
Short name:
GPIbB
Alternative name(s):
CD_antigen: CD42c
Gene namesi
Name:Gp1bb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:107852. Gp1bb.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 206180Platelet glycoprotein Ib beta chainPRO_0000021346Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 32By similarity
Disulfide bondi30 ↔ 39By similarity
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi93 ↔ 118By similarity
Disulfide bondi95 ↔ 141By similarity
Disulfide bondi147 – 147Interchain (with C-608 or C-609 in GP1BA)By similarity
Modified residuei186 – 1861Phosphoserine1 Publication
Modified residuei191 – 1911Phosphoserine; by PKABy similarity
Modified residuei193 – 1931PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP56400.
PRIDEiP56400.

PTM databases

PhosphoSiteiP56400.

Expressioni

Gene expression databases

BgeeiP56400.
CleanExiMM_GP1BB.
ExpressionAtlasiP56400. baseline and differential.
GenevestigatoriP56400.

Interactioni

Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliP56400.
SMRiP56400. Positions 26-143.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 147121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini173 – 20634CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei148 – 17225HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 5529LRRNTAdd
BLAST
Repeati60 – 8324LRRAdd
BLAST
Domaini89 – 14355LRRCTAdd
BLAST

Sequence similaritiesi

Contains 1 LRR (leucine-rich) repeat.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG266400.
GeneTreeiENSGT00530000064244.
HOVERGENiHBG051791.
InParanoidiP56400.
KOiK06262.
OrthoDBiEOG75MVZ1.
PhylomeDBiP56400.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56400-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSRPRGALS LLLLLLALLS RPASGCPAPC SCAGTLVDCG RRGLTWASLP
60 70 80 90 100
AAFPPDTTEL VLTGNNLTAL PPGLLDALPA LRAAHLGANP WRCDCRLLPL
110 120 130 140 150
RAWLAGRPER APYRDLRCVA PPALRGRLLP YVAEDELRAA CAPGLLCWGA
160 170 180 190 200
LVAQLALLVL GLLHALLLAL LLGRLRRLRA RARARSIQEF SLTAPLVAES

ARGGAS
Length:206
Mass (Da):21,763
Last modified:July 15, 1998 - v1
Checksum:iAC4BCB4DFA226F1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001419 Genomic DNA. Translation: BAA22424.1.
CCDSiCCDS49787.1.
RefSeqiNP_034457.1. NM_010327.2.
UniGeneiMm.475622.

Genome annotation databases

EnsembliENSMUST00000167388; ENSMUSP00000126292; ENSMUSG00000050761.
GeneIDi14724.
KEGGimmu:14724.
UCSCiuc007yoi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001419 Genomic DNA. Translation: BAA22424.1 .
CCDSi CCDS49787.1.
RefSeqi NP_034457.1. NM_010327.2.
UniGenei Mm.475622.

3D structure databases

ProteinModelPortali P56400.
SMRi P56400. Positions 26-143.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P56400.

Proteomic databases

PaxDbi P56400.
PRIDEi P56400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167388 ; ENSMUSP00000126292 ; ENSMUSG00000050761 .
GeneIDi 14724.
KEGGi mmu:14724.
UCSCi uc007yoi.1. mouse.

Organism-specific databases

CTDi 2812.
MGIi MGI:107852. Gp1bb.

Phylogenomic databases

eggNOGi NOG266400.
GeneTreei ENSGT00530000064244.
HOVERGENi HBG051791.
InParanoidi P56400.
KOi K06262.
OrthoDBi EOG75MVZ1.
PhylomeDBi P56400.

Enzyme and pathway databases

Reactomei REACT_225107. Platelet Adhesion to exposed collagen.

Miscellaneous databases

NextBioi 286743.
PROi P56400.
SOURCEi Search...

Gene expression databases

Bgeei P56400.
CleanExi MM_GP1BB.
ExpressionAtlasi P56400. baseline and differential.
Genevestigatori P56400.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the gene encoding mouse platelet glycoprotein Ib beta."
    Kitaguchi T., Murata M., Anbo H., Moriki T., Ikeda Y.
    Thromb. Res. 87:235-244(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGP1BB_MOUSE
AccessioniPrimary (citable) accession number: P56400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3