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P56400

- GP1BB_MOUSE

UniProt

P56400 - GP1BB_MOUSE

Protein

Platelet glycoprotein Ib beta chain

Gene

Gp1bb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.By similarity

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. cell adhesion Source: MGI

    Keywords - Biological processi

    Blood coagulation, Cell adhesion, Hemostasis

    Enzyme and pathway databases

    ReactomeiREACT_225107. Platelet Adhesion to exposed collagen.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet glycoprotein Ib beta chain
    Short name:
    GP-Ib beta
    Short name:
    GPIb-beta
    Short name:
    GPIbB
    Alternative name(s):
    CD_antigen: CD42c
    Gene namesi
    Name:Gp1bb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:107852. Gp1bb.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 206180Platelet glycoprotein Ib beta chainPRO_0000021346Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 32By similarity
    Disulfide bondi30 ↔ 39By similarity
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi93 ↔ 118By similarity
    Disulfide bondi95 ↔ 141By similarity
    Disulfide bondi147 – 147Interchain (with C-608 or C-609 in GP1BA)By similarity
    Modified residuei186 – 1861Phosphoserine1 Publication
    Modified residuei191 – 1911Phosphoserine; by PKABy similarity
    Modified residuei193 – 1931PhosphothreonineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP56400.
    PRIDEiP56400.

    PTM databases

    PhosphoSiteiP56400.

    Expressioni

    Gene expression databases

    ArrayExpressiP56400.
    BgeeiP56400.
    CleanExiMM_GP1BB.
    GenevestigatoriP56400.

    Interactioni

    Subunit structurei

    Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP56400.
    SMRiP56400. Positions 26-143.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 147121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini173 – 20634CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei148 – 17225HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 5529LRRNTAdd
    BLAST
    Repeati60 – 8324LRRAdd
    BLAST
    Domaini89 – 14355LRRCTAdd
    BLAST

    Sequence similaritiesi

    Contains 1 LRR (leucine-rich) repeat.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG266400.
    GeneTreeiENSGT00530000064244.
    HOVERGENiHBG051791.
    InParanoidiP56400.
    KOiK06262.
    OrthoDBiEOG75MVZ1.
    PhylomeDBiP56400.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF01463. LRRCT. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56400-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSRPRGALS LLLLLLALLS RPASGCPAPC SCAGTLVDCG RRGLTWASLP    50
    AAFPPDTTEL VLTGNNLTAL PPGLLDALPA LRAAHLGANP WRCDCRLLPL 100
    RAWLAGRPER APYRDLRCVA PPALRGRLLP YVAEDELRAA CAPGLLCWGA 150
    LVAQLALLVL GLLHALLLAL LLGRLRRLRA RARARSIQEF SLTAPLVAES 200
    ARGGAS 206
    Length:206
    Mass (Da):21,763
    Last modified:July 15, 1998 - v1
    Checksum:iAC4BCB4DFA226F1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001419 Genomic DNA. Translation: BAA22424.1.
    CCDSiCCDS49787.1.
    RefSeqiNP_034457.1. NM_010327.2.
    UniGeneiMm.475622.

    Genome annotation databases

    EnsembliENSMUST00000167388; ENSMUSP00000126292; ENSMUSG00000050761.
    GeneIDi14724.
    KEGGimmu:14724.
    UCSCiuc007yoi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001419 Genomic DNA. Translation: BAA22424.1 .
    CCDSi CCDS49787.1.
    RefSeqi NP_034457.1. NM_010327.2.
    UniGenei Mm.475622.

    3D structure databases

    ProteinModelPortali P56400.
    SMRi P56400. Positions 26-143.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P56400.

    Proteomic databases

    PaxDbi P56400.
    PRIDEi P56400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167388 ; ENSMUSP00000126292 ; ENSMUSG00000050761 .
    GeneIDi 14724.
    KEGGi mmu:14724.
    UCSCi uc007yoi.1. mouse.

    Organism-specific databases

    CTDi 2812.
    MGIi MGI:107852. Gp1bb.

    Phylogenomic databases

    eggNOGi NOG266400.
    GeneTreei ENSGT00530000064244.
    HOVERGENi HBG051791.
    InParanoidi P56400.
    KOi K06262.
    OrthoDBi EOG75MVZ1.
    PhylomeDBi P56400.

    Enzyme and pathway databases

    Reactomei REACT_225107. Platelet Adhesion to exposed collagen.

    Miscellaneous databases

    NextBioi 286743.
    PROi P56400.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56400.
    Bgeei P56400.
    CleanExi MM_GP1BB.
    Genevestigatori P56400.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF01463. LRRCT. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the gene encoding mouse platelet glycoprotein Ib beta."
      Kitaguchi T., Murata M., Anbo H., Moriki T., Ikeda Y.
      Thromb. Res. 87:235-244(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiGP1BB_MOUSE
    AccessioniPrimary (citable) accession number: P56400
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3