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P56400 (GP1BB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet glycoprotein Ib beta chain

Short name=GP-Ib beta
Short name=GPIb-beta
Short name=GPIbB
Alternative name(s):
CD_antigen=CD42c
Gene names
Name:Gp1bb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium By similarity.

Subunit structure

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Miscellaneous

Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.

Sequence similarities

Contains 1 LRR (leucine-rich) repeat.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 206180Platelet glycoprotein Ib beta chain
PRO_0000021346

Regions

Topological domain27 – 147121Extracellular Potential
Transmembrane148 – 17225Helical; Potential
Topological domain173 – 20634Cytoplasmic Potential
Domain27 – 5529LRRNT
Repeat60 – 8324LRR
Domain89 – 14355LRRCT

Amino acid modifications

Modified residue1861Phosphoserine Ref.2
Modified residue1911Phosphoserine; by PKA By similarity
Modified residue1931Phosphothreonine By similarity
Glycosylation661N-linked (GlcNAc...) Potential
Disulfide bond26 ↔ 32 By similarity
Disulfide bond30 ↔ 39 By similarity
Disulfide bond93 ↔ 118 By similarity
Disulfide bond95 ↔ 141 By similarity
Disulfide bond147Interchain (with C-608 or C-609 in GP1BA) By similarity

Sequences

Sequence LengthMass (Da)Tools
P56400 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: AC4BCB4DFA226F1D

FASTA20621,763
        10         20         30         40         50         60 
MGSRPRGALS LLLLLLALLS RPASGCPAPC SCAGTLVDCG RRGLTWASLP AAFPPDTTEL 

        70         80         90        100        110        120 
VLTGNNLTAL PPGLLDALPA LRAAHLGANP WRCDCRLLPL RAWLAGRPER APYRDLRCVA 

       130        140        150        160        170        180 
PPALRGRLLP YVAEDELRAA CAPGLLCWGA LVAQLALLVL GLLHALLLAL LLGRLRRLRA 

       190        200 
RARARSIQEF SLTAPLVAES ARGGAS 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the gene encoding mouse platelet glycoprotein Ib beta."
Kitaguchi T., Murata M., Anbo H., Moriki T., Ikeda Y.
Thromb. Res. 87:235-244(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB001419 Genomic DNA. Translation: BAA22424.1.
CCDSCCDS49787.1.
RefSeqNP_034457.1. NM_010327.2.
UniGeneMm.475622.

3D structure databases

ProteinModelPortalP56400.
SMRP56400. Positions 26-143.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP56400.

Proteomic databases

PaxDbP56400.
PRIDEP56400.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000167388; ENSMUSP00000126292; ENSMUSG00000050761.
GeneID14724.
KEGGmmu:14724.
UCSCuc007yoi.1. mouse.

Organism-specific databases

CTD2812.
MGIMGI:107852. Gp1bb.

Phylogenomic databases

eggNOGNOG266400.
GeneTreeENSGT00530000064244.
HOVERGENHBG051791.
InParanoidP56400.
KOK06262.
OrthoDBEOG75MVZ1.
PhylomeDBP56400.

Gene expression databases

ArrayExpressP56400.
BgeeP56400.
CleanExMM_GP1BB.
GenevestigatorP56400.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286743.
PROP56400.
SOURCESearch...

Entry information

Entry nameGP1BB_MOUSE
AccessionPrimary (citable) accession number: P56400
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot