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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei135L-tryptophanUniRule annotation1
Binding sitei186ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 13ATPUniRule annotation3
Nucleotide bindingi19 – 20ATPUniRule annotation2
Nucleotide bindingi147 – 149ATPUniRule annotation3
Nucleotide bindingi195 – 199ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:HP_1253
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366371 – 326Tryptophan--tRNA ligaseAdd BLAST326

Proteomic databases

PaxDbiP56396

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP1253

Structurei

3D structure databases

ProteinModelPortaliP56396
SMRiP56396
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 20"HIGH" regionUniRule annotation9
Motifi195 – 199"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

P56396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKKRVFSGI QPTGQIHLGN YLGAIKHWVE MQDEYENLFC VVNSHAITLP
60 70 80 90 100
IDPAFLKSQS YELVKLLLAC GIDPKQSGLF IQSEVDEHPA LAWLLNCQVS
110 120 130 140 150
MGEMQRMTQF KDKSLKNPKS VNVGLFNYPI LMASDILLYQ SDLVPVGEDQ
160 170 180 190 200
KQHLELTRNI AEKFNRDFGN CFKVPEPLIA KVGARVMGLD DPKVKMSKSH
210 220 230 240 250
QGANHAIFLL DEPDIIVKKI KKAATDSMGV IAFDEKREGI FNLLNIYMLL
260 270 280 290 300
SNESPENIEE RFKNKGYGDF KKELAEVMIQ ALKPIQERYK EISDDEVKAI
310 320
LNGGAEKARP LARATYQKAK ELMGLI
Length:326
Mass (Da):36,836
Last modified:May 30, 2000 - v2
Checksum:iFB352D7B685E2F80
GO

Sequence cautioni

The sequence AAD08297 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08297.1 Different initiation.
PIRiE64676
RefSeqiNP_208045.1, NC_000915.1

Genome annotation databases

EnsemblBacteriaiAAD08297; AAD08297; HP_1253
GeneIDi899025
KEGGiheo:C694_06475
hpy:HP1253
PATRICifig|85962.47.peg.1345

Similar proteinsi

Entry informationi

Entry nameiSYW_HELPY
AccessioniPrimary (citable) accession number: P56396
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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