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P56394

- COX17_MOUSE

UniProt

P56394 - COX17_MOUSE

Protein

Cytochrome c oxidase copper chaperone

Gene

Cox17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231CopperBy similarity
    Metal bindingi24 – 241CopperBy similarity

    GO - Molecular functioni

    1. copper chaperone activity Source: InterPro

    GO - Biological processi

    1. copper ion transport Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_199101. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase copper chaperone
    Gene namesi
    Name:Cox17
    Synonyms:Cox17a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1333806. Cox17.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6363Cytochrome c oxidase copper chaperonePRO_0000213539Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 55By similarity
    Disulfide bondi36 ↔ 45By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiP56394.
    PaxDbiP56394.
    PRIDEiP56394.

    PTM databases

    PhosphoSiteiP56394.

    Expressioni

    Gene expression databases

    ArrayExpressiP56394.
    BgeeiP56394.
    GenevestigatoriP56394.

    Interactioni

    Subunit structurei

    Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure By similarity.By similarity

    Protein-protein interaction databases

    IntActiP56394. 1 interaction.
    MINTiMINT-4091685.

    Structurei

    3D structure databases

    ProteinModelPortaliP56394.
    SMRiP56394. Positions 1-63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 2726Ala/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the COX17 family.Curated

    Phylogenomic databases

    eggNOGiNOG136703.
    HOGENOMiHOG000195037.
    HOVERGENiHBG054258.
    InParanoidiP56394.
    KOiK02260.
    OMAiIEAKECM.
    OrthoDBiEOG7ZWD4S.
    PhylomeDBiP56394.
    TreeFamiTF105074.

    Family and domain databases

    Gene3Di1.10.810.10. 1 hit.
    InterProiIPR009069. Cys_alpha_HP_mot_SF.
    IPR007745. Cyt_c_oxidase_Cu-chaperone.
    [Graphical view]
    PANTHERiPTHR16719. PTHR16719. 1 hit.
    PfamiPF05051. COX17. 1 hit.
    [Graphical view]
    ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47072. SSF47072. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56394-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGLAAASPA PPEAQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE   50
    AHKECMRALG FKI 63
    Length:63
    Mass (Da):6,784
    Last modified:January 23, 2007 - v2
    Checksum:i26787FE131159562
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA168035 mRNA. No translation available.
    BC048668 mRNA. Translation: AAH48668.1.
    CCDSiCCDS28165.1.
    RefSeqiNP_001017429.1. NM_001017429.2.
    XP_006521813.1. XM_006521750.1.
    UniGeneiMm.27396.

    Genome annotation databases

    EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516.
    ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464.
    ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516.
    GeneIDi12856.
    KEGGimmu:12856.
    UCSCiuc007zet.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA168035 mRNA. No translation available.
    BC048668 mRNA. Translation: AAH48668.1 .
    CCDSi CCDS28165.1.
    RefSeqi NP_001017429.1. NM_001017429.2.
    XP_006521813.1. XM_006521750.1.
    UniGenei Mm.27396.

    3D structure databases

    ProteinModelPortali P56394.
    SMRi P56394. Positions 1-63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56394. 1 interaction.
    MINTi MINT-4091685.

    PTM databases

    PhosphoSitei P56394.

    Proteomic databases

    MaxQBi P56394.
    PaxDbi P56394.
    PRIDEi P56394.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050273 ; ENSMUSP00000054086 ; ENSMUSG00000046516 .
    ENSMUST00000119704 ; ENSMUSP00000112386 ; ENSMUSG00000095464 .
    ENSMUST00000120495 ; ENSMUSP00000113430 ; ENSMUSG00000046516 .
    GeneIDi 12856.
    KEGGi mmu:12856.
    UCSCi uc007zet.1. mouse.

    Organism-specific databases

    CTDi 10063.
    MGIi MGI:1333806. Cox17.

    Phylogenomic databases

    eggNOGi NOG136703.
    HOGENOMi HOG000195037.
    HOVERGENi HBG054258.
    InParanoidi P56394.
    KOi K02260.
    OMAi IEAKECM.
    OrthoDBi EOG7ZWD4S.
    PhylomeDBi P56394.
    TreeFami TF105074.

    Enzyme and pathway databases

    Reactomei REACT_199101. Mitochondrial protein import.

    Miscellaneous databases

    ChiTaRSi COX17. mouse.
    NextBioi 282408.
    PROi P56394.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56394.
    Bgeei P56394.
    Genevestigatori P56394.

    Family and domain databases

    Gene3Di 1.10.810.10. 1 hit.
    InterProi IPR009069. Cys_alpha_HP_mot_SF.
    IPR007745. Cyt_c_oxidase_Cu-chaperone.
    [Graphical view ]
    PANTHERi PTHR16719. PTHR16719. 1 hit.
    Pfami PF05051. COX17. 1 hit.
    [Graphical view ]
    ProDomi PD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47072. SSF47072. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCOX17_MOUSE
    AccessioniPrimary (citable) accession number: P56394
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3