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P56394 (COX17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase copper chaperone
Gene names
Name:Cox17
Synonyms:Cox17a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length63 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX By similarity.

Subunit structure

Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure By similarity.

Subcellular location

Mitochondrion intermembrane space By similarity.

Sequence similarities

Belongs to the COX17 family.

Ontologies

Keywords
   Cellular componentMitochondrion
   LigandCopper
Metal-binding
   Molecular functionChaperone
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcopper ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrial intermembrane space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncopper chaperone activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6363Cytochrome c oxidase copper chaperone
PRO_0000213539

Regions

Compositional bias2 – 2726Ala/Pro-rich

Sites

Metal binding231Copper By similarity
Metal binding241Copper By similarity

Amino acid modifications

Disulfide bond26 ↔ 55 By similarity
Disulfide bond36 ↔ 45 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56394 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 26787FE131159562

FASTA636,784
        10         20         30         40         50         60 
MPGLAAASPA PPEAQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE AHKECMRALG 


FKI 

« Hide

References

« Hide 'large scale' references
[1]Marra M., Hillier L., Allen M., Bowles M., Dietrich N., Dubuque T., Geisel S., Kucaba T., Lacy M., Le M., Martin J., Morris M., Schellenberg K., Steptoe M., Tan F., Underwood K., Moore B., Theising B. expand/collapse author list , Wylie T., Lennon G., Soares B., Wilson R., Waterston R.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AA168035 mRNA. No translation available.
BC048668 mRNA. Translation: AAH48668.1.
RefSeqNP_001017429.1. NM_001017429.2.
XP_006521813.1. XM_006521750.1.
UniGeneMm.27396.

3D structure databases

ProteinModelPortalP56394.
SMRP56394. Positions 1-63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP56394. 1 interaction.
MINTMINT-4091685.

PTM databases

PhosphoSiteP56394.

Proteomic databases

PaxDbP56394.
PRIDEP56394.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516.
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464.
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516.
GeneID12856.
KEGGmmu:12856.
UCSCuc007zet.1. mouse.

Organism-specific databases

CTD10063.
MGIMGI:1333806. Cox17.

Phylogenomic databases

eggNOGNOG136703.
HOGENOMHOG000195037.
HOVERGENHBG054258.
InParanoidP56394.
KOK02260.
OMAIEAKECM.
OrthoDBEOG7ZWD4S.
PhylomeDBP56394.
TreeFamTF105074.

Gene expression databases

ArrayExpressP56394.
BgeeP56394.
GenevestigatorP56394.

Family and domain databases

Gene3D1.10.810.10. 1 hit.
InterProIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERPTHR16719. PTHR16719. 1 hit.
PfamPF05051. COX17. 1 hit.
[Graphical view]
ProDomPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47072. SSF47072. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCOX17. mouse.
NextBio282408.
PROP56394.
SOURCESearch...

Entry information

Entry nameCOX17_MOUSE
AccessionPrimary (citable) accession number: P56394
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot