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P56394

- COX17_MOUSE

UniProt

P56394 - COX17_MOUSE

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Protein

Cytochrome c oxidase copper chaperone

Gene
Cox17, Cox17a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Copper By similarity
Metal bindingi24 – 241Copper By similarity

GO - Molecular functioni

  1. copper chaperone activity Source: InterPro

GO - Biological processi

  1. copper ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase copper chaperone
Gene namesi
Name:Cox17
Synonyms:Cox17a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1333806. Cox17.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6363Cytochrome c oxidase copper chaperonePRO_0000213539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 55 By similarity
Disulfide bondi36 ↔ 45 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP56394.
PaxDbiP56394.
PRIDEiP56394.

PTM databases

PhosphoSiteiP56394.

Expressioni

Gene expression databases

ArrayExpressiP56394.
BgeeiP56394.
GenevestigatoriP56394.

Interactioni

Subunit structurei

Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure By similarity.

Protein-protein interaction databases

IntActiP56394. 1 interaction.
MINTiMINT-4091685.

Structurei

3D structure databases

ProteinModelPortaliP56394.
SMRiP56394. Positions 1-63.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 2726Ala/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the COX17 family.

Phylogenomic databases

eggNOGiNOG136703.
HOGENOMiHOG000195037.
HOVERGENiHBG054258.
InParanoidiP56394.
KOiK02260.
OMAiIEAKECM.
OrthoDBiEOG7ZWD4S.
PhylomeDBiP56394.
TreeFamiTF105074.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERiPTHR16719. PTHR16719. 1 hit.
PfamiPF05051. COX17. 1 hit.
[Graphical view]
ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47072. SSF47072. 1 hit.

Sequencei

Sequence statusi: Complete.

P56394-1 [UniParc]FASTAAdd to Basket

« Hide

MPGLAAASPA PPEAQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE   50
AHKECMRALG FKI 63
Length:63
Mass (Da):6,784
Last modified:January 23, 2007 - v2
Checksum:i26787FE131159562
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA168035 mRNA. No translation available.
BC048668 mRNA. Translation: AAH48668.1.
CCDSiCCDS28165.1.
RefSeqiNP_001017429.1. NM_001017429.2.
XP_006521813.1. XM_006521750.1.
UniGeneiMm.27396.

Genome annotation databases

EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516.
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464.
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516.
GeneIDi12856.
KEGGimmu:12856.
UCSCiuc007zet.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA168035 mRNA. No translation available.
BC048668 mRNA. Translation: AAH48668.1 .
CCDSi CCDS28165.1.
RefSeqi NP_001017429.1. NM_001017429.2.
XP_006521813.1. XM_006521750.1.
UniGenei Mm.27396.

3D structure databases

ProteinModelPortali P56394.
SMRi P56394. Positions 1-63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56394. 1 interaction.
MINTi MINT-4091685.

PTM databases

PhosphoSitei P56394.

Proteomic databases

MaxQBi P56394.
PaxDbi P56394.
PRIDEi P56394.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050273 ; ENSMUSP00000054086 ; ENSMUSG00000046516 .
ENSMUST00000119704 ; ENSMUSP00000112386 ; ENSMUSG00000095464 .
ENSMUST00000120495 ; ENSMUSP00000113430 ; ENSMUSG00000046516 .
GeneIDi 12856.
KEGGi mmu:12856.
UCSCi uc007zet.1. mouse.

Organism-specific databases

CTDi 10063.
MGIi MGI:1333806. Cox17.

Phylogenomic databases

eggNOGi NOG136703.
HOGENOMi HOG000195037.
HOVERGENi HBG054258.
InParanoidi P56394.
KOi K02260.
OMAi IEAKECM.
OrthoDBi EOG7ZWD4S.
PhylomeDBi P56394.
TreeFami TF105074.

Enzyme and pathway databases

Reactomei REACT_199101. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSi COX17. mouse.
NextBioi 282408.
PROi P56394.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56394.
Bgeei P56394.
Genevestigatori P56394.

Family and domain databases

Gene3Di 1.10.810.10. 1 hit.
InterProi IPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view ]
PANTHERi PTHR16719. PTHR16719. 1 hit.
Pfami PF05051. COX17. 1 hit.
[Graphical view ]
ProDomi PD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47072. SSF47072. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCOX17_MOUSE
AccessioniPrimary (citable) accession number: P56394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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