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Protein

Cytochrome c oxidase copper chaperone

Gene

Cox17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23CopperBy similarity1
Metal bindingi24CopperBy similarity1

GO - Molecular functioni

  • copper chaperone activity Source: GO_Central
  • copper ion binding Source: MGI
  • enzyme activator activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase copper chaperone
Gene namesi
Name:Cox17
Synonyms:Cox17a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1333806. Cox17.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002135392 – 63Cytochrome c oxidase copper chaperoneAdd BLAST62

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 55PROSITE-ProRule annotation
Disulfide bondi36 ↔ 45PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP56394.
PaxDbiP56394.
PeptideAtlasiP56394.
PRIDEiP56394.

PTM databases

iPTMnetiP56394.
PhosphoSitePlusiP56394.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046516.
ExpressionAtlasiP56394. baseline and differential.
GenevisibleiP56394. MM.

Interactioni

Subunit structurei

Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure (By similarity).By similarity

Protein-protein interaction databases

IntActiP56394. 1 interactor.
MINTiMINT-4091685.
STRINGi10090.ENSMUSP00000112386.

Structurei

3D structure databases

ProteinModelPortaliP56394.
SMRiP56394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 63CHCHPROSITE-ProRule annotationAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 36Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi45 – 55Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 27Ala/Pro-richAdd BLAST26

Sequence similaritiesi

Belongs to the COX17 family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3496. Eukaryota.
ENOG410XVYQ. LUCA.
GeneTreeiENSGT00390000002329.
HOGENOMiHOG000195037.
HOVERGENiHBG054258.
InParanoidiP56394.
KOiK02260.
OMAiGEEQCGH.
OrthoDBiEOG091G1BKO.
PhylomeDBiP56394.
TreeFamiTF105074.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERiPTHR16719. PTHR16719. 1 hit.
PfamiPF05051. COX17. 1 hit.
[Graphical view]
ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLAAASPA PPEAQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE
60
AHKECMRALG FKI
Length:63
Mass (Da):6,784
Last modified:January 23, 2007 - v2
Checksum:i26787FE131159562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA168035 mRNA. No translation available.
BC048668 mRNA. Translation: AAH48668.1.
CCDSiCCDS28165.1.
RefSeqiNP_001017429.1. NM_001017429.2.
XP_006521813.1. XM_006521750.3.
UniGeneiMm.27396.

Genome annotation databases

EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516.
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464.
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516.
GeneIDi12856.
KEGGimmu:12856.
UCSCiuc007zet.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA168035 mRNA. No translation available.
BC048668 mRNA. Translation: AAH48668.1.
CCDSiCCDS28165.1.
RefSeqiNP_001017429.1. NM_001017429.2.
XP_006521813.1. XM_006521750.3.
UniGeneiMm.27396.

3D structure databases

ProteinModelPortaliP56394.
SMRiP56394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56394. 1 interactor.
MINTiMINT-4091685.
STRINGi10090.ENSMUSP00000112386.

PTM databases

iPTMnetiP56394.
PhosphoSitePlusiP56394.

Proteomic databases

EPDiP56394.
PaxDbiP56394.
PeptideAtlasiP56394.
PRIDEiP56394.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516.
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464.
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516.
GeneIDi12856.
KEGGimmu:12856.
UCSCiuc007zet.1. mouse.

Organism-specific databases

CTDi10063.
MGIiMGI:1333806. Cox17.

Phylogenomic databases

eggNOGiKOG3496. Eukaryota.
ENOG410XVYQ. LUCA.
GeneTreeiENSGT00390000002329.
HOGENOMiHOG000195037.
HOVERGENiHBG054258.
InParanoidiP56394.
KOiK02260.
OMAiGEEQCGH.
OrthoDBiEOG091G1BKO.
PhylomeDBiP56394.
TreeFamiTF105074.

Miscellaneous databases

ChiTaRSiCox17. mouse.
PROiP56394.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046516.
ExpressionAtlasiP56394. baseline and differential.
GenevisibleiP56394. MM.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERiPTHR16719. PTHR16719. 1 hit.
PfamiPF05051. COX17. 1 hit.
[Graphical view]
ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX17_MOUSE
AccessioniPrimary (citable) accession number: P56394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.