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Protein

Cytochrome c oxidase copper chaperone

Gene

Cox17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231CopperBy similarity
Metal bindingi24 – 241CopperBy similarity

GO - Molecular functioni

  1. copper chaperone activity Source: InterPro

GO - Biological processi

  1. copper ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase copper chaperone
Gene namesi
Name:Cox17
Synonyms:Cox17a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1333806. Cox17.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6363Cytochrome c oxidase copper chaperonePRO_0000213539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 55By similarity
Disulfide bondi36 ↔ 45By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP56394.
PaxDbiP56394.
PRIDEiP56394.

PTM databases

PhosphoSiteiP56394.

Expressioni

Gene expression databases

BgeeiP56394.
ExpressionAtlasiP56394. baseline and differential.
GenevestigatoriP56394.

Interactioni

Subunit structurei

Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure (By similarity).By similarity

Protein-protein interaction databases

IntActiP56394. 1 interaction.
MINTiMINT-4091685.

Structurei

3D structure databases

ProteinModelPortaliP56394.
SMRiP56394. Positions 1-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 2726Ala/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the COX17 family.Curated

Phylogenomic databases

eggNOGiNOG136703.
HOGENOMiHOG000195037.
HOVERGENiHBG054258.
InParanoidiP56394.
KOiK02260.
OMAiGEEQCGH.
OrthoDBiEOG7ZWD4S.
PhylomeDBiP56394.
TreeFamiTF105074.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERiPTHR16719. PTHR16719. 1 hit.
PfamiPF05051. COX17. 1 hit.
[Graphical view]
ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47072. SSF47072. 1 hit.

Sequencei

Sequence statusi: Complete.

P56394-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGLAAASPA PPEAQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE
60
AHKECMRALG FKI
Length:63
Mass (Da):6,784
Last modified:January 23, 2007 - v2
Checksum:i26787FE131159562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA168035 mRNA. No translation available.
BC048668 mRNA. Translation: AAH48668.1.
CCDSiCCDS28165.1.
RefSeqiNP_001017429.1. NM_001017429.2.
XP_006521813.1. XM_006521750.1.
UniGeneiMm.27396.

Genome annotation databases

EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516.
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464.
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516.
GeneIDi12856.
KEGGimmu:12856.
UCSCiuc007zet.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA168035 mRNA. No translation available.
BC048668 mRNA. Translation: AAH48668.1.
CCDSiCCDS28165.1.
RefSeqiNP_001017429.1. NM_001017429.2.
XP_006521813.1. XM_006521750.1.
UniGeneiMm.27396.

3D structure databases

ProteinModelPortaliP56394.
SMRiP56394. Positions 1-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56394. 1 interaction.
MINTiMINT-4091685.

PTM databases

PhosphoSiteiP56394.

Proteomic databases

MaxQBiP56394.
PaxDbiP56394.
PRIDEiP56394.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516.
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464.
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516.
GeneIDi12856.
KEGGimmu:12856.
UCSCiuc007zet.1. mouse.

Organism-specific databases

CTDi10063.
MGIiMGI:1333806. Cox17.

Phylogenomic databases

eggNOGiNOG136703.
HOGENOMiHOG000195037.
HOVERGENiHBG054258.
InParanoidiP56394.
KOiK02260.
OMAiGEEQCGH.
OrthoDBiEOG7ZWD4S.
PhylomeDBiP56394.
TreeFamiTF105074.

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSiCox17. mouse.
NextBioi282408.
PROiP56394.
SOURCEiSearch...

Gene expression databases

BgeeiP56394.
ExpressionAtlasiP56394. baseline and differential.
GenevestigatoriP56394.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR009069. Cys_alpha_HP_mot_SF.
IPR007745. Cyt_c_oxidase_Cu-chaperone.
[Graphical view]
PANTHERiPTHR16719. PTHR16719. 1 hit.
PfamiPF05051. COX17. 1 hit.
[Graphical view]
ProDomiPD014904. Cyt_c_oxidase_Cu-chaperone. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47072. SSF47072. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCOX17_MOUSE
AccessioniPrimary (citable) accession number: P56394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.