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P56393

- COX7B_MOUSE

UniProt

P56393 - COX7B_MOUSE

Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

Cox7b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates By similarity.By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    GO - Biological processi

    1. central nervous system development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7B, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIIb
    Gene namesi
    Name:Cox7b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1913392. Cox7b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain Source: InterPro
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionBy similarityAdd
    BLAST
    Chaini25 – 8056Cytochrome c oxidase subunit 7B, mitochondrialPRO_0000006159Add
    BLAST

    Proteomic databases

    MaxQBiP56393.
    PaxDbiP56393.
    PRIDEiP56393.

    PTM databases

    PhosphoSiteiP56393.

    Expressioni

    Gene expression databases

    ArrayExpressiP56393.
    BgeeiP56393.
    CleanExiMM_COX7B.
    GenevestigatoriP56393.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033582.

    Structurei

    3D structure databases

    ProteinModelPortaliP56393.
    SMRiP56393. Positions 30-78.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 328Mitochondrial matrixBy similarity
    Topological domaini60 – 8021Mitochondrial intermembraneBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5927HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIIb family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46061.
    HOGENOMiHOG000059529.
    HOVERGENiHBG051092.
    InParanoidiP56393.
    KOiK02271.
    OMAiICKAKIE.
    OrthoDBiEOG7T7GWR.
    PhylomeDBiP56393.
    TreeFamiTF105068.

    Family and domain databases

    Gene3Di4.10.51.10. 1 hit.
    InterProiIPR008433. Cyt_c_oxidase_suVIIB.
    IPR023272. Cyt_c_oxidase_suVIIB_dom.
    [Graphical view]
    PANTHERiPTHR16716. PTHR16716. 1 hit.
    PfamiPF05392. COX7B. 1 hit.
    [Graphical view]
    SUPFAMiSSF81423. SSF81423. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56393-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPLAKNALS RLQVRSIQQV VARQSHQKRA PSFHDKYGNA ILAGGAIFCV   50
    STWTYTATQI GIEWNMSPVG RVTPKEWRDQ 80
    Length:80
    Mass (Da):9,011
    Last modified:July 15, 1998 - v1
    Checksum:iD68B28A9FAF1E9A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA033366 mRNA. No translation available.
    AA049075 mRNA. No translation available.
    AA032894 mRNA. No translation available.
    AA051290 mRNA. No translation available.
    AA086918 mRNA. No translation available.
    AA032640 mRNA. No translation available.
    AK002593 mRNA. Translation: BAB22214.1.
    BC024350 mRNA. Translation: AAH24350.1.
    CCDSiCCDS41096.1.
    RefSeqiNP_079655.1. NM_025379.2.
    UniGeneiMm.197728.

    Genome annotation databases

    EnsembliENSMUST00000033582; ENSMUSP00000033582; ENSMUSG00000031231.
    GeneIDi66142.
    KEGGimmu:66142.
    UCSCiuc009ubk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA033366 mRNA. No translation available.
    AA049075 mRNA. No translation available.
    AA032894 mRNA. No translation available.
    AA051290 mRNA. No translation available.
    AA086918 mRNA. No translation available.
    AA032640 mRNA. No translation available.
    AK002593 mRNA. Translation: BAB22214.1 .
    BC024350 mRNA. Translation: AAH24350.1 .
    CCDSi CCDS41096.1.
    RefSeqi NP_079655.1. NM_025379.2.
    UniGenei Mm.197728.

    3D structure databases

    ProteinModelPortali P56393.
    SMRi P56393. Positions 30-78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033582.

    PTM databases

    PhosphoSitei P56393.

    Proteomic databases

    MaxQBi P56393.
    PaxDbi P56393.
    PRIDEi P56393.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033582 ; ENSMUSP00000033582 ; ENSMUSG00000031231 .
    GeneIDi 66142.
    KEGGi mmu:66142.
    UCSCi uc009ubk.1. mouse.

    Organism-specific databases

    CTDi 1349.
    MGIi MGI:1913392. Cox7b.

    Phylogenomic databases

    eggNOGi NOG46061.
    HOGENOMi HOG000059529.
    HOVERGENi HBG051092.
    InParanoidi P56393.
    KOi K02271.
    OMAi ICKAKIE.
    OrthoDBi EOG7T7GWR.
    PhylomeDBi P56393.
    TreeFami TF105068.

    Miscellaneous databases

    ChiTaRSi COX7B. mouse.
    NextBioi 320754.
    PROi P56393.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56393.
    Bgeei P56393.
    CleanExi MM_COX7B.
    Genevestigatori P56393.

    Family and domain databases

    Gene3Di 4.10.51.10. 1 hit.
    InterProi IPR008433. Cyt_c_oxidase_suVIIB.
    IPR023272. Cyt_c_oxidase_suVIIB_dom.
    [Graphical view ]
    PANTHERi PTHR16716. PTHR16716. 1 hit.
    Pfami PF05392. COX7B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81423. SSF81423. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiCOX7B_MOUSE
    AccessioniPrimary (citable) accession number: P56393
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3