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Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

Cox7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
Gene namesi
Name:Cox7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1913392. Cox7b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 32Mitochondrial matrixBy similarity8
Transmembranei33 – 59HelicalBy similarityAdd BLAST27
Topological domaini60 – 80Mitochondrial intermembraneBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionBy similarityAdd BLAST24
ChainiPRO_000000615925 – 80Cytochrome c oxidase subunit 7B, mitochondrialAdd BLAST56

Proteomic databases

PaxDbiP56393.
PeptideAtlasiP56393.
PRIDEiP56393.
TopDownProteomicsiP56393.

PTM databases

iPTMnetiP56393.
PhosphoSitePlusiP56393.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031231.
CleanExiMM_COX7B.
ExpressionAtlasiP56393. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi211245. 1 interactor.
CORUMiP56393.
STRINGi10090.ENSMUSP00000033582.

Structurei

3D structure databases

ProteinModelPortaliP56393.
SMRiP56393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP56393.
KOiK02271.
OMAiAVWAYTA.
OrthoDBiEOG091G1342.
PhylomeDBiP56393.
TreeFamiTF105068.

Family and domain databases

CDDicd01403. Cyt_c_Oxidase_VIIb. 1 hit.
Gene3Di4.10.51.10. 1 hit.
InterProiView protein in InterPro
IPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiView protein in Pfam
PF05392. COX7B. 1 hit.
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLAKNALS RLQVRSIQQV VARQSHQKRA PSFHDKYGNA ILAGGAIFCV
60 70 80
STWTYTATQI GIEWNMSPVG RVTPKEWRDQ
Length:80
Mass (Da):9,011
Last modified:July 15, 1998 - v1
Checksum:iD68B28A9FAF1E9A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA033366 mRNA. No translation available.
AA049075 mRNA. No translation available.
AA032894 mRNA. No translation available.
AA051290 mRNA. No translation available.
AA086918 mRNA. No translation available.
AA032640 mRNA. No translation available.
AK002593 mRNA. Translation: BAB22214.1.
BC024350 mRNA. Translation: AAH24350.1.
CCDSiCCDS41096.1.
RefSeqiNP_079655.1. NM_025379.2.
UniGeneiMm.197728.

Genome annotation databases

EnsembliENSMUST00000033582; ENSMUSP00000033582; ENSMUSG00000031231.
GeneIDi66142.
KEGGimmu:66142.
UCSCiuc009ubk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCOX7B_MOUSE
AccessioniPrimary (citable) accession number: P56393
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 27, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families