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P56393

- COX7B_MOUSE

UniProt

P56393 - COX7B_MOUSE

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Protein
Cytochrome c oxidase subunit 7B, mitochondrial
Gene
Cox7b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates By similarity.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. central nervous system development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
Gene namesi
Name:Cox7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1913392. Cox7b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 328Mitochondrial matrix By similarity
Transmembranei33 – 5927Helical; By similarity
Add
BLAST
Topological domaini60 – 8021Mitochondrial intermembrane By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain Source: InterPro
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion By similarity
Add
BLAST
Chaini25 – 8056Cytochrome c oxidase subunit 7B, mitochondrial
PRO_0000006159Add
BLAST

Proteomic databases

MaxQBiP56393.
PaxDbiP56393.
PRIDEiP56393.

PTM databases

PhosphoSiteiP56393.

Expressioni

Gene expression databases

ArrayExpressiP56393.
BgeeiP56393.
CleanExiMM_COX7B.
GenevestigatoriP56393.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033582.

Structurei

3D structure databases

ProteinModelPortaliP56393.
SMRiP56393. Positions 30-78.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46061.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP56393.
KOiK02271.
OMAiICKAKIE.
OrthoDBiEOG7T7GWR.
PhylomeDBiP56393.
TreeFamiTF105068.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56393-1 [UniParc]FASTAAdd to Basket

« Hide

MLPLAKNALS RLQVRSIQQV VARQSHQKRA PSFHDKYGNA ILAGGAIFCV   50
STWTYTATQI GIEWNMSPVG RVTPKEWRDQ 80
Length:80
Mass (Da):9,011
Last modified:July 15, 1998 - v1
Checksum:iD68B28A9FAF1E9A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA033366 mRNA. No translation available.
AA049075 mRNA. No translation available.
AA032894 mRNA. No translation available.
AA051290 mRNA. No translation available.
AA086918 mRNA. No translation available.
AA032640 mRNA. No translation available.
AK002593 mRNA. Translation: BAB22214.1.
BC024350 mRNA. Translation: AAH24350.1.
CCDSiCCDS41096.1.
RefSeqiNP_079655.1. NM_025379.2.
UniGeneiMm.197728.

Genome annotation databases

EnsembliENSMUST00000033582; ENSMUSP00000033582; ENSMUSG00000031231.
GeneIDi66142.
KEGGimmu:66142.
UCSCiuc009ubk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA033366 mRNA. No translation available.
AA049075 mRNA. No translation available.
AA032894 mRNA. No translation available.
AA051290 mRNA. No translation available.
AA086918 mRNA. No translation available.
AA032640 mRNA. No translation available.
AK002593 mRNA. Translation: BAB22214.1 .
BC024350 mRNA. Translation: AAH24350.1 .
CCDSi CCDS41096.1.
RefSeqi NP_079655.1. NM_025379.2.
UniGenei Mm.197728.

3D structure databases

ProteinModelPortali P56393.
SMRi P56393. Positions 30-78.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033582.

PTM databases

PhosphoSitei P56393.

Proteomic databases

MaxQBi P56393.
PaxDbi P56393.
PRIDEi P56393.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033582 ; ENSMUSP00000033582 ; ENSMUSG00000031231 .
GeneIDi 66142.
KEGGi mmu:66142.
UCSCi uc009ubk.1. mouse.

Organism-specific databases

CTDi 1349.
MGIi MGI:1913392. Cox7b.

Phylogenomic databases

eggNOGi NOG46061.
HOGENOMi HOG000059529.
HOVERGENi HBG051092.
InParanoidi P56393.
KOi K02271.
OMAi ICKAKIE.
OrthoDBi EOG7T7GWR.
PhylomeDBi P56393.
TreeFami TF105068.

Miscellaneous databases

ChiTaRSi COX7B. mouse.
NextBioi 320754.
PROi P56393.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56393.
Bgeei P56393.
CleanExi MM_COX7B.
Genevestigatori P56393.

Family and domain databases

Gene3Di 4.10.51.10. 1 hit.
InterProi IPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view ]
PANTHERi PTHR16716. PTHR16716. 1 hit.
Pfami PF05392. COX7B. 1 hit.
[Graphical view ]
SUPFAMi SSF81423. SSF81423. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCOX7B_MOUSE
AccessioniPrimary (citable) accession number: P56393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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