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Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

Cox7a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-heart
Short name:
Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name:
Cytochrome c oxidase subunit VIIa-M
Gene namesi
Name:Cox7a1
Synonyms:Cox7a, Cox7ah
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1316714. Cox7a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 4625Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei47 – 7529HelicalBy similarityAdd
BLAST
Topological domaini76 – 805Mitochondrial intermembraneBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionBy similarityAdd
BLAST
Chaini22 – 8059Cytochrome c oxidase subunit 7A1, mitochondrialPRO_0000006150Add
BLAST

Proteomic databases

PaxDbiP56392.
PeptideAtlasiP56392.
PRIDEiP56392.

PTM databases

iPTMnetiP56392.
PhosphoSiteiP56392.

Expressioni

Gene expression databases

BgeeiP56392.
CleanExiMM_COX7A1.
ExpressionAtlasiP56392. baseline and differential.
GenevisibleiP56392. MM.

Interactioni

Protein-protein interaction databases

IntActiP56392. 1 interaction.
MINTiMINT-4092687.
STRINGi10090.ENSMUSP00000096193.

Structurei

3D structure databases

ProteinModelPortaliP56392.
SMRiP56392. Positions 22-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JE1I. Eukaryota.
ENOG410ZCEG. LUCA.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP56392.
KOiK02270.
OMAiSLYCLGW.
OrthoDBiEOG7BGHNV.
PhylomeDBiP56392.
TreeFamiTF105067.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALRVSQAL VRSFSSSTRS HLENRVAEKQ KLFQADNDLP VHLKGGGMDN
60 70 80
VLYRLTMTLT LGGTAYCLYC LGWASFPHKK
Length:80
Mass (Da):8,986
Last modified:July 15, 1998 - v1
Checksum:i9C6FB6C8E6E4C340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA027520 mRNA. No translation available.
AA444750 mRNA. No translation available.
AA218039 mRNA. No translation available.
AF037370 mRNA. Translation: AAC23485.1.
BC060974 mRNA. Translation: AAH60974.1.
CCDSiCCDS21081.1.
RefSeqiNP_034074.1. NM_009944.3.
UniGeneiMm.423030.

Genome annotation databases

EnsembliENSMUST00000098594; ENSMUSP00000096193; ENSMUSG00000074218.
GeneIDi12865.
KEGGimmu:12865.
UCSCiuc009gdp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA027520 mRNA. No translation available.
AA444750 mRNA. No translation available.
AA218039 mRNA. No translation available.
AF037370 mRNA. Translation: AAC23485.1.
BC060974 mRNA. Translation: AAH60974.1.
CCDSiCCDS21081.1.
RefSeqiNP_034074.1. NM_009944.3.
UniGeneiMm.423030.

3D structure databases

ProteinModelPortaliP56392.
SMRiP56392. Positions 22-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56392. 1 interaction.
MINTiMINT-4092687.
STRINGi10090.ENSMUSP00000096193.

PTM databases

iPTMnetiP56392.
PhosphoSiteiP56392.

Proteomic databases

PaxDbiP56392.
PeptideAtlasiP56392.
PRIDEiP56392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098594; ENSMUSP00000096193; ENSMUSG00000074218.
GeneIDi12865.
KEGGimmu:12865.
UCSCiuc009gdp.1. mouse.

Organism-specific databases

CTDi1346.
MGIiMGI:1316714. Cox7a1.

Phylogenomic databases

eggNOGiENOG410JE1I. Eukaryota.
ENOG410ZCEG. LUCA.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP56392.
KOiK02270.
OMAiSLYCLGW.
OrthoDBiEOG7BGHNV.
PhylomeDBiP56392.
TreeFamiTF105067.

Miscellaneous databases

PROiP56392.
SOURCEiSearch...

Gene expression databases

BgeeiP56392.
CleanExiMM_COX7A1.
ExpressionAtlasiP56392. baseline and differential.
GenevisibleiP56392. MM.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Tissue-specific expression and mapping of the Cox7ah gene in mouse."
    Jaradat S.A., Ko M.S., Grossman L.I.
    Genomics 49:363-370(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Lung and Testis.

Entry informationi

Entry nameiCX7A1_MOUSE
AccessioniPrimary (citable) accession number: P56392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.