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P56391

- CX6B1_MOUSE

UniProt

P56391 - CX6B1_MOUSE

Protein

Cytochrome c oxidase subunit 6B1

Gene

Cox6b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Connects the two COX monomers into the physiological dimeric form.By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 6B1
    Alternative name(s):
    Cytochrome c oxidase subunit VIb isoform 1
    Short name:
    COX VIb-1
    Gene namesi
    Name:Cox6b1
    Synonyms:Cox6b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107460. Cox6b1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrial intermembrane space Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 8685Cytochrome c oxidase subunit 6B1PRO_0000194915Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Disulfide bondi30 ↔ 65By similarity
    Disulfide bondi40 ↔ 54By similarity
    Modified residuei62 – 621N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    MaxQBiP56391.
    PaxDbiP56391.
    PRIDEiP56391.

    PTM databases

    PhosphoSiteiP56391.

    Expressioni

    Gene expression databases

    BgeeiP56391.
    CleanExiMM_COX6B1.
    GenevestigatoriP56391.

    Interactioni

    Protein-protein interaction databases

    BioGridi225497. 1 interaction.
    IntActiP56391. 3 interactions.
    MINTiMINT-1843690.
    STRINGi10090.ENSMUSP00000075150.

    Structurei

    3D structure databases

    ProteinModelPortaliP56391.
    SMRiP56391. Positions 8-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG279294.
    GeneTreeiENSGT00390000001191.
    HOGENOMiHOG000165128.
    HOVERGENiHBG051090.
    InParanoidiP56391.
    KOiK02267.
    OMAiFKFVTGG.
    OrthoDBiEOG7WDN54.
    PhylomeDBiP56391.
    TreeFamiTF105065.

    Family and domain databases

    Gene3Di1.10.10.140. 1 hit.
    InterProiIPR003213. Cyt_c_oxidase_su6B.
    [Graphical view]
    PfamiPF02297. COX6B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
    SUPFAMiSSF47694. SSF47694. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEDIKTKIK NYKTAPFDSR FPNQNQTKNC WQNYLDFHRC EKAMTAKGGD   50
    VSVCEWYRRV YKSLCPVSWV SAWDDRIAEG TFPGKI 86
    Length:86
    Mass (Da):10,071
    Last modified:January 23, 2007 - v2
    Checksum:iA2E96D96CC37509A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007996 mRNA. Translation: BAB25398.1.
    AK012686 mRNA. Translation: BAB28411.1.
    AK018721 mRNA. Translation: BAB31367.1.
    BC024343 mRNA. Translation: AAH24343.1.
    CCDSiCCDS39887.1.
    RefSeqiNP_079904.1. NM_025628.2.
    UniGeneiMm.400.

    Genome annotation databases

    EnsembliENSMUST00000075738; ENSMUSP00000075150; ENSMUSG00000036751.
    GeneIDi110323.
    KEGGimmu:110323.
    UCSCiuc009gfl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007996 mRNA. Translation: BAB25398.1 .
    AK012686 mRNA. Translation: BAB28411.1 .
    AK018721 mRNA. Translation: BAB31367.1 .
    BC024343 mRNA. Translation: AAH24343.1 .
    CCDSi CCDS39887.1.
    RefSeqi NP_079904.1. NM_025628.2.
    UniGenei Mm.400.

    3D structure databases

    ProteinModelPortali P56391.
    SMRi P56391. Positions 8-86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 225497. 1 interaction.
    IntActi P56391. 3 interactions.
    MINTi MINT-1843690.
    STRINGi 10090.ENSMUSP00000075150.

    PTM databases

    PhosphoSitei P56391.

    Proteomic databases

    MaxQBi P56391.
    PaxDbi P56391.
    PRIDEi P56391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075738 ; ENSMUSP00000075150 ; ENSMUSG00000036751 .
    GeneIDi 110323.
    KEGGi mmu:110323.
    UCSCi uc009gfl.1. mouse.

    Organism-specific databases

    CTDi 1340.
    MGIi MGI:107460. Cox6b1.

    Phylogenomic databases

    eggNOGi NOG279294.
    GeneTreei ENSGT00390000001191.
    HOGENOMi HOG000165128.
    HOVERGENi HBG051090.
    InParanoidi P56391.
    KOi K02267.
    OMAi FKFVTGG.
    OrthoDBi EOG7WDN54.
    PhylomeDBi P56391.
    TreeFami TF105065.

    Miscellaneous databases

    NextBioi 363775.
    PROi P56391.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56391.
    CleanExi MM_COX6B1.
    Genevestigatori P56391.

    Family and domain databases

    Gene3Di 1.10.10.140. 1 hit.
    InterProi IPR003213. Cyt_c_oxidase_su6B.
    [Graphical view ]
    Pfami PF02297. COX6B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000278. Cyt_c_oxidase_6B. 1 hit.
    SUPFAMi SSF47694. SSF47694. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney and Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 29-39; 48-58 AND 63-86, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCX6B1_MOUSE
    AccessioniPrimary (citable) accession number: P56391
    Secondary accession number(s): Q545A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3