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Protein

Cytochrome c oxidase subunit 6B1

Gene

Cox6b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Connects the two COX monomers into the physiological dimeric form.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase subunit VIb isoform 1
Short name:
COX VIb-1
Gene namesi
Name:Cox6b1
Synonyms:Cox6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107460 Cox6b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001949152 – 86Cytochrome c oxidase subunit 6B1Add BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Disulfide bondi30 ↔ 65PROSITE-ProRule annotation
Disulfide bondi40 ↔ 54PROSITE-ProRule annotation
Modified residuei62N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP56391
MaxQBiP56391
PaxDbiP56391
PeptideAtlasiP56391
PRIDEiP56391
TopDownProteomicsiP56391

PTM databases

iPTMnetiP56391
PhosphoSitePlusiP56391
SwissPalmiP56391

Expressioni

Gene expression databases

BgeeiENSMUSG00000036751
CleanExiMM_COX6B1
ExpressionAtlasiP56391 baseline and differential
GenevisibleiP56391 MM

Interactioni

Protein-protein interaction databases

BioGridi225497, 1 interactor
CORUMiP56391
IntActiP56391, 3 interactors
MINTiP56391
STRINGi10090.ENSMUSP00000075150

Structurei

3D structure databases

ProteinModelPortaliP56391
SMRiP56391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 73CHCHPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 40Cx9C motifPROSITE-ProRule annotationAdd BLAST11
Motifi54 – 65Cx10C motifPROSITE-ProRule annotationAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3057 Eukaryota
ENOG41121WM LUCA
GeneTreeiENSGT00390000001191
HOGENOMiHOG000165128
HOVERGENiHBG051090
InParanoidiP56391
KOiK02267
OMAiAPCKQFK
OrthoDBiEOG091G0UIB
PhylomeDBiP56391
TreeFamiTF105065

Family and domain databases

CDDicd00926 Cyt_c_Oxidase_VIb, 1 hit
Gene3Di1.10.10.140, 1 hit
InterProiView protein in InterPro
IPR003213 Cyt_c_oxidase_su6B
IPR036549 Cyt_c_oxidase_su6B_sf
PANTHERiPTHR11387 PTHR11387, 1 hit
PfamiView protein in Pfam
PF02297 COX6B, 1 hit
PIRSFiPIRSF000278 Cyt_c_oxidase_6B, 1 hit
SUPFAMiSSF47694 SSF47694, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDIKTKIK NYKTAPFDSR FPNQNQTKNC WQNYLDFHRC EKAMTAKGGD
60 70 80
VSVCEWYRRV YKSLCPVSWV SAWDDRIAEG TFPGKI
Length:86
Mass (Da):10,071
Last modified:January 23, 2007 - v2
Checksum:iA2E96D96CC37509A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007996 mRNA Translation: BAB25398.1
AK012686 mRNA Translation: BAB28411.1
AK018721 mRNA Translation: BAB31367.1
BC024343 mRNA Translation: AAH24343.1
CCDSiCCDS39887.1
RefSeqiNP_079904.1, NM_025628.2
UniGeneiMm.400

Genome annotation databases

EnsembliENSMUST00000075738; ENSMUSP00000075150; ENSMUSG00000036751
GeneIDi110323
KEGGimmu:110323
UCSCiuc009gfl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCX6B1_MOUSE
AccessioniPrimary (citable) accession number: P56391
Secondary accession number(s): Q545A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health