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Protein

Cytochrome c oxidase subunit 6B1

Gene

Cox6b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Connects the two COX monomers into the physiological dimeric form.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase subunit VIb isoform 1
Short name:
COX VIb-1
Gene namesi
Name:Cox6b1
Synonyms:Cox6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107460. Cox6b1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrial intermembrane space Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 8685Cytochrome c oxidase subunit 6B1PRO_0000194915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Disulfide bondi30 ↔ 65By similarity
Disulfide bondi40 ↔ 54By similarity
Modified residuei62 – 621N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP56391.
MaxQBiP56391.
PaxDbiP56391.
PeptideAtlasiP56391.
PRIDEiP56391.
TopDownProteomicsiP56391.

PTM databases

iPTMnetiP56391.
PhosphoSiteiP56391.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036751.
CleanExiMM_COX6B1.
GenevisibleiP56391. MM.

Interactioni

Protein-protein interaction databases

BioGridi225497. 1 interaction.
IntActiP56391. 3 interactions.
MINTiMINT-1843690.
STRINGi10090.ENSMUSP00000075150.

Structurei

3D structure databases

ProteinModelPortaliP56391.
SMRiP56391. Positions 8-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiP56391.
KOiK02267.
OMAiLDFHRCQ.
OrthoDBiEOG091G0UIB.
PhylomeDBiP56391.
TreeFamiTF105065.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDIKTKIK NYKTAPFDSR FPNQNQTKNC WQNYLDFHRC EKAMTAKGGD
60 70 80
VSVCEWYRRV YKSLCPVSWV SAWDDRIAEG TFPGKI
Length:86
Mass (Da):10,071
Last modified:January 23, 2007 - v2
Checksum:iA2E96D96CC37509A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007996 mRNA. Translation: BAB25398.1.
AK012686 mRNA. Translation: BAB28411.1.
AK018721 mRNA. Translation: BAB31367.1.
BC024343 mRNA. Translation: AAH24343.1.
CCDSiCCDS39887.1.
RefSeqiNP_079904.1. NM_025628.2.
UniGeneiMm.400.

Genome annotation databases

EnsembliENSMUST00000075738; ENSMUSP00000075150; ENSMUSG00000036751.
GeneIDi110323.
KEGGimmu:110323.
UCSCiuc009gfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007996 mRNA. Translation: BAB25398.1.
AK012686 mRNA. Translation: BAB28411.1.
AK018721 mRNA. Translation: BAB31367.1.
BC024343 mRNA. Translation: AAH24343.1.
CCDSiCCDS39887.1.
RefSeqiNP_079904.1. NM_025628.2.
UniGeneiMm.400.

3D structure databases

ProteinModelPortaliP56391.
SMRiP56391. Positions 8-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225497. 1 interaction.
IntActiP56391. 3 interactions.
MINTiMINT-1843690.
STRINGi10090.ENSMUSP00000075150.

PTM databases

iPTMnetiP56391.
PhosphoSiteiP56391.

Proteomic databases

EPDiP56391.
MaxQBiP56391.
PaxDbiP56391.
PeptideAtlasiP56391.
PRIDEiP56391.
TopDownProteomicsiP56391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075738; ENSMUSP00000075150; ENSMUSG00000036751.
GeneIDi110323.
KEGGimmu:110323.
UCSCiuc009gfl.1. mouse.

Organism-specific databases

CTDi1340.
MGIiMGI:107460. Cox6b1.

Phylogenomic databases

eggNOGiKOG3057. Eukaryota.
ENOG41121WM. LUCA.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiP56391.
KOiK02267.
OMAiLDFHRCQ.
OrthoDBiEOG091G0UIB.
PhylomeDBiP56391.
TreeFamiTF105065.

Miscellaneous databases

PROiP56391.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036751.
CleanExiMM_COX6B1.
GenevisibleiP56391. MM.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCX6B1_MOUSE
AccessioniPrimary (citable) accession number: P56391
Secondary accession number(s): Q545A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.