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P56391

- CX6B1_MOUSE

UniProt

P56391 - CX6B1_MOUSE

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Protein

Cytochrome c oxidase subunit 6B1

Gene

Cox6b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Connects the two COX monomers into the physiological dimeric form.By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. substantia nigra development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6B1
Alternative name(s):
Cytochrome c oxidase subunit VIb isoform 1
Short name:
COX VIb-1
Gene namesi
Name:Cox6b1
Synonyms:Cox6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:107460. Cox6b1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: MGI
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 8685Cytochrome c oxidase subunit 6B1PRO_0000194915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Disulfide bondi30 ↔ 65By similarity
Disulfide bondi40 ↔ 54By similarity
Modified residuei62 – 621N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

MaxQBiP56391.
PaxDbiP56391.
PRIDEiP56391.

PTM databases

PhosphoSiteiP56391.

Expressioni

Gene expression databases

BgeeiP56391.
CleanExiMM_COX6B1.
GenevestigatoriP56391.

Interactioni

Protein-protein interaction databases

BioGridi225497. 1 interaction.
IntActiP56391. 3 interactions.
MINTiMINT-1843690.
STRINGi10090.ENSMUSP00000075150.

Structurei

3D structure databases

ProteinModelPortaliP56391.
SMRiP56391. Positions 8-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG279294.
GeneTreeiENSGT00390000001191.
HOGENOMiHOG000165128.
HOVERGENiHBG051090.
InParanoidiP56391.
KOiK02267.
OMAiFKFVTGG.
OrthoDBiEOG7WDN54.
PhylomeDBiP56391.
TreeFamiTF105065.

Family and domain databases

Gene3Di1.10.10.140. 1 hit.
InterProiIPR003213. Cyt_c_oxidase_su6B.
[Graphical view]
PfamiPF02297. COX6B. 1 hit.
[Graphical view]
PIRSFiPIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMiSSF47694. SSF47694. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56391 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEDIKTKIK NYKTAPFDSR FPNQNQTKNC WQNYLDFHRC EKAMTAKGGD
60 70 80
VSVCEWYRRV YKSLCPVSWV SAWDDRIAEG TFPGKI
Length:86
Mass (Da):10,071
Last modified:January 23, 2007 - v2
Checksum:iA2E96D96CC37509A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007996 mRNA. Translation: BAB25398.1.
AK012686 mRNA. Translation: BAB28411.1.
AK018721 mRNA. Translation: BAB31367.1.
BC024343 mRNA. Translation: AAH24343.1.
CCDSiCCDS39887.1.
RefSeqiNP_079904.1. NM_025628.2.
UniGeneiMm.400.

Genome annotation databases

EnsembliENSMUST00000075738; ENSMUSP00000075150; ENSMUSG00000036751.
GeneIDi110323.
KEGGimmu:110323.
UCSCiuc009gfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007996 mRNA. Translation: BAB25398.1 .
AK012686 mRNA. Translation: BAB28411.1 .
AK018721 mRNA. Translation: BAB31367.1 .
BC024343 mRNA. Translation: AAH24343.1 .
CCDSi CCDS39887.1.
RefSeqi NP_079904.1. NM_025628.2.
UniGenei Mm.400.

3D structure databases

ProteinModelPortali P56391.
SMRi P56391. Positions 8-86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 225497. 1 interaction.
IntActi P56391. 3 interactions.
MINTi MINT-1843690.
STRINGi 10090.ENSMUSP00000075150.

PTM databases

PhosphoSitei P56391.

Proteomic databases

MaxQBi P56391.
PaxDbi P56391.
PRIDEi P56391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075738 ; ENSMUSP00000075150 ; ENSMUSG00000036751 .
GeneIDi 110323.
KEGGi mmu:110323.
UCSCi uc009gfl.1. mouse.

Organism-specific databases

CTDi 1340.
MGIi MGI:107460. Cox6b1.

Phylogenomic databases

eggNOGi NOG279294.
GeneTreei ENSGT00390000001191.
HOGENOMi HOG000165128.
HOVERGENi HBG051090.
InParanoidi P56391.
KOi K02267.
OMAi FKFVTGG.
OrthoDBi EOG7WDN54.
PhylomeDBi P56391.
TreeFami TF105065.

Miscellaneous databases

NextBioi 363775.
PROi P56391.
SOURCEi Search...

Gene expression databases

Bgeei P56391.
CleanExi MM_COX6B1.
Genevestigatori P56391.

Family and domain databases

Gene3Di 1.10.10.140. 1 hit.
InterProi IPR003213. Cyt_c_oxidase_su6B.
[Graphical view ]
Pfami PF02297. COX6B. 1 hit.
[Graphical view ]
PIRSFi PIRSF000278. Cyt_c_oxidase_6B. 1 hit.
SUPFAMi SSF47694. SSF47694. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 29-39; 48-58 AND 63-86, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCX6B1_MOUSE
AccessioniPrimary (citable) accession number: P56391
Secondary accession number(s): Q545A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3