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P56390

- CKS2_MOUSE

UniProt

P56390 - CKS2_MOUSE

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Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

Cks2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

GO - Biological processi

  1. meiosis I Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name:
CKS-2
Gene namesi
Name:Cks2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1913447. Cks2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 2PRO_0000206238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP56390.
PaxDbiP56390.
PRIDEiP56390.

PTM databases

PhosphoSiteiP56390.

Expressioni

Gene expression databases

BgeeiP56390.
CleanExiMM_CKS2.
ExpressionAtlasiP56390. baseline and differential.
GenevestigatoriP56390.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075250.

Structurei

3D structure databases

ProteinModelPortaliP56390.
SMRiP56390. Positions 2-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiNOG272189.
HOVERGENiHBG003626.
InParanoidiP56390.
KOiK02219.
OMAiFDDKFEY.
OrthoDBiEOG735413.
PhylomeDBiP56390.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56390-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKEQQK
Length:79
Mass (Da):9,874
Last modified:July 15, 1998 - v1
Checksum:i811B5926D91EEC5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA289122 mRNA. No translation available.
AA041913 mRNA. No translation available.
AK002451 mRNA. Translation: BAB22110.1.
BC022647 mRNA. Translation: AAH22647.1.
CCDSiCCDS36664.1.
RefSeqiNP_079691.1. NM_025415.3.
UniGeneiMm.222228.

Genome annotation databases

EnsembliENSMUST00000075853; ENSMUSP00000075250; ENSMUSG00000062248.
GeneIDi66197.
KEGGimmu:66197.
UCSCiuc007qmh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AA289122 mRNA. No translation available.
AA041913 mRNA. No translation available.
AK002451 mRNA. Translation: BAB22110.1 .
BC022647 mRNA. Translation: AAH22647.1 .
CCDSi CCDS36664.1.
RefSeqi NP_079691.1. NM_025415.3.
UniGenei Mm.222228.

3D structure databases

ProteinModelPortali P56390.
SMRi P56390. Positions 2-75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000075250.

PTM databases

PhosphoSitei P56390.

Proteomic databases

MaxQBi P56390.
PaxDbi P56390.
PRIDEi P56390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075853 ; ENSMUSP00000075250 ; ENSMUSG00000062248 .
GeneIDi 66197.
KEGGi mmu:66197.
UCSCi uc007qmh.2. mouse.

Organism-specific databases

CTDi 1164.
MGIi MGI:1913447. Cks2.

Phylogenomic databases

eggNOGi NOG272189.
HOVERGENi HBG003626.
InParanoidi P56390.
KOi K02219.
OMAi FDDKFEY.
OrthoDBi EOG735413.
PhylomeDBi P56390.
TreeFami TF101142.

Miscellaneous databases

NextBioi 320927.
PROi P56390.
SOURCEi Search...

Gene expression databases

Bgeei P56390.
CleanExi MM_CKS2.
ExpressionAtlasi P56390. baseline and differential.
Genevestigatori P56390.

Family and domain databases

Gene3Di 3.30.170.10. 1 hit.
InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view ]
Pfami PF01111. CKS. 1 hit.
[Graphical view ]
PRINTSi PR00296. CYCLINKINASE.
SMARTi SM01084. CKS. 1 hit.
[Graphical view ]
SUPFAMi SSF55637. SSF55637. 1 hit.
PROSITEi PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCKS2_MOUSE
AccessioniPrimary (citable) accession number: P56390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3