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Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

Cks2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: MGI
  • meiosis I Source: MGI
  • mitotic cell cycle phase transition Source: MGI
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name:
CKS-2
Gene namesi
Name:Cks2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913447. Cks2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7979Cyclin-dependent kinases regulatory subunit 2PRO_0000206238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP56390.
PaxDbiP56390.
PeptideAtlasiP56390.
PRIDEiP56390.

PTM databases

iPTMnetiP56390.
PhosphoSiteiP56390.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062248.
CleanExiMM_CKS2.
ExpressionAtlasiP56390. baseline and differential.
GenevisibleiP56390. MM.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075250.

Structurei

3D structure databases

ProteinModelPortaliP56390.
SMRiP56390. Positions 2-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
HOVERGENiHBG003626.
InParanoidiP56390.
KOiK02219.
OMAiKHVPKSH.
OrthoDBiEOG091G18GQ.
PhylomeDBiP56390.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKEQQK
Length:79
Mass (Da):9,874
Last modified:July 15, 1998 - v1
Checksum:i811B5926D91EEC5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA289122 mRNA. No translation available.
AA041913 mRNA. No translation available.
AK002451 mRNA. Translation: BAB22110.1.
BC022647 mRNA. Translation: AAH22647.1.
CCDSiCCDS36664.1.
RefSeqiNP_079691.1. NM_025415.3.
UniGeneiMm.222228.

Genome annotation databases

EnsembliENSMUST00000075853; ENSMUSP00000075250; ENSMUSG00000062248.
GeneIDi66197.
KEGGimmu:66197.
UCSCiuc007qmh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA289122 mRNA. No translation available.
AA041913 mRNA. No translation available.
AK002451 mRNA. Translation: BAB22110.1.
BC022647 mRNA. Translation: AAH22647.1.
CCDSiCCDS36664.1.
RefSeqiNP_079691.1. NM_025415.3.
UniGeneiMm.222228.

3D structure databases

ProteinModelPortaliP56390.
SMRiP56390. Positions 2-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075250.

PTM databases

iPTMnetiP56390.
PhosphoSiteiP56390.

Proteomic databases

EPDiP56390.
PaxDbiP56390.
PeptideAtlasiP56390.
PRIDEiP56390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075853; ENSMUSP00000075250; ENSMUSG00000062248.
GeneIDi66197.
KEGGimmu:66197.
UCSCiuc007qmh.2. mouse.

Organism-specific databases

CTDi1164.
MGIiMGI:1913447. Cks2.

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
HOVERGENiHBG003626.
InParanoidiP56390.
KOiK02219.
OMAiKHVPKSH.
OrthoDBiEOG091G18GQ.
PhylomeDBiP56390.
TreeFamiTF101142.

Miscellaneous databases

PROiP56390.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062248.
CleanExiMM_CKS2.
ExpressionAtlasiP56390. baseline and differential.
GenevisibleiP56390. MM.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKS2_MOUSE
AccessioniPrimary (citable) accession number: P56390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.