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P56390

- CKS2_MOUSE

UniProt

P56390 - CKS2_MOUSE

Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

Cks2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

    GO - Biological processi

    1. meiosis I Source: MGI

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 2
    Short name:
    CKS-2
    Gene namesi
    Name:Cks2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1913447. Cks2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 2PRO_0000206238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei4 – 41N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP56390.
    PRIDEiP56390.

    PTM databases

    PhosphoSiteiP56390.

    Expressioni

    Gene expression databases

    BgeeiP56390.
    CleanExiMM_CKS2.
    GenevestigatoriP56390.

    Interactioni

    Subunit structurei

    Forms a homohexamer that can probably bind six kinase subunits.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000075250.

    Structurei

    3D structure databases

    ProteinModelPortaliP56390.
    SMRiP56390. Positions 2-75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CKS family.Curated

    Phylogenomic databases

    eggNOGiNOG272189.
    HOVERGENiHBG003626.
    InParanoidiP56390.
    KOiK02219.
    OMAiFDDKFEY.
    OrthoDBiEOG735413.
    PhylomeDBiP56390.
    TreeFamiTF101142.

    Family and domain databases

    Gene3Di3.30.170.10. 1 hit.
    InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view]
    PfamiPF01111. CKS. 1 hit.
    [Graphical view]
    PRINTSiPR00296. CYCLINKINASE.
    SMARTiSM01084. CKS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55637. SSF55637. 1 hit.
    PROSITEiPS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56390-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ   50
    SLGWVHYMIH EPEPHILLFR RPLPKEQQK 79
    Length:79
    Mass (Da):9,874
    Last modified:July 15, 1998 - v1
    Checksum:i811B5926D91EEC5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA289122 mRNA. No translation available.
    AA041913 mRNA. No translation available.
    AK002451 mRNA. Translation: BAB22110.1.
    BC022647 mRNA. Translation: AAH22647.1.
    CCDSiCCDS36664.1.
    RefSeqiNP_079691.1. NM_025415.3.
    UniGeneiMm.222228.

    Genome annotation databases

    EnsembliENSMUST00000075853; ENSMUSP00000075250; ENSMUSG00000062248.
    GeneIDi66197.
    KEGGimmu:66197.
    UCSCiuc007qmh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AA289122 mRNA. No translation available.
    AA041913 mRNA. No translation available.
    AK002451 mRNA. Translation: BAB22110.1 .
    BC022647 mRNA. Translation: AAH22647.1 .
    CCDSi CCDS36664.1.
    RefSeqi NP_079691.1. NM_025415.3.
    UniGenei Mm.222228.

    3D structure databases

    ProteinModelPortali P56390.
    SMRi P56390. Positions 2-75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000075250.

    PTM databases

    PhosphoSitei P56390.

    Proteomic databases

    PaxDbi P56390.
    PRIDEi P56390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075853 ; ENSMUSP00000075250 ; ENSMUSG00000062248 .
    GeneIDi 66197.
    KEGGi mmu:66197.
    UCSCi uc007qmh.2. mouse.

    Organism-specific databases

    CTDi 1164.
    MGIi MGI:1913447. Cks2.

    Phylogenomic databases

    eggNOGi NOG272189.
    HOVERGENi HBG003626.
    InParanoidi P56390.
    KOi K02219.
    OMAi FDDKFEY.
    OrthoDBi EOG735413.
    PhylomeDBi P56390.
    TreeFami TF101142.

    Miscellaneous databases

    NextBioi 320927.
    PROi P56390.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56390.
    CleanExi MM_CKS2.
    Genevestigatori P56390.

    Family and domain databases

    Gene3Di 3.30.170.10. 1 hit.
    InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view ]
    Pfami PF01111. CKS. 1 hit.
    [Graphical view ]
    PRINTSi PR00296. CYCLINKINASE.
    SMARTi SM01084. CKS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55637. SSF55637. 1 hit.
    PROSITEi PS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiCKS2_MOUSE
    AccessioniPrimary (citable) accession number: P56390
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3