ID CART_MOUSE Reviewed; 129 AA. AC P56388; Q9QXZ8; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 16-NOV-2001, sequence version 2. DT 24-JAN-2024, entry version 152. DE RecName: Full=Cocaine- and amphetamine-regulated transcript protein; DE Contains: DE RecName: Full=CART(1-52); DE Contains: DE RecName: Full=CART(55-102); DE Contains: DE RecName: Full=CART(62-102); DE Flags: Precursor; GN Name=Cartpt; Synonyms=Cart; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING. RC STRAIN=129/SvJ; RX PubMed=10612705; DOI=10.1016/s0006-8993(99)01907-1; RA Adams L.D., Gong W., Vechia S.D., Hunter R.G., Kuhar M.J.; RT "CART: from gene to function."; RL Brain Res. 848:137-140(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG). RC STRAIN=C57BL/6J; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, PHOSPHORYLATION [LARGE RP SCALE ANALYSIS] AT SER-48 (ISOFORM SHORT), AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain, and Heart; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Satiety factor closely associated with the actions of leptin CC and neuropeptide y; this anorectic peptide inhibits both normal and CC starvation-induced feeding and completely blocks the feeding response CC induced by neuropeptide Y and regulated by leptin in the hypothalamus. CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Long; CC IsoId=P56388-1; Sequence=Displayed; CC Name=Short; CC IsoId=P56388-2; Sequence=VSP_000793; CC -!- SIMILARITY: Belongs to the CART family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF148071; AAF24168.1; -; Genomic_DNA. DR EMBL; BC056431; AAH56431.1; -; mRNA. DR CCDS; CCDS36763.1; -. [P56388-1] DR CCDS; CCDS88509.1; -. [P56388-2] DR RefSeq; NP_038760.3; NM_013732.7. [P56388-1] DR AlphaFoldDB; P56388; -. DR SMR; P56388; -. DR BioGRID; 205141; 1. DR STRING; 10090.ENSMUSP00000022150; -. DR iPTMnet; P56388; -. DR PhosphoSitePlus; P56388; -. DR PaxDb; 10090-ENSMUSP00000022150; -. DR PeptideAtlas; P56388; -. DR ProteomicsDB; 283675; -. [P56388-1] DR ProteomicsDB; 283676; -. [P56388-2] DR Antibodypedia; 24184; 253 antibodies from 30 providers. DR DNASU; 27220; -. DR Ensembl; ENSMUST00000022150.8; ENSMUSP00000022150.7; ENSMUSG00000021647.8. [P56388-1] DR Ensembl; ENSMUST00000224142.2; ENSMUSP00000152981.2; ENSMUSG00000021647.8. [P56388-2] DR GeneID; 27220; -. DR KEGG; mmu:27220; -. DR UCSC; uc007rpw.2; mouse. [P56388-1] DR AGR; MGI:1351330; -. DR CTD; 9607; -. DR MGI; MGI:1351330; Cartpt. DR VEuPathDB; HostDB:ENSMUSG00000021647; -. DR eggNOG; ENOG502S2YU; Eukaryota. DR GeneTree; ENSGT00390000018319; -. DR HOGENOM; CLU_157363_1_0_1; -. DR InParanoid; P56388; -. DR OMA; CNCPRGA; -. DR OrthoDB; 3971848at2759; -. DR PhylomeDB; P56388; -. DR TreeFam; TF332948; -. DR BioGRID-ORCS; 27220; 2 hits in 78 CRISPR screens. DR PRO; PR:P56388; -. DR Proteomes; UP000000589; Chromosome 13. DR RNAct; P56388; Protein. DR Bgee; ENSMUSG00000021647; Expressed in arcuate nucleus of hypothalamus and 81 other cell types or tissues. DR ExpressionAtlas; P56388; baseline and differential. DR GO; GO:0005615; C:extracellular space; IDA:HGNC-UCL. DR GO; GO:0030141; C:secretory granule; ISO:MGI. DR GO; GO:0045202; C:synapse; IEA:GOC. DR GO; GO:0005184; F:neuropeptide hormone activity; TAS:MGI. DR GO; GO:0008343; P:adult feeding behavior; IDA:HGNC-UCL. DR GO; GO:0009267; P:cellular response to starvation; IDA:HGNC-UCL. DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW. DR GO; GO:0032922; P:circadian regulation of gene expression; ISS:HGNC-UCL. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:HGNC-UCL. DR GO; GO:0001678; P:intracellular glucose homeostasis; ISS:HGNC-UCL. DR GO; GO:0032099; P:negative regulation of appetite; IMP:HGNC-UCL. DR GO; GO:0045779; P:negative regulation of bone resorption; IGI:HGNC-UCL. DR GO; GO:0070093; P:negative regulation of glucagon secretion; ISO:MGI. DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; TAS:HGNC-UCL. DR GO; GO:0007218; P:neuropeptide signaling pathway; TAS:MGI. DR GO; GO:0045777; P:positive regulation of blood pressure; ISS:HGNC-UCL. DR GO; GO:0032812; P:positive regulation of epinephrine secretion; ISS:HGNC-UCL. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:HGNC-UCL. DR GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:HGNC-UCL. DR GO; GO:0051971; P:positive regulation of transmission of nerve impulse; ISS:HGNC-UCL. DR GO; GO:0046850; P:regulation of bone remodeling; IMP:MGI. DR GO; GO:0050796; P:regulation of insulin secretion; ISO:MGI. DR GO; GO:0070253; P:somatostatin secretion; ISO:MGI. DR CDD; cd22741; CART_CTD-like; 1. DR Gene3D; 4.10.40.30; CART, C-terminal domain; 1. DR InterPro; IPR009106; CART. DR InterPro; IPR036722; CART_C_sf. DR PANTHER; PTHR16655; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PROTEIN; 1. DR PANTHER; PTHR16655:SF0; COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PROTEIN; 1. DR Pfam; PF06373; CART; 1. DR SUPFAM; SSF64546; Satiety factor CART (cocaine and amphetamine regulated transcript); 1. DR Genevisible; P56388; MM. PE 1: Evidence at protein level; KW Alternative splicing; Cleavage on pair of basic residues; Disulfide bond; KW Neuropeptide; Neurotransmitter; Phosphoprotein; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..27 FT /evidence="ECO:0000255" FT CHAIN 28..129 FT /note="Cocaine- and amphetamine-regulated transcript FT protein" FT /id="PRO_0000004436" FT PEPTIDE 28..79 FT /note="CART(1-52)" FT /evidence="ECO:0000250" FT /id="PRO_0000004437" FT PEPTIDE 82..129 FT /note="CART(55-102)" FT /evidence="ECO:0000250" FT /id="PRO_0000004438" FT PEPTIDE 89..129 FT /note="CART(62-102)" FT /evidence="ECO:0000255" FT /id="PRO_0000004439" FT MOD_RES 41 FT /note="Phosphotyrosine" FT /evidence="ECO:0000250|UniProtKB:P49192" FT MOD_RES 48 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT DISULFID 95..113 FT /evidence="ECO:0000250" FT DISULFID 101..121 FT /evidence="ECO:0000250" FT DISULFID 115..128 FT /evidence="ECO:0000250" FT VAR_SEQ 54..66 FT /note="Missing (in isoform Short)" FT /evidence="ECO:0000305" FT /id="VSP_000793" FT MOD_RES P56388-2:48 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" SQ SEQUENCE 129 AA; 14285 MW; E4CA6CE70BEE6DF2 CRC64; MESSRLRLLP LLGAALLLLL PLLGARAQED AELQPRALDI YSAVDDASHE KELPRRQLRA PGAMLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ CAVRKGARIG KLCDCPRGTS CNSFLLKCL //