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P56388

- CART_MOUSE

UniProt

P56388 - CART_MOUSE

Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

Cartpt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: MGI

    GO - Biological processi

    1. activation of MAPKK activity Source: HGNC
    2. adult feeding behavior Source: HGNC
    3. cellular glucose homeostasis Source: HGNC
    4. cellular response to starvation Source: HGNC
    5. circadian regulation of gene expression Source: HGNC
    6. G-protein coupled receptor signaling pathway Source: HGNC
    7. negative regulation of appetite Source: HGNC
    8. negative regulation of bone resorption Source: HGNC
    9. negative regulation of glucagon secretion Source: Ensembl
    10. negative regulation of osteoclast differentiation Source: HGNC
    11. neuropeptide signaling pathway Source: MGI
    12. positive regulation of blood pressure Source: HGNC
    13. positive regulation of epinephrine secretion Source: HGNC
    14. positive regulation of transmission of nerve impulse Source: HGNC
    15. regulation of bone remodeling Source: MGI
    16. regulation of insulin secretion Source: Ensembl
    17. somatostatin secretion Source: Ensembl
    18. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cocaine- and amphetamine-regulated transcript protein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Cartpt
    Synonyms:Cart
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1351330. Cartpt.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: HGNC
    2. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 129102Cocaine- and amphetamine-regulated transcript proteinPRO_0000004436Add
    BLAST
    Peptidei28 – 7952CART(1-52)By similarityPRO_0000004437Add
    BLAST
    Peptidei82 – 12948CART(55-102)By similarityPRO_0000004438Add
    BLAST
    Peptidei89 – 12941CART(62-102)Sequence AnalysisPRO_0000004439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi95 ↔ 113By similarity
    Disulfide bondi101 ↔ 121By similarity
    Disulfide bondi115 ↔ 128By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    MaxQBiP56388.
    PaxDbiP56388.
    PRIDEiP56388.

    PTM databases

    PhosphoSiteiP56388.

    Expressioni

    Gene expression databases

    BgeeiP56388.
    CleanExiMM_CARTPT.
    GenevestigatoriP56388.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022150.

    Structurei

    3D structure databases

    ProteinModelPortaliP56388.
    SMRiP56388. Positions 89-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CART family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47455.
    GeneTreeiENSGT00390000018319.
    HOGENOMiHOG000111306.
    HOVERGENiHBG018929.
    InParanoidiP56388.
    OMAiSHEKELP.
    OrthoDBiEOG7JDR0T.
    PhylomeDBiP56388.
    TreeFamiTF332948.

    Family and domain databases

    Gene3Di4.10.40.30. 1 hit.
    InterProiIPR009106. CART.
    [Graphical view]
    PANTHERiPTHR16655. PTHR16655. 1 hit.
    PfamiPF06373. CART. 1 hit.
    [Graphical view]
    SUPFAMiSSF64546. SSF64546. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P56388-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESSRLRLLP LLGAALLLLL PLLGARAQED AELQPRALDI YSAVDDASHE    50
    KELPRRQLRA PGAMLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ 100
    CAVRKGARIG KLCDCPRGTS CNSFLLKCL 129
    Length:129
    Mass (Da):14,285
    Last modified:November 16, 2001 - v2
    Checksum:iE4CA6CE70BEE6DF2
    GO
    Isoform Short (identifier: P56388-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         54-66: Missing.

    Show »
    Length:116
    Mass (Da):12,809
    Checksum:i9248CCBA89203754
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei54 – 6613Missing in isoform Short. CuratedVSP_000793Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148071 Genomic DNA. Translation: AAF24168.1.
    BC056431 mRNA. Translation: AAH56431.1.
    CCDSiCCDS36763.1. [P56388-1]
    RefSeqiNP_038760.3. NM_013732.7. [P56388-1]
    UniGeneiMm.75498.

    Genome annotation databases

    EnsembliENSMUST00000022150; ENSMUSP00000022150; ENSMUSG00000021647. [P56388-1]
    GeneIDi27220.
    KEGGimmu:27220.
    UCSCiuc007rpw.1. mouse. [P56388-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148071 Genomic DNA. Translation: AAF24168.1 .
    BC056431 mRNA. Translation: AAH56431.1 .
    CCDSi CCDS36763.1. [P56388-1 ]
    RefSeqi NP_038760.3. NM_013732.7. [P56388-1 ]
    UniGenei Mm.75498.

    3D structure databases

    ProteinModelPortali P56388.
    SMRi P56388. Positions 89-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022150.

    PTM databases

    PhosphoSitei P56388.

    Proteomic databases

    MaxQBi P56388.
    PaxDbi P56388.
    PRIDEi P56388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022150 ; ENSMUSP00000022150 ; ENSMUSG00000021647 . [P56388-1 ]
    GeneIDi 27220.
    KEGGi mmu:27220.
    UCSCi uc007rpw.1. mouse. [P56388-1 ]

    Organism-specific databases

    CTDi 9607.
    MGIi MGI:1351330. Cartpt.

    Phylogenomic databases

    eggNOGi NOG47455.
    GeneTreei ENSGT00390000018319.
    HOGENOMi HOG000111306.
    HOVERGENi HBG018929.
    InParanoidi P56388.
    OMAi SHEKELP.
    OrthoDBi EOG7JDR0T.
    PhylomeDBi P56388.
    TreeFami TF332948.

    Miscellaneous databases

    NextBioi 305124.
    PROi P56388.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56388.
    CleanExi MM_CARTPT.
    Genevestigatori P56388.

    Family and domain databases

    Gene3Di 4.10.40.30. 1 hit.
    InterProi IPR009106. CART.
    [Graphical view ]
    PANTHERi PTHR16655. PTHR16655. 1 hit.
    Pfami PF06373. CART. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64546. SSF64546. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: 129/SvJ.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCART_MOUSE
    AccessioniPrimary (citable) accession number: P56388
    Secondary accession number(s): Q9QXZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3