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P56388 (CART_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cocaine- and amphetamine-regulated transcript protein

Cleaved into the following 3 chains:

  1. CART(1-52)
  2. CART(55-102)
  3. CART(62-102)
Gene names
Name:Cartpt
Synonyms:Cart
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the CART family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionNeuropeptide
Neurotransmitter
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 15908120. Source: HGNC

activation of MAPKK activity

Inferred from direct assay PubMed 15908120. Source: HGNC

adult feeding behavior

Inferred from direct assay PubMed 9590691. Source: HGNC

cellular glucose homeostasis

Inferred from sequence or structural similarity. Source: HGNC

cellular response to starvation

Inferred from direct assay PubMed 9590691. Source: HGNC

circadian regulation of gene expression

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of appetite

Inferred from mutant phenotype PubMed 9590691. Source: HGNC

negative regulation of bone resorption

Inferred from genetic interaction PubMed 16614075. Source: HGNC

negative regulation of glucagon secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of osteoclast differentiation

Traceable author statement PubMed 16614075. Source: HGNC

neuropeptide signaling pathway

Traceable author statement Ref.1. Source: MGI

positive regulation of blood pressure

Inferred from sequence or structural similarity. Source: HGNC

positive regulation of epinephrine secretion

Inferred from sequence or structural similarity. Source: HGNC

positive regulation of transmission of nerve impulse

Inferred from sequence or structural similarity. Source: HGNC

regulation of bone remodeling

Inferred from mutant phenotype PubMed 15724149. Source: MGI

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

somatostatin secretion

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from direct assay PubMed 9590691. Source: HGNC

secretory granule

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionneuropeptide hormone activity

Traceable author statement Ref.1. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P56388-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P56388-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-66: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 129102Cocaine- and amphetamine-regulated transcript protein
PRO_0000004436
Peptide28 – 7952CART(1-52) By similarity
PRO_0000004437
Peptide82 – 12948CART(55-102) By similarity
PRO_0000004438
Peptide89 – 12941CART(62-102) Potential
PRO_0000004439

Amino acid modifications

Disulfide bond95 ↔ 113 By similarity
Disulfide bond101 ↔ 121 By similarity
Disulfide bond115 ↔ 128 By similarity

Natural variations

Alternative sequence54 – 6613Missing in isoform Short.
VSP_000793

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 16, 2001. Version 2.
Checksum: E4CA6CE70BEE6DF2

FASTA12914,285
        10         20         30         40         50         60 
MESSRLRLLP LLGAALLLLL PLLGARAQED AELQPRALDI YSAVDDASHE KELPRRQLRA 

        70         80         90        100        110        120 
PGAMLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ CAVRKGARIG KLCDCPRGTS 


CNSFLLKCL 

« Hide

Isoform Short [UniParc].

Checksum: 9248CCBA89203754
Show »

FASTA11612,809

References

« Hide 'large scale' references
[1]"CART: from gene to function."
Adams L.D., Gong W., Vechia S.D., Hunter R.G., Kuhar M.J.
Brain Res. 848:137-140(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: 129/SvJ.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF148071 Genomic DNA. Translation: AAF24168.1.
BC056431 mRNA. Translation: AAH56431.1.
RefSeqNP_038760.3. NM_013732.7.
UniGeneMm.75498.

3D structure databases

ProteinModelPortalP56388.
SMRP56388. Positions 89-129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022150.

PTM databases

PhosphoSiteP56388.

Proteomic databases

PaxDbP56388.
PRIDEP56388.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022150; ENSMUSP00000022150; ENSMUSG00000021647. [P56388-1]
GeneID27220.
KEGGmmu:27220.
UCSCuc007rpw.1. mouse. [P56388-1]

Organism-specific databases

CTD9607.
MGIMGI:1351330. Cartpt.

Phylogenomic databases

eggNOGNOG47455.
GeneTreeENSGT00390000018319.
HOGENOMHOG000111306.
HOVERGENHBG018929.
InParanoidP56388.
OMASHEKELP.
OrthoDBEOG7JDR0T.
PhylomeDBP56388.
TreeFamTF332948.

Gene expression databases

BgeeP56388.
CleanExMM_CARTPT.
GenevestigatorP56388.

Family and domain databases

Gene3D4.10.40.30. 1 hit.
InterProIPR009106. CART.
[Graphical view]
PANTHERPTHR16655. PTHR16655. 1 hit.
PfamPF06373. CART. 1 hit.
[Graphical view]
SUPFAMSSF64546. SSF64546. 1 hit.
ProtoNetSearch...

Other

NextBio305124.
PROP56388.
SOURCESearch...

Entry information

Entry nameCART_MOUSE
AccessionPrimary (citable) accession number: P56388
Secondary accession number(s): Q9QXZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 16, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot