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P56388

- CART_MOUSE

UniProt

P56388 - CART_MOUSE

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Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

Cartpt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: HGNC
  2. adult feeding behavior Source: HGNC
  3. cellular glucose homeostasis Source: HGNC
  4. cellular response to starvation Source: HGNC
  5. circadian regulation of gene expression Source: HGNC
  6. G-protein coupled receptor signaling pathway Source: HGNC
  7. negative regulation of appetite Source: HGNC
  8. negative regulation of bone resorption Source: HGNC
  9. negative regulation of glucagon secretion Source: Ensembl
  10. negative regulation of osteoclast differentiation Source: HGNC
  11. neuropeptide signaling pathway Source: MGI
  12. positive regulation of blood pressure Source: HGNC
  13. positive regulation of epinephrine secretion Source: HGNC
  14. positive regulation of transmission of nerve impulse Source: HGNC
  15. regulation of bone remodeling Source: MGI
  16. regulation of insulin secretion Source: Ensembl
  17. somatostatin secretion Source: Ensembl
  18. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Cocaine- and amphetamine-regulated transcript protein
Cleaved into the following 3 chains:
Gene namesi
Name:Cartpt
Synonyms:Cart
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1351330. Cartpt.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: HGNC
  2. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 129102Cocaine- and amphetamine-regulated transcript proteinPRO_0000004436Add
BLAST
Peptidei28 – 7952CART(1-52)By similarityPRO_0000004437Add
BLAST
Peptidei82 – 12948CART(55-102)By similarityPRO_0000004438Add
BLAST
Peptidei89 – 12941CART(62-102)Sequence AnalysisPRO_0000004439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 113By similarity
Disulfide bondi101 ↔ 121By similarity
Disulfide bondi115 ↔ 128By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiP56388.
PaxDbiP56388.
PRIDEiP56388.

PTM databases

PhosphoSiteiP56388.

Expressioni

Gene expression databases

BgeeiP56388.
CleanExiMM_CARTPT.
ExpressionAtlasiP56388. baseline and differential.
GenevestigatoriP56388.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022150.

Structurei

3D structure databases

ProteinModelPortaliP56388.
SMRiP56388. Positions 89-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CART family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47455.
GeneTreeiENSGT00390000018319.
HOGENOMiHOG000111306.
HOVERGENiHBG018929.
InParanoidiP56388.
OMAiSHEKELP.
OrthoDBiEOG7JDR0T.
PhylomeDBiP56388.
TreeFamiTF332948.

Family and domain databases

Gene3Di4.10.40.30. 1 hit.
InterProiIPR009106. CART.
[Graphical view]
PANTHERiPTHR16655. PTHR16655. 1 hit.
PfamiPF06373. CART. 1 hit.
[Graphical view]
SUPFAMiSSF64546. SSF64546. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P56388-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSRLRLLP LLGAALLLLL PLLGARAQED AELQPRALDI YSAVDDASHE
60 70 80 90 100
KELPRRQLRA PGAMLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ
110 120
CAVRKGARIG KLCDCPRGTS CNSFLLKCL
Length:129
Mass (Da):14,285
Last modified:November 16, 2001 - v2
Checksum:iE4CA6CE70BEE6DF2
GO
Isoform Short (identifier: P56388-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-66: Missing.

Show »
Length:116
Mass (Da):12,809
Checksum:i9248CCBA89203754
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei54 – 6613Missing in isoform Short. CuratedVSP_000793Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF148071 Genomic DNA. Translation: AAF24168.1.
BC056431 mRNA. Translation: AAH56431.1.
CCDSiCCDS36763.1. [P56388-1]
RefSeqiNP_038760.3. NM_013732.7. [P56388-1]
UniGeneiMm.75498.

Genome annotation databases

EnsembliENSMUST00000022150; ENSMUSP00000022150; ENSMUSG00000021647. [P56388-1]
GeneIDi27220.
KEGGimmu:27220.
UCSCiuc007rpw.1. mouse. [P56388-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF148071 Genomic DNA. Translation: AAF24168.1 .
BC056431 mRNA. Translation: AAH56431.1 .
CCDSi CCDS36763.1. [P56388-1 ]
RefSeqi NP_038760.3. NM_013732.7. [P56388-1 ]
UniGenei Mm.75498.

3D structure databases

ProteinModelPortali P56388.
SMRi P56388. Positions 89-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022150.

PTM databases

PhosphoSitei P56388.

Proteomic databases

MaxQBi P56388.
PaxDbi P56388.
PRIDEi P56388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022150 ; ENSMUSP00000022150 ; ENSMUSG00000021647 . [P56388-1 ]
GeneIDi 27220.
KEGGi mmu:27220.
UCSCi uc007rpw.1. mouse. [P56388-1 ]

Organism-specific databases

CTDi 9607.
MGIi MGI:1351330. Cartpt.

Phylogenomic databases

eggNOGi NOG47455.
GeneTreei ENSGT00390000018319.
HOGENOMi HOG000111306.
HOVERGENi HBG018929.
InParanoidi P56388.
OMAi SHEKELP.
OrthoDBi EOG7JDR0T.
PhylomeDBi P56388.
TreeFami TF332948.

Miscellaneous databases

NextBioi 305124.
PROi P56388.
SOURCEi Search...

Gene expression databases

Bgeei P56388.
CleanExi MM_CARTPT.
ExpressionAtlasi P56388. baseline and differential.
Genevestigatori P56388.

Family and domain databases

Gene3Di 4.10.40.30. 1 hit.
InterProi IPR009106. CART.
[Graphical view ]
PANTHERi PTHR16655. PTHR16655. 1 hit.
Pfami PF06373. CART. 1 hit.
[Graphical view ]
SUPFAMi SSF64546. SSF64546. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCART_MOUSE
AccessioniPrimary (citable) accession number: P56388
Secondary accession number(s): Q9QXZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 16, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3