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Protein

Beta-defensin 1

Gene

Defb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has bactericidal activity.By similarity

GO - Biological processi

  • acute inflammatory response Source: Ensembl
  • antibacterial humoral response Source: Ensembl
  • defense response to bacterium Source: MGI
  • defense response to Gram-positive bacterium Source: Ensembl
  • innate immune response Source: UniProtKB
  • innate immune response in mucosa Source: Ensembl
  • response to bacterium Source: UniProtKB
  • response to testosterone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Short name:
mBD-1
Alternative name(s):
Defensin, beta 1
Gene namesi
Name:Defb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1096878. Defb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3211By similarityPRO_0000006925Add
BLAST
Peptidei33 – 6937Beta-defensin 1PRO_0000006926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 66By similarity
Disulfide bondi44 ↔ 59By similarity
Disulfide bondi49 ↔ 67By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP56386.
PRIDEiP56386.

Expressioni

Tissue specificityi

Detected in kidney.1 Publication

Gene expression databases

BgeeiP56386.
CleanExiMM_DEFB1.
ExpressionAtlasiP56386. baseline and differential.
GenevisibleiP56386. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051754.

Structurei

3D structure databases

ProteinModelPortaliP56386.
SMRiP56386. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiP56386.
OMAiKIQGTCY.
OrthoDBiEOG77WWGH.
PhylomeDBiP56386.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTHYFLLVM ICFLFSQMEP GVGILTSLGR RTDQYKCLQH GGFCLRSSCP
60
SNTKLQGTCK PDKPNCCKS
Length:69
Mass (Da):7,749
Last modified:July 15, 1998 - v1
Checksum:i8B12DBD3BBF3ACE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA071757 mRNA. No translation available.
AA065510 mRNA. No translation available.
AA108061 mRNA. No translation available.
AA107538 mRNA. No translation available.
AA105324 mRNA. No translation available.
AF003525, AF003524 Genomic DNA. Translation: AAB72003.1.
BC024380 mRNA. Translation: AAH24380.1.
CCDSiCCDS40282.1.
RefSeqiNP_031869.1. NM_007843.3.
UniGeneiMm.431316.

Genome annotation databases

EnsembliENSMUST00000051017; ENSMUSP00000051754; ENSMUSG00000044748.
GeneIDi13214.
KEGGimmu:13214.
UCSCiuc009lby.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA071757 mRNA. No translation available.
AA065510 mRNA. No translation available.
AA108061 mRNA. No translation available.
AA107538 mRNA. No translation available.
AA105324 mRNA. No translation available.
AF003525, AF003524 Genomic DNA. Translation: AAB72003.1.
BC024380 mRNA. Translation: AAH24380.1.
CCDSiCCDS40282.1.
RefSeqiNP_031869.1. NM_007843.3.
UniGeneiMm.431316.

3D structure databases

ProteinModelPortaliP56386.
SMRiP56386. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051754.

Proteomic databases

PaxDbiP56386.
PRIDEiP56386.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051017; ENSMUSP00000051754; ENSMUSG00000044748.
GeneIDi13214.
KEGGimmu:13214.
UCSCiuc009lby.2. mouse.

Organism-specific databases

CTDi1672.
MGIiMGI:1096878. Defb1.

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiP56386.
OMAiKIQGTCY.
OrthoDBiEOG77WWGH.
PhylomeDBiP56386.

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-1461973. Defensins.

Miscellaneous databases

PROiP56386.
SOURCEiSearch...

Gene expression databases

BgeeiP56386.
CleanExiMM_DEFB1.
ExpressionAtlasiP56386. baseline and differential.
GenevisibleiP56386. MM.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1."
    Huttner K.M., Kozak C.A., Bevins C.L.
    FEBS Lett. 413:45-49(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  4. "A novel murine beta-defensin expressed in tongue, esophagus, and trachea."
    Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F., Bevins C.L., McCray P.B. Jr.
    J. Biol. Chem. 275:33314-33320(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: 129/SvJ, C57BL/6J and FVB.
    Tissue: Lung.

Entry informationi

Entry nameiDEFB1_MOUSE
AccessioniPrimary (citable) accession number: P56386
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.