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Protein

Beta-defensin 1

Gene

Defb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-MMU-1461957 Beta defensins
R-MMU-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Short name:
mBD-1
Alternative name(s):
Defensin, beta 1
Gene namesi
Name:Defb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1096878 Defb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000692522 – 32By similarityAdd BLAST11
PeptideiPRO_000000692633 – 69Beta-defensin 1Add BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 66By similarity
Disulfide bondi44 ↔ 59By similarity
Disulfide bondi49 ↔ 67By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP56386
PRIDEiP56386

Expressioni

Tissue specificityi

Detected in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000044748
CleanExiMM_DEFB1
ExpressionAtlasiP56386 baseline and differential
GenevisibleiP56386 MM

Interactioni

Subunit structurei

Monomer. Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051754

Structurei

3D structure databases

ProteinModelPortaliP56386
SMRiP56386
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7H1 Eukaryota
ENOG41119QC LUCA
GeneTreeiENSGT00390000017014
HOGENOMiHOG000112188
HOVERGENiHBG084156
InParanoidiP56386
OMAiKIQGTCY
OrthoDBiEOG091G18L0
PhylomeDBiP56386

Family and domain databases

InterProiView protein in InterPro
IPR001855 Defensin_beta-typ
PfamiView protein in Pfam
PF00711 Defensin_beta, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTHYFLLVM ICFLFSQMEP GVGILTSLGR RTDQYKCLQH GGFCLRSSCP
60
SNTKLQGTCK PDKPNCCKS
Length:69
Mass (Da):7,749
Last modified:July 15, 1998 - v1
Checksum:i8B12DBD3BBF3ACE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA071757 mRNA No translation available.
AA065510 mRNA No translation available.
AA108061 mRNA No translation available.
AA107538 mRNA No translation available.
AA105324 mRNA No translation available.
AF003525, AF003524 Genomic DNA Translation: AAB72003.1
BC024380 mRNA Translation: AAH24380.1
CCDSiCCDS40282.1
RefSeqiNP_031869.1, NM_007843.3
UniGeneiMm.431316

Genome annotation databases

EnsembliENSMUST00000051017; ENSMUSP00000051754; ENSMUSG00000044748
GeneIDi13214
KEGGimmu:13214
UCSCiuc009lby.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDEFB1_MOUSE
AccessioniPrimary (citable) accession number: P56386
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: January 31, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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