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Protein

ATP synthase F(0) complex subunit C3, mitochondrial

Gene

Atp5mc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei124Reversibly protonated during proton transportBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C3, mitochondrialCurated
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase membrane subunit c locus 3By similarity
ATP synthase proteolipid P3
ATPase protein 9
ATPase subunit c
Gene namesi
Name:Atp5mc3By similarity
Synonyms:Atp5g3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442035 Atp5g3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 66MitochondrionBy similarityAdd BLAST66
ChainiPRO_000000256867 – 141ATP synthase F(0) complex subunit C3, mitochondrialAdd BLAST75

Proteomic databases

PaxDbiP56384
PRIDEiP56384

PTM databases

PhosphoSitePlusiP56384

Expressioni

Gene expression databases

BgeeiENSMUSG00000018770
ExpressionAtlasiP56384 baseline and differential
GenevisibleiP56384 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018914

Structurei

3D structure databases

ProteinModelPortaliP56384
SMRiP56384
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3025 Eukaryota
COG0636 LUCA
GeneTreeiENSGT00390000006210
HOGENOMiHOG000235246
HOVERGENiHBG050605
InParanoidiP56384
KOiK02128
OMAiCKMFACA
OrthoDBiEOG091G13J1
PhylomeDBiP56384
TreeFamiTF300140

Family and domain databases

Gene3Di1.20.20.10, 1 hit
HAMAPiMF_01396 ATP_synth_c_bact, 1 hit
InterProiView protein in InterPro
IPR000454 ATP_synth_F0_csu
IPR020537 ATP_synth_F0_csu_DDCD_BS
IPR038662 ATP_synth_F0_csu_sf
IPR002379 ATPase_proteolipid_c-like_dom
IPR035921 F/V-ATP_Csub_sf
PANTHERiPTHR10031 PTHR10031, 1 hit
PfamiView protein in Pfam
PF00137 ATP-synt_C, 1 hit
PRINTSiPR00124 ATPASEC
SUPFAMiSSF81333 SSF81333, 1 hit
PROSITEiView protein in PROSITE
PS00605 ATPASE_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFACAKLART PALIRAGSRV AYRPISASVL SRPETRTGEG STVFNGAQNG
60 70 80 90 100
VCQLIRREFQ TSVISRDIDT AAKFIGAGAA TVGVAGSGAG IGTVFGSLII
110 120 130 140
GYARNPSLKQ QLFSYAILGF ALSEAMGLFC LMVAFLILFA M
Length:141
Mass (Da):14,745
Last modified:July 15, 1998 - v1
Checksum:i2B549F5AE7874554
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077930 mRNA Translation: BAC37071.1
AK087955 mRNA Translation: BAC40056.1
CCDSiCCDS16136.1
RefSeqiNP_001288650.1, NM_001301721.1
NP_778180.1, NM_175015.3
UniGeneiMm.2966

Genome annotation databases

EnsembliENSMUST00000018914; ENSMUSP00000018914; ENSMUSG00000018770
ENSMUST00000111996; ENSMUSP00000107627; ENSMUSG00000018770
GeneIDi228033
KEGGimmu:228033
UCSCiuc008kdm.2 mouse

Entry informationi

Entry nameiAT5G3_MOUSE
AccessioniPrimary (citable) accession number: P56384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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