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Protein

ATP synthase F(0) complex subunit C3, mitochondrial

Gene

Atp5g3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei124Reversibly protonated during proton transportBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C3, mitochondrial
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase proteolipid P3
ATPase protein 9
ATPase subunit c
Gene namesi
Name:Atp5g3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442035. Atp5g3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 66MitochondrionBy similarityAdd BLAST66
ChainiPRO_000000256867 – 141ATP synthase F(0) complex subunit C3, mitochondrialAdd BLAST75

Proteomic databases

PaxDbiP56384.
PRIDEiP56384.

PTM databases

PhosphoSitePlusiP56384.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018770.
ExpressionAtlasiP56384. baseline and differential.
GenevisibleiP56384. MM.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018914.

Structurei

3D structure databases

ProteinModelPortaliP56384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3025. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00390000006210.
HOGENOMiHOG000235246.
HOVERGENiHBG050605.
InParanoidiP56384.
KOiK02128.
OMAiCKMFACA.
OrthoDBiEOG091G13J1.
PhylomeDBiP56384.
TreeFamiTF300140.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiIPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
[Graphical view]
PfamiPF00137. ATP-synt_C. 1 hit.
[Graphical view]
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiPS00605. ATPASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFACAKLART PALIRAGSRV AYRPISASVL SRPETRTGEG STVFNGAQNG
60 70 80 90 100
VCQLIRREFQ TSVISRDIDT AAKFIGAGAA TVGVAGSGAG IGTVFGSLII
110 120 130 140
GYARNPSLKQ QLFSYAILGF ALSEAMGLFC LMVAFLILFA M
Length:141
Mass (Da):14,745
Last modified:July 15, 1998 - v1
Checksum:i2B549F5AE7874554
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077930 mRNA. Translation: BAC37071.1.
AK087955 mRNA. Translation: BAC40056.1.
CCDSiCCDS16136.1.
RefSeqiNP_001288650.1. NM_001301721.1.
NP_778180.1. NM_175015.3.
UniGeneiMm.2966.

Genome annotation databases

EnsembliENSMUST00000018914; ENSMUSP00000018914; ENSMUSG00000018770.
ENSMUST00000111996; ENSMUSP00000107627; ENSMUSG00000018770.
GeneIDi228033.
KEGGimmu:228033.
UCSCiuc008kdm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077930 mRNA. Translation: BAC37071.1.
AK087955 mRNA. Translation: BAC40056.1.
CCDSiCCDS16136.1.
RefSeqiNP_001288650.1. NM_001301721.1.
NP_778180.1. NM_175015.3.
UniGeneiMm.2966.

3D structure databases

ProteinModelPortaliP56384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018914.

PTM databases

PhosphoSitePlusiP56384.

Proteomic databases

PaxDbiP56384.
PRIDEiP56384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018914; ENSMUSP00000018914; ENSMUSG00000018770.
ENSMUST00000111996; ENSMUSP00000107627; ENSMUSG00000018770.
GeneIDi228033.
KEGGimmu:228033.
UCSCiuc008kdm.2. mouse.

Organism-specific databases

CTDi518.
MGIiMGI:2442035. Atp5g3.

Phylogenomic databases

eggNOGiKOG3025. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00390000006210.
HOGENOMiHOG000235246.
HOVERGENiHBG050605.
InParanoidiP56384.
KOiK02128.
OMAiCKMFACA.
OrthoDBiEOG091G13J1.
PhylomeDBiP56384.
TreeFamiTF300140.

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

ChiTaRSiAtp5g3. mouse.
PROiP56384.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018770.
ExpressionAtlasiP56384. baseline and differential.
GenevisibleiP56384. MM.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiIPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
[Graphical view]
PfamiPF00137. ATP-synt_C. 1 hit.
[Graphical view]
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiPS00605. ATPASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT5G3_MOUSE
AccessioniPrimary (citable) accession number: P56384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.