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Protein

ATP synthase F(0) complex subunit C2, mitochondrial

Gene

Atp5mc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei129Reversibly protonated during proton transportBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C2, mitochondrialCurated
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase membrane subunit c locus 2By similarity
ATP synthase proteolipid P2
ATPase protein 9
ATPase subunit c
Gene namesi
Name:Atp5mc2By similarity
Synonyms:Atp5g2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915192 Atp5g2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 71MitochondrionBy similarityAdd BLAST71
ChainiPRO_000000256372 – 146ATP synthase F(0) complex subunit C2, mitochondrialAdd BLAST75

Proteomic databases

PaxDbiP56383
PeptideAtlasiP56383
PRIDEiP56383
TopDownProteomicsiP56383

PTM databases

iPTMnetiP56383
PhosphoSitePlusiP56383

Expressioni

Gene expression databases

BgeeiENSMUSG00000062683
ExpressionAtlasiP56383 baseline and differential
GenevisibleiP56383 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136537

Structurei

3D structure databases

ProteinModelPortaliP56383
SMRiP56383
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3025 Eukaryota
COG0636 LUCA
GeneTreeiENSGT00390000006210
HOGENOMiHOG000235246
HOVERGENiHBG050605
InParanoidiP56383
KOiK02128
OMAiHPLKMYT
OrthoDBiEOG091G13J1
PhylomeDBiP56383
TreeFamiTF300140

Family and domain databases

Gene3Di1.20.20.10, 1 hit
HAMAPiMF_01396 ATP_synth_c_bact, 1 hit
InterProiView protein in InterPro
IPR000454 ATP_synth_F0_csu
IPR020537 ATP_synth_F0_csu_DDCD_BS
IPR038662 ATP_synth_F0_csu_sf
IPR002379 ATPase_proteolipid_c-like_dom
IPR035921 F/V-ATP_Csub_sf
PANTHERiPTHR10031 PTHR10031, 1 hit
PfamiView protein in Pfam
PF00137 ATP-synt_C, 1 hit
PRINTSiPR00124 ATPASEC
SUPFAMiSSF81333 SSF81333, 1 hit
PROSITEiView protein in PROSITE
PS00605 ATPASE_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYACSKFVST RSLIRSTSLR STSQLLSRPL SAVELKRPQM PTDESLSSLA
60 70 80 90 100
VRRPLTSLIP SRSFQTSAIS RDIDTAAKFI GAGAATVGVA GSGAGIGTVF
110 120 130 140
GSLIIGYARN PSLKQQLFSY AILGFALSEA MGLFCLMVAF LILFAM
Length:146
Mass (Da):15,476
Last modified:August 16, 2004 - v2
Checksum:iD49C8172BF16FBBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002311 mRNA Translation: BAB22005.1
AK007747 mRNA Translation: BAB25231.1
AK012279 mRNA Translation: BAB28137.1
AK075793 mRNA Translation: BAC35962.1
BC006813 mRNA Translation: AAH06813.1
BC081437 mRNA Translation: AAH81437.1
BC106138 mRNA Translation: AAI06139.1
CCDSiCCDS27888.1
RefSeqiNP_080744.1, NM_026468.2
UniGeneiMm.10314
Mm.381662

Genome annotation databases

EnsembliENSMUST00000075630; ENSMUSP00000075057; ENSMUSG00000062683
ENSMUST00000185641; ENSMUSP00000140414; ENSMUSG00000062683
GeneIDi67942
KEGGimmu:67942
UCSCiuc007xwr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAT5G2_MOUSE
AccessioniPrimary (citable) accession number: P56383
Secondary accession number(s): Q3KQM0, Q9CQ23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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