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P56378

- 68MP_HUMAN

UniProt

P56378 - 68MP_HUMAN

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Protein

6.8 kDa mitochondrial proteolipid

Gene

MP68

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
6.8 kDa mitochondrial proteolipid
Gene namesi
Name:MP68
Synonyms:C14orf2
ORF Names:PRO1574
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:1188. C14orf2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 3819HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 58586.8 kDa mitochondrial proteolipidPRO_0000064393Add
BLAST

Proteomic databases

MaxQBiP56378.
PaxDbiP56378.
PRIDEiP56378.

PTM databases

PhosphoSiteiP56378.

Expressioni

Gene expression databases

BgeeiP56378.
CleanExiHS_C14orf2.
ExpressionAtlasiP56378. baseline and differential.
GenevestigatoriP56378.

Organism-specific databases

HPAiHPA048772.
HPA058978.
HPA060520.

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.By similarity

Protein-protein interaction databases

BioGridi114928. 3 interactions.
STRINGi9606.ENSP00000401770.

Structurei

3D structure databases

ProteinModelPortaliP56378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47225.
GeneTreeiENSGT00390000016760.
HOGENOMiHOG000276668.
HOVERGENiHBG000027.
InParanoidiP56378.
KOiK18193.
OrthoDBiEOG7H795D.
PhylomeDBiP56378.
TreeFamiTF338412.

Family and domain databases

InterProiIPR012574. Mit_proteolip.
[Graphical view]
PANTHERiPTHR15233. PTHR15233. 1 hit.
PfamiPF08039. Mit_proteolip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P56378-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

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MLQSIIKNIW IPMKPYYTKV YQEIWIGMGL MGFIVYKIRA ADKRSKALKA

SAPAPGHH
Length:58
Mass (Da):6,662
Last modified:July 15, 1998 - v1
Checksum:i1B8A63046C0383F6
GO
Isoform 2 (identifier: P56378-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLYGTRGSDISHFQCQM

Note: No experimental confirmation available.

Show »
Length:75
Mass (Da):8,615
Checksum:i71F6B3697603EAD9
GO

Sequence cautioni

The sequence EAW81849.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91I → V.
Corresponds to variant rs1053419 [ dbSNP | Ensembl ].
VAR_014526

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MKLYGTRGSDISHFQCQM in isoform 2. 1 PublicationVSP_047043

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054175 mRNA. Translation: AAC39909.1.
AF116639 mRNA. Translation: AAF71062.1.
BX161388 mRNA. Translation: CAD61878.1.
AK312099 mRNA. Translation: BAG35035.1.
AL132712 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81849.1. Sequence problems.
CH471061 Genomic DNA. Translation: EAW81850.1.
BC000429 mRNA. Translation: AAH00429.1.
BC001944 mRNA. Translation: AAH01944.1.
CCDSiCCDS45169.1. [P56378-2]
CCDS9986.1. [P56378-1]
RefSeqiNP_001120865.1. NM_001127393.1. [P56378-2]
NP_004885.1. NM_004894.2. [P56378-1]
UniGeneiHs.109052.

Genome annotation databases

EnsembliENST00000286953; ENSP00000286953; ENSG00000156411. [P56378-1]
ENST00000414262; ENSP00000401770; ENSG00000156411. [P56378-2]
ENST00000554880; ENSP00000452133; ENSG00000156411. [P56378-1]
ENST00000557040; ENSP00000450894; ENSG00000156411. [P56378-1]
GeneIDi9556.
KEGGihsa:9556.
UCSCiuc001yoi.4. human. [P56378-1]
uc001yok.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054175 mRNA. Translation: AAC39909.1 .
AF116639 mRNA. Translation: AAF71062.1 .
BX161388 mRNA. Translation: CAD61878.1 .
AK312099 mRNA. Translation: BAG35035.1 .
AL132712 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81849.1 . Sequence problems.
CH471061 Genomic DNA. Translation: EAW81850.1 .
BC000429 mRNA. Translation: AAH00429.1 .
BC001944 mRNA. Translation: AAH01944.1 .
CCDSi CCDS45169.1. [P56378-2 ]
CCDS9986.1. [P56378-1 ]
RefSeqi NP_001120865.1. NM_001127393.1. [P56378-2 ]
NP_004885.1. NM_004894.2. [P56378-1 ]
UniGenei Hs.109052.

3D structure databases

ProteinModelPortali P56378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114928. 3 interactions.
STRINGi 9606.ENSP00000401770.

PTM databases

PhosphoSitei P56378.

Proteomic databases

MaxQBi P56378.
PaxDbi P56378.
PRIDEi P56378.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286953 ; ENSP00000286953 ; ENSG00000156411 . [P56378-1 ]
ENST00000414262 ; ENSP00000401770 ; ENSG00000156411 . [P56378-2 ]
ENST00000554880 ; ENSP00000452133 ; ENSG00000156411 . [P56378-1 ]
ENST00000557040 ; ENSP00000450894 ; ENSG00000156411 . [P56378-1 ]
GeneIDi 9556.
KEGGi hsa:9556.
UCSCi uc001yoi.4. human. [P56378-1 ]
uc001yok.3. human.

Organism-specific databases

CTDi 9556.
GeneCardsi GC14M104378.
HGNCi HGNC:1188. C14orf2.
HPAi HPA048772.
HPA058978.
HPA060520.
MIMi 604573. gene.
neXtProti NX_P56378.
PharmGKBi PA25514.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47225.
GeneTreei ENSGT00390000016760.
HOGENOMi HOG000276668.
HOVERGENi HBG000027.
InParanoidi P56378.
KOi K18193.
OrthoDBi EOG7H795D.
PhylomeDBi P56378.
TreeFami TF338412.

Miscellaneous databases

ChiTaRSi C14orf2. human.
GenomeRNAii 9556.
NextBioi 35517734.
PROi P56378.
SOURCEi Search...

Gene expression databases

Bgeei P56378.
CleanExi HS_C14orf2.
ExpressionAtlasi P56378. baseline and differential.
Genevestigatori P56378.

Family and domain databases

InterProi IPR012574. Mit_proteolip.
[Graphical view ]
PANTHERi PTHR15233. PTHR15233. 1 hit.
Pfami PF08039. Mit_proteolip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  2. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal liver.
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Neuroblastoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Synovium.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei68MP_HUMAN
AccessioniPrimary (citable) accession number: P56378
Secondary accession number(s): B2R588, G3V5Q3, Q86TT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3