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P56378

- 68MP_HUMAN

UniProt

P56378 - 68MP_HUMAN

Protein

6.8 kDa mitochondrial proteolipid

Gene

MP68

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    6.8 kDa mitochondrial proteolipid
    Gene namesi
    Name:MP68
    Synonyms:C14orf2
    ORF Names:PRO1574
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:1188. C14orf2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial proton-transporting ATP synthase complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25514.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 58586.8 kDa mitochondrial proteolipidPRO_0000064393Add
    BLAST

    Proteomic databases

    MaxQBiP56378.
    PaxDbiP56378.
    PRIDEiP56378.

    PTM databases

    PhosphoSiteiP56378.

    Expressioni

    Gene expression databases

    ArrayExpressiP56378.
    BgeeiP56378.
    CleanExiHS_C14orf2.
    GenevestigatoriP56378.

    Organism-specific databases

    HPAiHPA048772.
    HPA058978.
    HPA060520.

    Interactioni

    Subunit structurei

    Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.By similarity

    Protein-protein interaction databases

    BioGridi114928. 2 interactions.
    STRINGi9606.ENSP00000401770.

    Structurei

    3D structure databases

    ProteinModelPortaliP56378.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 3819HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47225.
    HOGENOMiHOG000276668.
    HOVERGENiHBG000027.
    InParanoidiP56378.
    KOiK18193.
    OrthoDBiEOG7H795D.
    PhylomeDBiP56378.
    TreeFamiTF338412.

    Family and domain databases

    InterProiIPR012574. Mit_proteolip.
    [Graphical view]
    PANTHERiPTHR15233. PTHR15233. 1 hit.
    PfamiPF08039. Mit_proteolip. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P56378-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLQSIIKNIW IPMKPYYTKV YQEIWIGMGL MGFIVYKIRA ADKRSKALKA   50
    SAPAPGHH 58
    Length:58
    Mass (Da):6,662
    Last modified:July 15, 1998 - v1
    Checksum:i1B8A63046C0383F6
    GO
    Isoform 2 (identifier: P56378-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MKLYGTRGSDISHFQCQM

    Note: No experimental confirmation available.

    Show »
    Length:75
    Mass (Da):8,615
    Checksum:i71F6B3697603EAD9
    GO

    Sequence cautioni

    The sequence EAW81849.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91I → V.
    Corresponds to variant rs1053419 [ dbSNP | Ensembl ].
    VAR_014526

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MKLYGTRGSDISHFQCQM in isoform 2. 1 PublicationVSP_047043

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054175 mRNA. Translation: AAC39909.1.
    AF116639 mRNA. Translation: AAF71062.1.
    BX161388 mRNA. Translation: CAD61878.1.
    AK312099 mRNA. Translation: BAG35035.1.
    AL132712 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81849.1. Sequence problems.
    CH471061 Genomic DNA. Translation: EAW81850.1.
    BC000429 mRNA. Translation: AAH00429.1.
    BC001944 mRNA. Translation: AAH01944.1.
    CCDSiCCDS45169.1. [P56378-2]
    CCDS9986.1. [P56378-1]
    RefSeqiNP_001120865.1. NM_001127393.1. [P56378-2]
    NP_004885.1. NM_004894.2. [P56378-1]
    UniGeneiHs.109052.

    Genome annotation databases

    EnsembliENST00000286953; ENSP00000286953; ENSG00000156411. [P56378-1]
    ENST00000414262; ENSP00000401770; ENSG00000156411. [P56378-2]
    ENST00000554880; ENSP00000452133; ENSG00000156411. [P56378-1]
    ENST00000557040; ENSP00000450894; ENSG00000156411. [P56378-1]
    GeneIDi9556.
    KEGGihsa:9556.
    UCSCiuc001yoi.4. human. [P56378-1]
    uc001yok.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054175 mRNA. Translation: AAC39909.1 .
    AF116639 mRNA. Translation: AAF71062.1 .
    BX161388 mRNA. Translation: CAD61878.1 .
    AK312099 mRNA. Translation: BAG35035.1 .
    AL132712 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81849.1 . Sequence problems.
    CH471061 Genomic DNA. Translation: EAW81850.1 .
    BC000429 mRNA. Translation: AAH00429.1 .
    BC001944 mRNA. Translation: AAH01944.1 .
    CCDSi CCDS45169.1. [P56378-2 ]
    CCDS9986.1. [P56378-1 ]
    RefSeqi NP_001120865.1. NM_001127393.1. [P56378-2 ]
    NP_004885.1. NM_004894.2. [P56378-1 ]
    UniGenei Hs.109052.

    3D structure databases

    ProteinModelPortali P56378.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114928. 2 interactions.
    STRINGi 9606.ENSP00000401770.

    PTM databases

    PhosphoSitei P56378.

    Proteomic databases

    MaxQBi P56378.
    PaxDbi P56378.
    PRIDEi P56378.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286953 ; ENSP00000286953 ; ENSG00000156411 . [P56378-1 ]
    ENST00000414262 ; ENSP00000401770 ; ENSG00000156411 . [P56378-2 ]
    ENST00000554880 ; ENSP00000452133 ; ENSG00000156411 . [P56378-1 ]
    ENST00000557040 ; ENSP00000450894 ; ENSG00000156411 . [P56378-1 ]
    GeneIDi 9556.
    KEGGi hsa:9556.
    UCSCi uc001yoi.4. human. [P56378-1 ]
    uc001yok.3. human.

    Organism-specific databases

    CTDi 9556.
    GeneCardsi GC14M104378.
    HGNCi HGNC:1188. C14orf2.
    HPAi HPA048772.
    HPA058978.
    HPA060520.
    MIMi 604573. gene.
    neXtProti NX_P56378.
    PharmGKBi PA25514.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47225.
    HOGENOMi HOG000276668.
    HOVERGENi HBG000027.
    InParanoidi P56378.
    KOi K18193.
    OrthoDBi EOG7H795D.
    PhylomeDBi P56378.
    TreeFami TF338412.

    Miscellaneous databases

    ChiTaRSi C14orf2. human.
    GenomeRNAii 9556.
    NextBioi 35517734.
    PROi P56378.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56378.
    Bgeei P56378.
    CleanExi HS_C14orf2.
    Genevestigatori P56378.

    Family and domain databases

    InterProi IPR012574. Mit_proteolip.
    [Graphical view ]
    PANTHERi PTHR15233. PTHR15233. 1 hit.
    Pfami PF08039. Mit_proteolip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    2. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Fetal liver.
    3. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Neuroblastoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Synovium.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei68MP_HUMAN
    AccessioniPrimary (citable) accession number: P56378
    Secondary accession number(s): B2R588, G3V5Q3, Q86TT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3