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P56377

- AP1S2_HUMAN

UniProt

P56377 - AP1S2_HUMAN

Protein

AP-1 complex subunit sigma-2

Gene

AP1S2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

    GO - Molecular functioni

    1. protein transporter activity Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. intracellular protein transport Source: InterPro
    3. membrane organization Source: Reactome
    4. post-Golgi vesicle-mediated transport Source: Reactome
    5. regulation of defense response to virus by virus Source: Reactome
    6. viral process Source: Reactome

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
    REACT_121399. MHC class II antigen presentation.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-1 complex subunit sigma-2
    Alternative name(s):
    Adaptor protein complex AP-1 subunit sigma-1B
    Adaptor-related protein complex 1 subunit sigma-1B
    Clathrin assembly protein complex 1 sigma-1B small chain
    Golgi adaptor HA1/AP1 adaptin sigma-1B subunit
    Sigma 1B subunit of AP-1 clathrin
    Sigma-adaptin 1B
    Sigma1B-adaptin
    Gene namesi
    Name:AP1S2
    ORF Names:DC22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:560. AP1S2.

    Subcellular locationi

    Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membraneclathrin-coated pit
    Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

    GO - Cellular componenti

    1. AP-type membrane coat adaptor complex Source: ProtInc
    2. coated pit Source: UniProtKB-SubCell
    3. cytoplasmic vesicle membrane Source: Reactome
    4. cytosol Source: Reactome
    5. Golgi membrane Source: Reactome
    6. lysosomal membrane Source: Reactome
    7. trans-Golgi network membrane Source: Reactome

    Keywords - Cellular componenti

    Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, X-linked 59 (MRX59) [MIM:300630]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX59 consists of a mild-to-profound mental retardation. Other features includes hypotonia early in life and delay in walking.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Mental retardation

    Organism-specific databases

    MIMi300630. phenotype.
    Orphaneti85335. Fried syndrome.
    1568. intellectual disability, X-linked - Dandy-Walker malformation - basal ganglia disease - Seizures.
    PharmGKBiPA24851.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157AP-1 complex subunit sigma-2PRO_0000193799Add
    BLAST

    Proteomic databases

    MaxQBiP56377.
    PaxDbiP56377.
    PRIDEiP56377.

    PTM databases

    PhosphoSiteiP56377.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiP56377.
    BgeeiP56377.
    CleanExiHS_AP1S2.
    GenevestigatoriP56377.

    Organism-specific databases

    HPAiHPA049894.

    Interactioni

    Subunit structurei

    Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1.

    Protein-protein interaction databases

    BioGridi114419. 7 interactions.
    MINTiMINT-3021368.
    STRINGi9606.ENSP00000328789.

    Structurei

    3D structure databases

    ProteinModelPortaliP56377.
    SMRiP56377. Positions 1-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5030.
    HOGENOMiHOG000185227.
    HOVERGENiHBG050517.
    KOiK12394.
    OMAiDMKVVYK.
    OrthoDBiEOG7S7SGC.
    PhylomeDBiP56377.
    TreeFamiTF312921.

    Family and domain databases

    InterProiIPR016635. AP_complex_ssu.
    IPR022775. AP_mu_sigma_su.
    IPR000804. Clathrin_sm-chain_CS.
    IPR011012. Longin-like_dom.
    [Graphical view]
    PANTHERiPTHR11753. PTHR11753. 1 hit.
    PfamiPF01217. Clat_adaptor_s. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
    SUPFAMiSSF64356. SSF64356. 1 hit.
    PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P56377-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE    50
    WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL 100
    DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV 150
    LEEIGLT 157
    Length:157
    Mass (Da):18,615
    Last modified:July 15, 1998 - v1
    Checksum:iDD9F59119909D89C
    GO
    Isoform 2 (identifier: P56377-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPAGCPPHSTTASLPQHGDRGFPFAAAAAAGQAPPRPRPAAAM
         143-157: EAETPRSVLEEIGLT → KTETMYHSKSFIGFKKAY

    Note: No experimental confirmation available.

    Show »
    Length:202
    Mass (Da):23,225
    Checksum:i69C7E1AE4CB98F02
    GO

    Sequence cautioni

    The sequence AAG44595.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → L in AAG44595. 1 PublicationCurated
    Sequence conflicti72 – 743DQD → ESRN in AAC72946. 1 PublicationCurated
    Sequence conflicti96 – 983SVC → QCL in AAC72946. 1 PublicationCurated
    Sequence conflicti143 – 1431E → EE in AAG44595. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MPAGCPPHSTTASLPQHGDR GFPFAAAAAAGQAPPRPRPA AAM in isoform 2. 1 PublicationVSP_053671
    Alternative sequencei143 – 15715EAETP…EIGLT → KTETMYHSKSFIGFKKAY in isoform 2. 1 PublicationVSP_053672Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015320 mRNA. Translation: BAA33392.1.
    AF251295 mRNA. Translation: AAG44595.1. Different initiation.
    BT006738 mRNA. Translation: AAP35384.1.
    AK299921 mRNA. Translation: BAG61756.1.
    AC004106 Genomic DNA. No translation available.
    BC001117 mRNA. Translation: AAH01117.1.
    BC071867 mRNA. Translation: AAH71867.1.
    AF091077 mRNA. Translation: AAC72946.1.
    CCDSiCCDS14173.1. [P56377-1]
    RefSeqiNP_003907.3. NM_003916.4. [P56377-1]
    XP_005274669.1. XM_005274612.2. [P56377-2]
    UniGeneiHs.121592.

    Genome annotation databases

    EnsembliENST00000329235; ENSP00000328789; ENSG00000182287. [P56377-1]
    GeneIDi8905.
    KEGGihsa:8905.
    UCSCiuc004cxi.4. human. [P56377-1]

    Polymorphism databases

    DMDMi3023308.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015320 mRNA. Translation: BAA33392.1 .
    AF251295 mRNA. Translation: AAG44595.1 . Different initiation.
    BT006738 mRNA. Translation: AAP35384.1 .
    AK299921 mRNA. Translation: BAG61756.1 .
    AC004106 Genomic DNA. No translation available.
    BC001117 mRNA. Translation: AAH01117.1 .
    BC071867 mRNA. Translation: AAH71867.1 .
    AF091077 mRNA. Translation: AAC72946.1 .
    CCDSi CCDS14173.1. [P56377-1 ]
    RefSeqi NP_003907.3. NM_003916.4. [P56377-1 ]
    XP_005274669.1. XM_005274612.2. [P56377-2 ]
    UniGenei Hs.121592.

    3D structure databases

    ProteinModelPortali P56377.
    SMRi P56377. Positions 1-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114419. 7 interactions.
    MINTi MINT-3021368.
    STRINGi 9606.ENSP00000328789.

    PTM databases

    PhosphoSitei P56377.

    Polymorphism databases

    DMDMi 3023308.

    Proteomic databases

    MaxQBi P56377.
    PaxDbi P56377.
    PRIDEi P56377.

    Protocols and materials databases

    DNASUi 8905.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329235 ; ENSP00000328789 ; ENSG00000182287 . [P56377-1 ]
    GeneIDi 8905.
    KEGGi hsa:8905.
    UCSCi uc004cxi.4. human. [P56377-1 ]

    Organism-specific databases

    CTDi 8905.
    GeneCardsi GC0XM015843.
    HGNCi HGNC:560. AP1S2.
    HPAi HPA049894.
    MIMi 300629. gene.
    300630. phenotype.
    neXtProti NX_P56377.
    Orphaneti 85335. Fried syndrome.
    1568. intellectual disability, X-linked - Dandy-Walker malformation - basal ganglia disease - Seizures.
    PharmGKBi PA24851.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5030.
    HOGENOMi HOG000185227.
    HOVERGENi HBG050517.
    KOi K12394.
    OMAi DMKVVYK.
    OrthoDBi EOG7S7SGC.
    PhylomeDBi P56377.
    TreeFami TF312921.

    Enzyme and pathway databases

    Reactomei REACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
    REACT_121399. MHC class II antigen presentation.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.

    Miscellaneous databases

    GeneWikii AP1S2.
    GenomeRNAii 8905.
    NextBioi 33457.
    PROi P56377.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56377.
    Bgeei P56377.
    CleanExi HS_AP1S2.
    Genevestigatori P56377.

    Family and domain databases

    InterProi IPR016635. AP_complex_ssu.
    IPR022775. AP_mu_sigma_su.
    IPR000804. Clathrin_sm-chain_CS.
    IPR011012. Longin-like_dom.
    [Graphical view ]
    PANTHERi PTHR11753. PTHR11753. 1 hit.
    Pfami PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015588. AP_complex_sigma. 1 hit.
    SUPFAMi SSF64356. SSF64356. 1 hit.
    PROSITEi PS00989. CLAT_ADAPTOR_S. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of novel clathrin adaptor-related proteins."
      Takatsu H., Sakurai M., Shin H.-W., Murakami K., Nakayama K.
      J. Biol. Chem. 273:24693-24700(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Novel genes expressed in human dendritic cell."
      Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Dendritic cell.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin and Uterus.
    7. "Full-insert sequence of mapped XREF EST."
      Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-98 (ISOFORM 1).
    8. "MUC1 membrane trafficking is modulated by multiple interactions."
      Kinlough C.L., Poland P.A., Bruns J.B., Harkleroad K.L., Hughey R.P.
      J. Biol. Chem. 279:53071-53077(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MUC1.
    9. Cited for: INVOLVEMENT IN MRX59.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAP1S2_HUMAN
    AccessioniPrimary (citable) accession number: P56377
    Secondary accession number(s): B4DSU4, O95326, Q9H2N6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3