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Protein

Acylphosphatase-1

Gene

Acyp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Its physiological role is not yet clear.

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241PROSITE-ProRule annotation
Active sitei42 – 421PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-1 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene namesi
Name:Acyp1
Synonyms:Acype
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913454. Acyp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9998Acylphosphatase-1PRO_0000158536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP56376.
MaxQBiP56376.
PaxDbiP56376.
PRIDEiP56376.

2D gel databases

REPRODUCTION-2DPAGEIPI00420440.

PTM databases

iPTMnetiP56376.
PhosphoSiteiP56376.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008822.
CleanExiMM_ACYP1.
ExpressionAtlasiP56376. baseline and differential.
GenevisibleiP56376. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008966.

Structurei

3D structure databases

ProteinModelPortaliP56376.
SMRiP56376. Positions 6-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9991Acylphosphatase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP56376.
KOiK01512.
PhylomeDBiP56376.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGDTLVSV DYEIFGKVQG VFFRKYTQAE GKKLGLVGWV QNTDRGTVQG
60 70 80 90
QLQGPVSKVR FMQQWLETRG SPKSHIDRAN FNNEKVIANL DYSDFQIVK
Length:99
Mass (Da):11,241
Last modified:January 23, 2007 - v2
Checksum:i3291F35B26338081
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004176 mRNA. Translation: BAB23208.1.
AK007244 mRNA. Translation: BAB24911.1.
AK018832 mRNA. Translation: BAB31454.1.
BC061088 mRNA. Translation: AAH61088.2.
BC116781 mRNA. Translation: AAI16782.1.
BC116783 mRNA. Translation: AAI16784.1.
CCDSiCCDS26055.1.
RefSeqiNP_079697.1. NM_025421.2.
XP_011242458.1. XM_011244156.1.
UniGeneiMm.311985.

Genome annotation databases

EnsembliENSMUST00000008966; ENSMUSP00000008966; ENSMUSG00000008822.
ENSMUST00000117138; ENSMUSP00000113161; ENSMUSG00000008822.
GeneIDi66204.
KEGGimmu:66204.
UCSCiuc007ogu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004176 mRNA. Translation: BAB23208.1.
AK007244 mRNA. Translation: BAB24911.1.
AK018832 mRNA. Translation: BAB31454.1.
BC061088 mRNA. Translation: AAH61088.2.
BC116781 mRNA. Translation: AAI16782.1.
BC116783 mRNA. Translation: AAI16784.1.
CCDSiCCDS26055.1.
RefSeqiNP_079697.1. NM_025421.2.
XP_011242458.1. XM_011244156.1.
UniGeneiMm.311985.

3D structure databases

ProteinModelPortaliP56376.
SMRiP56376. Positions 6-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008966.

PTM databases

iPTMnetiP56376.
PhosphoSiteiP56376.

2D gel databases

REPRODUCTION-2DPAGEIPI00420440.

Proteomic databases

EPDiP56376.
MaxQBiP56376.
PaxDbiP56376.
PRIDEiP56376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008966; ENSMUSP00000008966; ENSMUSG00000008822.
ENSMUST00000117138; ENSMUSP00000113161; ENSMUSG00000008822.
GeneIDi66204.
KEGGimmu:66204.
UCSCiuc007ogu.2. mouse.

Organism-specific databases

CTDi97.
MGIiMGI:1913454. Acyp1.

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP56376.
KOiK01512.
PhylomeDBiP56376.
TreeFamiTF300288.

Miscellaneous databases

PROiP56376.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008822.
CleanExiMM_ACYP1.
ExpressionAtlasiP56376. baseline and differential.
GenevisibleiP56376. MM.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACYP1_MOUSE
AccessioniPrimary (citable) accession number: P56376
Secondary accession number(s): Q0VG40, Q545K8, Q6P8S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.