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Protein

Acylphosphatase-1

Gene

Acyp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Its physiological role is not yet clear.

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei24PROSITE-ProRule annotation1
Active sitei42PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-1 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1
Gene namesi
Name:Acyp1
Synonyms:Acype
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913454. Acyp1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001585362 – 99Acylphosphatase-1Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP56376.
MaxQBiP56376.
PaxDbiP56376.
PRIDEiP56376.

2D gel databases

REPRODUCTION-2DPAGEIPI00420440.

PTM databases

iPTMnetiP56376.
PhosphoSitePlusiP56376.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008822.
CleanExiMM_ACYP1.
ExpressionAtlasiP56376. baseline and differential.
GenevisibleiP56376. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008966.

Structurei

3D structure databases

ProteinModelPortaliP56376.
SMRiP56376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 99Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP56376.
KOiK01512.
PhylomeDBiP56376.
TreeFamiTF300288.

Family and domain databases

InterProiView protein in InterPro
IPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
PfamiView protein in Pfam
PF00708. Acylphosphatase. 1 hit.
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiView protein in PROSITE
PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGDTLVSV DYEIFGKVQG VFFRKYTQAE GKKLGLVGWV QNTDRGTVQG
60 70 80 90
QLQGPVSKVR FMQQWLETRG SPKSHIDRAN FNNEKVIANL DYSDFQIVK
Length:99
Mass (Da):11,241
Last modified:January 23, 2007 - v2
Checksum:i3291F35B26338081
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004176 mRNA. Translation: BAB23208.1.
AK007244 mRNA. Translation: BAB24911.1.
AK018832 mRNA. Translation: BAB31454.1.
BC061088 mRNA. Translation: AAH61088.2.
BC116781 mRNA. Translation: AAI16782.1.
BC116783 mRNA. Translation: AAI16784.1.
CCDSiCCDS26055.1.
RefSeqiNP_079697.1. NM_025421.2.
UniGeneiMm.311985.

Genome annotation databases

EnsembliENSMUST00000008966; ENSMUSP00000008966; ENSMUSG00000008822.
ENSMUST00000117138; ENSMUSP00000113161; ENSMUSG00000008822.
GeneIDi66204.
KEGGimmu:66204.
UCSCiuc007ogu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004176 mRNA. Translation: BAB23208.1.
AK007244 mRNA. Translation: BAB24911.1.
AK018832 mRNA. Translation: BAB31454.1.
BC061088 mRNA. Translation: AAH61088.2.
BC116781 mRNA. Translation: AAI16782.1.
BC116783 mRNA. Translation: AAI16784.1.
CCDSiCCDS26055.1.
RefSeqiNP_079697.1. NM_025421.2.
UniGeneiMm.311985.

3D structure databases

ProteinModelPortaliP56376.
SMRiP56376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008966.

PTM databases

iPTMnetiP56376.
PhosphoSitePlusiP56376.

2D gel databases

REPRODUCTION-2DPAGEIPI00420440.

Proteomic databases

EPDiP56376.
MaxQBiP56376.
PaxDbiP56376.
PRIDEiP56376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008966; ENSMUSP00000008966; ENSMUSG00000008822.
ENSMUST00000117138; ENSMUSP00000113161; ENSMUSG00000008822.
GeneIDi66204.
KEGGimmu:66204.
UCSCiuc007ogu.2. mouse.

Organism-specific databases

CTDi97.
MGIiMGI:1913454. Acyp1.

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP56376.
KOiK01512.
PhylomeDBiP56376.
TreeFamiTF300288.

Miscellaneous databases

PROiP56376.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008822.
CleanExiMM_ACYP1.
ExpressionAtlasiP56376. baseline and differential.
GenevisibleiP56376. MM.

Family and domain databases

InterProiView protein in InterPro
IPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
PfamiView protein in Pfam
PF00708. Acylphosphatase. 1 hit.
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiView protein in PROSITE
PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACYP1_MOUSE
AccessioniPrimary (citable) accession number: P56376
Secondary accession number(s): Q0VG40, Q545K8, Q6P8S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: February 15, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.