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Reviewed, UniProtKB/Swiss-Prot P56376 (ACYP1_MOUSE)

Last modified November 3, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Acylphosphatase-1
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 1
    Acylphosphatase, organ-common type isozyme
Gene names
Name: Acyp1
Synonyms: Acype
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Its physiological role is not yet clear.

Catalytic activity

An acylphosphate + H2O = a carboxylate + phosphate.

Sequence similarities

Belongs to the acylphosphatase family.

Contains 1 acylphosphatase-like domain.

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Ontologies

Keywords
   Molecular functionHydrolase
   PTMAcetylation
Gene Ontology (GO)
   Molecular functionacylphosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 9998Acylphosphatase-1
PRO_0000158536

Regions

Domain9 – 9991Acylphosphatase-like

Sites

Active site241 Potential
Active site421 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity

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Sequences

Sequence LengthMass (Da)Tools
P56376-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3291F35B26338081

FASTA9911,241
        10         20         30         40         50         60 
MAEGDTLVSV DYEIFGKVQG VFFRKYTQAE GKKLGLVGWV QNTDRGTVQG QLQGPVSKVR 

        70         80         90 
FMQQWLETRG SPKSHIDRAN FNNEKVIANL DYSDFQIVK

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AK004176 mRNA. Translation: BAB23208.1.
AK007244 mRNA. Translation: BAB24911.1.
AK018832 mRNA. Translation: BAB31454.1.
BC061088 mRNA. Translation: AAH61088.2.
BC116781 mRNA. Translation: AAI16782.1.
BC116783 mRNA. Translation: AAI16784.1.
IPIIPI00420440.
RefSeqNP_079697.1.
UniGeneMm.311985

3D structure databases

HSSPHSSP built from PDB template 2ACY based on UniProtKB P41500.
SMRP56376. Positions 2-99.
ModBaseSearch...

Proteomic databases

PRIDEP56376.

Genome annotation databases

EnsemblENSMUST00000008966; ENSMUSP00000008966; ENSMUSG00000008822; Mus musculus. [Genome view]
ENSMUST00000117138; ENSMUSP00000113161; ENSMUSG00000008822; Mus musculus. [Genome view]
ENSMUST00000121930; ENSMUSP00000112609; ENSMUSG00000008822; Mus musculus. [Genome view]
GeneID66204.
KEGGmmu:66204.
UCSCuc007ogu.1. mouse.

Organism-specific databases

CTD66204.
MGIMGI:1913454. Acyp1.

Phylogenomic databases

HOVERGENP56376.
OMAHIDRANF.

Enzyme and pathway databases

BRENDA3.6.1.7. 244.

Gene expression databases

ArrayExpressP56376.
BgeeP56376.
CleanExMM_ACYP1.
GenevestigatorP56376.
GermOnlineENSMUSG00000008822. Mus musculus.

Family and domain databases

InterProIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PANTHERPTHR10029. Acylphosphatase. 1 hit.
PfamPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSPR00112. ACYLPHPHTASE.
ProDomPD001884. Acylphosphatase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio320955.
SOURCESearch...

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Entry information

Entry nameACYP1_MOUSE
AccessionPrimary (citable) accession number: P56376
Secondary accession number(s): Q0VG40, Q545K8, Q6P8S7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 3, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents