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Protein

Acylphosphatase-2

Gene

Acyp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei31PROSITE-ProRule annotation1
Active sitei49PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-2 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, muscle type isozyme
Acylphosphate phosphohydrolase 2
Gene namesi
Name:Acyp2
Synonyms:Acyp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1922822. Acyp2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585431 – 106Acylphosphatase-2Add BLAST106

Proteomic databases

PaxDbiP56375.
PeptideAtlasiP56375.
PRIDEiP56375.

PTM databases

iPTMnetiP56375.
PhosphoSitePlusiP56375.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060923.
CleanExiMM_ACYP2.
GenevisibleiP56375. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074195.

Structurei

3D structure databases

ProteinModelPortaliP56375.
SMRiP56375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 106Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP56375.
KOiK01512.
OMAiFKMFSIR.
OrthoDBiEOG091G0XR1.
PhylomeDBiP56375.
TreeFamiTF300288.

Family and domain databases

InterProiView protein in InterPro
IPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
PfamiView protein in Pfam
PF00708. Acylphosphatase. 1 hit.
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiView protein in PROSITE
PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P56375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGRRLAAM TELLKSVDYE VFGTVQGVCF RMYTEGEAKK RGLVGWVKNT
60 70 80 90 100
SKGTVTGQVQ GPEEKVDAMK SWLSKVGSPS SRIDRADFSN EKTISKLEYS

DFSIRY
Length:106
Mass (Da):11,878
Last modified:October 3, 2012 - v2
Checksum:i54866EE08A445B16
GO

Sequence cautioni

The sequence AAH27642 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4G → W in AAH27642 (PubMed:15489334).Curated1
Sequence conflicti22F → L in BAC32649 (PubMed:16141072).Curated1
Sequence conflicti63E → K in BAC32649 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046238 mRNA. Translation: BAC32649.1.
AK009134 mRNA. Translation: BAB26095.2.
AL844147, AL732595 Genomic DNA. Translation: CAI24140.2.
AL732595, AL844147 Genomic DNA. Translation: CAI26079.2.
BC027642 mRNA. Translation: AAH27642.1. Different initiation.
CCDSiCCDS24507.1.
RefSeqiNP_083620.1. NM_029344.3.
UniGeneiMm.390319.

Genome annotation databases

EnsembliENSMUST00000074613; ENSMUSP00000074195; ENSMUSG00000060923.
GeneIDi75572.
KEGGimmu:75572.
UCSCiuc007ihw.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACYP2_MOUSE
AccessioniPrimary (citable) accession number: P56375
Secondary accession number(s): Q5SPV7, Q8BQX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: June 7, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families