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Protein

Acylphosphatase-2

Gene

Acyp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei31 – 311PROSITE-ProRule annotation
Active sitei49 – 491PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-2 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, muscle type isozyme
Acylphosphate phosphohydrolase 2
Gene namesi
Name:Acyp2
Synonyms:Acyp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1922822. Acyp2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Acylphosphatase-2PRO_0000158543Add
BLAST

Proteomic databases

PaxDbiP56375.
PeptideAtlasiP56375.
PRIDEiP56375.

PTM databases

iPTMnetiP56375.
PhosphoSiteiP56375.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060923.
CleanExiMM_ACYP2.
GenevisibleiP56375. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074195.

Structurei

3D structure databases

ProteinModelPortaliP56375.
SMRiP56375. Positions 14-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 10691Acylphosphatase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP56375.
KOiK01512.
OMAiFRMYTEE.
OrthoDBiEOG091G0XR1.
PhylomeDBiP56375.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGRRLAAM TELLKSVDYE VFGTVQGVCF RMYTEGEAKK RGLVGWVKNT
60 70 80 90 100
SKGTVTGQVQ GPEEKVDAMK SWLSKVGSPS SRIDRADFSN EKTISKLEYS

DFSIRY
Length:106
Mass (Da):11,878
Last modified:October 3, 2012 - v2
Checksum:i54866EE08A445B16
GO

Sequence cautioni

The sequence AAH27642 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41G → W in AAH27642 (PubMed:15489334).Curated
Sequence conflicti22 – 221F → L in BAC32649 (PubMed:16141072).Curated
Sequence conflicti63 – 631E → K in BAC32649 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046238 mRNA. Translation: BAC32649.1.
AK009134 mRNA. Translation: BAB26095.2.
AL844147, AL732595 Genomic DNA. Translation: CAI24140.2.
AL732595, AL844147 Genomic DNA. Translation: CAI26079.2.
BC027642 mRNA. Translation: AAH27642.1. Different initiation.
CCDSiCCDS24507.1.
RefSeqiNP_083620.1. NM_029344.3.
UniGeneiMm.390319.

Genome annotation databases

EnsembliENSMUST00000074613; ENSMUSP00000074195; ENSMUSG00000060923.
GeneIDi75572.
KEGGimmu:75572.
UCSCiuc007ihw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046238 mRNA. Translation: BAC32649.1.
AK009134 mRNA. Translation: BAB26095.2.
AL844147, AL732595 Genomic DNA. Translation: CAI24140.2.
AL732595, AL844147 Genomic DNA. Translation: CAI26079.2.
BC027642 mRNA. Translation: AAH27642.1. Different initiation.
CCDSiCCDS24507.1.
RefSeqiNP_083620.1. NM_029344.3.
UniGeneiMm.390319.

3D structure databases

ProteinModelPortaliP56375.
SMRiP56375. Positions 14-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074195.

PTM databases

iPTMnetiP56375.
PhosphoSiteiP56375.

Proteomic databases

PaxDbiP56375.
PeptideAtlasiP56375.
PRIDEiP56375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074613; ENSMUSP00000074195; ENSMUSG00000060923.
GeneIDi75572.
KEGGimmu:75572.
UCSCiuc007ihw.1. mouse.

Organism-specific databases

CTDi98.
MGIiMGI:1922822. Acyp2.

Phylogenomic databases

eggNOGiKOG3360. Eukaryota.
ENOG41126ER. LUCA.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP56375.
KOiK01512.
OMAiFRMYTEE.
OrthoDBiEOG091G0XR1.
PhylomeDBiP56375.
TreeFamiTF300288.

Miscellaneous databases

PROiP56375.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060923.
CleanExiMM_ACYP2.
GenevisibleiP56375. MM.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACYP2_MOUSE
AccessioniPrimary (citable) accession number: P56375
Secondary accession number(s): Q5SPV7, Q8BQX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.