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Protein

Beta-crystallin A4

Gene

Cryba4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin A4
Alternative name(s):
Beta-A4 crystallin
Gene namesi
Name:Cryba4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi61962. Cryba4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 196195Beta-crystallin A4PRO_0000057547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP56374.
PRIDEiP56374.

PTM databases

PhosphoSiteiP56374.

Expressioni

Gene expression databases

BgeeiENSRNOG00000049770.
GenevisibleiP56374. RN.

Interactioni

Subunit structurei

Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066572.

Structurei

3D structure databases

ProteinModelPortaliP56374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 5140Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini52 – 9847Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini105 – 14642Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini147 – 19549Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1110N-terminal arm
Regioni99 – 1046Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IE7N. Eukaryota.
ENOG410YIM8. LUCA.
GeneTreeiENSGT00760000118812.
HOVERGENiHBG003364.
InParanoidiP56374.
OMAiFQVQSVR.
OrthoDBiEOG091G0JYH.
PhylomeDBiP56374.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033342. CRYBA4.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF19. PTHR11818:SF19. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQCTKSAG HWRVVVWDEE GFQGRRHEFT AECPSVLDLG FETVRSLKVL
60 70 80 90 100
SGAWVGFEHA GFQGQQYVLE RGDYPGWDAW GGNTAYPAER LTSFRPVACA
110 120 130 140 150
NHRDSRLTIF EQENFLGRKG ELSDDYPSLQ AMGWDGTEVG SFHVQSGAWV
160 170 180 190
CSQFPGYRGF QYVLESDHHS GDYKHFREWG SHAHTFQVQS VRRIQQ
Length:196
Mass (Da):22,382
Last modified:January 23, 2007 - v2
Checksum:i58527F2E0F5E1D20
GO

Mass spectrometryi

Molecular mass is 23922.0 Da from positions 2 - 196. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013247 mRNA. Translation: AAB67117.1.
RefSeqiNP_113877.1. NM_031689.1.
UniGeneiRn.10802.

Genome annotation databases

EnsembliENSRNOT00000073763; ENSRNOP00000066572; ENSRNOG00000049770.
GeneIDi64348.
KEGGirno:64348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013247 mRNA. Translation: AAB67117.1.
RefSeqiNP_113877.1. NM_031689.1.
UniGeneiRn.10802.

3D structure databases

ProteinModelPortaliP56374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066572.

PTM databases

PhosphoSiteiP56374.

Proteomic databases

PaxDbiP56374.
PRIDEiP56374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073763; ENSRNOP00000066572; ENSRNOG00000049770.
GeneIDi64348.
KEGGirno:64348.

Organism-specific databases

CTDi1413.
RGDi61962. Cryba4.

Phylogenomic databases

eggNOGiENOG410IE7N. Eukaryota.
ENOG410YIM8. LUCA.
GeneTreeiENSGT00760000118812.
HOVERGENiHBG003364.
InParanoidiP56374.
OMAiFQVQSVR.
OrthoDBiEOG091G0JYH.
PhylomeDBiP56374.

Miscellaneous databases

PROiP56374.

Gene expression databases

BgeeiENSRNOG00000049770.
GenevisibleiP56374. RN.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033342. CRYBA4.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF19. PTHR11818:SF19. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBA4_RAT
AccessioniPrimary (citable) accession number: P56374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.