P56373 (P2RX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
P2X purinoceptor 3
Short name=P2X3

Alternative name(s):
ATP receptor
Purinergic receptor

Gene names

Name:

P2RX3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for ATP that acts as a ligand-gated ion channel.
Subunit structure	Functional P2XRs are organized as homomeric and heteromeric trimers By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the P2X receptor family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavioral response to pain Inferred from electronic annotation. Source: Compara neuromuscular synaptic transmission Inferred from electronic annotation. Source: Compara peristalsis Inferred from electronic annotation. Source: Compara positive regulation of calcium ion transport into cytosol Non-traceable author statement PubMed 17895406. Source: BHF-UCL positive regulation of calcium-mediated signaling Non-traceable author statement PubMed 17895406. Source: BHF-UCL protein homooligomerization Inferred from electronic annotation. Source: Compara regulation of action potential in neuron Inferred from electronic annotation. Source: Compara regulation of synaptic plasticity Inferred from electronic annotation. Source: Compara response to ATP Inferred from electronic annotation. Source: Compara response to carbohydrate stimulus Inferred from electronic annotation. Source: Compara response to cold Inferred from electronic annotation. Source: Compara response to heat Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara sensory perception of taste Inferred from electronic annotation. Source: Compara urinary bladder smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara dendritic spine Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement PubMed 9221902. Source: ProtInc membrane raft Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara rough endoplasmic reticulum Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Non-traceable author statement PubMed 17895406. Source: BHF-UCL extracellular ATP-gated cation channel activity Non-traceable author statement PubMed 17895406. Source: BHF-UCL purinergic nucleotide receptor activity Non-traceable author statement PubMed 17895406. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	P2X purinoceptor 3		PRO_0000161551
Regions
	Topological domain	1 – 22	22	Cytoplasmic Potential
	Transmembrane	23 – 43	21	Helical; Name=1; Potential
	Topological domain	44 – 317	274	Extracellular Potential
	Transmembrane	318 – 338	21	Helical; Name=2; Potential
	Topological domain	339 – 397	59	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Glycosylation	194	1	N-linked (GlcNAc...) Potential
	Glycosylation	290	1	N-linked (GlcNAc...) Potential
	Disulfide bond	107 ↔ 153		By similarity
	Disulfide bond	116 ↔ 137		By similarity
	Disulfide bond	122 ↔ 147		By similarity
	Disulfide bond	203 ↔ 213		By similarity
	Disulfide bond	247 ↔ 256		By similarity
Natural variations
	Natural variant	383	1	A → V. Ref.2 Corresponds to variant rs2276038 [ dbSNP | Ensembl ].		VAR_034674
Experimental info
	Sequence conflict	126	1	R → P in CAA68947. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P56373 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 3CB0081E65748EED	FASTA	397	44,289
	10 20 30 40 50 60 MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ VRDTAIESSV 70 80 90 100 110 120 VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE NQMQGFCPES EEKYRCVSDS 130 140 150 160 170 180 QCGPERLPGG GILTGRCVNY SSVLRTCEIQ GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR 190 200 210 220 230 240 FPLFNFEKGN LLPNLTARDM KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG 250 260 270 280 290 300 IKIGWVCDLD KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 310 320 330 340 350 360 FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA DQYKAKKFEE 370 380 390 VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue." Garcia-Guzman M., Soto F., Gomez-Hernandez J.M., Lund P.E., Stuhmer W. Mol. Pharmacol. 51:109-118(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Cloning of a cDNA for human P2X3 purinoceptor variant." Funatsuki K., Tanaka R., Inagaki S., Kawamura Y., Hashimoto Y., Yukioka H., Okuda U., Katoh K. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-383. Tissue: Heart.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Web resources

Wikipedia

P2X receptor entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y07683 mRNA. Translation: CAA68947.1. AB016608 mRNA. Translation: BAA76515.1. AP000781 Genomic DNA. No translation available. BC074792 mRNA. Translation: AAH74792.1. BC074793 mRNA. Translation: AAH74793.1. BC109287 mRNA. Translation: AAI09288.1.
IPI	IPI00290106.
RefSeq	NP_002550.2. NM_002559.3.
UniGene	Hs.146738.
3D structure databases
ProteinModelPortal	P56373.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000263314.
PTM databases
PhosphoSite	P56373.
Polymorphism databases
DMDM	259016295.
Proteomic databases
PaxDb	P56373.
PRIDE	P56373.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263314; ENSP00000263314; ENSG00000109991.
GeneID	5024.
KEGG	hsa:5024.
UCSC	uc001nju.3. human.
Organism-specific databases
CTD	5024.
GeneCards	GC11P057105.
H-InvDB	HIX0035814.
HGNC	HGNC:8534. P2RX3.
MIM	600843. gene.
neXtProt	NX_P56373.
PharmGKB	PA32863.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40178.
HOGENOM	HOG000232042.
HOVERGEN	HBG053086.
InParanoid	P56373.
KO	K05217.
OMA	ISYFVGW.
PhylomeDB	P56373.
Gene expression databases
ArrayExpress	P56373.
Bgee	P56373.
CleanEx	HS_P2RX3.
Genevestigator	P56373.
GermOnline	ENSG00000109991. Homo sapiens.
Family and domain databases
Gene3D	2.60.490.10. 1 hit.
InterPro	IPR003046. P2X3_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor. [Graphical view]
PANTHER	PTHR10125. PTHR10125. 1 hit. PTHR10125:SF8. PTHR10125:SF8. 1 hit.
Pfam	PF00864. P2X_receptor. 1 hit. [Graphical view]
PRINTS	PR01310. P2X3RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMs	TIGR00863. P2X. 1 hit.
PROSITE	PS01212. P2X_RECEPTOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P56373.
ChEMBL	CHEMBL2998.
GenomeRNAi	5024.
NextBio	19340.
SOURCE	Search...

Entry information

Entry name

P2RX3_HUMAN

Accession

Primary (citable) accession number: P56373
Secondary accession number(s): Q6DK37, Q9UQB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.