P56373 (P2RX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 92.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: P2X purinoceptor 3 Short name=P2X3 Alternative name(s): ATP receptor Purinergic receptor | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 397 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Receptor for ATP that acts as a ligand-gated ion channel. |
| Subunit structure | Homo- or heteropolymers By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the P2X receptor family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Ionic channel Ligand-gated ion channel Receptor |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | positive regulation of calcium ion transport into cytosol Non-traceable author statement. Source: BHF-UCL positive regulation of calcium-mediated signalingNon-traceable author statement. Source: BHF-UCL |
| Cellular component | integral to plasma membrane Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Non-traceable author statement. Source: BHF-UCL extracellular ATP-gated cation channel activityNon-traceable author statement. Source: BHF-UCL purinergic nucleotide receptor activityNon-traceable author statement. Source: BHF-UCL |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 397 | 397 | P2X purinoceptor 3 | PRO_0000161551 | |||||
Regions | |||||||||
| Topological domain | 1 – 22 | 22 | Cytoplasmic Potential | ||||||
| Transmembrane | 23 – 43 | 21 | Helical; Name=1; Potential | ||||||
| Topological domain | 44 – 317 | 274 | Extracellular Potential | ||||||
| Transmembrane | 318 – 338 | 21 | Helical; Name=2; Potential | ||||||
| Topological domain | 339 – 397 | 59 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 139 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 170 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 194 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 290 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 383 | 1 | A → V. Ref.2 Corresponds to variant rs2276038 [ dbSNP | Ensembl ]. | VAR_034674 | |||||
Experimental info | |||||||||
| Sequence conflict | 126 | 1 | R → P in CAA68947. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue." Garcia-Guzman M., Soto F., Gomez-Hernandez J.M., Lund P.E., Stuhmer W. Mol. Pharmacol. 51:109-118(1997) [PubMed: 9016352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| [2] | "Cloning of a cDNA for human P2X3 purinoceptor variant." Funatsuki K., Tanaka R., Inagaki S., Kawamura Y., Hashimoto Y., Yukioka H., Okuda U., Katoh K. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-383. Tissue: Heart. |
| [3] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Web resources
| Wikipedia P2X receptor entry |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y07683 mRNA. Translation: CAA68947.1. AB016608 mRNA. Translation: BAA76515.1. AP000781 Genomic DNA. No translation available. BC074792 mRNA. Translation: AAH74792.1. BC074793 mRNA. Translation: AAH74793.1. BC109287 mRNA. Translation: AAI09288.1. |
| IPI | IPI00290106. |
| RefSeq | NP_002550.2. NM_002559.3. |
| UniGene | Hs.146738. |
3D structure databases | |
| ProteinModelPortal | P56373. |
| SMR | P56373. Positions 24-344. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P56373. |
PTM databases | |
| PhosphoSite | P56373. |
Polymorphism databases | |
| DMDM | 259016295. |
Proteomic databases | |
| PRIDE | P56373. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000263314; ENSP00000263314; ENSG00000109991. |
| GeneID | 5024. |
| KEGG | hsa:5024. |
Organism-specific databases | |
| CTD | 5024. |
| GeneCards | GC11P057105. |
| H-InvDB | HIX0035814. |
| HGNC | HGNC:8534. P2RX3. |
| MIM | 600843. gene. |
| neXtProt | NX_P56373. |
| PharmGKB | PA32863. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG06956. |
| GeneTree | ENSGT00390000016028. |
| HOGENOM | HBG713324. |
| HOVERGEN | HBG053086. |
| InParanoid | P56373. |
| OMA | ISYFVGW. |
| PhylomeDB | P56373. |
Gene expression databases | |
| ArrayExpress | P56373. |
| Bgee | P56373. |
| CleanEx | HS_P2RX3. |
| Genevestigator | P56373. |
| GermOnline | ENSG00000109991. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR003046. P2X3_purnocptor. IPR001429. P2X_purnocptor. [Graphical view] |
| KO | K05217. |
| PANTHER | PTHR10125. ATP_P2X_rcpt. 1 hit. PTHR10125:SF8. P2X3_purnocptor. 1 hit. |
| Pfam | PF00864. P2X_receptor. 1 hit. [Graphical view] |
| PRINTS | PR01310. P2X3RECEPTOR. PR01307. P2XRECEPTOR. |
| TIGRFAMs | TIGR00863. P2X. 1 hit. |
| PROSITE | PS01212. P2X_RECEPTOR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 19340. |
| SOURCE | Search... |
Entry information
| Entry name | P2RX3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P56373 Secondary accession number(s): Q6DK37, Q9UQB6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with