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P56373 (P2RX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2X purinoceptor 3

Short name=P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene names
Name:P2RX3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for ATP that acts as a ligand-gated ion channel.

Subunit structure

Functional P2XRs are organized as homomeric and heteromeric trimers By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the P2X receptor family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbehavioral response to pain

Inferred from electronic annotation. Source: Ensembl

neuromuscular synaptic transmission

Inferred from electronic annotation. Source: Ensembl

neuronal action potential

Inferred from electronic annotation. Source: Ensembl

peristalsis

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion transport into cytosol

Non-traceable author statement PubMed 17895406. Source: BHF-UCL

positive regulation of calcium-mediated signaling

Non-traceable author statement PubMed 17895406. Source: BHF-UCL

protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

purinergic nucleotide receptor signaling pathway

Non-traceable author statement PubMed 17895406. Source: GOC

regulation of synaptic plasticity

Inferred from electronic annotation. Source: Ensembl

response to ATP

Inferred from electronic annotation. Source: Ensembl

response to carbohydrate

Inferred from electronic annotation. Source: Ensembl

response to cold

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

sensory perception of taste

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement PubMed 9221902. Source: ProtInc

transport

Traceable author statement PubMed 9221902. Source: ProtInc

urinary bladder smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

dendritic spine

Inferred from electronic annotation. Source: Ensembl

integral component of nuclear inner membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of plasma membrane

Traceable author statement PubMed 9221902. Source: ProtInc

membrane raft

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

rough endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Non-traceable author statement PubMed 17895406. Source: BHF-UCL

extracellular ATP-gated cation channel activity

Non-traceable author statement PubMed 17895406. Source: BHF-UCL

purinergic nucleotide receptor activity

Non-traceable author statement PubMed 17895406. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397P2X purinoceptor 3
PRO_0000161551

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4321Helical; Name=1; Potential
Topological domain44 – 317274Extracellular Potential
Transmembrane318 – 33821Helical; Name=2; Potential
Topological domain339 – 39759Cytoplasmic Potential

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Disulfide bond107 ↔ 153 By similarity
Disulfide bond116 ↔ 137 By similarity
Disulfide bond122 ↔ 147 By similarity
Disulfide bond203 ↔ 213 By similarity
Disulfide bond247 ↔ 256 By similarity

Natural variations

Natural variant3831A → V. Ref.2
Corresponds to variant rs2276038 [ dbSNP | Ensembl ].
VAR_034674

Experimental info

Sequence conflict1261R → P in CAA68947. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P56373 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 3CB0081E65748EED

FASTA39744,289
        10         20         30         40         50         60 
MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ VRDTAIESSV 

        70         80         90        100        110        120 
VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE NQMQGFCPES EEKYRCVSDS 

       130        140        150        160        170        180 
QCGPERLPGG GILTGRCVNY SSVLRTCEIQ GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR 

       190        200        210        220        230        240 
FPLFNFEKGN LLPNLTARDM KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG 

       250        260        270        280        290        300 
IKIGWVCDLD KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 

       310        320        330        340        350        360 
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA DQYKAKKFEE 

       370        380        390 
VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue."
Garcia-Guzman M., Soto F., Gomez-Hernandez J.M., Lund P.E., Stuhmer W.
Mol. Pharmacol. 51:109-118(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Cloning of a cDNA for human P2X3 purinoceptor variant."
Funatsuki K., Tanaka R., Inagaki S., Kawamura Y., Hashimoto Y., Yukioka H., Okuda U., Katoh K.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-383.
Tissue: Heart.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

Wikipedia

P2X receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y07683 mRNA. Translation: CAA68947.1.
AB016608 mRNA. Translation: BAA76515.1.
AP000781 Genomic DNA. No translation available.
BC074792 mRNA. Translation: AAH74792.1.
BC074793 mRNA. Translation: AAH74793.1.
BC109287 mRNA. Translation: AAI09288.1.
RefSeqNP_002550.2. NM_002559.3.
UniGeneHs.146738.

3D structure databases

ProteinModelPortalP56373.
SMRP56373. Positions 24-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000263314.

Chemistry

BindingDBP56373.
ChEMBLCHEMBL2998.
GuidetoPHARMACOLOGY480.

Protein family/group databases

TCDB1.A.7.1.6. the atp-gated p2x receptor cation channel (p2x receptor) family.

PTM databases

PhosphoSiteP56373.

Polymorphism databases

DMDM259016295.

Proteomic databases

PaxDbP56373.
PRIDEP56373.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263314; ENSP00000263314; ENSG00000109991.
GeneID5024.
KEGGhsa:5024.
UCSCuc001nju.3. human.

Organism-specific databases

CTD5024.
GeneCardsGC11P057105.
H-InvDBHIX0035814.
HGNCHGNC:8534. P2RX3.
HPAHPA057776.
MIM600843. gene.
neXtProtNX_P56373.
PharmGKBPA32863.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40178.
HOGENOMHOG000232042.
HOVERGENHBG053086.
InParanoidP56373.
KOK05217.
OMAISYFVGW.
OrthoDBEOG78PV92.
PhylomeDBP56373.
TreeFamTF328633.

Gene expression databases

ArrayExpressP56373.
BgeeP56373.
CleanExHS_P2RX3.
GenevestigatorP56373.

Family and domain databases

Gene3D2.60.490.10. 1 hit.
InterProIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsTIGR00863. P2X. 1 hit.
PROSITEPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiP2RX3.
GenomeRNAi5024.
NextBio19340.
PROP56373.
SOURCESearch...

Entry information

Entry nameP2RX3_HUMAN
AccessionPrimary (citable) accession number: P56373
Secondary accession number(s): Q6DK37, Q9UQB6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM