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Protein

P2X purinoceptor 3

Gene

P2RX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

  1. ATP binding Source: BHF-UCL
  2. extracellular ATP-gated cation channel activity Source: BHF-UCL
  3. purinergic nucleotide receptor activity Source: BHF-UCL

GO - Biological processi

  1. behavioral response to pain Source: Ensembl
  2. neuromuscular synaptic transmission Source: Ensembl
  3. neuronal action potential Source: Ensembl
  4. peristalsis Source: Ensembl
  5. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
  6. positive regulation of calcium-mediated signaling Source: BHF-UCL
  7. protein homooligomerization Source: Ensembl
  8. purinergic nucleotide receptor signaling pathway Source: GOC
  9. regulation of synaptic plasticity Source: Ensembl
  10. response to ATP Source: Ensembl
  11. response to carbohydrate Source: Ensembl
  12. response to cold Source: Ensembl
  13. response to heat Source: Ensembl
  14. response to hypoxia Source: Ensembl
  15. response to mechanical stimulus Source: Ensembl
  16. sensory perception of taste Source: Ensembl
  17. signal transduction Source: ProtInc
  18. transport Source: ProtInc
  19. urinary bladder smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.7.1.6. the atp-gated p2x receptor cation channel (p2x receptor) family.

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 3
Short name:
P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8534. P2RX3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini44 – 317274ExtracellularSequence AnalysisAdd
BLAST
Transmembranei318 – 33821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini339 – 39759CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dendritic spine Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. integral component of nuclear inner membrane Source: GO_Central
  4. integral component of plasma membrane Source: ProtInc
  5. membrane raft Source: Ensembl
  6. neuronal cell body Source: Ensembl
  7. receptor complex Source: MGI
  8. rough endoplasmic reticulum Source: Ensembl
  9. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32863.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397P2X purinoceptor 3PRO_0000161551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 153By similarity
Disulfide bondi116 ↔ 137By similarity
Disulfide bondi122 ↔ 147By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi203 ↔ 213By similarity
Disulfide bondi247 ↔ 256By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56373.
PRIDEiP56373.

PTM databases

PhosphoSiteiP56373.

Expressioni

Gene expression databases

BgeeiP56373.
CleanExiHS_P2RX3.
ExpressionAtlasiP56373. baseline and differential.
GenevestigatoriP56373.

Organism-specific databases

HPAiHPA057776.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000263314.

Structurei

3D structure databases

ProteinModelPortaliP56373.
SMRiP56373. Positions 24-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40178.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP56373.
KOiK05217.
OMAiVGWVFLH.
OrthoDBiEOG78PV92.
PhylomeDBiP56373.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ
60 70 80 90 100
VRDTAIESSV VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE
110 120 130 140 150
NQMQGFCPES EEKYRCVSDS QCGPERLPGG GILTGRCVNY SSVLRTCEIQ
160 170 180 190 200
GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTARDM
210 220 230 240 250
KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD
260 270 280 290 300
KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA
310 320 330 340 350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA
360 370 380 390
DQYKAKKFEE VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH
Length:397
Mass (Da):44,289
Last modified:September 22, 2009 - v2
Checksum:i3CB0081E65748EED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261R → P in CAA68947 (PubMed:9016352).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti383 – 3831A → V.1 Publication
Corresponds to variant rs2276038 [ dbSNP | Ensembl ].
VAR_034674

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07683 mRNA. Translation: CAA68947.1.
AB016608 mRNA. Translation: BAA76515.1.
AP000781 Genomic DNA. No translation available.
BC074792 mRNA. Translation: AAH74792.1.
BC074793 mRNA. Translation: AAH74793.1.
BC109287 mRNA. Translation: AAI09288.1.
CCDSiCCDS7953.1.
RefSeqiNP_002550.2. NM_002559.3.
UniGeneiHs.146738.

Genome annotation databases

EnsembliENST00000263314; ENSP00000263314; ENSG00000109991.
GeneIDi5024.
KEGGihsa:5024.
UCSCiuc001nju.3. human.

Polymorphism databases

DMDMi259016295.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07683 mRNA. Translation: CAA68947.1.
AB016608 mRNA. Translation: BAA76515.1.
AP000781 Genomic DNA. No translation available.
BC074792 mRNA. Translation: AAH74792.1.
BC074793 mRNA. Translation: AAH74793.1.
BC109287 mRNA. Translation: AAI09288.1.
CCDSiCCDS7953.1.
RefSeqiNP_002550.2. NM_002559.3.
UniGeneiHs.146738.

3D structure databases

ProteinModelPortaliP56373.
SMRiP56373. Positions 24-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263314.

Chemistry

BindingDBiP56373.
ChEMBLiCHEMBL2998.
GuidetoPHARMACOLOGYi480.

Protein family/group databases

TCDBi1.A.7.1.6. the atp-gated p2x receptor cation channel (p2x receptor) family.

PTM databases

PhosphoSiteiP56373.

Polymorphism databases

DMDMi259016295.

Proteomic databases

PaxDbiP56373.
PRIDEiP56373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263314; ENSP00000263314; ENSG00000109991.
GeneIDi5024.
KEGGihsa:5024.
UCSCiuc001nju.3. human.

Organism-specific databases

CTDi5024.
GeneCardsiGC11P057105.
H-InvDBHIX0035814.
HGNCiHGNC:8534. P2RX3.
HPAiHPA057776.
MIMi600843. gene.
neXtProtiNX_P56373.
PharmGKBiPA32863.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40178.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP56373.
KOiK05217.
OMAiVGWVFLH.
OrthoDBiEOG78PV92.
PhylomeDBiP56373.
TreeFamiTF328633.

Miscellaneous databases

ChiTaRSiP2RX3. human.
GeneWikiiP2RX3.
GenomeRNAii5024.
NextBioi19340.
PROiP56373.
SOURCEiSearch...

Gene expression databases

BgeeiP56373.
CleanExiHS_P2RX3.
ExpressionAtlasiP56373. baseline and differential.
GenevestigatoriP56373.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue."
    Garcia-Guzman M., Soto F., Gomez-Hernandez J.M., Lund P.E., Stuhmer W.
    Mol. Pharmacol. 51:109-118(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Cloning of a cDNA for human P2X3 purinoceptor variant."
    Funatsuki K., Tanaka R., Inagaki S., Kawamura Y., Hashimoto Y., Yukioka H., Okuda U., Katoh K.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-383.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiP2RX3_HUMAN
AccessioniPrimary (citable) accession number: P56373
Secondary accession number(s): Q6DK37, Q9UQB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 22, 2009
Last modified: March 4, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.