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Protein

P2X purinoceptor 3

Gene

P2RX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

  • ATP binding Source: BHF-UCL
  • extracellular ATP-gated cation channel activity Source: BHF-UCL
  • purinergic nucleotide receptor activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109991-MONOMER.
ReactomeiR-HSA-139853. Elevation of cytosolic Ca2+ levels.
R-HSA-418346. Platelet homeostasis.

Protein family/group databases

TCDBi1.A.7.1.6. the atp-gated p2x receptor cation channel (p2x receptor) family.

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 3
Short name:
P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8534. P2RX3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 317ExtracellularSequence analysisAdd BLAST274
Transmembranei318 – 338Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini339 – 397CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5024.
OpenTargetsiENSG00000109991.
PharmGKBiPA32863.

Chemistry databases

ChEMBLiCHEMBL2998.
GuidetoPHARMACOLOGYi480.

Polymorphism and mutation databases

BioMutaiP2RX3.
DMDMi259016295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615511 – 397P2X purinoceptor 3Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi107 ↔ 153By similarity
Disulfide bondi116 ↔ 137By similarity
Disulfide bondi122 ↔ 147By similarity
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Glycosylationi170N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi203 ↔ 213By similarity
Disulfide bondi247 ↔ 256By similarity
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP56373.
PaxDbiP56373.
PRIDEiP56373.

PTM databases

iPTMnetiP56373.
PhosphoSitePlusiP56373.

Expressioni

Gene expression databases

BgeeiENSG00000109991.
CleanExiHS_P2RX3.
ExpressionAtlasiP56373. baseline and differential.
GenevisibleiP56373. HS.

Organism-specific databases

HPAiHPA057776.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000263314.

Chemistry databases

BindingDBiP56373.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SVJX-ray2.98A6-364[»]
5SVKX-ray2.77A/B6-364[»]
5SVLX-ray2.90A/B6-364[»]
5SVMX-ray3.09A/B6-364[»]
5SVPX-ray3.30A/B6-364[»]
5SVQX-ray3.25A6-364[»]
5SVRX-ray3.13A6-364[»]
5SVSX-ray4.03A6-364[»]
5SVTX-ray3.79A6-364[»]
ProteinModelPortaliP56373.
SMRiP56373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP56373.
KOiK05217.
OMAiVLRTCEI.
OrthoDBiEOG091G0A2U.
PhylomeDBiP56373.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ
60 70 80 90 100
VRDTAIESSV VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE
110 120 130 140 150
NQMQGFCPES EEKYRCVSDS QCGPERLPGG GILTGRCVNY SSVLRTCEIQ
160 170 180 190 200
GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTARDM
210 220 230 240 250
KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD
260 270 280 290 300
KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA
310 320 330 340 350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA
360 370 380 390
DQYKAKKFEE VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH
Length:397
Mass (Da):44,289
Last modified:September 22, 2009 - v2
Checksum:i3CB0081E65748EED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126R → P in CAA68947 (PubMed:9016352).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034674383A → V.1 PublicationCorresponds to variant rs2276038dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07683 mRNA. Translation: CAA68947.1.
AB016608 mRNA. Translation: BAA76515.1.
AP000781 Genomic DNA. No translation available.
BC074792 mRNA. Translation: AAH74792.1.
BC074793 mRNA. Translation: AAH74793.1.
BC109287 mRNA. Translation: AAI09288.1.
CCDSiCCDS7953.1.
RefSeqiNP_002550.2. NM_002559.3.
XP_011543371.1. XM_011545069.2.
XP_011543372.1. XM_011545070.2.
UniGeneiHs.146738.

Genome annotation databases

EnsembliENST00000263314; ENSP00000263314; ENSG00000109991.
GeneIDi5024.
KEGGihsa:5024.
UCSCiuc001nju.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07683 mRNA. Translation: CAA68947.1.
AB016608 mRNA. Translation: BAA76515.1.
AP000781 Genomic DNA. No translation available.
BC074792 mRNA. Translation: AAH74792.1.
BC074793 mRNA. Translation: AAH74793.1.
BC109287 mRNA. Translation: AAI09288.1.
CCDSiCCDS7953.1.
RefSeqiNP_002550.2. NM_002559.3.
XP_011543371.1. XM_011545069.2.
XP_011543372.1. XM_011545070.2.
UniGeneiHs.146738.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SVJX-ray2.98A6-364[»]
5SVKX-ray2.77A/B6-364[»]
5SVLX-ray2.90A/B6-364[»]
5SVMX-ray3.09A/B6-364[»]
5SVPX-ray3.30A/B6-364[»]
5SVQX-ray3.25A6-364[»]
5SVRX-ray3.13A6-364[»]
5SVSX-ray4.03A6-364[»]
5SVTX-ray3.79A6-364[»]
ProteinModelPortaliP56373.
SMRiP56373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263314.

Chemistry databases

BindingDBiP56373.
ChEMBLiCHEMBL2998.
GuidetoPHARMACOLOGYi480.

Protein family/group databases

TCDBi1.A.7.1.6. the atp-gated p2x receptor cation channel (p2x receptor) family.

PTM databases

iPTMnetiP56373.
PhosphoSitePlusiP56373.

Polymorphism and mutation databases

BioMutaiP2RX3.
DMDMi259016295.

Proteomic databases

EPDiP56373.
PaxDbiP56373.
PRIDEiP56373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263314; ENSP00000263314; ENSG00000109991.
GeneIDi5024.
KEGGihsa:5024.
UCSCiuc001nju.4. human.

Organism-specific databases

CTDi5024.
DisGeNETi5024.
GeneCardsiP2RX3.
H-InvDBHIX0035814.
HGNCiHGNC:8534. P2RX3.
HPAiHPA057776.
MIMi600843. gene.
neXtProtiNX_P56373.
OpenTargetsiENSG00000109991.
PharmGKBiPA32863.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
GeneTreeiENSGT00390000016028.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiP56373.
KOiK05217.
OMAiVLRTCEI.
OrthoDBiEOG091G0A2U.
PhylomeDBiP56373.
TreeFamiTF328633.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109991-MONOMER.
ReactomeiR-HSA-139853. Elevation of cytosolic Ca2+ levels.
R-HSA-418346. Platelet homeostasis.

Miscellaneous databases

ChiTaRSiP2RX3. human.
GeneWikiiP2RX3.
GenomeRNAii5024.
PROiP56373.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109991.
CleanExiHS_P2RX3.
ExpressionAtlasiP56373. baseline and differential.
GenevisibleiP56373. HS.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX3_HUMAN
AccessioniPrimary (citable) accession number: P56373
Secondary accession number(s): Q6DK37, Q9UQB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.