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Protein

Ras-related protein Rab-4A

Gene

Rab4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity
Nucleotide bindingi156 – 1583GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • membrane organization Source: Reactome
  • protein transport Source: MGI
  • Rab protein signal transduction Source: Ensembl
  • regulation of endocytosis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4A
Gene namesi
Name:Rab4a
Synonyms:Rab4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:105069. Rab4a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Ras-related protein Rab-4APRO_0000121094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei190 – 1901PhosphoserineBy similarity
Modified residuei204 – 2041Phosphoserine; by CDK1By similarity
Lipidationi216 – 2161S-geranylgeranyl cysteineBy similarity
Modified residuei218 – 2181Cysteine methyl esterBy similarity
Lipidationi218 – 2181S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP56371.
PRIDEiP56371.

PTM databases

PhosphoSiteiP56371.
SwissPalmiP56371.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019478.
CleanExiMM_RAB4A.
GenevisibleiP56371. MM.

Interactioni

Subunit structurei

Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin. Interacts with RAB11FIP1, RABEP1 and ZFYVE20 (By similarity). Interacts with RUFY1. Interacts with SGSM1, SGSM2 and SGSM3.By similarity2 Publications

Protein-protein interaction databases

BioGridi202546. 1 interaction.
IntActiP56371. 19 interactions.
MINTiMINT-255793.
STRINGi10090.ENSMUSP00000113401.

Structurei

3D structure databases

ProteinModelPortaliP56371.
SMRiP56371. Positions 7-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0086. Eukaryota.
ENOG410XQ9X. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP56371.
KOiK07879.
OMAiMVKLQIW.
OrthoDBiEOG091G0QOB.
PhylomeDBiP56371.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF
60 70 80 90 100
GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET
110 120 130 140 150
YNALTNWLTD ARMLASQNIV LILCGNKKDL DADREVTFLE ASRFAQENEL
160 170 180 190 200
MFLETSALTG ENVEEAFMQC ARKILNKIES GELDPERMGS GIQYGDAALR
210
QLRSPRRTQA PSAQECGC
Length:218
Mass (Da):24,409
Last modified:March 6, 2013 - v2
Checksum:iE471820A506CDA01
GO

Sequence cautioni

The sequence BAA24034 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481V → M in BAA24034 (PubMed:8950022).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86563 mRNA. Translation: BAA24034.1. Different initiation.
AB232591 mRNA. Translation: BAF02853.1.
AK136566 mRNA. Translation: BAE23048.1.
AK161877 mRNA. Translation: BAE36619.1.
AC147266 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11755.1.
CCDSiCCDS52703.1.
RefSeqiNP_033029.2. NM_009003.3.
UniGeneiMm.9221.

Genome annotation databases

EnsembliENSMUST00000117702; ENSMUSP00000113401; ENSMUSG00000019478.
ENSMUST00000118535; ENSMUSP00000113886; ENSMUSG00000019478.
GeneIDi19341.
KEGGimmu:19341.
UCSCiuc009nwo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86563 mRNA. Translation: BAA24034.1. Different initiation.
AB232591 mRNA. Translation: BAF02853.1.
AK136566 mRNA. Translation: BAE23048.1.
AK161877 mRNA. Translation: BAE36619.1.
AC147266 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11755.1.
CCDSiCCDS52703.1.
RefSeqiNP_033029.2. NM_009003.3.
UniGeneiMm.9221.

3D structure databases

ProteinModelPortaliP56371.
SMRiP56371. Positions 7-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202546. 1 interaction.
IntActiP56371. 19 interactions.
MINTiMINT-255793.
STRINGi10090.ENSMUSP00000113401.

PTM databases

PhosphoSiteiP56371.
SwissPalmiP56371.

Proteomic databases

PaxDbiP56371.
PRIDEiP56371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117702; ENSMUSP00000113401; ENSMUSG00000019478.
ENSMUST00000118535; ENSMUSP00000113886; ENSMUSG00000019478.
GeneIDi19341.
KEGGimmu:19341.
UCSCiuc009nwo.2. mouse.

Organism-specific databases

CTDi5867.
MGIiMGI:105069. Rab4a.

Phylogenomic databases

eggNOGiKOG0086. Eukaryota.
ENOG410XQ9X. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP56371.
KOiK07879.
OMAiMVKLQIW.
OrthoDBiEOG091G0QOB.
PhylomeDBiP56371.
TreeFamiTF300032.

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

PROiP56371.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019478.
CleanExiMM_RAB4A.
GenevisibleiP56371. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB4A_MOUSE
AccessioniPrimary (citable) accession number: P56371
Secondary accession number(s): Q3TSQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 6, 2013
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.