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Protein

Ras-related protein Rab-4A

Gene

Rab4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4
Nucleotide bindingi156 – 158GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • membrane organization Source: Reactome
  • protein transport Source: MGI
  • Rab protein signal transduction Source: Ensembl
  • regulation of endocytosis Source: MGI

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660499. Synthesis of PIPs at the plasma membrane.
R-MMU-8854214. TBC/RABGAPs.
R-MMU-8875656. MET receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4A
Gene namesi
Name:Rab4a
Synonyms:Rab4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:105069. Rab4a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210941 – 218Ras-related protein Rab-4AAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190PhosphoserineBy similarity1
Modified residuei204Phosphoserine; by CDK1By similarity1
Lipidationi216S-geranylgeranyl cysteineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP56371.
PRIDEiP56371.

PTM databases

PhosphoSitePlusiP56371.
SwissPalmiP56371.

Expressioni

Tissue specificityi

Expressed in the central nervous system, including cortex, cerebellum, midbrain and spinal cord, and in the kidney, lung, liver and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000019478.
CleanExiMM_RAB4A.
ExpressionAtlasiP56371. baseline and differential.
GenevisibleiP56371. MM.

Interactioni

Subunit structurei

Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin. Interacts with RAB11FIP1, RABEP1 and ZFYVE20. Interacts with RABEP1 and RBSN (By similarity). Interacts (in GTP-bound form) with GRIPAP1 (via N-terminus) (By similarity). Interacts with RUFY1 (PubMed:11172003). Interacts with SGSM1, SGSM2 and SGSM3 (PubMed:17509819). Does not interact with HPS4 (PubMed:20048159).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202546. 1 interactor.
IntActiP56371. 19 interactors.
MINTiMINT-255793.
STRINGi10090.ENSMUSP00000113401.

Structurei

3D structure databases

ProteinModelPortaliP56371.
SMRiP56371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0086. Eukaryota.
ENOG410XQ9X. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP56371.
KOiK07879.
OMAiQNICILL.
OrthoDBiEOG091G0QOB.
PhylomeDBiP56371.
TreeFamiTF300032.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

P56371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF
60 70 80 90 100
GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET
110 120 130 140 150
YNALTNWLTD ARMLASQNIV LILCGNKKDL DADREVTFLE ASRFAQENEL
160 170 180 190 200
MFLETSALTG ENVEEAFMQC ARKILNKIES GELDPERMGS GIQYGDAALR
210
QLRSPRRTQA PSAQECGC
Length:218
Mass (Da):24,409
Last modified:March 6, 2013 - v2
Checksum:iE471820A506CDA01
GO

Sequence cautioni

The sequence BAA24034 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48V → M in BAA24034 (PubMed:8950022).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86563 mRNA. Translation: BAA24034.1. Different initiation.
AB232591 mRNA. Translation: BAF02853.1.
AK136566 mRNA. Translation: BAE23048.1.
AK161877 mRNA. Translation: BAE36619.1.
AC147266 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11755.1.
CCDSiCCDS52703.1.
RefSeqiNP_033029.2. NM_009003.3.
UniGeneiMm.9221.

Genome annotation databases

EnsembliENSMUST00000117702; ENSMUSP00000113401; ENSMUSG00000019478.
ENSMUST00000118535; ENSMUSP00000113886; ENSMUSG00000019478.
GeneIDi19341.
KEGGimmu:19341.
UCSCiuc009nwo.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRAB4A_MOUSE
AccessioniPrimary (citable) accession number: P56371
Secondary accession number(s): Q3TSQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 6, 2013
Last modified: November 22, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families