Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P56283 (ANFC_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-type natriuretic peptide

Cleaved into the following 3 chains:

  1. CNP-22
  2. CNP-29
  3. CNP-53
Gene names
Name:NPPC
Synonyms:CNP
OrganismOvis aries (Sheep) [Complete proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the natriuretic peptide family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 7350 Potential
PRO_0000001569
Peptide74 – 12653CNP-53 By similarity
PRO_0000001570
Peptide98 – 12629CNP-29 By similarity
PRO_0000001571
Peptide105 – 12622CNP-22
PRO_0000001572

Amino acid modifications

Disulfide bond110 ↔ 126 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56283 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 83C21B3C49A8F18B

FASTA12613,317
        10         20         30         40         50         60 
MHLSQLLACA LLLSLLSLRP SEAKPGAPPK VPRTPPGEEV AEPQAAGGGQ KKGDKTPGGG 

        70         80         90        100        110        120 
GANLKDDRSR LLRDLRVDTK SRAAWTRLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS 


MSGLGC 

« Hide

References

[1]"The characterization of ovine genes for atrial, brain, and C-type natriuretic peptides."
Aitken G.D., Raizis A.M., Yandle T.G., George P.M., Espiner E.A., Cameron V.A.
Domest. Anim. Endocrinol. 16:115-121(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF037467 Genomic DNA. Translation: AAB92261.1.
RefSeqNP_001009479.1. NM_001009479.1.
UniGeneOar.3302.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493773.

Organism-specific databases

CTD4880.

Phylogenomic databases

HOVERGENHBG004229.

Family and domain databases

InterProIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view]
PfamPF00212. ANP. 1 hit.
[Graphical view]
PRINTSPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameANFC_SHEEP
AccessionPrimary (citable) accession number: P56283
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families