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P56283

- ANFC_SHEEP

UniProt

P56283 - ANFC_SHEEP

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Protein

C-type natriuretic peptide

Gene

NPPC

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

  1. receptor binding Source: AgBase

GO - Biological processi

  1. cGMP biosynthetic process Source: UniProtKB
  2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
  3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
  4. ossification Source: UniProtKB-KW
  5. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  6. regulation of blood vessel size Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:NPPC
Synonyms:CNP
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 7350Sequence AnalysisPRO_0000001569Add
BLAST
Peptidei74 – 12653CNP-53By similarityPRO_0000001570Add
BLAST
Peptidei98 – 12629CNP-29By similarityPRO_0000001571Add
BLAST
Peptidei105 – 12622CNP-22PRO_0000001572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 126By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004229.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLSQLLACA LLLSLLSLRP SEAKPGAPPK VPRTPPGEEV AEPQAAGGGQ
60 70 80 90 100
KKGDKTPGGG GANLKDDRSR LLRDLRVDTK SRAAWTRLLH EHPNARKYKG
110 120
GNKKGLSKGC FGLKLDRIGS MSGLGC
Length:126
Mass (Da):13,317
Last modified:July 15, 1998 - v1
Checksum:i83C21B3C49A8F18B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037467 Genomic DNA. Translation: AAB92261.1.
RefSeqiNP_001009479.1. NM_001009479.1.
UniGeneiOar.3302.

Genome annotation databases

GeneIDi493773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037467 Genomic DNA. Translation: AAB92261.1 .
RefSeqi NP_001009479.1. NM_001009479.1.
UniGenei Oar.3302.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493773.

Organism-specific databases

CTDi 4880.

Phylogenomic databases

HOVERGENi HBG004229.

Family and domain databases

InterProi IPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
[Graphical view ]
Pfami PF00212. ANP. 1 hit.
[Graphical view ]
PRINTSi PR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTi SM00183. NAT_PEP. 1 hit.
[Graphical view ]
PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The characterization of ovine genes for atrial, brain, and C-type natriuretic peptides."
    Aitken G.D., Raizis A.M., Yandle T.G., George P.M., Espiner E.A., Cameron V.A.
    Domest. Anim. Endocrinol. 16:115-121(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiANFC_SHEEP
AccessioniPrimary (citable) accession number: P56283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3