Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56283

- ANFC_SHEEP

UniProt

P56283 - ANFC_SHEEP

Protein

C-type natriuretic peptide

Gene

NPPC

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 By similarity.By similarity

    GO - Molecular functioni

    1. receptor binding Source: AgBase

    GO - Biological processi

    1. cGMP biosynthetic process Source: UniProtKB
    2. growth plate cartilage chondrocyte differentiation Source: UniProtKB
    3. growth plate cartilage chondrocyte proliferation Source: UniProtKB
    4. ossification Source: UniProtKB-KW
    5. receptor guanylyl cyclase signaling pathway Source: UniProtKB
    6. regulation of blood vessel size Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hormone, Vasoactive

    Keywords - Biological processi

    Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type natriuretic peptide
    Cleaved into the following 3 chains:
    Gene namesi
    Name:NPPC
    Synonyms:CNP
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 7350Sequence AnalysisPRO_0000001569Add
    BLAST
    Peptidei74 – 12653CNP-53By similarityPRO_0000001570Add
    BLAST
    Peptidei98 – 12629CNP-29By similarityPRO_0000001571Add
    BLAST
    Peptidei105 – 12622CNP-22PRO_0000001572Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi110 ↔ 126By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the natriuretic peptide family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG004229.

    Family and domain databases

    InterProiIPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view]
    PfamiPF00212. ANP. 1 hit.
    [Graphical view]
    PRINTSiPR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTiSM00183. NAT_PEP. 1 hit.
    [Graphical view]
    PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLSQLLACA LLLSLLSLRP SEAKPGAPPK VPRTPPGEEV AEPQAAGGGQ    50
    KKGDKTPGGG GANLKDDRSR LLRDLRVDTK SRAAWTRLLH EHPNARKYKG 100
    GNKKGLSKGC FGLKLDRIGS MSGLGC 126
    Length:126
    Mass (Da):13,317
    Last modified:July 15, 1998 - v1
    Checksum:i83C21B3C49A8F18B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037467 Genomic DNA. Translation: AAB92261.1.
    RefSeqiNP_001009479.1. NM_001009479.1.
    UniGeneiOar.3302.

    Genome annotation databases

    GeneIDi493773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037467 Genomic DNA. Translation: AAB92261.1 .
    RefSeqi NP_001009479.1. NM_001009479.1.
    UniGenei Oar.3302.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493773.

    Organism-specific databases

    CTDi 4880.

    Phylogenomic databases

    HOVERGENi HBG004229.

    Family and domain databases

    InterProi IPR002406. C_natriurtcpep.
    IPR000663. Natr_peptide.
    [Graphical view ]
    Pfami PF00212. ANP. 1 hit.
    [Graphical view ]
    PRINTSi PR00713. CNATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTi SM00183. NAT_PEP. 1 hit.
    [Graphical view ]
    PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The characterization of ovine genes for atrial, brain, and C-type natriuretic peptides."
      Aitken G.D., Raizis A.M., Yandle T.G., George P.M., Espiner E.A., Cameron V.A.
      Domest. Anim. Endocrinol. 16:115-121(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiANFC_SHEEP
    AccessioniPrimary (citable) accession number: P56283
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3