ID   TCL1A_MOUSE             Reviewed;         116 AA.
AC   P56280;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   27-MAR-2024, entry version 148.
DE   RecName: Full=T-cell leukemia/lymphoma protein 1A;
DE   AltName: Full=Oncogene TCL-1;
DE            Short=Oncogene TCL1;
DE   AltName: Full=Protein p14 TCL1;
GN   Name=Tcl1a; Synonyms=Tcl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9285687; DOI=10.1038/sj.onc.1201246;
RA   Narducci M.G., Virgilio L., Engiles J.B., Buchberg A.M., Billips L.,
RA   Facchiano A., Croce C.M., Russo G., Rothstein J.L.;
RT   "The murine Tcl1 oncogene: embryonic and lymphoid cell expression.";
RL   Oncogene 15:919-926(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Egg;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=10716693; DOI=10.1073/pnas.97.7.3028;
RA   Pekarsky Y., Koval A., Hallas C., Bichi R., Tresini M., Malstrom S.,
RA   Russo G., Tsichlis P., Croce C.M.;
RT   "Tcl1 enhances Akt kinase activity and mediates its nuclear
RT   translocation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RX   PubMed=11679718; DOI=10.1107/s090744490101352x;
RA   Petock J.M., Torshin I.Y., Wang Y.-F., Du Bois G.C., Croce C.M.,
RA   Harrison R.W., Weber I.T.;
RT   "Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL
RT   oncogene family.";
RL   Acta Crystallogr. D 57:1545-1551(2001).
CC   -!- FUNCTION: Enhances the phosphorylation and activation of AKT1 and AKT2.
CC       Enhances cell proliferation, stabilizes mitochondrial membrane
CC       potential and promotes cell survival (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain).
CC       Interacts with PNPT1; the interaction has no effect on PNPT1
CC       exonuclease activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10716693}. Nucleus
CC       {ECO:0000269|PubMed:10716693}. Microsome {ECO:0000250}. Endoplasmic
CC       reticulum {ECO:0000250}. Note=Microsomal fraction. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCL1 family. {ECO:0000305}.
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DR   EMBL; AF031956; AAB87461.1; -; mRNA.
DR   EMBL; Y15376; CAA75599.1; -; mRNA.
DR   EMBL; BC052336; AAH52336.1; -; mRNA.
DR   CCDS; CCDS36549.1; -.
DR   RefSeq; NP_033363.1; NM_009337.3.
DR   PDB; 1JNP; X-ray; 2.50 A; A/B=1-116.
DR   PDBsum; 1JNP; -.
DR   AlphaFoldDB; P56280; -.
DR   SMR; P56280; -.
DR   BioGRID; 204023; 1.
DR   STRING; 10090.ENSMUSP00000098632; -.
DR   iPTMnet; P56280; -.
DR   PhosphoSitePlus; P56280; -.
DR   REPRODUCTION-2DPAGE; P56280; -.
DR   PaxDb; 10090-ENSMUSP00000036066; -.
DR   Antibodypedia; 65; 463 antibodies from 40 providers.
DR   DNASU; 21432; -.
DR   Ensembl; ENSMUST00000041316.15; ENSMUSP00000036066.9; ENSMUSG00000041359.15.
DR   GeneID; 21432; -.
DR   KEGG; mmu:21432; -.
DR   UCSC; uc007oyd.2; mouse.
DR   AGR; MGI:1097166; -.
DR   CTD; 21432; -.
DR   MGI; MGI:1097166; Tcl1.
DR   VEuPathDB; HostDB:ENSMUSG00000041359; -.
DR   eggNOG; ENOG502TDVJ; Eukaryota.
DR   GeneTree; ENSGT00390000006885; -.
DR   HOGENOM; CLU_168379_0_1_1; -.
DR   InParanoid; P56280; -.
DR   OMA; ILYHIKF; -.
DR   OrthoDB; 4568983at2759; -.
DR   PhylomeDB; P56280; -.
DR   TreeFam; TF337903; -.
DR   BioGRID-ORCS; 21432; 2 hits in 78 CRISPR screens.
DR   ChiTaRS; Tcl1; mouse.
DR   EvolutionaryTrace; P56280; -.
DR   PRO; PR:P56280; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; P56280; Protein.
DR   Bgee; ENSMUSG00000041359; Expressed in animal zygote and 18 other cell types or tissues.
DR   ExpressionAtlas; P56280; baseline and differential.
DR   GO; GO:0005938; C:cell cortex; IDA:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:1990917; C:ooplasm; IDA:MGI.
DR   GO; GO:0045120; C:pronucleus; IDA:MGI.
DR   GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; ISO:MGI.
DR   GO; GO:0032148; P:activation of protein kinase B activity; IMP:CACAO.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; ISO:MGI.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR   GO; GO:0010918; P:positive regulation of mitochondrial membrane potential; ISO:MGI.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR   GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISO:MGI.
DR   GO; GO:2000036; P:regulation of stem cell population maintenance; IGI:MGI.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI.
DR   Gene3D; 2.40.15.10; TCL1/MTCP1; 1.
DR   InterPro; IPR004832; TCL1_MTCP1.
DR   InterPro; IPR036672; TCL1_MTCP1_sf.
DR   PANTHER; PTHR14060; PROTEIN P13 MTCP-1; 1.
DR   PANTHER; PTHR14060:SF4; T-CELL LEUKEMIA_LYMPHOMA PROTEIN 1A; 1.
DR   Pfam; PF01840; TCL1_MTCP1; 1.
DR   SUPFAM; SSF50904; Oncogene products; 1.
DR   Genevisible; P56280; MM.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Endoplasmic reticulum; Microsome; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..116
FT                   /note="T-cell leukemia/lymphoma protein 1A"
FT                   /id="PRO_0000184489"
FT   STRAND          16..20
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          22..24
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          26..28
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          33..40
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          42..44
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          46..51
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   TURN            63..65
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          74..76
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          82..84
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          89..94
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          96..100
FT                   /evidence="ECO:0007829|PDB:1JNP"
FT   STRAND          102..107
FT                   /evidence="ECO:0007829|PDB:1JNP"
SQ   SEQUENCE   116 AA;  14112 MW;  46DEED2F973F389A CRC64;
     MATQRAHRAE TPAHPNRLWI WEKHVYLDEF RRSWLPVVIK SNEKFQVILR QEDVTLGEAM
     SPSQLVPYEL PLMWQLYPKD RYRSCDSMYW QILYHIKFRD VEDMLLELID SESNDE
//