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Protein

T-cell leukemia/lymphoma protein 1A

Gene

Tcl1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).By similarity

GO - Biological processi

  1. stem cell maintenance Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name:
Oncogene TCL1
Protein p14 TCL1
Gene namesi
Name:Tcl1a
Synonyms:Tcl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1097166. Tcl1.

Subcellular locationi

  1. Cytoplasm 1 Publication
  2. Nucleus 1 Publication
  3. Microsome By similarity
  4. Endoplasmic reticulum By similarity

  5. Note: Microsomal fraction.By similarity

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. endoplasmic reticulum Source: UniProtKB-SubCell
  3. nucleus Source: MGI
  4. pronucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116T-cell leukemia/lymphoma protein 1APRO_0000184489Add
BLAST

Proteomic databases

PRIDEiP56280.

2D gel databases

REPRODUCTION-2DPAGEP56280.

PTM databases

PhosphoSiteiP56280.

Expressioni

Gene expression databases

BgeeiP56280.
CleanExiMM_TCL1.
ExpressionAtlasiP56280. baseline and differential.
GenevestigatoriP56280.

Interactioni

Subunit structurei

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity (By similarity).By similarity

Protein-protein interaction databases

BioGridi204023. 1 interaction.
STRINGi10090.ENSMUSP00000098632.

Structurei

Secondary structure

1
116
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 205Combined sources
Beta strandi22 – 243Combined sources
Beta strandi26 – 283Combined sources
Beta strandi33 – 408Combined sources
Beta strandi42 – 443Combined sources
Beta strandi46 – 516Combined sources
Turni63 – 653Combined sources
Beta strandi74 – 763Combined sources
Beta strandi82 – 843Combined sources
Beta strandi89 – 946Combined sources
Beta strandi96 – 1005Combined sources
Beta strandi102 – 1076Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JNPX-ray2.50A/B1-116[»]
ProteinModelPortaliP56280.
SMRiP56280. Positions 8-108.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56280.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiNOG42423.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
InParanoidiP56280.
KOiK10167.
OMAiNQRTWLP.
OrthoDBiEOG7MD4S1.
PhylomeDBiP56280.
TreeFamiTF337903.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.

Sequencei

Sequence statusi: Complete.

P56280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQRAHRAE TPAHPNRLWI WEKHVYLDEF RRSWLPVVIK SNEKFQVILR
60 70 80 90 100
QEDVTLGEAM SPSQLVPYEL PLMWQLYPKD RYRSCDSMYW QILYHIKFRD
110
VEDMLLELID SESNDE
Length:116
Mass (Da):14,112
Last modified:July 15, 1998 - v1
Checksum:i46DEED2F973F389A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031956 mRNA. Translation: AAB87461.1.
Y15376 mRNA. Translation: CAA75599.1.
BC052336 mRNA. Translation: AAH52336.1.
CCDSiCCDS36549.1.
RefSeqiNP_033363.1. NM_009337.3.
UniGeneiMm.18154.

Genome annotation databases

EnsembliENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359.
GeneIDi21432.
KEGGimmu:21432.
UCSCiuc007oyd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031956 mRNA. Translation: AAB87461.1.
Y15376 mRNA. Translation: CAA75599.1.
BC052336 mRNA. Translation: AAH52336.1.
CCDSiCCDS36549.1.
RefSeqiNP_033363.1. NM_009337.3.
UniGeneiMm.18154.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JNPX-ray2.50A/B1-116[»]
ProteinModelPortaliP56280.
SMRiP56280. Positions 8-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204023. 1 interaction.
STRINGi10090.ENSMUSP00000098632.

PTM databases

PhosphoSiteiP56280.

2D gel databases

REPRODUCTION-2DPAGEP56280.

Proteomic databases

PRIDEiP56280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359.
GeneIDi21432.
KEGGimmu:21432.
UCSCiuc007oyd.2. mouse.

Organism-specific databases

CTDi21432.
MGIiMGI:1097166. Tcl1.

Phylogenomic databases

eggNOGiNOG42423.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
InParanoidiP56280.
KOiK10167.
OMAiNQRTWLP.
OrthoDBiEOG7MD4S1.
PhylomeDBiP56280.
TreeFamiTF337903.

Miscellaneous databases

EvolutionaryTraceiP56280.
NextBioi300772.
PROiP56280.
SOURCEiSearch...

Gene expression databases

BgeeiP56280.
CleanExiMM_TCL1.
ExpressionAtlasiP56280. baseline and differential.
GenevestigatoriP56280.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.
  3. Cited for: SUBCELLULAR LOCATION.
  4. "Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family."
    Petock J.M., Torshin I.Y., Wang Y.-F., Du Bois G.C., Croce C.M., Harrison R.W., Weber I.T.
    Acta Crystallogr. D 57:1545-1551(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Entry informationi

Entry nameiTCL1A_MOUSE
AccessioniPrimary (citable) accession number: P56280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: January 7, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.