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P56280

- TCL1A_MOUSE

UniProt

P56280 - TCL1A_MOUSE

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Protein

T-cell leukemia/lymphoma protein 1A

Gene
Tcl1a, Tcl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival By similarity.

GO - Biological processi

  1. stem cell maintenance Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name:
Oncogene TCL1
Protein p14 TCL1
Gene namesi
Name:Tcl1a
Synonyms:Tcl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1097166. Tcl1.

Subcellular locationi

Cytoplasm. Nucleus. Microsome By similarity. Endoplasmic reticulum By similarity
Note: Microsomal fraction By similarity.1 Publication

GO - Cellular componenti

  1. cell cortex Source: MGI
  2. endoplasmic reticulum Source: UniProtKB-SubCell
  3. nucleus Source: MGI
  4. pronucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116T-cell leukemia/lymphoma protein 1APRO_0000184489Add
BLAST

Proteomic databases

PRIDEiP56280.

2D gel databases

REPRODUCTION-2DPAGEP56280.

PTM databases

PhosphoSiteiP56280.

Expressioni

Gene expression databases

BgeeiP56280.
CleanExiMM_TCL1.
GenevestigatoriP56280.

Interactioni

Subunit structurei

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098632.

Structurei

Secondary structure

1
116
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 205
Beta strandi22 – 243
Beta strandi26 – 283
Beta strandi33 – 408
Beta strandi42 – 443
Beta strandi46 – 516
Turni63 – 653
Beta strandi74 – 763
Beta strandi82 – 843
Beta strandi89 – 946
Beta strandi96 – 1005
Beta strandi102 – 1076

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JNPX-ray2.50A/B1-116[»]
ProteinModelPortaliP56280.
SMRiP56280. Positions 8-108.

Miscellaneous databases

EvolutionaryTraceiP56280.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.

Phylogenomic databases

eggNOGiNOG42423.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
KOiK10167.
OMAiNQRTWLP.
OrthoDBiEOG7MD4S1.
PhylomeDBiP56280.
TreeFamiTF337903.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.

Sequencei

Sequence statusi: Complete.

P56280-1 [UniParc]FASTAAdd to Basket

« Hide

MATQRAHRAE TPAHPNRLWI WEKHVYLDEF RRSWLPVVIK SNEKFQVILR    50
QEDVTLGEAM SPSQLVPYEL PLMWQLYPKD RYRSCDSMYW QILYHIKFRD 100
VEDMLLELID SESNDE 116
Length:116
Mass (Da):14,112
Last modified:July 15, 1998 - v1
Checksum:i46DEED2F973F389A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031956 mRNA. Translation: AAB87461.1.
Y15376 mRNA. Translation: CAA75599.1.
BC052336 mRNA. Translation: AAH52336.1.
CCDSiCCDS36549.1.
RefSeqiNP_033363.1. NM_009337.3.
UniGeneiMm.18154.

Genome annotation databases

EnsembliENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359.
GeneIDi21432.
KEGGimmu:21432.
UCSCiuc007oyd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031956 mRNA. Translation: AAB87461.1 .
Y15376 mRNA. Translation: CAA75599.1 .
BC052336 mRNA. Translation: AAH52336.1 .
CCDSi CCDS36549.1.
RefSeqi NP_033363.1. NM_009337.3.
UniGenei Mm.18154.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JNP X-ray 2.50 A/B 1-116 [» ]
ProteinModelPortali P56280.
SMRi P56280. Positions 8-108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000098632.

PTM databases

PhosphoSitei P56280.

2D gel databases

REPRODUCTION-2DPAGE P56280.

Proteomic databases

PRIDEi P56280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041316 ; ENSMUSP00000036066 ; ENSMUSG00000041359 .
GeneIDi 21432.
KEGGi mmu:21432.
UCSCi uc007oyd.2. mouse.

Organism-specific databases

CTDi 21432.
MGIi MGI:1097166. Tcl1.

Phylogenomic databases

eggNOGi NOG42423.
GeneTreei ENSGT00390000006885.
HOGENOMi HOG000037945.
HOVERGENi HBG052523.
KOi K10167.
OMAi NQRTWLP.
OrthoDBi EOG7MD4S1.
PhylomeDBi P56280.
TreeFami TF337903.

Miscellaneous databases

EvolutionaryTracei P56280.
NextBioi 300772.
PROi P56280.
SOURCEi Search...

Gene expression databases

Bgeei P56280.
CleanExi MM_TCL1.
Genevestigatori P56280.

Family and domain databases

Gene3Di 2.40.15.10. 1 hit.
InterProi IPR004832. TCL1_MTCP1.
[Graphical view ]
Pfami PF01840. TCL1_MTCP1. 1 hit.
[Graphical view ]
ProDomi PD015575. TCL1_MTCP1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50904. SSF50904. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.
  3. Cited for: SUBCELLULAR LOCATION.
  4. "Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family."
    Petock J.M., Torshin I.Y., Wang Y.-F., Du Bois G.C., Croce C.M., Harrison R.W., Weber I.T.
    Acta Crystallogr. D 57:1545-1551(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Entry informationi

Entry nameiTCL1A_MOUSE
AccessioniPrimary (citable) accession number: P56280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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