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P56280 (TCL1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name=Oncogene TCL1
Protein p14 TCL1
Gene names
Name:Tcl1a
Synonyms:Tcl1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival By similarity.

Subunit structure

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity By similarity.

Subcellular location

Cytoplasm. Nucleus. Microsome By similarity. Endoplasmic reticulum By similarity. Note: Microsomal fraction By similarity. Ref.3

Sequence similarities

Belongs to the TCL1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 116116T-cell leukemia/lymphoma protein 1A
PRO_0000184489

Secondary structure

......................... 116
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56280 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 46DEED2F973F389A

FASTA11614,112
        10         20         30         40         50         60 
MATQRAHRAE TPAHPNRLWI WEKHVYLDEF RRSWLPVVIK SNEKFQVILR QEDVTLGEAM 

        70         80         90        100        110 
SPSQLVPYEL PLMWQLYPKD RYRSCDSMYW QILYHIKFRD VEDMLLELID SESNDE 

« Hide

References

« Hide 'large scale' references
[1]"The murine Tcl1 oncogene: embryonic and lymphoid cell expression."
Narducci M.G., Virgilio L., Engiles J.B., Buchberg A.M., Billips L., Facchiano A., Croce C.M., Russo G., Rothstein J.L.
Oncogene 15:919-926(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Egg.
[3]"Tcl1 enhances Akt kinase activity and mediates its nuclear translocation."
Pekarsky Y., Koval A., Hallas C., Bichi R., Tresini M., Malstrom S., Russo G., Tsichlis P., Croce C.M.
Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[4]"Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family."
Petock J.M., Torshin I.Y., Wang Y.-F., Du Bois G.C., Croce C.M., Harrison R.W., Weber I.T.
Acta Crystallogr. D 57:1545-1551(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF031956 mRNA. Translation: AAB87461.1.
Y15376 mRNA. Translation: CAA75599.1.
BC052336 mRNA. Translation: AAH52336.1.
CCDSCCDS36549.1.
RefSeqNP_033363.1. NM_009337.3.
UniGeneMm.18154.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JNPX-ray2.50A/B1-116[»]
ProteinModelPortalP56280.
SMRP56280. Positions 8-108.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000098632.

PTM databases

PhosphoSiteP56280.

2D gel databases

REPRODUCTION-2DPAGEP56280.

Proteomic databases

PRIDEP56280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359.
GeneID21432.
KEGGmmu:21432.
UCSCuc007oyd.2. mouse.

Organism-specific databases

CTD21432.
MGIMGI:1097166. Tcl1.

Phylogenomic databases

eggNOGNOG42423.
GeneTreeENSGT00390000006885.
HOGENOMHOG000037945.
HOVERGENHBG052523.
KOK10167.
OMANQRTWLP.
OrthoDBEOG7MD4S1.
PhylomeDBP56280.
TreeFamTF337903.

Gene expression databases

BgeeP56280.
CleanExMM_TCL1.
GenevestigatorP56280.

Family and domain databases

Gene3D2.40.15.10. 1 hit.
InterProIPR004832. TCL1_MTCP1.
[Graphical view]
PfamPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50904. SSF50904. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP56280.
NextBio300772.
PROP56280.
SOURCESearch...

Entry information

Entry nameTCL1A_MOUSE
AccessionPrimary (citable) accession number: P56280
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot