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P56280

- TCL1A_MOUSE

UniProt

P56280 - TCL1A_MOUSE

Protein

T-cell leukemia/lymphoma protein 1A

Gene

Tcl1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival By similarity.By similarity

    GO - Biological processi

    1. stem cell maintenance Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell leukemia/lymphoma protein 1A
    Alternative name(s):
    Oncogene TCL-1
    Short name:
    Oncogene TCL1
    Protein p14 TCL1
    Gene namesi
    Name:Tcl1a
    Synonyms:Tcl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1097166. Tcl1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Microsome By similarity. Endoplasmic reticulum By similarity
    Note: Microsomal fraction.By similarity

    GO - Cellular componenti

    1. cell cortex Source: MGI
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. nucleus Source: MGI
    4. pronucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116T-cell leukemia/lymphoma protein 1APRO_0000184489Add
    BLAST

    Proteomic databases

    PRIDEiP56280.

    2D gel databases

    REPRODUCTION-2DPAGEP56280.

    PTM databases

    PhosphoSiteiP56280.

    Expressioni

    Gene expression databases

    BgeeiP56280.
    CleanExiMM_TCL1.
    GenevestigatoriP56280.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204023. 1 interaction.
    STRINGi10090.ENSMUSP00000098632.

    Structurei

    Secondary structure

    1
    116
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi16 – 205
    Beta strandi22 – 243
    Beta strandi26 – 283
    Beta strandi33 – 408
    Beta strandi42 – 443
    Beta strandi46 – 516
    Turni63 – 653
    Beta strandi74 – 763
    Beta strandi82 – 843
    Beta strandi89 – 946
    Beta strandi96 – 1005
    Beta strandi102 – 1076

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JNPX-ray2.50A/B1-116[»]
    ProteinModelPortaliP56280.
    SMRiP56280. Positions 8-108.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56280.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCL1 family.Curated

    Phylogenomic databases

    eggNOGiNOG42423.
    GeneTreeiENSGT00390000006885.
    HOGENOMiHOG000037945.
    HOVERGENiHBG052523.
    KOiK10167.
    OMAiNQRTWLP.
    OrthoDBiEOG7MD4S1.
    PhylomeDBiP56280.
    TreeFamiTF337903.

    Family and domain databases

    Gene3Di2.40.15.10. 1 hit.
    InterProiIPR004832. TCL1_MTCP1.
    [Graphical view]
    PfamiPF01840. TCL1_MTCP1. 1 hit.
    [Graphical view]
    ProDomiPD015575. TCL1_MTCP1. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50904. SSF50904. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATQRAHRAE TPAHPNRLWI WEKHVYLDEF RRSWLPVVIK SNEKFQVILR    50
    QEDVTLGEAM SPSQLVPYEL PLMWQLYPKD RYRSCDSMYW QILYHIKFRD 100
    VEDMLLELID SESNDE 116
    Length:116
    Mass (Da):14,112
    Last modified:July 15, 1998 - v1
    Checksum:i46DEED2F973F389A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031956 mRNA. Translation: AAB87461.1.
    Y15376 mRNA. Translation: CAA75599.1.
    BC052336 mRNA. Translation: AAH52336.1.
    CCDSiCCDS36549.1.
    RefSeqiNP_033363.1. NM_009337.3.
    UniGeneiMm.18154.

    Genome annotation databases

    EnsembliENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359.
    GeneIDi21432.
    KEGGimmu:21432.
    UCSCiuc007oyd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031956 mRNA. Translation: AAB87461.1 .
    Y15376 mRNA. Translation: CAA75599.1 .
    BC052336 mRNA. Translation: AAH52336.1 .
    CCDSi CCDS36549.1.
    RefSeqi NP_033363.1. NM_009337.3.
    UniGenei Mm.18154.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JNP X-ray 2.50 A/B 1-116 [» ]
    ProteinModelPortali P56280.
    SMRi P56280. Positions 8-108.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204023. 1 interaction.
    STRINGi 10090.ENSMUSP00000098632.

    PTM databases

    PhosphoSitei P56280.

    2D gel databases

    REPRODUCTION-2DPAGE P56280.

    Proteomic databases

    PRIDEi P56280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041316 ; ENSMUSP00000036066 ; ENSMUSG00000041359 .
    GeneIDi 21432.
    KEGGi mmu:21432.
    UCSCi uc007oyd.2. mouse.

    Organism-specific databases

    CTDi 21432.
    MGIi MGI:1097166. Tcl1.

    Phylogenomic databases

    eggNOGi NOG42423.
    GeneTreei ENSGT00390000006885.
    HOGENOMi HOG000037945.
    HOVERGENi HBG052523.
    KOi K10167.
    OMAi NQRTWLP.
    OrthoDBi EOG7MD4S1.
    PhylomeDBi P56280.
    TreeFami TF337903.

    Miscellaneous databases

    EvolutionaryTracei P56280.
    NextBioi 300772.
    PROi P56280.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56280.
    CleanExi MM_TCL1.
    Genevestigatori P56280.

    Family and domain databases

    Gene3Di 2.40.15.10. 1 hit.
    InterProi IPR004832. TCL1_MTCP1.
    [Graphical view ]
    Pfami PF01840. TCL1_MTCP1. 1 hit.
    [Graphical view ]
    ProDomi PD015575. TCL1_MTCP1. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50904. SSF50904. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg.
    3. Cited for: SUBCELLULAR LOCATION.
    4. "Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family."
      Petock J.M., Torshin I.Y., Wang Y.-F., Du Bois G.C., Croce C.M., Harrison R.W., Weber I.T.
      Acta Crystallogr. D 57:1545-1551(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

    Entry informationi

    Entry nameiTCL1A_MOUSE
    AccessioniPrimary (citable) accession number: P56280
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3