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Protein

T-cell leukemia/lymphoma protein 1A

Gene

TCL1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.4 Publications

GO - Biological processi

  • multicellular organism development Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

SIGNORiP56279.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name:
Oncogene TCL1
Protein p14 TCL1
Gene namesi
Name:TCL1A
Synonyms:TCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:11648. TCL1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1. 1 Publication1
Mutagenesisi30K → M: Slightly reduced binding to AKT2. 1 Publication1
Mutagenesisi36 – 38PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3. 1 Publication3
Mutagenesisi46Q → R: Slightly increased binding to AKT2. 1 Publication1
Mutagenesisi74I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1. 1 Publication1
Mutagenesisi106M → V: Slightly increased binding to AKT2. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8115.
MalaCardsiTCL1A.
OpenTargetsiENSG00000100721.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA36400.

Polymorphism and mutation databases

BioMutaiTCL1A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844881 – 114T-cell leukemia/lymphoma protein 1AAdd BLAST114

Proteomic databases

EPDiP56279.
MaxQBiP56279.
PaxDbiP56279.
PeptideAtlasiP56279.
PRIDEiP56279.

PTM databases

iPTMnetiP56279.
PhosphoSitePlusiP56279.

Expressioni

Tissue specificityi

Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

Gene expression databases

BgeeiENSG00000100721.
CleanExiHS_TCL1A.
ExpressionAtlasiP56279. baseline and differential.
GenevisibleiP56279. HS.

Organism-specific databases

HPAiCAB004045.
HPA016604.

Interactioni

Subunit structurei

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-749995,EBI-749995
AKT1B0LPE53EBI-749995,EBI-10175397
ALS2CR12Q96Q353EBI-749995,EBI-750451
CADPSA2RRN75EBI-749995,EBI-10179719
CALCOCO2Q131377EBI-749995,EBI-739580
CARD9Q9H2573EBI-749995,EBI-751319
CEP55D3DR373EBI-749995,EBI-10173536
CEP55Q53EZ43EBI-749995,EBI-747776
DKFZp451B226Q5HYH73EBI-749995,EBI-10173842
DNMT3AQ9Y6K13EBI-749995,EBI-923653
GOLGA2A0A0C4DGS54EBI-749995,EBI-11522202
GOLGA2Q083793EBI-749995,EBI-618309
LSM3P623103EBI-749995,EBI-348239
PRTFDC1Q9NRG15EBI-749995,EBI-739759
TCF4P158843EBI-749995,EBI-533224
TP53BP2Q13625-33EBI-749995,EBI-10175039
TRAF1Q130777EBI-749995,EBI-359224
TTC33Q6PID65EBI-749995,EBI-2555404
TXLNAP402223EBI-749995,EBI-359793
WDR47O949673EBI-749995,EBI-723239
WDYHV1Q96HA84EBI-749995,EBI-741158

Protein-protein interaction databases

BioGridi113783. 26 interactors.
DIPiDIP-60787N.
IntActiP56279. 27 interactors.
MINTiMINT-1454936.
STRINGi9606.ENSP00000385036.

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Beta strandi16 – 22Combined sources7
Beta strandi25 – 28Combined sources4
Beta strandi33 – 42Combined sources10
Turni43 – 45Combined sources3
Beta strandi46 – 53Combined sources8
Helixi64 – 67Combined sources4
Beta strandi74 – 78Combined sources5
Beta strandi84 – 86Combined sources3
Beta strandi91 – 100Combined sources10
Beta strandi103 – 111Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JSGX-ray2.50A1-114[»]
ProteinModelPortaliP56279.
SMRiP56279.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56279.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiENOG410JEFE. Eukaryota.
ENOG4111B9D. LUCA.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
InParanoidiP56279.
KOiK10167.
OMAiNQRTWLP.
OrthoDBiEOG091G0ZI2.
PhylomeDBiP56279.
TreeFamiTF337903.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.

Sequencei

Sequence statusi: Complete.

P56279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL
60 70 80 90 100
LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI
110
DGVEDMLLEL LPDD
Length:114
Mass (Da):13,460
Last modified:July 15, 1998 - v1
Checksum:i90D55ABC97C36D04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106M → V in CAG33077 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05371856V → I.Corresponds to variant rs17093294dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82240 mRNA. Translation: CAA57708.1.
CR456796 mRNA. Translation: CAG33077.1.
BC003574 mRNA. Translation: AAH03574.1.
BC005831 mRNA. Translation: AAH05831.1.
BC014024 mRNA. Translation: AAH14024.1.
CCDSiCCDS9941.1.
PIRiI38286.
RefSeqiNP_001092195.1. NM_001098725.1.
NP_068801.1. NM_021966.2.
XP_016877165.1. XM_017021676.1.
XP_016877166.1. XM_017021677.1.
UniGeneiHs.2484.

Genome annotation databases

EnsembliENST00000402399; ENSP00000385036; ENSG00000100721.
ENST00000554012; ENSP00000451506; ENSG00000100721.
ENST00000555202; ENSP00000450496; ENSG00000100721.
ENST00000556450; ENSP00000450701; ENSG00000100721.
GeneIDi8115.
KEGGihsa:8115.
UCSCiuc001yfb.5. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82240 mRNA. Translation: CAA57708.1.
CR456796 mRNA. Translation: CAG33077.1.
BC003574 mRNA. Translation: AAH03574.1.
BC005831 mRNA. Translation: AAH05831.1.
BC014024 mRNA. Translation: AAH14024.1.
CCDSiCCDS9941.1.
PIRiI38286.
RefSeqiNP_001092195.1. NM_001098725.1.
NP_068801.1. NM_021966.2.
XP_016877165.1. XM_017021676.1.
XP_016877166.1. XM_017021677.1.
UniGeneiHs.2484.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JSGX-ray2.50A1-114[»]
ProteinModelPortaliP56279.
SMRiP56279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113783. 26 interactors.
DIPiDIP-60787N.
IntActiP56279. 27 interactors.
MINTiMINT-1454936.
STRINGi9606.ENSP00000385036.

PTM databases

iPTMnetiP56279.
PhosphoSitePlusiP56279.

Polymorphism and mutation databases

BioMutaiTCL1A.

Proteomic databases

EPDiP56279.
MaxQBiP56279.
PaxDbiP56279.
PeptideAtlasiP56279.
PRIDEiP56279.

Protocols and materials databases

DNASUi8115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402399; ENSP00000385036; ENSG00000100721.
ENST00000554012; ENSP00000451506; ENSG00000100721.
ENST00000555202; ENSP00000450496; ENSG00000100721.
ENST00000556450; ENSP00000450701; ENSG00000100721.
GeneIDi8115.
KEGGihsa:8115.
UCSCiuc001yfb.5. human.

Organism-specific databases

CTDi8115.
DisGeNETi8115.
GeneCardsiTCL1A.
HGNCiHGNC:11648. TCL1A.
HPAiCAB004045.
HPA016604.
MalaCardsiTCL1A.
MIMi186960. gene.
neXtProtiNX_P56279.
OpenTargetsiENSG00000100721.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA36400.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEFE. Eukaryota.
ENOG4111B9D. LUCA.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
InParanoidiP56279.
KOiK10167.
OMAiNQRTWLP.
OrthoDBiEOG091G0ZI2.
PhylomeDBiP56279.
TreeFamiTF337903.

Enzyme and pathway databases

SIGNORiP56279.

Miscellaneous databases

ChiTaRSiTCL1A. human.
EvolutionaryTraceiP56279.
GeneWikiiTCL1A.
GenomeRNAii8115.
PROiP56279.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100721.
CleanExiHS_TCL1A.
ExpressionAtlasiP56279. baseline and differential.
GenevisibleiP56279. HS.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCL1A_HUMAN
AccessioniPrimary (citable) accession number: P56279
Secondary accession number(s): Q6IBK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.