T-cell leukemia/lymphoma protein 1A

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P56279 (TCL1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 120. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
T-cell leukemia/lymphoma protein 1A

Alternative name(s):
Oncogene TCL-1
Short name=Oncogene TCL1
Protein p14 TCL1

Gene names

Name:	TCL1A
Synonyms:	TCL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Ref.5 Ref.6 Ref.7 Ref.8
Subunit structure	Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Microsome. Endoplasmic reticulum. Note: Microsomal fraction. Ref.4
Tissue specificity	Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Involvement in disease	Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv₁₄(q11;q32) that involves the T-cell receptor alpha/delta loci.
Sequence similarities	Belongs to the TCL1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum Microsome Nucleus
Coding sequence diversity	Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Traceable author statement Ref.1. Source: ProtInc stem cell maintenance Inferred from electronic annotation. Source: Compara
Cellular_component	cell cortex Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell pronucleus Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 114

114

T-cell leukemia/lymphoma protein 1A

PRO_0000184488

Natural variations

Natural variant

V → I.
Corresponds to variant rs17093294 [ dbSNP | Ensembl ].

VAR_053718

Experimental info

Mutagenesis

D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1. Ref.8

Mutagenesis

K → M: Slightly reduced binding to AKT2. Ref.8

Mutagenesis

36 – 38

PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3. Ref.8

Mutagenesis

Q → R: Slightly increased binding to AKT2. Ref.8

Mutagenesis

I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1. Ref.8

Mutagenesis

106

M → V: Slightly increased binding to AKT2. Ref.8

Sequence conflict

106

M → V in CAG33077. Ref.2

Secondary structure

114

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P56279 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 90D55ABC97C36D04
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FASTA

114

13,460

        10         20         30         40         50         60 
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR 

        70         80         90        100        110 
PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the TCL1 gene involved in T-cell malignancies." Virgilio L., Narducci M.G., Isobe M., Billips L.G., Cooper M.D., Croce C.M., Russo G. Proc. Natl. Acad. Sci. U.S.A. 91:12530-12534(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell and Lymph.
[4]	"Characterization and localization of the TCL-1 oncogene product." Fu T.-B., Virgilio L., Narducci M.G., Facchiano A., Russo G., Croce C.M. Cancer Res. 54:6297-6301(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[5]	"The protooncogene TCL1 is an Akt kinase coactivator." Laine J., Kuenstle G., Obata T., Sha M., Noguchi M. Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
[6]	"Tcl1 enhances Akt kinase activity and mediates its nuclear translocation." Pekarsky Y., Koval A., Hallas C., Bichi R., Tresini M., Malstrom S., Russo G., Tsichlis P., Croce C.M. Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKT1.
[7]	"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family." Laine J., Kuenstle G., Obata T., Noguchi M. J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKT3.
[8]	"Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1." Kuenstle G., Laine J., Pierron G., Kagami S., Nakajima H., Hoh F., Roumestand C., Stern M.H., Noguchi M. Mol. Cell. Biol. 22:1513-1525(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKT1; AKT2 AND AKT3, MUTAGENESIS OF ASP-16; LYS-30; 36-PRO--THR-38; GLN-46; ILE-74 AND MET-106.
[9]	"The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity." French S.W., Dawson D.W., Chen H.-W., Rainey R.N., Sievers S.A., Balatoni C.E., Wong L., Troke J.J., Nguyen M.T.N., Koehler C.M., Teitell M.A. Cancer Lett. 248:198-210(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PNPT1.
[10]	"Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology." Hoh F., Yang Y.-S., Guignard L., Padilla A., Stern M.-H., Lhoste J.-M., van Tilbourgh H. Structure 6:147-155(1998) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X82240 mRNA. Translation: CAA57708.1.
CR456796 mRNA. Translation: CAG33077.1.
BC003574 mRNA. Translation: AAH03574.1.
BC005831 mRNA. Translation: AAH05831.1.
BC014024 mRNA. Translation: AAH14024.1.

IPI

IPI00178749.

PIR

I38286.

RefSeq

NP_001092195.1. NM_001098725.1.
NP_068801.1. NM_021966.2.

UniGene

Hs.2484.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JSG	X-ray	2.50	A	1-114	[»]

ProteinModelPortal

P56279.

ModBase

Search...

Protein-protein interaction databases

IntAct

P56279. 2 interactions.

MINT

MINT-1454936.

STRING

9606.ENSP00000216612.

PTM databases

PhosphoSite

P56279.

Polymorphism databases

DMDM

3024699.

Proteomic databases

PaxDb

P56279.

PRIDE

P56279.

Protocols and materials databases

DNASU

8115.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000402399; ENSP00000385036; ENSG00000100721.
ENST00000554012; ENSP00000451506; ENSG00000100721.
ENST00000555202; ENSP00000450496; ENSG00000100721.
ENST00000556450; ENSP00000450701; ENSG00000100721.

GeneID

8115.

KEGG

hsa:8115.

UCSC

uc001yfb.4. human.

Organism-specific databases

CTD

8115.

GeneCards

GC14M096177.

HGNC

HGNC:11648. TCL1A.

HPA

CAB004045.
HPA016604.

MIM

186960. gene.

neXtProt

NX_P56279.

PharmGKB

PA36400.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42423.

HOGENOM

HOG000037945.

HOVERGEN

HBG052523.

InParanoid

P56279.

K10167.

OMA

NQRTWLP.

OrthoDB

EOG444KMS.

PhylomeDB

P56279.

Gene expression databases

ArrayExpress

P56279.

Bgee

P56279.

CleanEx

HS_TCL1A.

Genevestigator

P56279.

GermOnline

ENSG00000100721. Homo sapiens.

Family and domain databases

Gene3D

2.40.15.10. 1 hit.

InterPro

IPR004832. TCL1_MTCP1.
[Graphical view]

Pfam

PF01840. TCL1_MTCP1. 1 hit.
[Graphical view]

ProDom

PD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF50904. TCL1_MTCP1. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P56279.

GenomeRNAi

8115.

NextBio

30770.

SOURCE

Search...

Entry information

Entry name

TCL1A_HUMAN

Accession

Primary (citable) accession number: P56279
Secondary accession number(s): Q6IBK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Natural variations

Experimental info

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents