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P56279

- TCL1A_HUMAN

UniProt

P56279 - TCL1A_HUMAN

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Protein

T-cell leukemia/lymphoma protein 1A

Gene
TCL1A, TCL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.4 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. stem cell maintenance Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name:
Oncogene TCL1
Protein p14 TCL1
Gene namesi
Name:TCL1A
Synonyms:TCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:11648. TCL1A.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Microsome. Endoplasmic reticulum
Note: Microsomal fraction.1 Publication

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. endoplasmic reticulum Source: UniProtKB-SubCell
  3. pronucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi16 – 161D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1. 1 Publication
Mutagenesisi30 – 301K → M: Slightly reduced binding to AKT2. 1 Publication
Mutagenesisi36 – 383PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3. 1 Publication
Mutagenesisi46 – 461Q → R: Slightly increased binding to AKT2. 1 Publication
Mutagenesisi74 – 741I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1. 1 Publication
Mutagenesisi106 – 1061M → V: Slightly increased binding to AKT2. 1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA36400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114T-cell leukemia/lymphoma protein 1APRO_0000184488Add
BLAST

Proteomic databases

MaxQBiP56279.
PaxDbiP56279.
PRIDEiP56279.

PTM databases

PhosphoSiteiP56279.

Expressioni

Tissue specificityi

Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

Gene expression databases

ArrayExpressiP56279.
BgeeiP56279.
CleanExiHS_TCL1A.
GenevestigatoriP56279.

Organism-specific databases

HPAiCAB004045.
HPA016604.

Interactioni

Subunit structurei

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.5 Publications

Protein-protein interaction databases

BioGridi113783. 11 interactions.
DIPiDIP-60787N.
IntActiP56279. 2 interactions.
MINTiMINT-1454936.
STRINGi9606.ENSP00000216612.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 103
Beta strandi16 – 227
Beta strandi25 – 284
Beta strandi33 – 4210
Turni43 – 453
Beta strandi46 – 538
Helixi64 – 674
Beta strandi74 – 785
Beta strandi84 – 863
Beta strandi91 – 10010
Beta strandi103 – 1119

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JSGX-ray2.50A1-114[»]
ProteinModelPortaliP56279.
SMRiP56279. Positions 4-114.

Miscellaneous databases

EvolutionaryTraceiP56279.

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.

Phylogenomic databases

eggNOGiNOG42423.
HOGENOMiHOG000037945.
HOVERGENiHBG052523.
InParanoidiP56279.
KOiK10167.
OMAiKITFATH.
OrthoDBiEOG7MD4S1.
PhylomeDBiP56279.
TreeFamiTF337903.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.

Sequencei

Sequence statusi: Complete.

P56279-1 [UniParc]FASTAAdd to Basket

« Hide

MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL    50
LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI 100
DGVEDMLLEL LPDD 114
Length:114
Mass (Da):13,460
Last modified:July 15, 1998 - v1
Checksum:i90D55ABC97C36D04
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561V → I.
Corresponds to variant rs17093294 [ dbSNP | Ensembl ].
VAR_053718

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061M → V in CAG33077. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82240 mRNA. Translation: CAA57708.1.
CR456796 mRNA. Translation: CAG33077.1.
BC003574 mRNA. Translation: AAH03574.1.
BC005831 mRNA. Translation: AAH05831.1.
BC014024 mRNA. Translation: AAH14024.1.
CCDSiCCDS9941.1.
PIRiI38286.
RefSeqiNP_001092195.1. NM_001098725.1.
NP_068801.1. NM_021966.2.
UniGeneiHs.2484.

Genome annotation databases

EnsembliENST00000402399; ENSP00000385036; ENSG00000100721.
ENST00000554012; ENSP00000451506; ENSG00000100721.
ENST00000555202; ENSP00000450496; ENSG00000100721.
ENST00000556450; ENSP00000450701; ENSG00000100721.
GeneIDi8115.
KEGGihsa:8115.
UCSCiuc001yfb.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82240 mRNA. Translation: CAA57708.1 .
CR456796 mRNA. Translation: CAG33077.1 .
BC003574 mRNA. Translation: AAH03574.1 .
BC005831 mRNA. Translation: AAH05831.1 .
BC014024 mRNA. Translation: AAH14024.1 .
CCDSi CCDS9941.1.
PIRi I38286.
RefSeqi NP_001092195.1. NM_001098725.1.
NP_068801.1. NM_021966.2.
UniGenei Hs.2484.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JSG X-ray 2.50 A 1-114 [» ]
ProteinModelPortali P56279.
SMRi P56279. Positions 4-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113783. 11 interactions.
DIPi DIP-60787N.
IntActi P56279. 2 interactions.
MINTi MINT-1454936.
STRINGi 9606.ENSP00000216612.

PTM databases

PhosphoSitei P56279.

Proteomic databases

MaxQBi P56279.
PaxDbi P56279.
PRIDEi P56279.

Protocols and materials databases

DNASUi 8115.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000402399 ; ENSP00000385036 ; ENSG00000100721 .
ENST00000554012 ; ENSP00000451506 ; ENSG00000100721 .
ENST00000555202 ; ENSP00000450496 ; ENSG00000100721 .
ENST00000556450 ; ENSP00000450701 ; ENSG00000100721 .
GeneIDi 8115.
KEGGi hsa:8115.
UCSCi uc001yfb.4. human.

Organism-specific databases

CTDi 8115.
GeneCardsi GC14M096177.
HGNCi HGNC:11648. TCL1A.
HPAi CAB004045.
HPA016604.
MIMi 186960. gene.
neXtProti NX_P56279.
Orphaneti 99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBi PA36400.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42423.
HOGENOMi HOG000037945.
HOVERGENi HBG052523.
InParanoidi P56279.
KOi K10167.
OMAi KITFATH.
OrthoDBi EOG7MD4S1.
PhylomeDBi P56279.
TreeFami TF337903.

Miscellaneous databases

EvolutionaryTracei P56279.
GeneWikii TCL1A.
GenomeRNAii 8115.
NextBioi 30770.
PROi P56279.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56279.
Bgeei P56279.
CleanExi HS_TCL1A.
Genevestigatori P56279.

Family and domain databases

Gene3Di 2.40.15.10. 1 hit.
InterProi IPR004832. TCL1_MTCP1.
[Graphical view ]
Pfami PF01840. TCL1_MTCP1. 1 hit.
[Graphical view ]
ProDomi PD015575. TCL1_MTCP1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50904. SSF50904. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell and Lymph.
  4. "Characterization and localization of the TCL-1 oncogene product."
    Fu T.-B., Virgilio L., Narducci M.G., Facchiano A., Russo G., Croce C.M.
    Cancer Res. 54:6297-6301(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
  5. "The protooncogene TCL1 is an Akt kinase coactivator."
    Laine J., Kuenstle G., Obata T., Sha M., Noguchi M.
    Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
  6. Cited for: FUNCTION, INTERACTION WITH AKT1.
  7. "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."
    Laine J., Kuenstle G., Obata T., Noguchi M.
    J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AKT3.
  8. "Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1."
    Kuenstle G., Laine J., Pierron G., Kagami S., Nakajima H., Hoh F., Roumestand C., Stern M.H., Noguchi M.
    Mol. Cell. Biol. 22:1513-1525(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AKT1; AKT2 AND AKT3, MUTAGENESIS OF ASP-16; LYS-30; 36-PRO--THR-38; GLN-46; ILE-74 AND MET-106.
  9. "The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity."
    French S.W., Dawson D.W., Chen H.-W., Rainey R.N., Sievers S.A., Balatoni C.E., Wong L., Troke J.J., Nguyen M.T.N., Koehler C.M., Teitell M.A.
    Cancer Lett. 248:198-210(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PNPT1.
  10. "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology."
    Hoh F., Yang Y.-S., Guignard L., Padilla A., Stern M.-H., Lhoste J.-M., van Tilbourgh H.
    Structure 6:147-155(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Entry informationi

Entry nameiTCL1A_HUMAN
AccessioniPrimary (citable) accession number: P56279
Secondary accession number(s): Q6IBK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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