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Reviewed, UniProtKB/Swiss-Prot P56279 (TCL1A_HUMAN)

Last modified November 25, 2008. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    T-cell leukemia/lymphoma protein 1A
Alternative name(s):
    Protein p14 TCL1
    Oncogene TCL1
      Short name=TCL-1
Gene names
Name: TCL1A
Synonyms: TCL1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Subunit structure

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.

Subcellular location

CytoplasmBy similarity. NucleusBy similarity. Microsome. Endoplasmic reticulum. Note= Microsomal fraction.

Tissue specificity

Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

Involvement in disease

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta locuses.

Sequence similarities

Belongs to the TCL1 family.

Ontologies

Keywords

   Cellular componentCytoplasm
Endoplasmic reticulum
Microsome
Nucleus
   Coding sequence diversityChromosomal rearrangement
   DiseaseProto-oncogene
   Technical term3D-structure

Gene Ontology (GO)

   Biological processmulticellular organismal development Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-KW

microsome

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 114114T-cell leukemia/lymphoma protein 1A
PRO_0000184488

Experimental info

Mutagenesis161D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1
Mutagenesis301K → M: Slightly reduced binding to AKT2
Mutagenesis36 – 383PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3
Mutagenesis461Q → R: Slightly increased binding to AKT2
Mutagenesis741I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1
Mutagenesis1061M → V: Slightly increased binding to AKT2
Sequence conflict1061M → V in CAG33077. Ref.2

Secondary structure

..................... 114
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56279-1 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 90D55ABC97C36D04

FASTA11413,460
        10         20         30         40         50         60 
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR 

        70         80         90        100        110 
PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the TCL1 gene involved in T-cell malignancies."
Virgilio L., Narducci M.G., Isobe M., Billips L.G., Cooper M.D., Croce C.M., Russo G.
Proc. Natl. Acad. Sci. U.S.A. 91:12530-12534(1994) [PubMed: 7809072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell and Lymph.
[4]"Characterization and localization of the TCL-1 oncogene product."
Fu T.-B., Virgilio L., Narducci M.G., Facchiano A., Russo G., Croce C.M.
Cancer Res. 54:6297-6301(1994) [PubMed: 7987816] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[5]"The protooncogene TCL1 is an Akt kinase coactivator."
Laine J., Kuenstle G., Obata T., Sha M., Noguchi M.
Mol. Cell 6:395-407(2000) [PubMed: 10983986] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
[6]"Tcl1 enhances Akt kinase activity and mediates its nuclear translocation."
Pekarsky Y., Koval A., Hallas C., Bichi R., Tresini M., Malstrom S., Russo G., Tsichlis P., Croce C.M.
Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000) [PubMed: 10716693] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT1.
[7]"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."
Laine J., Kuenstle G., Obata T., Noguchi M.
J. Biol. Chem. 277:3743-3751(2002) [PubMed: 11707444] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT3.
[8]"Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1."
Kuenstle G., Laine J., Pierron G., Kagami S., Nakajima H., Hoh F., Roumestand C., Stern M.H., Noguchi M.
Mol. Cell. Biol. 22:1513-1525(2002) [PubMed: 11839817] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT1; AKT2 AND AKT3, MUTAGENESIS OF ASP-16; LYS-30; 36-PRO--THR-38; GLN-46; ILE-74 AND MET-106.
[9]"The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity."
French S.W., Dawson D.W., Chen H.-W., Rainey R.N., Sievers S.A., Balatoni C.E., Wong L., Troke J.J., Nguyen M.T.N., Koehler C.M., Teitell M.A.
Cancer Lett. 248:198-210(2007) [PubMed: 16934922] [Abstract]
Cited for: INTERACTION WITH PNPT1.
[10]"Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology."
Hoh F., Yang Y.-S., Guignard L., Padilla A., Stern M.-H., Lhoste J.-M., van Tilbourgh H.
Structure 6:147-155(1998) [PubMed: 9519406] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

X82240 mRNA. Translation: CAA57708.1.
CR456796 mRNA. Translation: CAG33077.1.
BC003574 mRNA. Translation: AAH03574.1.
BC005831 mRNA. Translation: AAH05831.1.
BC014024 mRNA. Translation: AAH14024.1.
PIRI38286.
RefSeqNP_001092195.1.
NP_068801.1.
UniGeneHs.2484

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1JSGX-ray2.50A1-114[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP56279.

PTM databases

PhosphoSiteP56279.

Genome annotation databases

EnsemblENSG00000100721. Homo sapiens. [Contig view]
GeneID8115.
KEGGhsa:8115.

Organism-specific databases

H-InvDBHIX0011943.
HGNCHGNC:11648. TCL1A.
HPACAB004045.
HPA016604.
MIM186960. gene.
Orphanet86872. T-cell large granular lymphocyte leukaemia.
PharmGKBPA36400.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP56279.
HOVERGENP56279.

Gene expression databases

ArrayExpressP56279.
CleanExHS_TCL1A.
GermOnlineENSG00000100721. Homo sapiens.

Family and domain databases

InterProIPR004832. TCL1_MTCP1.
[Graphical view]
Gene3DG3DSA:2.40.15.10. TCL1_MTCP1. 1 hit.
PfamPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

LinkHubP56279.
NextBio30770.
SOURCESearch...

Entry information

Entry nameTCL1A_HUMAN
AccessionPrimary (citable) accession number: P56279
Secondary accession number(s): Q6IBK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 25, 2008
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents