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P56279 (TCL1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name=Oncogene TCL1
Protein p14 TCL1
Gene names
Name:TCL1A
Synonyms:TCL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Ref.5 Ref.6 Ref.7 Ref.8

Subunit structure

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Microsome. Endoplasmic reticulum. Note: Microsomal fraction. Ref.4

Tissue specificity

Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

Involvement in disease

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv14(q11;q32) that involves the T-cell receptor alpha/delta loci.

Sequence similarities

Belongs to the TCL1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 114114T-cell leukemia/lymphoma protein 1A
PRO_0000184488

Natural variations

Natural variant561V → I.
Corresponds to variant rs17093294 [ dbSNP | Ensembl ].
VAR_053718

Experimental info

Mutagenesis161D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1. Ref.8
Mutagenesis301K → M: Slightly reduced binding to AKT2. Ref.8
Mutagenesis36 – 383PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3. Ref.8
Mutagenesis461Q → R: Slightly increased binding to AKT2. Ref.8
Mutagenesis741I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1. Ref.8
Mutagenesis1061M → V: Slightly increased binding to AKT2. Ref.8
Sequence conflict1061M → V in CAG33077. Ref.2

Secondary structure

..................... 114
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56279 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 90D55ABC97C36D04

FASTA11413,460
        10         20         30         40         50         60 
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR 

        70         80         90        100        110 
PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the TCL1 gene involved in T-cell malignancies."
Virgilio L., Narducci M.G., Isobe M., Billips L.G., Cooper M.D., Croce C.M., Russo G.
Proc. Natl. Acad. Sci. U.S.A. 91:12530-12534(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell and Lymph.
[4]"Characterization and localization of the TCL-1 oncogene product."
Fu T.-B., Virgilio L., Narducci M.G., Facchiano A., Russo G., Croce C.M.
Cancer Res. 54:6297-6301(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[5]"The protooncogene TCL1 is an Akt kinase coactivator."
Laine J., Kuenstle G., Obata T., Sha M., Noguchi M.
Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
[6]"Tcl1 enhances Akt kinase activity and mediates its nuclear translocation."
Pekarsky Y., Koval A., Hallas C., Bichi R., Tresini M., Malstrom S., Russo G., Tsichlis P., Croce C.M.
Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT1.
[7]"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."
Laine J., Kuenstle G., Obata T., Noguchi M.
J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT3.
[8]"Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1."
Kuenstle G., Laine J., Pierron G., Kagami S., Nakajima H., Hoh F., Roumestand C., Stern M.H., Noguchi M.
Mol. Cell. Biol. 22:1513-1525(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AKT1; AKT2 AND AKT3, MUTAGENESIS OF ASP-16; LYS-30; 36-PRO--THR-38; GLN-46; ILE-74 AND MET-106.
[9]"The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity."
French S.W., Dawson D.W., Chen H.-W., Rainey R.N., Sievers S.A., Balatoni C.E., Wong L., Troke J.J., Nguyen M.T.N., Koehler C.M., Teitell M.A.
Cancer Lett. 248:198-210(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PNPT1.
[10]"Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology."
Hoh F., Yang Y.-S., Guignard L., Padilla A., Stern M.-H., Lhoste J.-M., van Tilbourgh H.
Structure 6:147-155(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X82240 mRNA. Translation: CAA57708.1.
CR456796 mRNA. Translation: CAG33077.1.
BC003574 mRNA. Translation: AAH03574.1.
BC005831 mRNA. Translation: AAH05831.1.
BC014024 mRNA. Translation: AAH14024.1.
CCDSCCDS9941.1.
PIRI38286.
RefSeqNP_001092195.1. NM_001098725.1.
NP_068801.1. NM_021966.2.
UniGeneHs.2484.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JSGX-ray2.50A1-114[»]
ProteinModelPortalP56279.
SMRP56279. Positions 4-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113783. 11 interactions.
DIPDIP-60787N.
IntActP56279. 2 interactions.
MINTMINT-1454936.
STRING9606.ENSP00000216612.

PTM databases

PhosphoSiteP56279.

Proteomic databases

MaxQBP56279.
PaxDbP56279.
PRIDEP56279.

Protocols and materials databases

DNASU8115.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000402399; ENSP00000385036; ENSG00000100721.
ENST00000554012; ENSP00000451506; ENSG00000100721.
ENST00000555202; ENSP00000450496; ENSG00000100721.
ENST00000556450; ENSP00000450701; ENSG00000100721.
GeneID8115.
KEGGhsa:8115.
UCSCuc001yfb.4. human.

Organism-specific databases

CTD8115.
GeneCardsGC14M096177.
HGNCHGNC:11648. TCL1A.
HPACAB004045.
HPA016604.
MIM186960. gene.
neXtProtNX_P56279.
Orphanet99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBPA36400.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42423.
HOGENOMHOG000037945.
HOVERGENHBG052523.
InParanoidP56279.
KOK10167.
OMAKITFATH.
OrthoDBEOG7MD4S1.
PhylomeDBP56279.
TreeFamTF337903.

Gene expression databases

ArrayExpressP56279.
BgeeP56279.
CleanExHS_TCL1A.
GenevestigatorP56279.

Family and domain databases

Gene3D2.40.15.10. 1 hit.
InterProIPR004832. TCL1_MTCP1.
[Graphical view]
PfamPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50904. SSF50904. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP56279.
GeneWikiTCL1A.
GenomeRNAi8115.
NextBio30770.
PROP56279.
SOURCESearch...

Entry information

Entry nameTCL1A_HUMAN
AccessionPrimary (citable) accession number: P56279
Secondary accession number(s): Q6IBK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM